| Not Yet Recruiting | The CDAC Study - Cerebral Dysfunction After Coronary Revascularization NCT07491120 | The Scripps Research Institute | — |
| Not Yet Recruiting | Feasibility of A Smartphone Application Intervention in Community Settings: A Pretest-Posttest Pilot Study NCT07313540 | The University of Texas Medical Branch, Galveston | N/A |
| Not Yet Recruiting | AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions NCT06950060 | University of Alabama at Birmingham | N/A |
| Not Yet Recruiting | Community-Based Social Connection Intervention Program to Improve Cardiovascular and Brain Health NCT07319663 | Universidad de Especialidades Espiritu Santo | N/A |
| Not Yet Recruiting | Evaluating Health Outcomes of AI-Based Fitness Wearables & App Programs in Elderly With Cognitive Decline NCT07207993 | The University of Tennessee, Knoxville | N/A |
| Enrolling By Invitation | Psychological and Lifestyle Factors That Predict Adherence of Multi-domain Interventions for Promoting Brain H NCT07387523 | Institut Guttmann | N/A |
| Not Yet Recruiting | Long-Term Effects of Walnut Consumption on Brain Function NCT07422220 | Maastricht University Medical Center | N/A |
| Recruiting | Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive NCT07220694 | SF Research Institute, Inc. | N/A |
| Recruiting | Microbiota Mediated Flavonoid Metabolites for Cognitive Health NCT07226674 | University of Ulster | N/A |
| Recruiting | Effects of Turning Based Dual Task Training on Balance and Mild Cognitive Impairment in Diabetic Peripheral Ne NCT07394504 | Foundation University Islamabad | N/A |
| Recruiting | Exercise Adherence and Cognitive Decline: Phase 2 NCT07127965 | University of Colorado, Boulder | N/A |
| Completed | Innovative Cognitive Impairment Case Finding and Engagement for Diverse Participation in Alzheimer's Disease C NCT07016178 | Indiana University | N/A |
| Recruiting | Plant-based Diets and Healthy Aging NCT07151365 | National Health Research Institutes, Taiwan | — |
| Not Yet Recruiting | The Resistant Starch Intervention for Cognitive Enhancement NCT07152483 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Recruiting | TRIAD - Tracking Risk in Integrated Alzheimer's Diagnostics. NCT07399418 | Istituti Clinici Scientifici Maugeri SpA | — |
| Completed | Cognitive Stimulation in Older Adults With Alzheimer's Disease NCT07041008 | Rsocialform - Geriatria, Lda | N/A |
| Recruiting | Door-Through-Door Companion Rideshare Technology for Individuals With Alzheimer's Disease and Related Dementia NCT06850870 | Onward Health, Inc | Phase 1 |
| Completed | Establishing Clinical Utility Evidence for a Novel Alzheimer's Disease Blood-Based Biomarker Assay NCT07099001 | Qure Healthcare, LLC | N/A |
| Not Yet Recruiting | Smartphone Multimodal Health Intervention for Neurological Enhancement (SHINE) NCT07092371 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Active Not Recruiting | Impact of a Novel Brain Longevity Supplement Containing the Postbiotic Urolithin A (Mitopure) on Cognitive Fun NCT07060898 | Amazentis SA | N/A |
| Active Not Recruiting | Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pi NCT07000734 | Washington University School of Medicine | Phase 2 |
| Recruiting | Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans NCT06217575 | University of Alabama at Birmingham | N/A |
| Recruiting | Precision Stratification for Frailty and Cognitive Decline NCT07081282 | National University of Singapore | N/A |
| Recruiting | Cognitive Screening Made Easy for PCPs - Administrative Supplement NCT06928298 | University of Texas at Austin | N/A |
| Not Yet Recruiting | Minocycline in Neurocognitive Outcomes - Sickle Cell Disease NCT05605366 | University of Cincinnati | Phase 1 |
| Enrolling By Invitation | ADL+2.0: Intervention for Prevention of Cognitive Decline in Community-dwelling Older Adults NCT07141160 | Tan Tock Seng Hospital | N/A |
| Recruiting | Memantine and Exercise to Improve Cognitive Function and Modulate Biological Pathways of Cognitive Decline Dur NCT06727773 | UNC Lineberger Comprehensive Cancer Center | Phase 2 |
| Recruiting | The Impacts of Chronic Non-specific Low Back Pain on Cognitive Functions of Older Adults: A Longitudinal Study NCT07134699 | The Hong Kong Polytechnic University | — |
| Enrolling By Invitation | The Benefits of Nostalgia-Based Virtual Reality Brain Health Interventions on Nostalgia Tendencies, Life Satis NCT06973551 | National Taiwan Normal University | N/A |
| Completed | Multicomponent Program for Addressing Cognition in Rural Communities NCT07018830 | Pennington Biomedical Research Center | N/A |
| Completed | Exploring the Impact of Dementia Prevention Programs Using Robots as Intervention Tools on Community Elderly NCT06984458 | National Taiwan Normal University | N/A |
| Recruiting | Broccoli Sprout Extract for Cognitive Function NCT07334366 | Pusan National University Yangsan Hospital | N/A |
| Recruiting | TMS for Cognitive Decline in Aging and Preclinical AD NCT06956300 | Massachusetts General Hospital | N/A |
| Completed | Effects of Auri Super Mushroom Daily Gummies on Cognitive Health NCT07198399 | Auri Nutrition | N/A |
| Recruiting | The Efficacy of a Technology-Assisted Block Training Program on Cognitive Function, Hand Dexterity, and Grip S NCT07315724 | National Taipei University of Nursing and Health Sciences | N/A |
| Not Yet Recruiting | Holistic Integration for Healthy Longevity and Aging in Place NCT06882434 | National Taiwan University Hospital | N/A |
| Active Not Recruiting | Efficacy of a Multidomain Intervention on Lifestyle Risk Factors for Dementia Prevention NCT06748625 | LuciLab | Phase 3 |
| Recruiting | Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU) NCT06627894 | Indiana University | N/A |
| Recruiting | Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biom NCT06669546 | University of Bern | N/A |
| Recruiting | Study Evaluating the Quality and Effects of Lion's Mane Product on Cognitive Health NCT06870136 | M2 Ingredients | — |
| Active Not Recruiting | Effect of a Multidomain Intervention Plus Turmeric on the Prevention of Cognitive Decline in People Over 55 Ye NCT07284316 | Instituto Mexicano del Seguro Social | Phase 2 / Phase 3 |
| Not Yet Recruiting | Effects of Blood Pressure on Cognition and Cerebral Hemodynamics in PD NCT06252376 | University of California, San Diego | N/A |
| Recruiting | Sleep Impairment in Subjects at Risk of Developing Alzheimer's Disease NCT05649514 | University Hospital, Montpellier | N/A |
| Recruiting | Lifestyle Intervention in the Memory Clinics of General and Academic Hospitals Trial NCT06832761 | Maastricht University Medical Center | N/A |
| Not Yet Recruiting | Effects of 3-Month Melatonin Treatment on Regional Cerebellar Structure and Blood Biomarkers in Alzheimer's Di NCT06756828 | Saint Vincent's Hospital, Korea | N/A |
| Recruiting | Polyphenols and Cognitive Decline NCT06507254 | University of California, Los Angeles | N/A |
| Recruiting | Phospholipid-rich Dairy Extract for Cognitive Function NCT07011680 | Pusan National University Yangsan Hospital | N/A |
| Recruiting | A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors NCT06411561 | University of Washington | N/A |
| Completed | Augmented Reality Treadmill Walking for Cognitive and Physical Health in Older Adults NCT07074613 | National Taiwan College of Performing Arts | N/A |
| Recruiting | Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Reme NCT06733714 | Universidade Federal do Rio de Janeiro | N/A |
| Not Yet Recruiting | Efficacy and Safety of Immersive Virtual Reality for Post-stroke Cognitive Impairment NCT06704360 | Dingqun Bai | N/A |
| Withdrawn | Neuromodulation Effects in Older Adults NCT06665022 | University of Florida | N/A |
| Not Yet Recruiting | Clinical Application and Usability of Blood Biomarkers As Screening Tool in Alzheimer Disease: a Validation St NCT06699992 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Recruiting | Association of POCD With Circulating Biomarkers in Patients Undergoing TUR of Bladder Tumor NCT07165236 | Osijek University Hospital | — |
| Enrolling By Invitation | ViewMind Atlas Cognition NCT06746844 | ViewMind | N/A |
| Recruiting | The Effect of Cancer Treatments on Speech Perception in Noise, Cognition, and Hearing-Related Quality of Life NCT06551857 | Turku University Hospital | — |
| Recruiting | Brain Activation Pattern Caused by Immersive Virtual Reality Pathfinding Task in Stroke Patients: an FNIRS Stu NCT06703320 | Dingqun Bai | — |
| Active Not Recruiting | Healthy heaAring for Healthy Ageing: Data-driven Hearing Rehabilitation Intervention to Promote Healthy Hearin NCT06495268 | Kuopio University Hospital | N/A |
| Recruiting | Exercise Adherence and Cognitive Decline NCT06769022 | University of Colorado, Boulder | N/A |
| Recruiting | Optimizing CNS DHA Delivery in Elderly Adults at Risk for Dementia NCT06933095 | University of Cincinnati | N/A |
| Recruiting | Additional Effects of Immersive vr 360 Degree Videos With Aerobic Exercises on Cognitive Functions in Elderly NCT07242495 | Foundation University Islamabad | N/A |
| Recruiting | Effects of Video Games and Ball Tossing on Eye Hand Coordination in Elderly With Mild Cognitive Impairment. NCT07182396 | Foundation University Islamabad | N/A |
| Recruiting | Preliminary Research Using Artificial Intelligence Technology to Identify Differences in Facial Expressions Be NCT06513403 | National Taiwan University Hospital | — |
| Recruiting | Association Between Blood Pressure and Risk of PSCI NCT06730711 | First Affiliated Hospital of Chongqing Medical University | — |
| Not Yet Recruiting | A Home-based e-Health Intervention in the Elderly: MOVI-ageing NCT05928078 | University of Castilla-La Mancha | N/A |
| Completed | Effects of Acute Pain on Motor Learning in Young vs Older Adults NCT05471557 | University of Delaware | N/A |
| Recruiting | δ in Dementia Clinical Trials NCT05592678 | The University of Texas Health Science Center at San Antonio | N/A |
| Completed | Auditory-Cognitive Dual-Task Intervention for Older Adults With Hearing Loss NCT06486285 | The Hong Kong Polytechnic University | N/A |
| Recruiting | Biomarkers Related to PSCI: An fNIRS Study NCT06703307 | Dingqun Bai | — |
| Not Yet Recruiting | RQC for the Prevention of Alzheimer's Disease and Retinal Amyloid-β NCT06470061 | Zaparackas and Knepper LTD | Phase 2 |
| Recruiting | Reducing Cognitive Impairment by Management of Heart Failure as a Modifiable Risk Factor NCT06088212 | Baker Heart and Diabetes Institute | N/A |
| Recruiting | Measuring and Mapping Cognitive Decline After Brain Radiosurgery NCT06466720 | University of Nottingham | — |
| Recruiting | The Peripheral Blood Multi-Omics Study on Sleep Loss NCT06492109 | First Affiliated Hospital of Zhejiang University | N/A |
| Recruiting | Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery NCT06452147 | Second Affiliated Hospital of Wenzhou Medical University | N/A |
| Not Yet Recruiting | The Effectiveness of a Dual-task Training Program NCT06450119 | Taipei Medical University | N/A |
| Not Yet Recruiting | How Does Pianistic Musical Training Influence the Development of Alzheimer's Disease? NCT06378372 | David Franco Castellanos | N/A |
| Completed | 40 Hz Transcranial Alternating Current Stimulation for Inducing Gamma Oscillations NCT06740864 | The National Brain Mapping Laboratory (NBML) | N/A |
| Recruiting | Cognitive Screening and Multidomain Intervention Targeting Cognitive Decline in Type 2 Diabetes (The Brain Car NCT07250789 | Steno Diabetes Center Copenhagen | N/A |
| Recruiting | mPATH for Low-income Older Adults NCT05935241 | Johns Hopkins University | N/A |
| Recruiting | Depth of Anesthesia on Postoperative Delirium and Cognitive After Surgery NCT06268080 | Auckland City Hospital | N/A |
| Active Not Recruiting | A Clinical Trial to Investigate the Efficacy of a Supplement to Improve and Maintain Cognitive Function and Me NCT06523218 | Scale Media Inc | N/A |
| Completed | SCGs as a Proxy for Determining the Cognitive Status of Older Adults NCT06367231 | University of Alberta | — |
| Recruiting | A Mechanistic Study to Investigate tDCS and Working Memory in MCI Patients NCT05998031 | University of Florida | N/A |
| Recruiting | The Effects of Successful OSA Treatment on Memory and AD Biomarkers in Older Adults Study NCT05988385 | California Pacific Medical Center Research Institute | N/A |
| Recruiting | The Impacts of Chronic Non-specific Low Back Pain on Cognitive Functions of Older Adults NCT06704425 | The Hong Kong Polytechnic University | — |
| Completed | Brain Vascular and Neurocognitive Health NCT06497413 | The University of Texas at Arlington | N/A |
| Unknown | BreinZorg: Feasibility Study Into an Online Lifestyle Platform for MCI and SCD NCT06309758 | Radboud University Medical Center | N/A |
| Completed | Zinde Zihin Program to Reduce Alzheimer's Disease Risk in Adults Aged 65 and Older NCT07244848 | Burdur Mehmet Akif Ersoy University | N/A |
| Recruiting | Enhancing Attention and Wellbeing Using Digital Therapeutics NCT06397469 | University of California, San Francisco | N/A |
| Recruiting | Face-to-face vs Online Physical Exercise in Seniors Living in Nursing Homes (ExerMOT-NH) NCT06352749 | University of the Basque Country (UPV/EHU) | N/A |
| Recruiting | Lithium Treatment to Prevent Cognitive Impairment After Brain Radiotherapy NCT06051240 | Region Stockholm | Phase 2 |
| Recruiting | Essential Fats For Enhancing Cognitive Thinking (EFFECT) Study NCT06223672 | Ohio State University | N/A |
| Active Not Recruiting | Cognitive Screening Made Easy for PCPs - R33 Phase NCT06162026 | University of Texas at Austin | N/A |
| Not Yet Recruiting | Cognitive and Neural Assessment Platform and Localized Norm for Macau Older Adults. NCT06239922 | University of Macau | — |
| Recruiting | Primary Care Detection of Cognitive Impairment Leveraging Health & Consumer Technologies in Underserved Commun NCT05607732 | Northwestern University | N/A |
| Enrolling By Invitation | Multicomponent Training on Functional and Cognitive Performance of Hospitalized Older People NCT06682598 | Federal University of Rio Grande do Sul | N/A |
| Active Not Recruiting | Anti-inflammatory Probiotics in Cognitive Functioning NCT07165977 | University of Social Sciences and Humanities, Warsaw | N/A |
| Completed | Effects of Task-Oriented Station Training on Cognitive Levels and Hand Functions in Geriatric Residents of Nur NCT06417073 | Çankırı Karatekin University | N/A |
| Unknown | SCED Myokines and Cognition in SCI NCT05822297 | Adelante, Centre of Expertise in Rehabilitation and Audiology | N/A |
| Recruiting | MIND Foods and Aerobic Training in Black Adults With HTN NCT06152614 | Indiana University | N/A |
| Recruiting | Cognitive and Vascular Functioning Following TBI NCT06034509 | Walter Reed National Military Medical Center | — |
| Unknown | Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey NCT06025877 | C2N Diagnostics | — |
| Enrolling By Invitation | The Effect of Computerized Vestibular Function Assessment and Training System Combined With Cognitive/Motor Du NCT05990023 | Taipei Medical University | N/A |
| Recruiting | MindWalk Intervention for Older South Asian Caregivers of People With Cognitive Disabilities (CD) NCT06002919 | University of Illinois at Chicago | N/A |
| Unknown | Cognitive Training for Digital Biomarkers NCT06090942 | Taipei Medical University | N/A |
| Completed | The Impact of Goode Health Beverage on Markers of Physiological and Neurocognitive Health NCT06245382 | The University of Texas at Arlington | N/A |
| Completed | Long-term Effects of Blueberry Supplementation on Brain Health in Older Adults NCT05764824 | Brigham and Women's Hospital | N/A |
| Completed | Hong Kong Cohort of Abnormal Sleep in Ageing Population (HK-ASAP): Focusing on Brain Health and Sleep Quality NCT06170073 | Chinese University of Hong Kong | — |
| Completed | Time Restricted Eating Plus Exercise for Weight Management NCT05290233 | University of Illinois at Chicago | N/A |
| Completed | Preoperative Cognitive Reserve in Older Surgical Patients: A Feasibility Study NCT06245005 | Ohio State University | — |
| Unknown | Healthy Body & Mind Program for Older Adults Living With Osteoarthritis and Cognitive Decline NCT06070818 | The University of New South Wales | N/A |
| Recruiting | Sleep and Circadian Rhythm Biomarkers of Postoperative Delirium NCT06052397 | Massachusetts General Hospital | — |
| Recruiting | Investigating Neurocognitive Disorders Epidemiology NCT06375213 | King Chulalongkorn Memorial Hospital | — |
| Recruiting | Brain Health Virtual Reality Study NCT06124339 | University of California, San Diego | N/A |
| Completed | The Impact of KETO5 XOGenius Beverage on Markers of Physiological and Neurocognitive Health NCT06318390 | The University of Texas at Arlington | N/A |
| Unknown | Effects of Multidomain Intervention on Cognitive Function in Community-dwelling Elderly NCT06180161 | Chang Gung Memorial Hospital | N/A |
| Not Yet Recruiting | Non-invasive Brain Stimulation and Strategic Memory Training NCT05929872 | IRCCS National Neurological Institute "C. Mondino" Foundation | N/A |
| Unknown | MIND Diet and Cognitive Function in Adults With MCI NCT05975723 | Zhejiang University | N/A |
| Recruiting | A New 360° Dual-task Based Protocol for the Pre-clinical In-hospital and At-home Rehabilitation of Elderly: DU NCT06290167 | Istituto Auxologico Italiano | N/A |
| Active Not Recruiting | Effect of Equol Supplementation on Arterial Stiffness and Cognition in Healthy Volunteers NCT05741060 | Akira Sekikawa | Phase 2 |
| Completed | Effects of Gamma-tACS on Memory and Sleep NCT05907707 | University of North Carolina, Chapel Hill | N/A |
| Recruiting | A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses NCT05877196 | Arizona State University | N/A |
| Unknown | A Supplement on Cognitive Function and Brain Activity in Middle Age and Older Healthy Adults NCT05892627 | Aberystwyth University | EARLY_Phase 1 |
| Enrolling By Invitation | REpeated ASSEssment of SurvivorS in Intracerebral Hemorrhage Study NCT05611918 | Johns Hopkins University | — |
| Recruiting | Oriental Intervention for Enhanced Neurocognitive Health (ORIENT) Diet in Patients With Intracranial / Carotid NCT05922137 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Active Not Recruiting | Double-task Exercise in Older Adults at Risk of Cognitive Decline (MeMo-Health-Cog-3 Program) NCT04068376 | Instituto Mexicano del Seguro Social | N/A |
| Completed | Brain Health Together: A Live-Streaming Group-Based Digital Program NCT05818423 | University of California, San Francisco | N/A |
| Completed | Effect of Different Exercise Modalities on Cardiovascular and Cognitive Response in Postmenopausal Women NCT06533982 | University of Poitiers | N/A |
| Completed | Effects of Walkasins on Gait Speed of Individuals With Mild Cognitive Impairments NCT05723822 | RxFunction Inc. | N/A |
| Unknown | Study of Cognitive Reserve Disorder Affecting Depression in Aged Related Hearing Loss Via Rest State EEG NCT05892731 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | — |
| Active Not Recruiting | Digitally Supported Lifestyle Programme to Promote Brain Health Among Older Adults NCT05565170 | Finnish Institute for Health and Welfare | N/A |
| Unknown | Hyperbaric Oxygen Therapy Improves Brain Function in Patients With Cognitive Decline After COVID-19 Infection. NCT05715801 | The First Affiliated Hospital of Zhejiang Chinese Medical University | N/A |
| Recruiting | METformin and FINGER Intervention to Prevent Cognitive Impairment and Disability in Older Adults at Risk for D NCT05109169 | Imperial College London | Phase 2 |
| Completed | Personalized Virtual Reality Naturalistic Scenarios in Cognitive Impairment NCT05863065 | University of Padova | N/A |
| Recruiting | WHIte MAtter Hyperintensity Shape and Glymphatics NCT06010511 | Leiden University Medical Center | — |
| Recruiting | Cognition and QoL After Thyroid Surgery NCT05088187 | Karolinska University Hospital | — |
| Completed | Sleep, Diet, Exercise and Older Persons NCT05735353 | University of Miami | N/A |
| Active Not Recruiting | ACHIEVE Brain Health Follow-Up Study NCT05532657 | Johns Hopkins University | Phase 3 |
| Active Not Recruiting | Biomarkers Associated With Postoperative Cognitive Dysfunction NCT05464355 | University of Oxford | — |
| Active Not Recruiting | A Pivotal Study of Sensory Stimulation in Alzheimer's Disease (Hope Study, CA-0011) NCT05637801 | Cognito Therapeutics, Inc. | N/A |
| Completed | Effects of a Colon-delivered Multivitamin Supplement on Brain Functioning, Immunometabolic- and Intestinal Mar NCT05675007 | Donders Centre for Cognitive Neuroimaging | N/A |
| Completed | Study of Epidemiologic Investigation and Mechanism of Brain Network of Otologic and Cognitive Function With Po NCT05787301 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | — |
| Completed | Anti-Ageing Health Supplement From Ginger Extracts NCT06828783 | National University of Malaysia | N/A |
| Unknown | Hyperspectral Retinal Observations for the Cross-sectional Detection of Alzheimer's Disease NCT05604183 | Mantis Photonics AB | N/A |
| Completed | Blood Flow Restriction and High-intense Resistance Training in Aging: Interactions Between Neuroplasticity and NCT05744167 | Lithuanian Sports University | N/A |
| Completed | Normative Database and Test-Retest Reliability for BrainCheck Assessments NCT05497427 | BrainCheck, Inc. | — |
| Recruiting | Developing and Assessing an Innovative Exergaming Technology for Older Adults Living in Long-term Care Homes NCT05130203 | University of Toronto | N/A |
| Completed | Comparison of Three Motor-cognitive Training Programs NCT04504643 | Aix Marseille Université | N/A |
| Completed | Peanuts and Neurocognitive / Cardiovascular Health in Black Individuals NCT06318377 | The University of Texas at Arlington | N/A |
| Completed | Virtual Reality-based Mindful Movement Therapy for Seniors NCT06334328 | Drexel University | N/A |
| Recruiting | MASCoD - Multidimensional Assessment of Subjective Cognitive Decline NCT05815329 | Istituti Clinici Scientifici Maugeri SpA | N/A |
| Completed | Brain Healthy Soul Food Diet Intervention Among Older African Americans NCT05414682 | University of Kansas Medical Center | N/A |
| Completed | The Effect of Occupational Activities and Finger Exercise Program on Hand Grip Strength and Activities of Dail NCT07033338 | Emel Dogan | N/A |
| Active Not Recruiting | Preventing Cognitive Decline with Metformin NCT04511416 | Garvan Institute of Medical Research | Phase 3 |
| Completed | Agility Training for Older Adults to Improve Fall Risk Factors NCT05727254 | Oliver Faude | N/A |
| Recruiting | Preventing Cognitive Decline by Reducing BP Target Trial NCT05106036 | University of Texas Southwestern Medical Center | N/A |
| Active Not Recruiting | Tau Pet Imaging in the Aging Brain Cohort Dedicated to Diversity Study NCT05393388 | University of Pennsylvania | — |
| Unknown | Cognitively Enriched Walking Program NCT05500183 | University Ghent | N/A |
| Completed | Effect of Individual Cognitive Stimulation on Memory and Executive Function in Older Adults With Alzheimer's D NCT05433493 | Rsocialform - Geriatria, Lda | N/A |
| Recruiting | Pre-operative Mapping of the Anterior Temporal Lobe Using Functional MRI Innovative Techniques in in Drug-resi NCT05339438 | Central Hospital, Nancy, France | N/A |
| Completed | A Prospective, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effects of LasoperinTM on Co NCT05994391 | Lindenwood University | N/A |
| Unknown | Cognitive Stimulation and Chemobrain. An Innovative Intervention for Cancer Survivors NCT05409248 | Universidad Antonio de Nebrija | N/A |
| Completed | Health and Energy Through Active Living Every Day After Cancer Intervention for Cancer Survivors NCT05356988 | American Cancer Society, Inc. | N/A |
| Completed | Evaluation of Cognitive State in Seniors Using Neurosteer EEG System NCT05528445 | Neurosteer Ltd. | — |
| Recruiting | Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D) NCT05277558 | Washington University School of Medicine | — |
| Recruiting | Successful Aging and Age-related Decline NCT06376656 | Sunway University | N/A |
| Unknown | Physical and Cognitive Training System for Neurocognitive Protection and Enhancement in Older Adults NCT05163769 | Duke-NUS Graduate Medical School | N/A |
| Unknown | Anxiety Related to the Diagnosis of Alzheimer's Disease or Related Diseases NCT04342520 | Hospices Civils de Lyon | — |
| Completed | The Effects of a Multidomain Lifestyle Intervention on Brain Functioning and Its Relation With Immunometabolic NCT05777863 | Donders Centre for Cognitive Neuroimaging | N/A |
| Completed | Rhythmically Entrained Exercise in Community-Dwelling Older Adults NCT05462977 | University of North Carolina, Greensboro | N/A |
| Completed | Efficacy of a Mobile-based Multidomain Intervention to Improve Cognitive Function and Health-related Outcomes NCT05675137 | Silvia Health | N/A |
| Terminated | Coach Pilot Study: Assessing Cognitive Function and Related Small Vessel Disease Markers After Intracerebral H NCT05499169 | Leiden University Medical Center | — |
| Withdrawn | Cardiovascular Disease Cohort NCT05309824 | Westlake University | — |
| Unknown | Effectiveness of AMICOPE Intervention to Maintain Self-Perceived Health and Intrinsic Capacity in Older People NCT05249504 | Fundacio Salut i Envelliment UAB | N/A |
| Unknown | The Effect of Intranasal Insulin Administration on Cognitive Function After Cardiac Surgery. NCT03324867 | McGill University Health Centre/Research Institute of the McGill University Health Centre | N/A |
| Recruiting | Glucose Variability and Cognition in Prediabetes NCT04201600 | University of Maryland, Baltimore | — |
| Completed | The Impact of Exercise on Hippocampus-dependent Cognition and the Gut Microbiota NCT05397990 | King's College London | N/A |
| Active Not Recruiting | Dutch Multidomain Lifestyle Intervention in Older Adults at Risk of Cognitive Decline NCT05256199 | Alzheimercentrum Amsterdam | N/A |
| Completed | Efficacy of a Multimodal Brain Health Intervention for Older African Americans NCT04863378 | Oregon Health and Science University | N/A |
| Completed | Happy Older Latinos Are Active - Cognitive Decline NCT04791709 | University of Miami | N/A |
| Completed | The PROtein Enriched MEDiterranean Diet and EXercise Trial for Older Adults At Risk of Undernutrition NCT05166564 | Queen's University, Belfast | N/A |
| Recruiting | Dexmedetomidine or Clonidine Infusion for Prevention of Delirium After Open Heart Surgery NCT05029050 | Oslo University Hospital | Phase 4 |
| Recruiting | Polypill and RiscOMeter to Prevent StrOke and CogniTive ImpairmEnt (PROMOTE) NCT05155137 | Hospital Moinhos de Vento | Phase 3 |
| Active Not Recruiting | Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients Patients NCT04337255 | Rush University Medical Center | N/A |
| Recruiting | Redesigning the Surgical Pathway (PROMoTE) NCT05114876 | Sunnybrook Health Sciences Centre | N/A |
| Enrolling By Invitation | Preventing Cognitive Decline: The CITA GO-ON Multi-domain Intervention Study NCT04840030 | Fundacion CITA-alzheimer | N/A |
| Completed | Multidomain Intervention on Modifiable Lifestyle Risk Factors for Dementia Prevention NCT05141578 | LuciLab | N/A |
| Withdrawn | The Effect of Blueberry Supplementation on Cognitive Functioning in Older Adults NCT07170943 | Wageningen University | N/A |
| Completed | Smart Cupboard-based System for Memory Assessment in Alzheimer's Patients NCT05202197 | Universidad de Zaragoza | — |
| Unknown | Effect of Hypoxic Conditioning on Cerebrovascular Health in the Elderly NCT05048680 | University Hospital, Grenoble | N/A |
| Terminated | A Study to Evaluate the Safety, Tolerability, and Pharmacodynamics of SDI-118 in Elderly Male and Female Study NCT05199142 | Syndesi Therapeutics | Phase 1 |
| Recruiting | Cognitive Impairment in Colorectal Cancer Patients Receiving Cytotoxic Chemotherapy NCT05014399 | Joseph McCollom | — |
| Completed | Fitness, Ageing, and Bilingualism (FAB): The Benefits of Regular Exercise and Bilingualism for Language Abilit NCT07443189 | University of Agder | N/A |
| Completed | Cognitive Screening Made Easy for PCPs NCT05082883 | University of Texas at Austin | — |
| Completed | Diagnosis, Incidence and Consequences of PACU-Delirium NCT04978870 | Universitätsklinikum Hamburg-Eppendorf | — |
| Unknown | Open-label, Post-marketing, Prospective Study to Assess Impact of COVID-19 on Cognitive Function in Patients NCT04950673 | Cognivue, Inc. | — |
| Completed | Evaluation of the Wits Workout Wellness Program for Older Adults NCT04928885 | University of Illinois at Chicago | N/A |
| Recruiting | Prediction of Heart Failure and Cognitive Decline in Type 2 Diabetes NCT04583800 | University Hospital, Lille | — |
| Unknown | CURATE.AI COR-Tx Trial for Post Brain Radiotherapy Patients NCT04848935 | National University Hospital, Singapore | N/A |
| Completed | Reducing the Effects of Aging on Cognition With Therapeutic Intervention of an Oral Nutrient (REACTION): A Pil NCT04147624 | University of Miami | Phase 2 |
| Active Not Recruiting | The Influence of Tai Chi Practice on Blood Pressure and Brain Health Among Older Adults with Hypertension (ACT NCT04384263 | University of Connecticut | N/A |
| Unknown | Analysis of Inflammatory Predictors and Gene Expression in Patients With Mild Cognitive Impairment NCT04934423 | Federal University of Paraíba | N/A |
| Recruiting | Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease NCT04800588 | Neurobehavioral Systems, Inc. | N/A |
| Completed | Prefrontal Cortex Dynamics of the Elderly During a Cognitive Stimulation Programme NCT04693611 | CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas | N/A |
| Active Not Recruiting | Advancing Postmenopausal Preventive Therapy NCT04103476 | University of Southern California | Phase 2 |
| Unknown | Effects of Multimodal Training of Combined Cognitive and/or Physical Training on Cognition and Fitness of Olde NCT04727450 | Hong Kong Baptist University | N/A |
| Completed | Endoprosthesis Metal Toxicity Study NCT04755140 | Mayo Clinic | — |
| Completed | The Efficacy of VESPA 2.0 for Cognitive Rehabilitation in Patients With Mild Cognitive Impairment NCT06281314 | IRCCS Centro Neurolesi Bonino Pulejo | N/A |
| Completed | Correlation Between Montreal Cognitive Assessment and Voice Therapy Outcomes in the Aging Treatment- Seeking P NCT05187910 | University of California, San Francisco | N/A |
| Completed | Quality Improvement PrecivityAD Clinician Survey (QUIP I) NCT05477056 | C2N Diagnostics | — |
| Active Not Recruiting | Dopaminergic Dysfunction in Late-Life Depression NCT04469959 | Vanderbilt University Medical Center | Phase 2 |
| Completed | Effect of Individual Reminiscence Therapy in the Elderly People With Neurocognitive Disorders NCT04658394 | Rsocialform - Geriatria, Lda | N/A |
| Completed | Early Cognitive Intervention in Delirium NCT04740567 | Vanderbilt University Medical Center | N/A |
| Completed | Preventing Cognitive Decline NCT05446909 | Arizona State University | N/A |
| Unknown | Social and Cognitive Online Training: the SCOT Project NCT05023187 | Università degli Studi di Trento | N/A |
| Completed | Manipulating Cognitive Intensity During Aerobic Exercise NCT06479265 | University of Southern California | — |
| Completed | Yoga, Aerobic and Stretching Exercise Effects on Neurocognition NCT04323163 | University of Illinois at Urbana-Champaign | N/A |
| Completed | The Effects of Microbiological Spectrum Changes to Improve Cognitive Health in Aging Population NCT05051501 | National Institute of Mental Health, Czech Republic | Phase 2 |
| Completed | Post COVID19 Functional and Cognitive Assessments NCT04860206 | Science and Research Centre Koper | — |
| Unknown | Reducing Dementia Risk With Digital Health Coaching NCT04559789 | Neurotrack Technologies, Inc. | N/A |
| Completed | Response of Sex Hormones and Different Functions to Exercise and Diet in Elderly Women NCT04492540 | Cairo University | N/A |
| Completed | Cognitive Functions After COVID-19 NCT04978246 | Medipol University | — |
| Completed | The Effects of Chicken Extract and a Peptide Supplement for the Prevention of Cognitive Decline in Non-demente NCT04555655 | Brand's Suntory Asia | EARLY_Phase 1 |
| Recruiting | MS-NEUROPLAST: Neuroplasticity of Cortical Areas Induced by Cognitive Training in Patients with Multiple Scler NCT04806568 | Aristotle University Of Thessaloniki | N/A |
| Completed | Crossover Trial for Nicotinamide Riboside in Subjective Cognitive Decline and Mild Cognitive Impairment NCT04078178 | Steven E Arnold, MD | N/A |
| Completed | Remote Monitoring and Virtual Collaborative Care For Hypertension Control To Prevent Cognitive Decline NCT04585880 | University of Kansas Medical Center | N/A |
| Completed | Intervention on Modifiable Lifestyle Risk Factors for Dementia Prevention NCT04616794 | LuciLab | N/A |
| Completed | Fish Oil for Cognitive Function, Sleep Quality, and Bone Density NCT06614374 | Jingjing Jiao | N/A |
| Completed | Lifestyle Physical Activity and Cognitive Training Interventions NCT04556305 | Rush University Medical Center | N/A |
| Completed | The Effects of Intermittent Theta Burst Stimulation in MCI and Early AD NCT04555941 | Taipei Medical University Shuang Ho Hospital | Phase 2 |
| Unknown | PRedicting the EVolution of SubjectIvE Cognitive Decline to Alzheimer's Disease With Machine Learning NCT05569083 | Azienda Ospedaliero-Universitaria Careggi | — |
| Unknown | Effect of Antiinflammatory Treatment Versus Hand Training on Neuropsychiatric Comorbidity in RA-patients NCT04378621 | Vastra Gotaland Region | N/A |
| Recruiting | Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient NCT03839784 | Stanford University | — |
| Completed | My Healthy Brain: Preserving and Promoting Brain Health Through Evidence-based Practices NCT04537728 | Massachusetts General Hospital | N/A |
| Completed | Modulation Effects of Baduanjin Exercise on Subjective Cognitive Decline NCT04009382 | Massachusetts General Hospital | N/A |
| Recruiting | GnRH Therapy on Cognition in Down Syndrome NCT04390646 | Nelly Pitteloud | Phase 2 / Phase 3 |
| Unknown | Brain-Health Lifestyle Restructuring Intervention NCT04576624 | National Cheng Kung University | N/A |
| Completed | Open-Label Study of Omega 3 Oil Supplementation for Aging-Related Cognitive Decline NCT04484454 | Neurological Associates of West Los Angeles | N/A |
| Completed | Care at 360º: A Long-term Individual Cognitive Stimulation Program NCT04417751 | CEDIARA - Assoc. Solidariedade Social de Ribeira de Fráguas | N/A |
| Unknown | Association of Centre of Excellence Self- Administered Questionnaire Score and Frailty Levels NCT03991806 | Jewish General Hospital | — |
| Active Not Recruiting | Educational and Cultural Engagement and Incidence of Health Adverse Events NCT03987360 | Jewish General Hospital | — |
| Terminated | Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial (TRIDENT) Cognitive Sub-Study NCT03785067 | The George Institute | Phase 3 |
| Completed | The Effect of Transcranial Direct Current Stimulation on Visual Attention - Single Sessions NCT04134195 | Masaryk University | N/A |
| Suspended | Major Memory 2: A Long-term Group Cognitive Stimulation Program NCT04178564 | Rsocialform - Geriatria, Lda | N/A |
| Unknown | Validation Study SCOBES-AR NCT04204239 | FH Joanneum Gesellschaft mbH | — |
| Unknown | Post-stroke Immunological Changes in Young Stroke Patients NCT03725137 | University Medicine Greifswald | — |
| Unknown | Cognitive Status After Removal of Skull Base Meningioma NCT04635657 | Ohio State University | — |
| Recruiting | Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging NCT03954899 | Natalie Denburg | N/A |
| Completed | Prevention of Cognitive Decline in ApoE4 Carriers With Subjective Cognitive Decline After EGCG and a Multimoda NCT03978052 | Parc de Salut Mar | N/A |
| Completed | Exploratory Clinical Study and Validation of Blood Biomarkers for Alzheimer's Disease NCT07294586 | Amoneta Diagnostics SAS | — |
| Active Not Recruiting | Implementation of Multifaceted Patient-Centered Treatment Strategies for Intensive Blood Pressure Control in M NCT04797403 | Tulane University | N/A |
| Completed | Memantine for Prevention of Cognitive Decline in Patients With Breast Cancer NCT04033419 | UNC Lineberger Comprehensive Cancer Center | Phase 2 |
| Completed | Evaluation of Cognitive State Using Neurosteer EEG System NCT04386902 | Neurosteer Ltd. | — |
| Active Not Recruiting | Statins in Reducing Events in the Elderly Mind (STAREE-Mind) Imaging Substudy NCT05586750 | Monash University | Phase 4 |
| Completed | CAMCI: Advancing the Use of Computerized Screening in Healthcare NCT03512301 | Psychology Software Tools, Inc. | N/A |
| Completed | Multicentre Study About the Effect of Individual Reminiscence Therapy NCT04047238 | Rsocialform - Geriatria, Lda | N/A |
| Unknown | Cerebrovascular Correlates of Dementia in Rural Communities - The Three Villages Study NCT04123171 | Universidad de Especialidades Espiritu Santo | — |
| Completed | Neuropsychological Indicators of SCD Progression NCT04880252 | Centre Hospitalier Universitaire, Amiens | — |
| Completed | Computerized Cognitive Training in MS NCT03737825 | University of California, San Francisco | N/A |
| Completed | Movement Intervention for Memory Enhancement NCT03475316 | Albert Einstein College of Medicine | N/A |
| Completed | Testing Ramipril to Prevent Memory Loss in People With Glioblastoma NCT03475186 | Wake Forest University Health Sciences | Phase 2 |
| Completed | Development of Automated Analysis to Electroencephelogram (EEG) Data in Patients Treated at the Sagol Hyperbar NCT04095377 | QuantalX Neuroscience | — |
| Active Not Recruiting | High-dose Vitamin D Supplements in Older Adults NCT03613116 | University of California, Davis | Phase 2 |
| Completed | The Music, Sleep and Dementia Study NCT04157244 | University of Pennsylvania | N/A |
| Completed | Dairy Based Probiotic Intervention and Cognitive, Emotional, and Inflammatory Outcomes NCT04643080 | University of Idaho | N/A |
| Completed | Upper Limb Reeducation Across Life Span NCT03997591 | Instituto Politécnico de Leiria | — |
| Completed | Active Ageing and Health NCT03858114 | University of Cagliari | N/A |
| Unknown | Health After eaRly Menopause Due to Oophorectomy NCT03835793 | The Netherlands Cancer Institute | — |
| Completed | Cognitive Decline and Alzheimer's Disease in the Dallas Lifespan Brain Study NCT04080544 | Neil M Rofsky, MD, MHA | Phase 2 |
| Unknown | The Factors Affecting the Achievement of Glucose Monitor in the Patients on Diabetes NCT03804658 | Taichung Veterans General Hospital | — |
| Unknown | Combined Lumbosacral Nerve Block Versus Spinal Anesthesia for Cognitive Function After Hip Prothesis NCT03794427 | Makassed General Hospital | N/A |
| Unknown | Healthy Older People Everyday (HOPE) - Role of Healthy Diet on Muscle and Bone Health NCT03786835 | National University Hospital, Singapore | N/A |
| Completed | Compensatory Brain Activity in Older Adults. NCT06235840 | Kazimierz Wielki University | N/A |
| Completed | Cognitive Training and Social Interaction Effects on Cognitive Performance of Older Adults NCT05016336 | Bar-Ilan University, Israel | N/A |
| Completed | The Heart & Mind Study NCT03545958 | Western University, Canada | N/A |
| Completed | Renew NCP-5 for the Treatment of Mild Cognitive Impairment Due to Alzheimer's Disease (AD) or Mild Dementia of NCT03721705 | Renew Research, LLC | Phase 3 |
| Active Not Recruiting | Cognitive Changes and Neural Correlates After Rehabilitation of Masticatory Function in Elderly -an Interventi NCT04458207 | Folktandvården Stockholms län AB | N/A |
| Completed | Vitamin D to Improve Outcomes by Leveraging Early Treatment: Long-term Brain Outcomes in Vitamin D Deficient P NCT03733418 | Vanderbilt University Medical Center | — |
| Completed | Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study NCT03617302 | Gary L. Pierce, PhD | EARLY_Phase 1 |
| Completed | Early Postoperative Cognitive Impairment in Elderly Patients Following Ocular Surgery NCT03775343 | Medical University of Vienna | — |
| Completed | Multicultural Healthy Diet to Reduce Cognitive Decline NCT03240406 | Albert Einstein College of Medicine | N/A |
| Completed | The Impact of Cranberries On the Microbiome and the Brain in Healthy Ageing sTudy (COMBAT) NCT03679533 | University of East Anglia | N/A |
| Unknown | High Dose Omega 3 in People at Risk for Dementia NCT03926351 | University Hospital, Akershus | Phase 2 |
| Completed | Bingocize: A Novel Mobile Application for Older Adult Health NCT03629912 | Western Kentucky University | N/A |
| Completed | Resistance Training and Neuroimaging NCT03982550 | Todd Schroeder | N/A |
| Completed | Evaluation of Pilot Community-based Multi-domain Program Older Adults at Risk of Cognitive Impairment NCT04440969 | Geriatric Education and Research Institute | N/A |
| Completed | Evaluation of the Online Memory & Aging Program and Online Goal Management Training NCT03602768 | Baycrest | N/A |
| Completed | Noninvasive Brain Stimulation for Mild Cognitive Impairment NCT03331796 | Palo Alto Veterans Institute for Research | N/A |
| Completed | Curcumin and Vascular and Cognitive Function in Patients With Chronic Kidney Disease NCT03223883 | Diana Jalal | Phase 2 |
| Unknown | Study of Tolerability, Safety and Efficacy of Sensory Stimulation at Multiple Dose Levels to Improve Brain Fun NCT03661034 | Cognito Therapeutics, Inc. | N/A |
| Recruiting | Biomarker Exploration in Aging, Cognition and Neurodegeneration NCT03860857 | University of California, Irvine | Phase 3 |
| Unknown | Study of Postoperative Cognitive Decline in Aged Patients NCT03765840 | Jia-feng Wang | — |
| Active Not Recruiting | Multi-Center Study of Sensory Stimulation to Improve Brain Function NCT03556280 | Cognito Therapeutics, Inc. | N/A |
| Completed | Characterization of the DELPhI System in Assessing Brain's Functionality in Different Neurological Disorders NCT03832413 | QuantalX Neuroscience | — |
| Completed | Intermittent Energy Restriction and Chewing on Neural Stem Cell Ageing and Adult Hippocampal Neurogenesis Asso NCT03457870 | King's College London | N/A |
| Recruiting | Development of a Prediction Model for Delirium After Cardiac Surgery Using a Novel Self-Administered Preoperat NCT03360838 | University Hospital, Basel, Switzerland | — |
| Completed | Digital Cognition in Multiple Sclerosis NCT03569618 | University of California, San Francisco | N/A |
| Completed | GOIZ ZAINDU Feasibility Multi Domain Trial to Prevent Dementia. NCT06163716 | Fundacion CITA-alzheimer | N/A |
| Completed | Cohort Study of Risk Factors for Postoperative Cognitive Decline NCT03676738 | Oregon Health and Science University | — |
| Completed | Combined Model of Online Remote Interventions for Cancer-Related Cognitive Impairment NCT04210778 | Hadassah Medical Organization | N/A |