| Not Yet Recruiting | Novel Technologies to Measure Vision-related Quality of Life NCT07489898 | Nisha Nixon | — |
| Not Yet Recruiting | Study on the Application of ¹⁸F-FCOB04, a MAO-B Targeted PET Imaging Agent, in Neurodegenerative Diseases NCT07470710 | Peking Union Medical College Hospital | EARLY_Phase 1 |
| Recruiting | Slowing Cognitive Decline in Alpha-synucleinopathies by Enhancing Physical Activity NCT07324330 | University Hospital, Bonn | N/A |
| Recruiting | Validation of the VIRADIA App for Neurological and Cognitive Diagnostics in Virtual Reality NCT07268079 | Gametherapy | — |
| Not Yet Recruiting | Clinical Research on Stem Cell Therapy for Parkinson's Disease NCT07232147 | Liaoning Medical Diagnosis and Treatment Technology Research and Development Co., Ltd. | Phase 1 |
| Active Not Recruiting | Decision-making, Ethical Consent, and Interactive Dialogue in Ongoing Neurocognitive Decline - DECISION NCT07514520 | Ludwig-Maximilians - University of Munich | — |
| Not Yet Recruiting | Establish the First International Database on Semi-quantitative Values Obtained in Scintigraphy With Datscan® NCT06828705 | Central Hospital, Nancy, France | — |
| Not Yet Recruiting | Slow-SPEED: Slowing Parkinson's Early Through Exercise Dosage NCT06993142 | Radboud University Medical Center | N/A |
| Recruiting | Saliva and Extracellular Vesicles for Neurodegenerative Diseases NCT06869135 | Fondazione Don Carlo Gnocchi Onlus | — |
| Recruiting | Sleep Disordered Breathing and Multimorbidity: The Xiangya SDB Cohort Study NCT06755840 | Xiangya Hospital of Central South University | — |
| Enrolling By Invitation | Simulation-informed Modelling and Personalized Evaluation (SIMPLE) in Ageing Populations NCT06572332 | Chinese University of Hong Kong | — |
| Completed | NAD+ Oral Supplement Pilot Intervention in Adult Females NCT06579209 | University of Rhode Island | N/A |
| Recruiting | A Phase 3 Study of NTLA-2001 in ATTRv-PN NCT06672237 | Intellia Therapeutics | Phase 3 |
| Recruiting | Neurodegenerative Diseases Progression Markers (MARKERS-NDD) NCT06596746 | Casa di Cura San Raffaele Cassino | — |
| Not Yet Recruiting | Multimodal Markers of Neurodegenerative Disorders at Presymptomatic Stages NCT06516016 | Paris Brain Institute (ICM) | — |
| Recruiting | A Low-Cost Balance Training Platform Using Augmented Reality in Neurorehabilitation: a Usability Study NCT06627387 | Hospital Universitari Vall d'Hebron Research Institute | N/A |
| Not Yet Recruiting | Cognitive Impairment Cohort Study of the Elderly Population in YuGarden NCT06325527 | Ruijin Hospital | — |
| Recruiting | Blood And Tears in Alzheimer's Disease NCT06567431 | Danish Dementia Research Centre | — |
| Unknown | The Clinical Impact of the Novel Alzheimer's Blood-based Biomarkers NCT06246019 | Hospital del Mar Research Institute (IMIM) | — |
| Recruiting | Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-Netherlands NCT06193252 | Radboud University Medical Center | N/A |
| Active Not Recruiting | AMX0035 and Progressive Supranuclear Palsy NCT06122662 | Amylyx Pharmaceuticals Inc. | Phase 2 / Phase 3 |
| Terminated | Continuation Study for Latozinemab NCT06111014 | Alector Inc. | Phase 3 |
| Enrolling By Invitation | Normal Chinese Lifespan Brain Charts Initiative (NCLBCI) NCT06643858 | Beijing Tiantan Hospital | — |
| Recruiting | Memory Deterioration in Alzheimer Disease NCT07118137 | Norwegian University of Science and Technology | — |
| Unknown | CSF1R PET Probe [18F]CSF-23 in Alzheimer's Disease Brain Imaging NCT06148233 | Huashan Hospital | N/A |
| Unknown | Single Arm Clinical Trial of Small Molecule Natural Flavonoid Compounds for Intervention in Neurodegenerative NCT05947409 | Mei Han | N/A |
| Recruiting | Allopregnanolone Regenerative Therapeutic for Mild Alzheimer's Disease NCT04838301 | University of Arizona | Phase 2 |
| Unknown | Randomized Control Trial of Small-Molecule Natural Flavonoids Intervention for Neurodegenerative Diseases NCT05947396 | Mei Han | N/A |
| Not Yet Recruiting | Clinical Effect of Acupuncture in Neurodegenerative Diseases on Traumatic Brain Injury Patients NCT05839132 | China Medical University Hospital | N/A |
| Withdrawn | Study to Assess the Efficacy of XPro1595 in Patients With Mild Cognitive Impairment With Biomarkers of Inflamm NCT05321498 | Inmune Bio, Inc. | Phase 2 |
| Recruiting | Study to Evaluate the Efficacy and Safety of ATNC-MDD V1(TMS With Cognitive Training) in Mild Alzheimer's Deme NCT06088121 | Advanced Technology & Communications | N/A |
| Recruiting | Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive NCT05741853 | University of Texas at Austin | N/A |
| Recruiting | Effects of Long Term Ventilation Support on the Quality of Life of ALS Patients and Their Families NCT05744310 | Haukeland University Hospital | N/A |
| Completed | Home-Based Exercise in Primary Progressive Aphasia (HEPPA) NCT06181500 | Montreal Heart Institute | N/A |
| Completed | A First Time in Human Study of SNP318 as a Treatment for Neurodegenerative Diseases Including Alzheimer's Dise NCT05792163 | SciNeuro | Phase 1 |
| Unknown | Longitudinal Tracking of Patients Diagnosed With Neurodegenerative Movement Disorders NCT05486806 | Brigham and Women's Hospital | — |
| Active Not Recruiting | A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZ NCT05738486 | Eli Lilly and Company | Phase 3 |
| Terminated | An Open-Label Extension of XPro1595 in Patients With Alzheimer's Disease NCT05522387 | Inmune Bio, Inc. | Phase 2 |
| Recruiting | Adherence to Long-term Exoskeleton Rehabilitation to Treat Lower Limb Weakness and / or Deficiencies in Adult NCT06538974 | Wandercraft | N/A |
| Active Not Recruiting | Development and Test of a Headset for BCI Until Obtaining an Efficient and Comfortable System That Can be Used NCT04380649 | Centre Hospitalier Universitaire de Nice | N/A |
| Recruiting | Home Exercise for Individuals with Neurodegenerative Disease NCT05443906 | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | N/A |
| Unknown | Tau And Connectomics In TES Study NCT05490576 | Macquarie University, Australia | Phase 1 |
| Withdrawn | Experimentation of a Personalized Physical Self-education Program at Home: Feasibility Study (PROSOL TELEKINEC NCT05597592 | Centre Hospitalier Universitaire de Nice | N/A |
| Recruiting | Characterization of the Serotonin 2A Receptor Selective PET Tracer [18F]MH.MZ in Patients With Neurodegenerati NCT05357612 | Vanderbilt University Medical Center | Phase 4 |
| Not Yet Recruiting | Cognitive Impairment Cohort Study of the Elderly Population in SheMountain NCT05667935 | Ruijin Hospital | — |
| Recruiting | Probiotics in Mild Alzheimer's Disease NCT06181513 | University of Nicosia | EARLY_Phase 1 |
| Completed | Using Neuroimaging to Early Diagnose Alzheimer's Disease Through Hippocampal Atrophy Assessment NCT06965816 | Centre Hospitalier de Saint-Denis | — |
| Unknown | Clinical Study of [18F] PM-PBB3 PET Imaging of Tau Protein in Neurodegenerative Diseases NCT06344845 | Peking Union Medical College Hospital | N/A |
| Recruiting | A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5 NCT05508789 | Eli Lilly and Company | Phase 3 |
| Completed | Investigating ProCare4Life Impact on Quality of Life of Elderly Subjects With Neurodegenerative Diseases NCT05538455 | Casa di Cura Privata del Policlinico SpA | N/A |
| Completed | The Role of Humanoid Robot in Neuropsychological Assessment and Cognitive Training. NCT05788133 | IRCCS Centro Neurolesi Bonino Pulejo | N/A |
| Completed | Extension of AOC 1001-CS1 (MARINA) Study in Adult Myotonic Dystrophy Type 1 (DM1) Patients NCT05479981 | Avidity Biosciences, Inc. | Phase 2 |
| Unknown | Role of Saffron and Chamomile in the Management of Parkinson's Disease NCT05696665 | Jinnah Postgraduate Medical Centre | N/A |
| Recruiting | Serotonin Release in Premotor and Motor PD NCT05516732 | University of Exeter | — |
| Recruiting | Molecular and Functional Imaging in Monogenic PD. NCT05518617 | University of Exeter | — |
| Completed | Assessing a Novel Virtual Environment That Assists With Activities of Daily Living NCT05418296 | mandy | N/A |
| Recruiting | Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Ribo NCT05245903 | Mclean Hospital | — |
| Recruiting | Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq) NCT05354622 | Boston Children's Hospital | — |
| Completed | HIFT in People With Parkinson's Disease NCT05482776 | University of Valencia | N/A |
| Unknown | Immunohistochemical Study of Neurodegenerative Diseases NCT05518409 | First Affiliated Hospital of Zhejiang University | N/A |
| Unknown | Clearance Mechanisms in Atypical Neurodegenerative Diseases NCT05317871 | Ludwig-Maximilians - University of Munich | — |
| Recruiting | Exploring the Recovery Function of Sleep in Neurodegeneration NCT05402488 | University of Zurich | N/A |
| Completed | Clinical Application of the Prototype J-PET Device NCT06211803 | Jagiellonian University | — |
| Recruiting | Shanghai At Risk for Alzheimer's Disease: a Cohort Study NCT05597410 | Ruijin Hospital | — |
| Completed | A Study of XPro1595 in Patients With Early Alzheimer's Disease With Biomarkers of Inflammation NCT05318976 | Inmune Bio, Inc. | Phase 2 |
| Recruiting | Molecular Imaging of Inflammation in Parkinson's Disease Using LPS and TSPO-PET/MR NCT05205291 | University of Exeter | — |
| Unknown | [18F]MC225-PET in Neurodegenerative Disease NCT05853471 | University Medical Center Groningen | Phase 1 / Phase 2 |
| Completed | Risk of Developing Dementia and Associated Factors in Patients With Normal Brain FDG PET NCT04804722 | Central Hospital, Nancy, France | — |
| Completed | Harmony at Home: A Pilot Telehealth Program for Rural ADRD Caregivers NCT05202223 | Elizabeth K Rhodus | N/A |
| Active Not Recruiting | Sociodemographic Factors and Criminal Behaviour Preceding Neurodegenerative Disease - Retrospective Register S NCT06209515 | Kuopio University Hospital | — |
| Completed | Understanding Ayurveda Disease Conditions and Treatment Responses NCT06167226 | Ayurai Private Limited | — |
| Unknown | Role and Mechanism of Probiotics in Improving Motor Symptoms in Mild to Moderate Parkinson's Disease NCT04871464 | Beijing Friendship Hospital | Phase 4 |
| Completed | A FIH Study to Assess the Safety and Tolerability of NS Intravenous NS101 Infusion NCT05143463 | Neuracle Science Co., LTD. | Phase 1 |
| Recruiting | Longitudinal Investigation of I2BS in PD NCT05516719 | University of Exeter | — |
| Completed | Evaluation of the Peripheral Nerve Ultrasound as a Diagnostic Tool in CANVAS Neuropathies NCT05095870 | Centre Hospitalier Universitaire de Nīmes | — |
| Unknown | Cerebrovascular Reactivity and Oxygen Metabolism as Markers of Neurodegeneration After Traumatic Brain Injury NCT04820881 | Washington D.C. Veterans Affairs Medical Center | — |
| Unknown | Long-term Follow-up in Severe Traumatic Brain Injury NCT05235802 | Karolinska University Hospital | — |
| Completed | Pilot Pragmatic Clinical Trial to Embed Tele-Savvy Into Health Care Systems NCT05080777 | UConn Health | N/A |
| Recruiting | Neurofilament Light Chain And Voice Acoustic Analyses In Dementia Diagnosis NCT06339190 | Monash University | — |
| Completed | Dopaminergic Therapy for Frontotemporal Dementia Patients NCT04937452 | I.R.C.C.S. Fondazione Santa Lucia | Phase 2 |
| Completed | Validation of the NeuroTec Loft NCT04793555 | University of Bern | N/A |
| Completed | Personalized Parkinson Project PSP Cohort NCT05501431 | Radboud University Medical Center | — |
| Completed | The Efficacy of VESPA 2.0 for Cognitive Rehabilitation in Patients With Mild Cognitive Impairment NCT06281314 | IRCCS Centro Neurolesi Bonino Pulejo | N/A |
| Completed | A Bridging Study on Efficacy and Safety of [18F]Florbetaben PET for Diagnosis of Alzheimer Disease Subjects in NCT05527288 | Sinotau Pharmaceutical Group | N/A |
| Completed | Exploratory Evaluation of [11C]MPC6827 NCT04575727 | Columbia University | EARLY_Phase 1 |
| Unknown | Near-Infrared Laser Stimulation for Various Neurological Conditions NCT04489082 | Neurological Associates of West Los Angeles | N/A |
| Unknown | Intensive Multidisciplinary Rehabilitation and Biomarkers in Parkinson's Disease NCT05452655 | Fondazione Don Carlo Gnocchi Onlus | N/A |
| Active Not Recruiting | The Personalized Parkinson Project De Novo Cohort NCT04985539 | Radboud University Medical Center | — |
| Completed | A First in Human Study to Assess the Safety, Tolerability and Pharmacokinetics of ONO-2808-01 in Healthy Parti NCT04578028 | Ono Pharmaceutical Co., Ltd. | Phase 1 |
| Completed | Big Data and Genomic Imaging for the Development of Biomarkers and Nanovector Drugs Innovative for Diagnosis a NCT05761535 | IRCCS SYNLAB SDN | — |
| Unknown | Pilot Study About Extra Virgin Olive Oil "Coratina" in Mild Cognitive Impairment and Alzheimer's Disease Patie NCT04229186 | University of Bari Aldo Moro | N/A |
| Suspended | Focused Ultrasound and Exosomes to Treat Depression, Anxiety, and Dementias NCT04202770 | Neurological Associates of West Los Angeles | N/A |
| Unknown | Study of Neurodegenerative Diseases Induced Stem Cells in Patients and Healthy Family Controls. NCT03682458 | Neuromed IRCCS | — |
| Unknown | Neurodegenerative Diseases Registry NCT04472130 | Vincent Mok | — |
| Unknown | Inflammation and Neurocognitive Damage Markers in Elderly People With Obstructive Sleep Apnea NCT04882020 | Hospital de Clinicas de Porto Alegre | — |
| Completed | Metabolomics Profiling Research of Human Cerebrospinal Fluid in Aging Process NCT04315038 | Chang Gung Memorial Hospital | — |
| Completed | Neuropsychological Indicators of SCD Progression NCT04880252 | Centre Hospitalier Universitaire, Amiens | — |
| Completed | NAD-supplementation in Drug naïve Parkinson's Disease NCT03816020 | Haukeland University Hospital | N/A |
| Unknown | Ccf mtDNA as a Neurodegenerative Biomarker NCT03938909 | Neuromed IRCCS | — |
| Terminated | Mindfulness for Alzheimer Caregivers NCT03858283 | Universidad Miguel Hernandez de Elche | N/A |
| Recruiting | Translocator Protein PET/CT in Various TSPO-Related Disease NCT06725719 | Tianjin Medical University | — |
| Completed | Supporting Elderly People With Cognitive Impairment During and After Hospital Stays- Intersectoral Care Manage NCT03359408 | German Center for Neurodegenerative Diseases (DZNE) | N/A |
| Unknown | Correlation Between Melatonin Levels in Different Biological Fluids NCT05784090 | Istituto Auxologico Italiano | — |
| Completed | A Double-Blind, Placebo-Controlled Safety and Efficacy Study of NA-831 NCT03538522 | Biomed Industries, Inc. | Phase 2 |
| Completed | Increasing Diagnosis Rates While Reducing Examination Time: Can MR Fingerprinting Deliver on Its Promise? NCT06251830 | IRCCS Fondazione Stella Maris | — |
| Recruiting | Tau PET/CT in Various Tau-Related Disease Patients NCT06690983 | Tianjin Medical University | — |
| Completed | Citicoline Concentration in Human Vitreous NCT04003090 | Istituto di Ricerca Neuroftalmologia S.r.l. | N/A |
| Completed | Smell, Voice and Nasal Swabs as Markers for Neuro-degenerative Disorders NCT03299062 | University of Arkansas | N/A |
| Completed | Striatal Dopamine Transmission in Individuals With Isolated Rapid Eye Movement Sleep With Atonia: a Search for NCT03353207 | Chinese University of Hong Kong | — |
| Completed | Clinical Study to Test the Safety of CDNF by Brain Infusion in Patients With Parkinson's Disease NCT03295786 | Herantis Pharma Plc. | Phase 1 / Phase 2 |
| Unknown | Community-based Cohort of Functional Decline in Subjective Cognitive Complaint Elderly NCT04265482 | Geroscience Center for Brain Health and Metabolism (Gero) | — |
| Recruiting | Systematic Assessment of Laryngopharyngeal Function in Patients With Neurodegenerative Diseases NCT04706234 | Kliniken Beelitz GmbH | — |
| Withdrawn | Contribution of the Therapies of Resolution of Problem in the Care of the Natural Caregivers of Patients Affec NCT03438513 | University Hospital, Montpellier | — |
| Completed | AMX0035 in Patients With Amyotrophic Lateral Sclerosis (ALS) NCT03127514 | Amylyx Pharmaceuticals Inc. | Phase 2 |
| Completed | Safety and Efficacy Study of VY-AADC01 for Advanced Parkinson's Disease NCT03065192 | Neurocrine Biosciences | Phase 1 |
| Completed | Evaluation of the Organization of Continuity of Care for Home Hospice Patients by Four Parisian Health Network NCT03336489 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Recruiting | Neurologic Stem Cell Treatment Study NCT02795052 | MD Stem Cells | N/A |
| Completed | [18F]THK-5351 Positron Emission Computed Tomography Study of Normal, Mild Cognitive Impairment, Alzheimer's Di NCT02656498 | Jae Seung Kim | Phase 2 |
| Completed | Study of Cerebral Glucose Metabolism in Neurodegenerative Diseases and Head Trauma NCT06180213 | IRCCS San Raffaele | — |
| Completed | CNS Tau Kinetics in Healthy Aging and Alzheimer's Disease NCT03938870 | Washington University School of Medicine | — |
| Active Not Recruiting | Mobile Parkinson Observatory for Worldwide, Evidence-based Research (mPower) NCT02696603 | Sage Bionetworks | N/A |
| Completed | Study Assessing Safety and Therapeutic Activity of AFFITOPE® PD01A and PD03A in Patients With Early MSA NCT02270489 | Affiris AG | Phase 1 |
| Completed | Study Assessing Tolerability and Safety of AFFITOPE® PD03A in Patients With Early Parkinson's Disease NCT02267434 | Affiris AG | Phase 1 |
| Unknown | Quantification of Transition Metals NCT02222779 | University of Cologne | — |
| Completed | VA Cultivating Access to Resources, Education, and Skills for Dementia Caregivers NCT02106065 | VA Office of Research and Development | N/A |
| Recruiting | Observational Pharmaco-Epidemiology Research & Analysis NCT03813862 | Epividian | — |
| Completed | Yogic Breathing Changes Salivary Components NCT02108769 | Medical University of South Carolina | N/A |
| Completed | Safety and Clinical Outcomes Study: SVF Deployment for Orthopedic, Neurologic, Urologic, and Cardio-pulmonary NCT01953523 | Elliot Lander | N/A |
| Recruiting | New CSF Biomarkers for Alzheimer's Disease NCT03621839 | Central Hospital, Nancy, France | — |
| Recruiting | Beta Amyloid PET/CT in Various Aβ-Related Disease NCT06725706 | Tianjin Medical University | — |
| Unknown | The Long-Term Safety and Efficacy Follow-Up Study of Subjects Who Completed the Phase I Clinical Trial of Neur NCT01696591 | Duk Lyul Na | — |
| Completed | A Longitudinal Study of Amyotrophic Lateral Sclerosis (ALS) Biomarkers NCT01495390 | Massachusetts General Hospital | — |
| Completed | Evaluation of Web-based Training to Educate Physicians in the Methods of Interpreting Florbetapir-PET Scans NCT01550549 | Avid Radiopharmaceuticals | N/A |
| Completed | Effect of Undenatured Cysteine-Rich Whey Protein Isolate (HMS 90®) in Patients With Parkinson's Disease NCT01662414 | Chulalongkorn University | Phase 4 |
| Completed | Observational Study of the Prevalence of CCSVI in Multiple Sclerosis and in Other Neurodegenerative Diseases NCT01384825 | Fondazione Italiana Sclerosi Multipla | — |
| Unknown | Electronic Nose for Diagnosis of Neurodegenerative Diseases Via Breath Samples NCT01291550 | Rambam Health Care Campus | — |
| Withdrawn | Establishment of a Human Tissue Bank for Studying the Microbial Etiology of Neurodegenerative Diseases NCT01954875 | Wake Forest University Health Sciences | — |
| Completed | Clinical Evaluation of Florbetapir F 18 (18F-AV-45) NCT01518374 | Avid Radiopharmaceuticals | Phase 2 |
| Completed | Health Technology Assessment of Diagnostic Approaches in Alzheimer's Disease NCT01450891 | Maastricht University Medical Center | — |
| Completed | Resource Use and Disease Course in Dementia (REDIC) NCT01920100 | Sykehuset Innlandet HF | — |
| Completed | Database of Positon Emission Tomography (PET) Digital Brain Exams, in 50th Age of Patients NCT04163276 | Central Hospital, Nancy, France | — |
| Terminated | Visual Motor Coordination NCT00568243 | National Eye Institute (NEI) | — |
| Completed | Follow Up Safety Study of SCH 420814 in Subjects With Parkinson's Disease (P05175) NCT00537017 | Merck Sharp & Dohme LLC | Phase 2 |
| Completed | Dyskinesia in Parkinson's Disease (Study P04501) NCT00406029 | Merck Sharp & Dohme LLC | Phase 2 |
| Terminated | Quantitative Measurement of Nutritional Substrate Utilization in Patients With Amyotrophic Lateral Sclerosis ( NCT00714220 | Drexel University College of Medicine | — |
| Completed | Biodistribution and Safety of a Radiopharmaceutical in Healthy Subjects NCT00316797 | Institute for Neurodegenerative Disorders | Phase 1 |
| Completed | Magnetic Resonance Imaging (MRI) of Brain Iron in Neurodegenerative Disease NCT00249080 | Albany Medical College | — |
| Completed | The Moli-sani Study NCT03242109 | Neuromed IRCCS | — |
| Unknown | Northern Sweden Health and Disease Study NCT03426488 | Umeå University | — |
| Unknown | Promoting Informed Decision Making Through Advance Care Planning NCT02211287 | Queen's University, Belfast | N/A |