NCT02628509

Von Willebrand Factor As a Biological Sensor of Blood Flow in Percutaneous Cardiac Procedure

Onset and Offset of Von Willebrand Factor Multimemirization Defects in Cardiovascular Disease: the Case of the Molecular Sensor of Blood Flow

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 500 (estimated)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The WITAVI study was designed to explore the kinetic and associated outcome of Von Willebrand Factor-multimerizaton defects associated with devices in cardiovascular diseases.

Detailed description

This study was designed to understand the Von Willebrand Factor (VWF) abnormalities observed in association with implantation of different devices in cardiovascular diseases (percutaneous valve replacement and circulatory support devices). The main objective of the study was to describe the time-course of VWF abnormalities onset/offset during implantation of devices in cardiovascular diseases. Adult patients \> 18 years who need a CF-LVAD or trans-aortic valve implantation are included in this cohort; Blood samples are obtained just before procedures

Conditions

• Heart Failure
• Aortic Stenosis

Interventions

Type	Name	Description
DEVICE	cardiac devices	patients receiving mechanical circulatory support or undergoing trans aortic valve replacement

Timeline

• Start date: 2012-08-01
• Primary completion: 2017-12-01
• Completion: 2018-01-01
• First posted: 2015-12-11
• Last updated: 2017-02-09

Locations

1 site across 1 country: France