NCT05948930

Working Memory and Physical Exercise Training in Patients With Mild Cognitive Impairment

Adaptive Working Memory and Physical Exercise Training to Improve Brain and Mitochondrial Function in MCI

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: University of Maryland, Baltimore · Academic / Other
• Sex: All
• Age: 50 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The prevalence of dementia will double in the next three decades in the U.S.; effective treatment or prevention for dementia is urgently needed. The current exploratory project aims to evaluate and understand how the brain and cognition may improve after a 12-week intervention that combines brain training and aerobic exercise training to improve brain function, both in those with mild cognitive impairment (some with possible prodromal Alzheimer's disease) and with healthy aging. Findings from this pilot project will guide and refine the development of a future larger clinical trial that aligns with the goals of the National Alzheimer's Plan of Action (NAPA), especially regarding "Prevent and Effectively Treat Alzheimer's Disease (AD) by 2025.

Conditions

• Mild Cognitive Impairment

Interventions

Type	Name	Description
BEHAVIORAL	Progressive aerobic exercise	Progressive aerobic exercise
BEHAVIORAL	Adaptive cognitive training	Adaptive cognitive training
BEHAVIORAL	Combined	Combine adaptive cognitive and progressive aerobic exercise training

Timeline

• Start date: 2024-01-08
• Primary completion: 2026-02-07
• Completion: 2026-08-07
• First posted: 2023-07-17
• Last updated: 2025-04-11

Locations

1 site across 1 country: United States