NCT07170943

The Effect of Blueberry Supplementation on Cognitive Functioning in Older Adults

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Wageningen University · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Accepted

Summary

In this randomized placebo controlled intervention study, the effect of 12 weeks of supplementation with either 150g whole blueberries, freeze-dried blueberry powder (dose equivalent to 150g berries) versus placebo on cognitive functioning will be investigated in older adults.

Detailed description

Dementia is a public health priority. The prevalence of dementia is rapidly increasing due to population ageing, posing a great social and economic impact on caregivers, families and society. This, in combination with the lack of effective treatment options, demonstrates the urgent need for better understanding on how to prevent and slow down progression of this condition. As ageing and dementia are associated with increased levels of inflammation, nutritional compounds that exhibit anti-inflammatory properties may propose a solution. Blueberries, a good source of anthocyanins, have shown anti-inflammatory properties in several human trials. Therefore, in this randomized placebo controlled intervention study, we aim to investigate the effect of 12 weeks of supplementation with either 150g whole blueberries or freeze-dried blueberry powder (dose equivalent to 150g berries) versus placebo on cognitive functioning in overweight older adults with mild memory complaints. Secondary objectives include the assessment of whole blueberry and freeze-dried blueberry powder supplementation on inflammatory markers, oxidative stress, intestinal health markers, vascular and metabolic health markers, mental well-being, and levels of neurotransmitters.

Conditions

• Cognitive Decline
• Cognition Disorders in Old Age
• Aging

Interventions

Type	Name	Description
OTHER	Blueberry	Daily consumption of blueberries
DIETARY_SUPPLEMENT	Freeze-dried blueberry powder	Daily consumption of a freeze-dried blueberry powder
DIETARY_SUPPLEMENT	Placebo powder	Daily consumption of a placebo powder

Timeline

• Start date: 2021-11-01
• Primary completion: 2022-10-01
• Completion: 2022-10-01
• First posted: 2025-09-12
• Last updated: 2025-09-12