NCT04880252

Neuropsychological Indicators of SCD Progression

In Individuals With Subjective Cognitive Decline, Age, Memory and Action Speed Scores at Baseline Predict Progression to Cognitive Impairment

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 80 (actual)
• Sponsor: Centre Hospitalier Universitaire, Amiens · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Some patients with subjective cognitive decline (SCD) progress to neurocognitive disorders (NCD), whereas others remain stable; however, the neuropsychological determinants of this progression have not been identified. The investigators objective was to examine baseline neuropsychological indicators that could discriminate between people in whom the SCD progressed to a mild or major NCD and people in whom the SCD remained stable. The investigators retrospectively included patients consulting for SCD at a university medical center's memory center (Amiens, France) and who had undergone three or more neuropsychological assessments at least 6 months apart. The relationship between domain-specific scores and the global cognitive score (GCS, as a function of final status (stable SCD vs. progression toward a mild or major NCD)) was examined using a generalized linear mixed model.

Conditions

• Biomarkers
• Cognitive Assessment
• Cognitive Decline
• Neurocognitive Disorders
• Neurodegenerative Diseases
• Subjective Cognitive Decline

Timeline

• Start date: 2019-05-01
• Primary completion: 2020-05-01
• Completion: 2020-05-01
• First posted: 2021-05-10
• Last updated: 2021-05-10

Locations

1 site across 1 country: France