NCT05629104

Prediction of Long-term Outcome in Aortic Stenosis After Valve Intervention

Biological Valve Prosthesis in Aortic Stenosis - Imaging, Biomarkers, Physical Performance and Patient Related Factors Predictive to Long-term Outcome (Bio-AS)

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: Uppsala University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

Patients with severe aortic stenosis accepted for transcatheter intervention or open surgery are included before the intervention, and then followed up with clinical visits during the first year after intervention. Imaging with echocardiography and computed tomography (CT) are performed together with additional imaging with magnetic resonance imaging (MRI) and Positron emissions tomography (PET)-CT in a subgroup of the study population. Blood samples, physical performance and questionnaires with focus on frailty and heart failure are also collected at each visit. A follow up with information of the outcomes after 2-5 years will be performed through national registries.

Conditions

• Aortic Stenosis

Interventions

Type	Name	Description
OTHER	There is no intervention since it is an observational study patients are treated according to clinical praxis	No intervention

Timeline

• Start date: 2019-05-15
• Primary completion: 2024-12-01
• Completion: 2027-12-01
• First posted: 2022-11-29
• Last updated: 2022-11-29

Locations

1 site across 1 country: Sweden