NCT06567431

Blood And Tears in Alzheimer's Disease

Examination of Alzheimer's Disease Biomarkers in Tears and Dry Blood Spots

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 600 (estimated)
• Sponsor: Danish Dementia Research Centre · Network
• Sex: All
• Age: 30 Years
• Healthy volunteers: Not accepted

Summary

This study aims to investigate whether biomarkers of Alzheimer's disease can be found in tearfluid, as well as dried bloodspots in patients with Alzheimer's disease, other dementia diagnoses compared to controls.

Detailed description

Participants under investigation of a neurodegenerative disease who have a planned lumbar puncture in the Memory clinic will be invited to this study. On the same day of the lumbar puncture, tear fluid and dry blod spots will be collected. Tear fluid is collected using Shirmer's test. Dried blood spots are obtained by a small prick in the finger with a lancet. The blood droplet is transferred onto a special piece of filter paper, where it dries. As a sub-study, participants who have provided written consent specifically for this purpose will repeat the test with dried blood spots at home one week after participating in the study. The samples are submitted to the Memory Clinic at the participant's next scheduled appointment. Tear fluid, dried blood spots, as well as blood and cerebrospinal fluid will be examined for AD-related pathology.

Conditions

• Neurodegenerative Diseases

Timeline

• Start date: 2024-03-18
• Primary completion: 2026-01-31
• Completion: 2028-12-31
• First posted: 2024-08-22
• Last updated: 2024-08-22

Locations

1 site across 1 country: Denmark