| Not Yet Recruiting | Under-Represented Communities Diagnosed With SCD or MCI Through Tele-Cog NCT06542458 | Ohio State University | — |
| Not Yet Recruiting | Gaze and Gait Training With rTMS NCT05864313 | University of Florida | N/A |
| Not Yet Recruiting | Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 2 NCT07485712 | Weill Medical College of Cornell University | N/A |
| Not Yet Recruiting | Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 1 NCT05811338 | Weill Medical College of Cornell University | N/A |
| Not Yet Recruiting | SleepSMART for Veterans With Insomnia and Mild Cognitive Impairment NCT07397182 | VA Office of Research and Development | N/A |
| Recruiting | EVASION: Effect of VisuAl Stimulation on attentION NCT05791994 | University Hospital, Angers | N/A |
| Not Yet Recruiting | Human Mesenchymal Stem Cells & Monoclonal Antibodies in the Treatment for Mild Cognitive Impairment or Early A NCT07512362 | Bernard (Barry) Baumel | Phase 2 |
| Not Yet Recruiting | Light and Sleep Fragmentation NCT06009289 | Stanford University | Phase 4 |
| Not Yet Recruiting | Improving Neurological Health With Acetylcholine Via Neuroplasticity-based Computerized Exercise in Mild Cogni NCT07243600 | Posit Science Corporation | N/A |
| Not Yet Recruiting | Center for Research and Education on Aging and Technology Enhancement - CREATE V - Project 3 NCT07485725 | Weill Medical College of Cornell University | N/A |
| Recruiting | PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairme NCT07169630 | National Institute of Mental Health (NIMH) | Phase 1 |
| Not Yet Recruiting | An Intervention to Reduce Discrepancy in Everyday Preferences NCT03577418 | Mclean Hospital | N/A |
| Not Yet Recruiting | Auditory Sleep Stimulation or Sham in People With Parkinson Disease Mild Cognitive Impairment During Cognitive NCT07441915 | University of Zurich | N/A |
| Not Yet Recruiting | Telehealth-Adapted Compensatory Training and Intervention for Cognition NCT07366346 | University of Florida | N/A |
| Not Yet Recruiting | Implementation of AIP Services for Older Adults With AD NCT07361601 | Northwestern University | — |
| Not Yet Recruiting | Evaluation of a Digital Neurorehabilitation Program Using Exergames for Adults With Mild Cognitive Impairment NCT07423260 | European University of Madrid | N/A |
| Recruiting | Feasibility and Adherence to a Technology-assisted Home-based Strength Training Program in Adults With Type 2 NCT07416799 | The University of Texas Medical Branch, Galveston | N/A |
| Not Yet Recruiting | Ketogenic Diet to Reduce Osteoarthritis Pain in MCI NCT07417891 | University of Kansas Medical Center | N/A |
| Not Yet Recruiting | The Brain Health PRO Online Risk Factor Reduction Study to Prevent Dementia NCT07364019 | University of British Columbia | N/A |
| Not Yet Recruiting | Dyadic Management Intervention in Older People With Co-occurring Cognitive Impairment and Diabetes as a Supple NCT07496359 | The Hong Kong Polytechnic University | N/A |
| Not Yet Recruiting | Use of Wearables for Identifying Factors Associated With Mild Cognitive Impairment and Early-Stage Alzheimer's NCT07391436 | Getúlio Vargas University Hospital | — |
| Recruiting | Sense4Safety Intervention NCT07220668 | University of Pennsylvania | Phase 1 / Phase 2 |
| Not Yet Recruiting | NeuroCare Community Project: A Community Based Prospective Observational Study for Early Alzheimer's Detection NCT07347574 | Hong Kong University of Science and Technology | — |
| Recruiting | Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive NCT07220694 | SF Research Institute, Inc. | N/A |
| Recruiting | CPAP vs MAD for OSA in Patients With Cognitive Impairment. A Randomized Clinical Trial NCT06983769 | National University Hospital, Singapore | N/A |
| Not Yet Recruiting | Glymphatic Function TMS Study NCT07192913 | University of Arizona | Phase 2 |
| Not Yet Recruiting | Epileptic Hippocampus in Alzheimer's Disease NCT05899764 | University of California, Los Angeles | Phase 1 / Phase 2 |
| Completed | Health Benefits of Nutraceutical Supplementation in Older Adults. NCT07534878 | GPLIFE HEALTHCARE PRIVATE LIMITED | Phase 4 |
| Recruiting | The Use of Rhythmic Light Therapy in Mild Cognitive Impairment NCT07318038 | Icahn School of Medicine at Mount Sinai | N/A |
| Recruiting | GAMES Intervention in MCI (Mild Cognitive Impairment) NCT07296133 | Emory University | N/A |
| Recruiting | Impact of a Multicomponent Exercise Program on Cognitive and Functional Outcomes in Patients With Mild Cogniti NCT07334392 | University of Patras | N/A |
| Withdrawn | The DURATION Study: reDUcing sedentaRy behAviour to Maintain cogniTIve functiON. NCT04323423 | Western University, Canada | N/A |
| Recruiting | Prediction of Cognitive Test Performance Using AI-Based Analysis of Narrative Speech NCT07511270 | Chang Gung Memorial Hospital | N/A |
| Recruiting | Neuclare Device for Temporary Improvement of Executive Function in Patients With Mild Cognitive Impairment and NCT07239310 | Deepsonbio | N/A |
| Recruiting | Comparison of High-Intensity Interval Training and Moderate-Intensity Continuous Training in Mild Cognitive Im NCT07248709 | Riphah International University | N/A |
| Not Yet Recruiting | Sensory Enrichment Using Aromatherapy for Neurobehavioral and Psychological Symptoms in Early Dementia NCT07234357 | National Cancer Centre, Singapore | N/A |
| Recruiting | Evaluation of Cerogrin for Auricular Vagus Nerve Stimulation in Vascular Dementia or Vascular Mild Cognitive I NCT07149038 | Neurogrin Inc. | N/A |
| Recruiting | Effects of Transcranial Ultrasound Stimulation (TUS) on Neurological and Cognitive Outcomes in Neurodegenerati NCT07207122 | Sanmai Technologies PBC dba Sanmai | N/A |
| Recruiting | GLP-1/GCG Dual Agonist in Type 2 Diabetes With Early Dementia (LIGHT-COG Study) NCT07083154 | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | Phase 3 |
| Completed | Arts-based Social Prescribing for Mental Health NCT07137572 | KAVADIA ELENI | N/A |
| Not Yet Recruiting | Telerehabilitation of Balance Clinical and Economic Decision Support System NCT06534164 | University College, London | N/A |
| Not Yet Recruiting | Comfortage - AD Prevention Strategies NCT06896201 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Not Yet Recruiting | 2-Hydroxybenzylamine (2-HOBA) Study in Early Alzheimer's Patients NCT06432166 | MTI Biotech Inc | Phase 1 / Phase 2 |
| Not Yet Recruiting | Neuromodulation and FMRI in Neurodegenerative Diseases Study NCT06873750 | Sunnybrook Health Sciences Centre | N/A |
| Recruiting | The Efficacy and Safety of Metformin Intervention in Elderly Overweight or Obesity With Mild Cognitive Impairm NCT07395960 | Fudan University | Phase 1 / Phase 2 |
| Recruiting | BID LTM Digital Intervention in Aging NCT06916221 | University of California, San Francisco | N/A |
| Not Yet Recruiting | Community-based Multi-domain Intervention to Detect and Delay Cognitive Decline in Community-dwelling Older Ad NCT07099040 | Singapore General Hospital | N/A |
| Recruiting | Olfactory Training in Mild Cognitive Impairment NCT06825403 | Jeffrey Motter | N/A |
| Not Yet Recruiting | The Brain&Senses Study NCT06991816 | University of Campania Luigi Vanvitelli | — |
| Not Yet Recruiting | Improvement of Fish Oil in Obesity With Mild Cognitive Impairment NCT06992726 | Weiwei Ma | Phase 4 |
| Recruiting | Locomotion Adaptation Deficits in Older Adults With Mild Cognitive Impairment and Alzheimers Disease NCT06484244 | Emory University | N/A |
| Recruiting | Voice Technology-Based Self-Management Intervention NCT06982261 | Emory University | N/A |
| Recruiting | Dementia-friendly Apothecaries as a Resource for Mental Heath in the Elderly NCT07504965 | Ludwig-Maximilians - University of Munich | — |
| Not Yet Recruiting | The COMFORTage Project at Ace Alzheimer Center Barcelona NCT07031167 | Fundació ACE Institut Català de Neurociències Aplicades | N/A |
| Recruiting | Spatial Memory Training and Cognitive Function NCT07002996 | Douglas Mental Health University Institute | N/A |
| Not Yet Recruiting | Developing a Nonpharmacological Pain Intervention for Community-dwelling Older Adults With Dementia NCT06264362 | Drexel University | N/A |
| Recruiting | Ultralow Dose PET Imaging of 18F-Florbetapir, 18F-Flutemetamol NCT07012993 | Akiva Mintz | Phase 2 |
| Recruiting | Preventing Falls in Older Adults With Cognitive Frailty NCT06854731 | University of British Columbia | N/A |
| Recruiting | VR Pupillometry in Cognitive Impairment NCT07402356 | Max-Planck-Institute of Psychiatry | — |
| Withdrawn | SNIFF - 3-Week Aptar CPS Device NCT05006599 | Wake Forest University Health Sciences | Phase 2 |
| Not Yet Recruiting | Personalized Medicine in the Elderly With Vision Impairment and Mild Cognitive Impairment NCT06942728 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Recruiting | Comparison of the Effects of Bimanual, Finger and VR Exercises in PwMCI NCT06935812 | Eastern Mediterranean University | N/A |
| Recruiting | TREAD: Time Restricted Eating Intervention for Alzheimer's Disease NCT06548191 | University of California, San Diego | Phase 1 |
| Recruiting | Effects of Shuttle Balance Training on Balance , Gait and Postural Control in Children With Mild Cognitive Imp NCT06974890 | Riphah International University | N/A |
| Recruiting | A Socio-Technological Intervention in Community-Based Healthcare for Individuals With Mild Cognitive Impairmen NCT06984367 | Istituto Nazionale di Ricovero e Cura per Anziani | N/A |
| Recruiting | Combined STN and NBM Deep Brain Stimulation for Mild Cognitive Impairment in Parkinson's Disease NCT05968703 | Helen M. Bronte-Stewart | N/A |
| Recruiting | Observation of Inhalation of CXMCI-01 Essential Oil on Patients With Mild Cognitive Impairment NCT06902181 | China Medical University Hospital | N/A |
| Not Yet Recruiting | Monitoring of Brain Metabolites Using Proton and Deuterium MR Techniques NCT06705010 | Insel Gruppe AG, University Hospital Bern | N/A |
| Enrolling By Invitation | Software Validation Study-Cognitive Status Indicator NCT06809725 | Spark Neuro Inc. | N/A |
| Not Yet Recruiting | An Observational Study of Patients Living With Chronic Neurological Diseases NCT05796037 | Target PharmaSolutions, Inc. | — |
| Recruiting | Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-I NCT06897670 | Mayo Clinic | — |
| Not Yet Recruiting | Marker of Brain Insulin Resistance in AD Prognosis NCT06825663 | Central Hospital, Nancy, France | N/A |
| Recruiting | Screening for Anti-amyloid Treatment Eligibility Using Digital Cognition and Blood-based Biomarkers NCT07041450 | MoCA Clinic and Institute | — |
| Recruiting | A Study of NTRX-07 in Participants With Alzheimer's Disease NCT07058688 | NeuroTherapia, Inc. | Phase 2 |
| Recruiting | Race-Based Stress and Cognitive Training for MCI NCT06330844 | Rosalind Franklin University of Medicine and Science | N/A |
| Completed | Effects of Bidomain Cognitive and Aerobic Training on Cognitive Functioning in Mild Cognitive Impairment. NCT06867016 | Riphah International University | N/A |
| Recruiting | Korean Joint Registry for Alzheimer's Treatment and Diagnostics (JOY-ALZ) NCT06889818 | Ewha Womans University Mokdong Hospital | — |
| Recruiting | Five Lives MED to Improve Cognitive Function in Mild Cognitive Impairment NCT06598163 | SharpTx | N/A |
| Not Yet Recruiting | Navigating the Clinical Research Process for Mild Cognitive Impairment NCT06207903 | Power Life Sciences Inc. | — |
| Not Yet Recruiting | Phenserine on the Alzheimer's Treatment Horizon, Study 1 NCT06774261 | Helse Stavanger HF | Phase 1 |
| Recruiting | Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease NCT05904132 | Massachusetts General Hospital | N/A |
| Active Not Recruiting | You, Me and Nature Pilot Study NCT06451978 | Harmony Jiang | N/A |
| Recruiting | Online Interplay Between Deciding and Acting With Mild Cognitive Impairment NCT06493422 | University of Delaware | N/A |
| Enrolling By Invitation | Neurophysiological Benefits of Live Music for Early Alzheimer's Patients and Their Caregivers NCT06940687 | Yale University | N/A |
| Not Yet Recruiting | Exploring Feasibility, Acceptability and Impact of Using Neurofeedback with Persons with Mild Cognitive Impair NCT06762522 | Queen's University | N/A |
| Completed | The Effects of a Line Dance Program on Cognitive Function, Physical Function, and Quality of Life in Older Adu NCT07058844 | Wanyu Shu | N/A |
| Recruiting | Healthy Aging as Black Adults, In It Together: a Comparative Effectiveness Study of Chronic Pain and Cognitive NCT06246929 | Massachusetts General Hospital | N/A |
| Recruiting | Effectiveness of TeleVR App in Cognitive Decline and MCI Patients NCT06793735 | IRCCS Centro Neurolesi Bonino Pulejo | N/A |
| Recruiting | A Novel Multi-Modal Approach to Promote Functional Outcomes in Cognitively Frail Older Adults NCT07497334 | The Hong Kong Polytechnic University | N/A |
| Completed | A Digital Cognitive Behavioural Therapy for Insomnia Intervention in Mild Cognitive Impairment and Mild Dement NCT07363928 | University College Cork | N/A |
| Completed | Efficacy of Sublingual 5-MeO-DMT for Reducing Anxiety and Depression in MCI NCT06812221 | Biomind Labs Inc. | Phase 1 / Phase 2 |
| Completed | Investigating the Impact of Duration and Amount of Light on the Circadian System Response - Aim 3 NCT06595030 | Icahn School of Medicine at Mount Sinai | N/A |
| Withdrawn | Clinical Trial of AGB101 for Mild Cognitive Impairment NCT05986721 | AgeneBio | Phase 2 |
| Recruiting | Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Reme NCT06733714 | Universidade Federal do Rio de Janeiro | N/A |
| Not Yet Recruiting | Cognitive Integrated Motor Training (CM) to Improve Gait and Balance and Reduce Falls in Older Adults With Mil NCT06719297 | Kessler Foundation | N/A |
| Recruiting | Memory Enhancement Using Transcranial Alternating Current Stimulation NCT06202872 | Amsterdam UMC, location VUmc | N/A |
| Enrolling By Invitation | WAVE: AudioVisual Stimulation Enhances Cognitive, Mental and Physical Health in Elderly NCT06686563 | Maria Paço | N/A |
| Active Not Recruiting | Effect of Vitamin D and Folic Acid on Mild Cognitive Impairment NCT07486141 | Capital Medical University | N/A |
| Active Not Recruiting | Single-dose Ketamine Treatment to Improve Depression in Mild Cognitive Impairment NCT06069843 | Icahn School of Medicine at Mount Sinai | Phase 2 |
| Active Not Recruiting | The Effect of Combination of Mediterranean Diet and Oleocanthal in Patients with Mild Cognitive Impairment NCT06705738 | Aristotle University Of Thessaloniki | N/A |
| Active Not Recruiting | A Single-center, Self-controlled, Prospective Case Series Pilot Study to Assess the Effect of Lamivudine (3TC) NCT06519357 | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | Phase 2 |
| Recruiting | The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adul NCT06027554 | UConn Health | Phase 2 |
| Recruiting | Non-randomized Clinical Trial on Cognitive Stimulation With Virtual Reality in Patients With Mild Cognitive Im NCT06977815 | Badalona Serveis Assistencials | N/A |
| Enrolling By Invitation | The Effect of TPS on Cognitive Functions in Older Adults With MCI NCT06407141 | The University of Hong Kong | N/A |
| Withdrawn | Investigating Brain Insulin Resistance in Alzheimer Disease with IntraNasal Insulin : a Multimodal Neuroimagin NCT06391853 | Erasme University Hospital | N/A |
| Recruiting | Evaluation Study for the Chef Anchor 3.0 Program NCT06572748 | The University of Hong Kong | N/A |
| Not Yet Recruiting | Virtual Reality Cognitive Training for Older Adults With Mild Cognitive Impairment NCT06392412 | Da-Yeh University | N/A |
| Recruiting | Assessing Cognitive Decline at Home NCT06704971 | Stanford University | — |
| Recruiting | tDCS for Post-Stroke Cognitive Impairment NCT06516588 | University of Oklahoma | Phase 2 |
| Recruiting | Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and NCT06584357 | GAP Innovations, PBC | — |
| Completed | Neurobic Exercise Program on Cognitive Abilities NCT06601751 | Riphah International University | N/A |
| Completed | A Trial of Combined Subthreshold Depression in Older Adults With Mild Cognitive Impairment Participating in Ar NCT06706739 | Fujian Medical University | N/A |
| Not Yet Recruiting | Study on Ginkgo Biolba Extract Fifty and Mild Cognitive Impairment Associated With CSVD NCT06495476 | Beijing Tiantan Hospital | Phase 4 |
| Enrolling By Invitation | Integrating eSAGE With EHR Data Using Machine Learning for the Early Detection and Monitoring of Cognitive Imp NCT06017505 | Douglas Scharre | — |
| Recruiting | Effectiveness of Non-pharmacological Interventions for Dementia Prevention in Elderly Patients With Mild Cogni NCT06453746 | Gia Dinh People Hospital | N/A |
| Active Not Recruiting | Resistance Exercise Training in Individuals Aged 60 and Older With Mild Cognitive Impairment NCT06470568 | Universidad de La Frontera | N/A |
| Recruiting | Study to Understand Novel Biomarkers in Researching Dementia NCT06547099 | Washington University School of Medicine | — |
| Recruiting | LEADing Dementia End-of-Life Planning Conversations NCT05909189 | University of Utah | N/A |
| Completed | Deprescribing in Patients Living With Dementia With Caregiver and Provider Nudges NCT06347172 | Brigham and Women's Hospital | N/A |
| Not Yet Recruiting | Evaluation of Cognitive and Physical Training on MCI Elders NCT06572878 | Taipei Medical University | N/A |
| Recruiting | Efficacy of a Multicomponent Intervention on Cognitive Function for the Caregiver-patient Dyad NCT06408103 | Universidad de Santander | N/A |
| Recruiting | Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric) NCT06413173 | United States Naval Medical Center, San Diego | N/A |
| Recruiting | OTC Hearing Aid and MCI NCT06112860 | Northwestern University | N/A |
| Recruiting | A Feasiblity Study of Green Activity Program for People Living With Memory Challenges NCT06403345 | Indiana University | N/A |
| Enrolling By Invitation | Impact of Yoga on Cognitive Function NCT06434168 | Auburn University | N/A |
| Recruiting | Case-Finding for Neurocognitive Disorders in Pavia NCT06983119 | IRCCS National Neurological Institute "C. Mondino" Foundation | N/A |
| Not Yet Recruiting | RQC for the Prevention of Alzheimer's Disease and Retinal Amyloid-β NCT06470061 | Zaparackas and Knepper LTD | Phase 2 |
| Not Yet Recruiting | Dual-Task Training for People With Mild Cognitive Impairment and Mild Dementia NCT06348810 | Taipei Medical University | N/A |
| Active Not Recruiting | Effectiveness of Strength-based Intervention for Elderly With Dementia Living in the Community NCT07037550 | The University of Hong Kong | N/A |
| Recruiting | Multimodal Assesment of Alzheimer Patients NCT06448403 | Norwegian University of Science and Technology | — |
| Recruiting | Paper-Based and Smartphone-Based Memory Supports NCT06444841 | Baylor University | N/A |
| Completed | Binaural Beats and Cognitive Physical Dual-task Training for Enhancing Cognitive Function in Older Adults With NCT07110870 | Foundation University Islamabad | N/A |
| Recruiting | Novel Augmentation of DAOIB and Antioxidant for Early Dementia NCT06467539 | Chang Gung Memorial Hospital | Phase 2 |
| Recruiting | Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity NCT05655325 | Columbia University | N/A |
| Recruiting | Transcranial Magnetic Stimulation for MCI NCT05992831 | Medical University of South Carolina | N/A |
| Recruiting | Non-invasive Brain Stimulation for the Treatment of Mild Cognitive Impairment in Parkinson's Disease NCT06399731 | Amsterdam UMC | N/A |
| Recruiting | Evaluation of the Effects of a Nutritional Intervention of Ketogenic Medium-chain Triglycerides and B-vitamins NCT06347315 | Société des Produits Nestlé (SPN) | N/A |
| Recruiting | MCI Speech in Noise NCT06102486 | Dartmouth-Hitchcock Medical Center | — |
| Recruiting | Effects of Brain Training Games on Cognitive Function and Quality of Life in MCI NCT06437704 | Riphah International University | N/A |
| Recruiting | Multimodal Investigation of Neural Plasticity NCT06453980 | University of Michigan | N/A |
| Completed | ALIGN: Aligning Medications With What Matters Most (Demonstration) NCT06335953 | Johns Hopkins University | N/A |
| Not Yet Recruiting | The Feasibility and Effect of Digital Cognitive Training in Mild Cognitive Impairment NCT06399978 | Pernille Louise Kjeldsen | N/A |
| Not Yet Recruiting | Efficacy of Different Doses of Tai Chi Chuan on Cognitive Function in Persons With Mild Cognitive Impairment NCT06375720 | Lidian Chen | N/A |
| Completed | SCGs as a Proxy for Determining the Cognitive Status of Older Adults NCT06367231 | University of Alberta | — |
| Not Yet Recruiting | Effects of Tai Chi Chuan With Different Doses on Cognitive Function in Elderly Patients With Mild Cognitive Im NCT06372535 | Lidian Chen | N/A |
| Recruiting | Feasibility Study of Virtual Sail 3D in Cognitive Functions NCT06579378 | University of Cagliari | N/A |
| Recruiting | Effect of LEQEMBI on Cerebral and Retinal Amyloid in Mild Cognitive Impairment Due to Alzheimer's Disease NCT06400368 | NeuroVision Imaging | — |
| Completed | Effect of Perch Essence on Cognitive Function Status in Subjects With Mild Cognitive Impairment NCT07239635 | Taipei Medical University | N/A |
| Unknown | BreinZorg: Feasibility Study Into an Online Lifestyle Platform for MCI and SCD NCT06309758 | Radboud University Medical Center | N/A |
| Recruiting | Low-intensity Physical-cognitive Exercise and Cognitive Function NCT06201533 | Chiang Mai University | N/A |
| Completed | Effects of Henagliflozin on the Brain Function in T2DM Patients With Mild Cognitive Impairment: a Randomized, NCT06085703 | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | N/A |
| Recruiting | Effects of a Computerized Cognitive Stimulation Intervention Adapted to the Level of Cognitive Reserve NCT06279325 | Universidad de Zaragoza | N/A |
| Not Yet Recruiting | The Treatment of High Intensity Transcranial Current Stimulation for Alzheimer's Disease NCT06380725 | Anhui Provincial Hospital | N/A |
| Recruiting | Feasibility of Implementing Time-restricted Eating in Women With Mild Cognitive Impairment NCT05858008 | Julie Pendergast | N/A |
| Recruiting | Effects of a Computerised Cognitive Stimulation Versus Stimulating Leisure Activities NCT06058611 | Universidad de Zaragoza | N/A |
| Completed | Spanish Linguistic Validation, Validity and Reliability Test of Frail´BESTest in Elderly Institutionalized Fra NCT06438718 | Instituto de Investigación Sanitaria Aragón | — |
| Not Yet Recruiting | Cognitive Impairment Cohort Study of the Elderly Population in YuGarden NCT06325527 | Ruijin Hospital | — |
| Recruiting | A rTMS and Virtual Reality Based Cognitive Rehabilitation Program for MCI NCT06024473 | Central Arkansas Veterans Healthcare System | N/A |
| Recruiting | Neuromodulation of Memory in Aging NCT05460468 | Duke University | N/A |
| Not Yet Recruiting | Precision Probiotic Supplementation in Individuals With Mild Cognitive Impairment NCT06278688 | National Yang Ming Chiao Tung University | N/A |
| Unknown | Cognitive Remediation VR Tool for People With MCI: a Feasibility RCT NCT06270966 | University of Cagliari | N/A |
| Recruiting | Spatial Navigation for the Early Detection of Alzheimer's Disease. NCT06385951 | University Hospital, Ghent | N/A |
| Active Not Recruiting | Music Improvisation Training on Cognitive Function in Older Adults NCT06721390 | University of California, San Francisco | N/A |
| Not Yet Recruiting | Improving the Referral of Patients With Suspected Cognitive Impairment and Early Dementia NCT05890313 | Universidade do Porto | N/A |
| Recruiting | The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function NCT06335836 | The First Affiliated Hospital with Nanjing Medical University | — |
| Recruiting | bpMedManage: Digital Technology to Support Adherence to Hypertension Medications NCT06307574 | University of Arizona | N/A |
| Enrolling By Invitation | Extension to a Pivotal Study of Sensory Stimulation in Alzheimer's Disease (OLE Hope Study, CA-0015) NCT06245031 | Cognito Therapeutics, Inc. | N/A |
| Completed | Effects of Resisted Versus Balance Exercises on Cognitive And Motor Function In Patients With Mild Cognitive I NCT06308237 | Riphah International University | N/A |
| Completed | A Light Exposure Tracker Designed to Improve Circadian Rhythms - Aim 1 NCT06356337 | Icahn School of Medicine at Mount Sinai | N/A |
| Unknown | The Impact of 6-months of Resistance Training on Brain and Muscle Health in Older Adults With MCI NCT06252844 | Lithuanian Sports University | N/A |
| Completed | Cognitive Intervention With Go and Chess in Early and Subjective Cognitive Decline NCT06281652 | University of Milano Bicocca | N/A |
| Recruiting | Thinking About Memory: How Confident Are You in Your Memory, and Does it Change With Age? NCT06539403 | King's College London | — |
| Completed | Association of Perceived Occupational Performance and Satisfaction, Balance, Gait, and Fear of Falling in Olde NCT06513325 | Gulhane School of Medicine | — |
| Recruiting | COMMETS- Combination MCI Metabolic Syndrome NCT06072963 | Rutgers, The State University of New Jersey | Phase 2 |
| Unknown | Noninvasive Temporal Interference Stimulation: Modulating Associative Memory by Targeting Deep-brain Targets NCT05805215 | Masaryk University | N/A |
| Recruiting | CBD for Individuals at Risk for Alzheimer's Disease NCT05822362 | University of Colorado, Denver | Phase 2 |
| Recruiting | HOme-based Brain Monitoring With a GARment-EEG to Study Cognitive Decline in the Aging Population NCT06993207 | Bitbrain | — |
| Completed | Cognitive Therapy Software for Improving Cognitive Function for Patients With Mild Cognitive Impairment NCT06264557 | Rowan | N/A |
| Recruiting | Development of Pressure Sensor Based Dementia and Fall Prevention Program for Older Adults NCT06664229 | Sunmi Song | N/A |
| Unknown | Nurse-led Clinics Training Program on Mild Cognitive Impairment Patients NCT06198530 | Xuanwu Hospital, Beijing | N/A |
| Recruiting | CogT pSOPT Intervention Study NCT06005038 | Stanford University | Phase 1 |
| Recruiting | Working Memory and Physical Exercise Training in Patients With Mild Cognitive Impairment NCT05948930 | University of Maryland, Baltimore | N/A |
| Completed | ENHANCING PHYSICAL and COGNITIVE EFFICIENCY in INDIVIDUALS AT RISK of DEMENTIA USING WHOLE-BODY ELECTROMYOSTIM NCT06669598 | University of Molise | N/A |
| Completed | Effects of Thai Dance With Twenty-five Squares in Elderly With Mild Cognitive Impairment NCT06236646 | Chulalongkorn University | N/A |
| Recruiting | Wayfinding Intervention and Long-Term Memory NCT05625425 | University of California, San Francisco | N/A |
| Recruiting | Effectiveness of an ACT-Based Cognitive Intervention on Quality of Life and Cognitive Function in Elderly Resi NCT06753578 | Instituto de Investigación Marqués de Valdecilla | N/A |
| Completed | Evaluation of the Effectiveness and Safety of Transcranial Direct Current Stimulation in Combination With Nasa NCT07290686 | Medical University of Lodz | N/A |
| Completed | Effects of Olfactory Training on the Brain Function in T2DM Patients With Mild Cognitive Impairment NCT06327633 | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | N/A |
| Recruiting | Causal Effect of Coenzyme Q10 Nutrition and Cognitive Dysfunction in the Metabolic Storm (Hyperglycemia and Sa NCT06040905 | Chung Shan Medical University | N/A |
| Completed | Efficacy of MindAhead's Digital Behavioral Activation Therapy in Adults with MCI or Mild Dementia NCT06149013 | MindAhead UG | N/A |
| Recruiting | Memory Support System Feasibility Study NCT05999929 | Bruyère Health Research Institute. | N/A |
| Completed | Improving Sleep and AD Biomarkers NCT06029894 | Emory University | N/A |
| Terminated | Hearing Health for Korean American Older Adults With Mild Cognitive Impairment NCT06068933 | Johns Hopkins University | N/A |
| Completed | Effects Multimodal Mind and Body Approach for MCI NCT06814483 | Massachusetts General Hospital | Phase 1 |
| Unknown | Effects of Telerehabilitation on Brain Network Connectivity NCT06278818 | University of Pavia | N/A |
| Recruiting | Evaluating Novel Healthcare Approaches to Nurturing and Caring for Hospitalized Elders NCT05929703 | University of Michigan | N/A |
| Recruiting | Resistance Training to Individuals for Cognitive Impairment With Dementia NCT06185010 | University of Beira Interior | N/A |
| Active Not Recruiting | A Scalable Nutrition Adherence Intervention NCT06121986 | Florida State University | N/A |
| Unknown | Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey NCT06025877 | C2N Diagnostics | — |
| Recruiting | Improving Prognostic Confidence in Neurodegenerative Diseases Causing Dementia Using Peripheral Biomarkers and NCT06529744 | University Health Network, Toronto | — |
| Active Not Recruiting | Remote Game-based Exercise Program for Cognitive and Motor Function Improvement NCT05235113 | University of California, Los Angeles | N/A |
| Recruiting | Anxiety Sensitivity Treatment to Reduce Anxiety in Alzheimer's NCT05748613 | Florida State University | N/A |
| Active Not Recruiting | Eye Scanning for Safety Driving NCT06396273 | Loughborough University | — |
| Active Not Recruiting | rTMS in Older Adults With MCI and AUD NCT05896332 | Medical University of South Carolina | Phase 1 |
| Completed | Cognitive Stimulation Therapy and Olderly People With Mild Cognitive Impairment NCT06115785 | Ejdane Coskun | N/A |
| Completed | Development and Evaluation of Virtual Reality Experiences for Cognitive Stimulation at the Sociosanitary Cente NCT06155721 | Badalona Serveis Assistencials | N/A |
| Recruiting | Virtual Therapeutics for MCI NCT06079411 | Istituto Auxologico Italiano | N/A |
| Active Not Recruiting | Effectiveness and Cost-Effectiveness of Cognitive Stimulation Therapy - Spain (CST-ES) in People Living With D NCT06372002 | Instituto de Mayores y Servicios Sociales (IMSERSO) | N/A |
| Not Yet Recruiting | Multimodal Deep Learning for the Diagnosis and Assessment of Alzheimer's Disease NCT06081569 | First Hospital of China Medical University | — |
| Unknown | Brain Insulin Resistance in Mild Cognitive Impairment NCT06116188 | Turku University Hospital | — |
| Enrolling By Invitation | MR Elastography of Cognitive Impairment NCT06029114 | Mayo Clinic | — |
| Unknown | engAGE: Managing cognitivE decliNe throuGh Theatre Therapy, Artificial Intelligence and Social Robots drivEn I NCT06302686 | Istituto Nazionale di Ricovero e Cura per Anziani | N/A |
| Recruiting | COGNIFOOD-Changing the Carbohydrate/Fat-ratio to Prevent Cognitive Decline and Alzheimer Pathology: A Pilot St NCT06105320 | Karolinska University Hospital | N/A |
| Unknown | the Effects of Different Treatment Schemes on Cognitive Function of Patients With Idiopathic Membranous Nephro NCT06245707 | Beijing Friendship Hospital | N/A |
| Unknown | Randomized Clinical Trial of Donepezil for the Treatment of Mild Cognitive Impairment in Parkinson's Disease NCT05709301 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | Phase 2 |
| Unknown | Minds Navigating the Diagnosis of Mild Cognitive Impairment NCT05690243 | Tuscaloosa Research & Education Advancement Corporation | N/A |
| Recruiting | Impact of Intensive Computerized Cognitive Training NCT06130735 | Brigham and Women's Hospital | N/A |
| Enrolling By Invitation | Can (Optical Coherence Tomography) Pictures of the Retina Detect Alzheimer's Disease at Its Earliest Stages? NCT06023446 | University of California, Davis | — |
| Recruiting | Sleep Apnea, Neurocognitive Decline and Brain Imaging in Patients With Subjective or Mild Cognitive Impairment NCT06150352 | The University of Hong Kong | — |
| Recruiting | Engage for Late-Life Depression and Comorbid Executive Dysfunction NCT05356611 | University of Nevada, Las Vegas | N/A |
| Unknown | Effects of Multimodal Music Intervention on Mild Cognitive Impairment Elderly NCT06324227 | National Yang Ming Chiao Tung University | N/A |
| Enrolling By Invitation | An Intergenerational, Cognitively Enriched Intervention for MCI Patients and Their Children. NCT06221579 | University Ghent | N/A |
| Unknown | The Rapid Diagnosis of MCI and Depression in Patients Ages 60 and Over NCT06011681 | Miro Health | — |
| Completed | A Pilot Randomized Controlled Trial: CoINTEGRATE NCT05732285 | University of Michigan | N/A |
| Completed | Patient Priorities Care Among Persons Living With Mild Cognitive Impairment and Dementia NCT06001775 | Indiana University | N/A |
| Active Not Recruiting | Dual-task Exercise in People With Cognitive Impairment NCT06389812 | Loughborough University | N/A |
| Completed | Brain Health & the Microbiome NCT06039267 | George Washington University | — |
| Recruiting | Phase 2 - Rhythmic Light Therapy for Alzheimer's Disease Patients NCT05016219 | Icahn School of Medicine at Mount Sinai | N/A |
| Unknown | Effect of Menopause Hormone Therapy In Postmenopausal Women With CSVD And MCI NCT05982470 | Beijing Tiantan Hospital | Phase 2 |
| Terminated | Home-based tDCS in Frontotemporal Dementia or Alzheimer's Disease NCT05978804 | Johns Hopkins University | N/A |
| Recruiting | Brain Health Virtual Reality Study NCT06124339 | University of California, San Diego | N/A |
| Completed | Time Restricted Eating for Metabolic and Psychological Optimization NCT05997316 | University of North Carolina, Chapel Hill | N/A |
| Completed | Neurological Changes With a Memory Self-efficacy Training Protocol NCT04077320 | Western University, Canada | N/A |
| Not Yet Recruiting | iPACES v3 MCI NIA Protocol Copied for iPACES v4 PD NINDS NCT05810454 | iPACES LLC | N/A |
| Completed | Precision Medicine Approach for Early Dementia & Mild Cognitive Impairment NCT05894954 | Alzheimer's Prevention and Reversal Project, Inc. | Phase 3 |
| Recruiting | TabCAT Brain Health Assessment in Primary Care NCT06090578 | University of California, San Francisco | N/A |
| Unknown | MIND Diet and Cognitive Function in Adults With MCI NCT05975723 | Zhejiang University | N/A |
| Completed | Investigating Mild Cognitive Impairment in Patients And Controls With TD-fNIRS NCT05996575 | Kernel | — |
| Recruiting | A Study of Dual-task Exercise Training to Prevent Falls Among Older Adults With Mild Cognitive Impairment NCT05725668 | Oregon Research Institute | N/A |
| Completed | Effects of Cognitive-motor Training on Cognition, Depression and Daily Functioning in Patients With Mild Cogni NCT06313931 | Universidad de Zaragoza | N/A |
| Enrolling By Invitation | Assessing and Improving the Durability of Compensatory Cognitive Training for Older Veterans NCT05770479 | VA Office of Research and Development | N/A |
| Completed | The Effect of Vırtual Reality Application ın Elderly People With Mild Cognitive Impairment NCT06500650 | Saglik Bilimleri Universitesi | N/A |
| Recruiting | Improve New Learning and Memory in Individuals With Mild Cognitive Impairment NCT05396248 | Kessler Foundation | N/A |
| Active Not Recruiting | Effects of Yeast Beta-glucan on Cognitive Function in Patients With Mild Cognitive Impairment NCT06083350 | Xiaofan Xu | N/A |
| Completed | Validation of the MBI-C Scale in French NCT06516159 | University Hospital, Toulouse | — |
| Recruiting | A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses NCT05877196 | Arizona State University | N/A |
| Enrolling By Invitation | BioFINDER-Brown: Examination of Alzheimer's Disease Biomarkers NCT05457998 | Butler Hospital | — |
| Enrolling By Invitation | Alzheimer's Disease Neuroimaging Initiative 4 NCT05617014 | University of Southern California | — |
| Unknown | Digital Therapeutics Research on Efficiency About Mild Cognitive Impairment Study NCT05938426 | Emocog Inc. | N/A |
| Recruiting | SYNERGIC-2 Trial (SYNchronizing, Exercises and Remedies to GaIn Cognition@home) NCT05375513 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Not Yet Recruiting | Effects of tDCS on Cognition in MCI: A RCT NCT05584748 | Tung Wah College | N/A |
| Active Not Recruiting | Remote Technologies in Early Stages of Alzheimer's Disease NCT07521865 | University of Bern | — |
| Unknown | Intervention Effect of Yizhi Baduanjin on Patients With Mild Cognitive Impairment NCT05899777 | Shanghai University of Traditional Chinese Medicine | N/A |
| Recruiting | Comparison of Two Non-invasive Neuromodulation Techniques as Synergistic Therapy to Cognitive Stimulation in A NCT06467253 | Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente | N/A |
| Completed | A One-year Trajectory of Depression Status Changes in Older Adults With MCI and SD: a Longitudinal Cohort Stud NCT06308627 | Fujian Medical University | — |
| Completed | The Activation and Walking Speed of the Prefrontal Cortex of the Elderly Mild Cognitive Impairment During Dual NCT05885867 | Sahmyook University | — |
| Recruiting | Closed-Loop Brain Stimulation as a Potential Intervention for Cognitive Decline NCT05907343 | University of Texas at Austin | N/A |
| Completed | Shared Decision Making About Medication Use for People With Multiple Health Problems NCT05156073 | Johns Hopkins University | N/A |
| Recruiting | Shanghai Non-pharmacological Intervention for Mild Cognitive Impairment and Mild Alzheimer's Disease NCT05887674 | Ruijin Hospital | N/A |
| Recruiting | Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD NCT05881239 | Massachusetts General Hospital | — |
| Enrolling By Invitation | MIBG in Aging and Neurologic Disorders NCT05514106 | Mayo Clinic | Phase 4 |
| Terminated | Comprehensive Cognitive and Affective Intervention for Mild Cognitive Impairment (MCI) for Foreign-Born Arab A NCT05854290 | University of Michigan | N/A |
| Completed | Cognitive Outcomes of Brain Stimulation As a Later-in-Life Treatment NCT05564715 | University of Texas Southwestern Medical Center | N/A |
| Recruiting | Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease NCT06538311 | Massachusetts General Hospital | EARLY_Phase 1 |
| Recruiting | Optical Neuroimaging and Cognition NCT05460143 | University of Cambridge | — |
| Unknown | Protecting Alzheimer Caregivers Using Technology Through Staying Sharp NCT05260515 | Oregon Health and Science University | Phase 1 / Phase 2 |
| Recruiting | EfFect of Ablation of Persistent AtriaL Fibrillation on COgNitive Function in Individuals With Mild Cognitive NCT05790707 | Poitiers University Hospital | N/A |
| Recruiting | Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History NCT05446584 | University of Texas Southwestern Medical Center | Phase 2 |
| Completed | Sleep Disturbance in MCI: A Study of a Cognitive Behavioural Therapy Digital Intervention NCT05568381 | University of Sydney | N/A |
| Active Not Recruiting | Care Partner-Assisted Diabetes Self-Management Through Linking Continuous Glucose Monitoring With Mobile Healt NCT05601583 | NYU Langone Health | Phase 1 |
| Completed | Brain Health Together: A Live-Streaming Group-Based Digital Program NCT05818423 | University of California, San Francisco | N/A |
| Completed | Effectiveness and Cost-Effectiveness of Robot Therapy With the Paro Robot in People Living With Dementia NCT05884424 | Instituto de Mayores y Servicios Sociales (IMSERSO) | N/A |
| Completed | Dual-task Training for Function in MCI NCT04059705 | State University of New York at Buffalo | N/A |
| Active Not Recruiting | Virtual Reality and Computerized Cognitive Intervention for Mild Cognitive Impairment in Heart Failure NCT05601817 | Indiana University | N/A |
| Unknown | Effectiveness of an Intervention Using Observation/Action Therapy Among Patients With Mild Cognitive Impairmen NCT05934344 | Universidad Europea de Madrid | N/A |
| Completed | DIGITAL Biomarker: Blood Based Biomarkers in the Primary Care Setting for Alzheimer's Disease NCT05844488 | Indiana University | — |
| Unknown | E-health Enhanced Motor-cognitive Training for AED Discharged Older Adults With Cognitive Frailty NCT05750121 | The Hong Kong Polytechnic University | N/A |
| Recruiting | Developing an Artificial Intelligence System to Detect Cognitive Impairment NCT05794451 | University of Haifa | — |
| Recruiting | Innate Immunity Stimulation Via TLR9 in Early AD NCT05606341 | NYU Langone Health | Phase 1 |
| Unknown | Modulating Cortical Dynamics of Dual-task Standing in MCI NCT05680701 | Hebrew SeniorLife | N/A |
| Unknown | Prediction, Prevention, Predisposition: Applications in Neurology and Endocrinology NCT06227364 | IRCCS Centro Neurolesi Bonino Pulejo | — |
| Completed | Comparative Effects of a2 Skim Milk on Mild Cognitive Impairment in Older Adults NCT05741047 | a2 Milk Company Ltd. | N/A |
| Recruiting | Sleep Apnea and Cognitive Function in Subjects With Subjective or Mild Cognitive Impairment NCT06089096 | The University of Hong Kong | — |
| Terminated | Event-Related Potential (ERP) Components in Clinical Diagnosis NCT05673759 | Boston University | — |
| Recruiting | Cognitive Vulnerability to Stress in Individuals at Risk for Alzheimer's Disease NCT05795634 | Johns Hopkins University | N/A |
| Active Not Recruiting | Turkish Speech Analysis Development Study NCT05732519 | mihrimah ozturk | — |
| Completed | 7T MRI for Light Therapy in Patients With Mild Cognitive Impairment and Mild AD NCT05596994 | Icahn School of Medicine at Mount Sinai | N/A |
| Unknown | IHT for Mild Cognitive Impairment NCT05495087 | University of North Texas Health Science Center | N/A |
| Recruiting | Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND) NCT05565833 | University of Virginia | Phase 2 |
| Recruiting | Study of Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of NIO752 in Early Alzheimer's Disease Pa NCT05469360 | Novartis Pharmaceuticals | Phase 1 |
| Active Not Recruiting | PRogram to Improve Stress-levels and Enhance Memory NCT05845918 | Emory University | N/A |
| Recruiting | The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study NCT05574400 | University of Michigan | Phase 2 |
| Active Not Recruiting | Behavioral Change Following Alzheimer's Disease (AD) Biomarker Disclosure NCT05584241 | University of Michigan | N/A |
| Completed | Effects of Walkasins on Gait Speed of Individuals With Mild Cognitive Impairments NCT05723822 | RxFunction Inc. | N/A |
| Unknown | The Effects of Exercise on Synaptic Plasticity in Individuals With Mild Cognitive Impairment and in Healthy Ag NCT05663918 | McMaster University | N/A |
| Unknown | Stories in the Moment: Dance Program for People Living With Dementia NCT06221202 | DanceStream Projects | N/A |
| Recruiting | rTMS for Apathy Clinical Trial NCT05561205 | Sunnybrook Health Sciences Centre | N/A |
| Recruiting | Home Sleep Therapy for Older Adults With MCI NCT05771844 | Brain Electrophysiology Laboratory Company | N/A |
| Completed | Keeping on Course: A Communication-Focused Psychoeducational Program NCT05423912 | Emory University | N/A |
| Unknown | Computerized Cognitive Training to Protect Cognitive Function Among Hypertension Patients NCT05704270 | Beijing Anzhen Hospital | N/A |