NCT05402488

Exploring the Recovery Function of Sleep in Neurodegeneration

Exploring the Recovery Function of Sleep in Neurodegeneration - an Observational Cross-Sectional Study

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The overall objective of this study is to identify the best approach for assessing the recovery function of sleep in neurodegenerative diseases associated with abnormal protein aggregation with regard to the conception of future intervention studies. To this end, the investigators will follow an exploratory approach in a preferably broad data set collected in patients with neurodegenerative diseases associated with abnormal protein aggregation and in healthy humans.

Detailed description

First, the investigators want to assess the relationship between sleep parameters (e.g. sleep intensity) and behavioral/cognitive performance and subjective measures (e.g. sleep quality, mood, and sleepiness) in patients with neurodegenerative disorders associated with abnormal protein aggregation. Healthy subjects will be assessed for procedure validation and reference purposes. Second, the investigators want to probe whether associations can be influenced by modulation of sleep parameters by means of auditory stimulation.

Conditions

• Neurodegenerative Diseases

Interventions

Type	Name	Description
BEHAVIORAL	Auditory stimulation	Auditory stimulation during sleep

Timeline

• Start date: 2022-03-14
• Primary completion: 2025-12-01
• Completion: 2026-06-01
• First posted: 2022-06-02
• Last updated: 2022-06-02

Locations

1 site across 1 country: Switzerland