NCT06448403

Multimodal Assesment of Alzheimer Patients

Multimodal Assessment of Cognitive Impairment in Alzheimer Patients

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 60 (estimated)
• Sponsor: Norwegian University of Science and Technology · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Accepted

Summary

The goal of this study is to learn more about the changes in the brains of patients with cognitive impairment (MCI) and Alzheimer's Disease (AD). The main questions the study aims to answer are: 1. What findings can be used to earlier detect patients that will develop Alzheimers? 2. Which differences are seen between healthy and cognitively impaired patients? 3. Which differences are seen between patients with Alzheimers disease? Participants will undergo: * Cognitive tests * Magnetic resonance imaging (MRI) * Electroencephalography (EEG) * Blood sample collection * Fecal sample collection * A randomized group will undergo polysomnography analysis.

Detailed description

The projects aims to map brain changes in patients with mild cognitive impairment (MCI) and Alzheimer's Disease (AD) by combining different assesment modalities. In the MRI, researchers will get the opportunity to analyse both structural and functional brain changes. In the EEG, changes in elctrical activites will be measured. The blood samples allow researchers to analyse specific dementia and inflammation proteins, while fecal speciments can be used to assess bacterial composition. Additionally, the cognitive testing allow to assess the specific part of cognitive function which is affected.

Conditions

• Mild Cognitive Impairment
• Alzheimer Disease, Late Onset
• Cognitive Impairment
• Dementia

Interventions

Type	Name	Description
DEVICE	MRI Scanning	MRI scanning with volumetric, resting and activity-based sequences.
DEVICE	64-channel EEG	EEG to quantifiy electric activity.
DEVICE	Polysomnography	A randomized group will undergo polysomnography.
BIOLOGICAL	Blood samples	Analysis of specific blood biomarkers.
BIOLOGICAL	Fecal samples	Analysis of bacterial composition.
BEHAVIORAL	Cognitive tests	Interview-based cognitive tests for assesment of cognitive levels.

Timeline

• Start date: 2024-07-01
• Primary completion: 2030-12-29
• Completion: 2030-12-29
• First posted: 2024-06-07
• Last updated: 2025-08-07

Locations

1 site across 1 country: Norway