NCT05864313

Gaze and Gait Training With rTMS

Gaze and Gait Training With Neuromodulation

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University of Florida · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to evaluate the feasibility of combining repetitive transcranial magnetic stimulation (rTMS), gaze and gait training to improve walking and balance in people with or without mild cognitive impairment.

Detailed description

The study plan is to recruit a total of 15 cognitively impaired and 15 healthy adults. The study will involve two visits. Each study visit will involve: * Real rTMS or sham rTMS that last about 60 minutes * Gaze stabilization exercise via a virtual reality headset for about 1-hour * Target stepping on a treadmill for about 1-hour Researchers will compare changes in gaze and gait following training sessions with real rTMS and sham rTMS.

Conditions

• Mild Cognitive Impairment

Interventions

Type	Name	Description
DEVICE	Repetitive Transcranial Magnetic Stimulation (rTMS)	10 Hz rTMS for 5 seconds over the frontal eye fields with 25 second intertrain interval for 10 trains (500 pulses) at 90% of the resting motor threshold,
BEHAVIORAL	Gait training	Subjects will practice stepping on virtual targets with real-time feedback of their foot position displayed on a screen while walking on a treadmill.
BEHAVIORAL	Gaze training	Subjects will perform gaze stabilization and gaze shifting exercise via a virtual reality headset.
DEVICE	Sham rTMS	Sham rTMS stimulation will produce discharge noise and vibration without stimulating the cerebral cortex.

Timeline

• Start date: 2026-09-01
• Primary completion: 2028-09-01
• Completion: 2028-09-01
• First posted: 2023-05-18
• Last updated: 2025-10-28

Regulatory

• FDA-regulated device study