Trials / Unknown
UnknownNCT00830726
Water- and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease
Water-and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease, Evaluated by the Excretion of Aquaporin-2 and Epithelial Sodium Channels in the Urine
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 150 (estimated)
- Sponsor
- Kolding Sygehus · Academic / Other
- Sex
- All
- Age
- 30 Years – 80 Years
- Healthy volunteers
- Accepted
Summary
The purpose of the study is to determine whether the excretion of renal water- and salt-channels in the urine reflects the handling of water and salt in the kidneys, and whether the excretion can be used to monitor and/or predict the effects of treatment of certain heart or lung diseases.
Detailed description
The purpose of the study is to determine whether the excretion of renal water- and salt-channels (Aquaporin-2 and Epithelial Sodium Channels) in the urine accurately reflects the handling of water and salt in the distal tubules af the kidneys, and whether quantification of these channels in the urine is useful to monitor and/or predict the effects of pharmacologic or surgical treatment of Heart Failure and heart failure-related diseases (Aortic stenosis, acute and chronic ischemic heart disease or pulmonary hypertension)
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Pharmacologic and mechanical heart failure treatment | Optimised, standard, evidence based heart failure therapy including the use of biventricular pacing. |
| PROCEDURE | Aortic valve replacement | Standard aortic valve replacement as per standard criteria in the department of thoracic surgery. |
| PROCEDURE | Revascularisation in Acute Coronary Syndrome | Standard percutaneous or surgical revascularisation in ACS. |
| PROCEDURE | Revascularisation in chronic stable angina pectoris | Standard percutaneous or surgical revascularisation |
Timeline
- Start date
- 2009-02-01
- Primary completion
- 2012-02-01
- Completion
- 2012-02-01
- First posted
- 2009-01-28
- Last updated
- 2011-06-23
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT00830726. Inclusion in this directory is not an endorsement.