NCT06703307

Biomarkers Related to PSCI: An fNIRS Study

Identifying Biomarkers Related to Post-stroke Cognitive Impairment: A fNIRS Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Dingqun Bai · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This is an fNIRS study performed to identify biomarkers related to post-stroke cognitive impairment.

Detailed description

This was an initial screening and preliminary intervention study. Both healthy subject and stroke patients will be included in this study. Brain functional activation of each subject during the cognitive task (Stroop task, 1-back task and verbal fluency test) will be evaluated using functional near-infrared spectroscopy (fNIRS). Cognitive function related scale assessment included Mental State Examination Scale (MMSE), Montreal Cognitive Assessment (MoCA), drawing clock test (DCT), Shape trials test A.B (STT-A, STT-B), standardized digital modal test (SDMT), auditory verbal learning test-Huashan version (AVLT-H), and activity of daily living (ADL) scale will be used to evaluate the function of each patient. Biomarkers related to post-stroke cognitive impairment will be identified by by comparing differences in brain activation and brain network connectivity between patients and healthy subjects.

Conditions

• Stroke
• Cognitive Decline

Timeline

• Start date: 2024-08-01
• Primary completion: 2025-04-01
• Completion: 2025-04-30
• First posted: 2024-11-25
• Last updated: 2024-11-26

Locations

1 site across 1 country: China