NCT05761535

Big Data and Genomic Imaging for the Development of Biomarkers and Nanovector Drugs Innovative for Diagnosis and Therapy of Inflammatory Processes in Dementia

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 137 (actual)
• Sponsor: IRCCS SYNLAB SDN · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Accepted

Summary

The correlation between data obtained by "imaging" in patients with neurodegenerative diseases characterized by inflammation and the presence in the peripheral blood of the same patients "biopsies liquid biopsies" of specific circulating nucleic acids, could enable the development of methods and algorithms capable of identifying novel biomarkers that serve as targets for the development of probes diagnostics and therapeutics. This is the context for the project idea, which is aimed at developing development of a performant multi parameter system capable of identifying novel biomarkers of microglial polarization that can be used for diagnostic and prognostic purposes in determining the staging/progression of neurodegenerative disease

Conditions

• Neurodegenerative Diseases

Interventions

Type	Name	Description
RADIATION	Magnetic Resonance (MR) and positron emission tomograph (PET) imaging analyses	Regarding the neurological MR protocol, the following may be acquired: * 3D T1 and T2 high-resolution sequences, acquired in a specific plane and Multiplanar reformation (MPR) reconstructed in the remaining orthogonal planes, for morphological assessment of the different structures under examination; * diffusion sequences for the evaluation of the connection between different areas within a specific organ; * perfusion sequences (ASL, arterial spin labeling) for the evaluation of perfusion without ev mdc administration; * susceptibility sequences for noninvasive assessment of vasculature and deposits of iron.

Timeline

• Start date: 2020-06-17
• Primary completion: 2023-02-28
• Completion: 2023-06-30
• First posted: 2023-03-09
• Last updated: 2024-03-25

Locations

1 site across 1 country: Italy