NCT04268160

GPx Activity in Subjects With Aortic Stenosis Undergoing TAVR

Glutathione Peroxidase Activity in Subjects With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.

• Status: Withdrawn
• Phase: —
• Study type: Observational
• Enrollment: 0 (actual)
• Sponsor: University of Florida · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The aim of this project is to investigate the association of glutathione peroxidase (GPx) and severe aortic stenosis (AS), as well as the impact of transcatheter aortic valve replacement (TAVR) on GPx activity post-procedure. The burden of oxidative stress will be determined by the measurement of GPx, superoxide dismutase (SOD) and lipoprotein A (Lp(a)). We hypothesize GPx activity is reduced in participants with severe AS vs control groups and GPx activity is to increase after TAVR is performed.

Conditions

• Glutathione Peroxidase Activity
• Aortic Stenosis
• Transcatheter Aortic Valve Replacement

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Blood draw to measure GPx activity	Routine blood draw to measure levels of blood markers.
DIAGNOSTIC_TEST	Blood draw to measure SOD activity	Routine blood draw to measure levels of blood markers.
DIAGNOSTIC_TEST	Blood draw to measure Lp(a) levels	Routine blood draw to measure levels of blood markers.

Timeline

• Start date: 2020-11-01
• Primary completion: 2021-06-15
• Completion: 2021-06-15
• First posted: 2020-02-13
• Last updated: 2021-06-30

Locations

1 site across 1 country: United States