NCT05518409

Immunohistochemical Study of Neurodegenerative Diseases

Immunohistochemical Study of Peripheral Blood Mononuclear Cells in Sporadic Alzheimer's Disease and Dementia With Lewy Body

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: First Affiliated Hospital of Zhejiang University · Academic / Other
• Sex: All
• Age: 55 Years – 100 Years
• Healthy volunteers: Accepted

Summary

The subject uses cytof to analyze PBMC of sporadic AD and DLB, which is used to reveal the differences in immune characteristics of the two diseases at the single-cell level, build immune models for specific diseases, and define these two neurodegenerative diseases with high precision from the level of molecular immunity. To provide basis for further study of the immunohistochemical differences between the two diseases, and provide objective support for clinical diagnosis and differential diagnosis.

Conditions

• Alzheimer Disease
• Lewy Body Disease
• Neurodegenerative Diseases

Interventions

Type	Name	Description
BIOLOGICAL	Detection of cytof in peripheral PBMC	Each subject needs to take 5ml of peripheral venous blood to extract PBMC cells, and then conduct cytof detection. This is a mass spectrometry flow cytometry method based on single cell level. It has the ability to analyze all immune cells with high resolution.
DRUG	Donepezil for patients with AD and DLB	The subjects in AD and DLB groups were given donepezil at an initial dose of 5mg and then increased to 10mg one month later. Lasting for 1 year.

Timeline

• Start date: 2022-04-01
• Primary completion: 2023-12-01
• Completion: 2023-12-30
• First posted: 2022-08-26
• Last updated: 2023-09-14

Locations

1 site across 1 country: China