NCT06325527

Cognitive Impairment Cohort Study of the Elderly Population in YuGarden

Shanghai Cognitive Impairment Study of the Elderly Population: YuGarden Cohort

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 1,872 (estimated)
• Sponsor: Ruijin Hospital · Academic / Other
• Sex: All
• Age: 60 Years – 85 Years
• Healthy volunteers: Accepted

Summary

The goal of this prospective observational research with an 8-year follow-up is to study the cognitive changes in the elderly in YuGarden community, Shanghai, China. The main questions it aims to answer are: * incidence of cognitive impairment in community (converting to mild cognitive impairment or Alzheimer's disease) * to build a predictive model for the progression of cognitive impairment

Detailed description

This study is a prospective observational study which involves a large sample cohort of the elderly aged 60 to 85 years in YuGarden community, Shanghai, China, with an 8-year follow-up. Demographic information, peripheral organs evaluation (facial expression, hearing, OCT angiography), cognitive tests (MMSE, ADL), biospecimen (peripheral blood, urine, feces, gingival crevicular fluid), speech information, neuroimaging (MRI, PET) and electroencephalogram (EEG) will be collected and analyzed. Follow-up visits will be conducted twice a year for 4 visits and each visit includes cognitive tests, biospecimen collection, speech test, MRI and EEG. The primary outcome is the incidence of cognitive impairment indicating people who convert to mild cognitive impairment (MCI) or Alzheimer's disease (AD). Furthermore, a predictive model for the progression of cognitive impairment will be constructed.

Conditions

• Alzheimer Disease
• Neurodegenerative Diseases
• Cognitive Impairment
• Mild Cognitive Impairment

Timeline

• Start date: 2024-04-01
• Primary completion: 2031-04-01
• Completion: 2031-06-01
• First posted: 2024-03-22
• Last updated: 2024-03-22

Locations

1 site across 1 country: China