Trials / Active Not Recruiting
Active Not RecruitingNCT05586750
Statins in Reducing Events in the Elderly Mind (STAREE-Mind) Imaging Substudy
Clinical Trial to Determine the Effects of Statins on Brain Health - STAREE-Mind Imaging Substudy
- Status
- Active Not Recruiting
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 341 (actual)
- Sponsor
- Monash University · Academic / Other
- Sex
- All
- Age
- 70 Years
- Healthy volunteers
- Accepted
Summary
The STAREE-Mind imaging sub-study will examine the effect of statin treatment over a 4-year period, compared with placebo, on markers of brain health.
Detailed description
STAREE-Mind imaging is a sub-study nested in the Statins in Reducing Events in the Elderly (STAREE) double blind randomised placebo-controlled trial. STAREE is investigating whether statins can prolong good health and maintain independence amongst older people and is enrolling. STAREE-Mind imaging aims to recruit a sub-group of 340 participants, and will involve an additional suite of brain imaging in these participants, at recruitment (before medication is commenced) and at 4 years follow-up. It will provide crucial information about the clinical effects of statins on brain health in older individuals.
Conditions
- Dementia, Mixed
- Dementia, Vascular
- Dementia of Alzheimer Type
- Cognitive Decline
- White Matter Hyperintensity
- Aging
- Neuro-Degenerative Disease
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Atorvastatin 40 Mg Oral Tablet | 40 mg atorvastatin (2 x 20 mg atorvastatin daily), taken orally |
| DRUG | Placebo | 2 x 20mg placebo (daily), taken orally. Identical appearance to study drug |
Timeline
- Start date
- 2019-09-19
- Primary completion
- 2026-09-01
- Completion
- 2026-09-01
- First posted
- 2022-10-19
- Last updated
- 2025-05-22
Locations
2 sites across 1 country: Australia
Source: ClinicalTrials.gov record NCT05586750. Inclusion in this directory is not an endorsement.