NCT05443906

Home Exercise for Individuals with Neurodegenerative Disease

Study of Adapted Exercise and Mindfulness Interventions to Improve Motor Function and Sleep Quality in Individuals with Neurodegenerative Disease

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Hugo W. Moser Research Institute at Kennedy Krieger, Inc. · Academic / Other
• Sex: All
• Age: 5 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The primary goal of this study is to address the need for targeted therapeutic interventions for impairments that impact walking in related neurodegenerative diseases.

Detailed description

This study will inform clinicians in quantitatively assessing baseline disease severity, selectively applying the appropriate exercise to the disease pathology, and measuring efficacy of the exercise intervention. As part of this overall goal, the aims are to: A. Determine feasibility of remotely supervised exercise programs. B. Optimize remote outcome measures for clinical monitoring and towards future clinical trials. C. Measure changes in balance and walking post intervention.

Conditions

• Neurodegenerative Diseases
• Leukodystrophy
• Ataxia
• LBSL
• Leukoencephalopathy with Brain Stem and Spinal Cord Involvement and High Lactate Syndrome (Disorder)
• Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation
• Cerebellar Ataxia
• Adrenomyeloneuropathy

Interventions

Type	Name	Description
BEHAVIORAL	Home exercise	Exercise to address limitations impacting walking

Timeline

• Start date: 2023-02-13
• Primary completion: 2026-07-30
• Completion: 2027-07-30
• First posted: 2022-07-05
• Last updated: 2025-03-10

Locations

1 site across 1 country: United States