NCT01755936

The Role of Myocardial Fibrosis in Patients With Aortic Stenosis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 203 (actual)
• Sponsor: University of Edinburgh · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Aortic stenosis is the most common adult valvular heart disease in the western world. Heart failure and sudden cardiac death are complications associated with aortic stenosis. In symptomatic individuals, valve replacement is often the only effective treatment. However, there are no good markers to identify patients who may benefit from early surgery before symptoms developed. The purpose of the study is to test the hypothesis that the presence heart muscle scarring on the cardiac magnetic resonance imaging may predict a worse outcome in patients with aortic stenosis, and thus may be helpful in identifying patients for early valve replacement.

Detailed description

Congestive heart failure and sudden cardiac death are associated complications of aortic stenosis. Currently, the indications for valvular replacement are based on the valvular severity evaluated by echocardiography and the presence of symptoms. There is some evidence to suggest the presence of myocardial fibrosis is associated with a poor outcome in patients with aortic stenosis. The aim of this prospective study is to investigate the prognostic implications of myocardial fibrosis in patients with aortic stenosis. The presence of myocardial fibrosis will be identified by delayed enhancement with the cardiac magnetic resonance imaging at 3T. We will also be evaluating the application of T1 mapping techniques to detect diffuse myocardial fibrosis.

Conditions

• Aortic Stenosis

Interventions

Type	Name	Description
OTHER	Cardiac Magnetic Resonance Imaging	For the evaluation of left ventricular volumes, function and mass. Also for the assessment of myocardial fibrosis based on the presence of delayed enhancement. Novel application of T1 mapping techniques will be evaluated.
OTHER	Echocardiography	Assessment of aortic stenosis severity. Also evaluate diastolic and systolic function.
OTHER	72 hour Holter Monitor	This will enable us to detect abnormal heart rhythms which may be associated with myocardial fibrosis

Timeline

• Start date: 2012-01-01
• Primary completion: 2016-01-01
• Completion: 2017-08-01
• First posted: 2012-12-24
• Last updated: 2018-06-25

Locations

1 site across 1 country: United Kingdom