NCT05614986

Prospective Evaluation of Neurocognition in Patients Undergoing Transcatheter Aortic Valve Replacement

Prospective Evaluation of Neurocognition in Patients Undergoing Transcatheter Aortic Valve Replacement: Periprocedural Changes and Predictors of Improvement

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 81 (actual)
• Sponsor: Baylor Research Institute · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This trail is for patients with mild cognitive impairment (MCI) who are receiving a transcatheter aortic valve replacement (TAVR). We will assess changes in neurocognition following TAVR with the 5 minute Montreal Cognitive Assessment (mini MoCA) when comparing pre procedure with post procedure assessments.

Detailed description

Patients with mild cognitive impairment who are being treated with a TAVR can choose to take part in this trial. This trial will prospectively enroll patients at 4 Baylor Scott \& White facilities. 80 patients will be enrolled between all sites. The mini MoCA will be conducted at the following time points: pre TAVR, 30 days post TAVR, and 6 months post TAVR. All other data will be collected from patient charts and are considered standard part of their care.

Conditions

• Mild Cognitive Impairment
• Aortic Stenosis

Interventions

Type	Name	Description
OTHER	5 minute Montreal Cognitive Assessment (mini MoCA)	The mini MoCA will be completed by the patient before TAVR, and 30 days and 6 months after TAVR

Timeline

• Start date: 2022-01-17
• Primary completion: 2023-10-02
• Completion: 2024-02-27
• First posted: 2022-11-14
• Last updated: 2026-01-27

Locations

4 sites across 1 country: United States