NCT05790707

EfFect of Ablation of Persistent AtriaL Fibrillation on COgNitive Function in Individuals With Mild Cognitive Impairment

EfFect of Ablation of Persistent AtriaL Fibrillation on COgNitive Function in Individuals With Mild Cognitive Impairment : - The FALCON Study-

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Poitiers University Hospital · Academic / Other
• Sex: All
• Age: 60 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to evaluate the effect of catheter ablation of persistent atrial fibrillation on cognitive function in patients with mild cognitive impairment. Participants will be randomized into antiarrhythmic drugs alone or atrial fibrillation ablation + antiarrhythmic drugs.

Conditions

• Mild Cognitive Impairment
• Persistent Atrial Fibrillation

Interventions

Type	Name	Description
PROCEDURE	Atrial fibrillation ablation + antiarrhythmic drugs	Atrial fibrillation ablation will be performed with endovascular catheters and will be done either with radiofrequency, cryoballoon or pulsed field ablation. Amiodarone, flecainide, sotalol, propafenone are the anti arrhythmic drugs allowed.
DRUG	Antiarrhythmic drug	Amiodarone, flecainide, sotalol, propafenone are the anti arrhythmic drugs allowed.

Timeline

• Start date: 2023-04-21
• Primary completion: 2027-01-01
• Completion: 2027-07-01
• First posted: 2023-03-30
• Last updated: 2026-01-23

Locations

8 sites across 1 country: France