NCT03617302

Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study

Effects of Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: Gary L. Pierce, PhD · Academic / Other
• Sex: All
• Age: 50 Years – 79 Years
• Healthy volunteers: Accepted

Summary

This study investigates the effect of dietary inorganic nitrate supplementation on 1) large elastic artery stiffness and hemodynamics and 2) cerebrovascular function in middle-aged and older adults. Participants will be randomized to consume either nitrate-containing or nitrate-depleted beetroot juice.

Detailed description

Reduced nitric oxide bioavailability with aging contributes in part to increased large central artery stiffness and cerebrovascular dysfunction. Large central artery stiffness is a risk factor for cognitive decline mediated in part by the development of cerebrovascular dysfunction. This study will investigate the degree to which improving nitric oxide bioavailability using dietary inorganic nitrate supplementation improves cerebrovascular function through reductions in large central artery stiffness in middle-aged and older adults.

Conditions

• Aging
• Arterial Stiffness
• Endothelial Dysfunction
• Hypertension
• Cognitive Decline

Interventions

Type	Name	Description
DRUG	Experimental: Nitrate-containing	Experimental
DRUG	Placebo: Nitrate-depleted	Placebo

Timeline

• Start date: 2018-11-01
• Primary completion: 2022-12-30
• Completion: 2024-06-30
• First posted: 2018-08-06
• Last updated: 2026-03-04
• Results posted: 2026-03-04

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study