| Withdrawn | VAPorized Administration of Bumetanide for Outpatient Relief in Heart Failure NCT07375212 | Prisma Health-Upstate | Phase 4 |
| Recruiting | Effect of Losartan on the Neurohumoral Axis and Ventricular Remodeling of Patients With Severe Aortic Regurgit NCT07099859 | Vitor Emer Egypto Rosa | Phase 4 |
| Active Not Recruiting | Comparison of Noninvasive vs. Invasive Hemodynamic Measurements NCT06689215 | Nihon Kohden | — |
| Completed | Food Is Medicine for Patients With Heart Failure NCT06540118 | University of California, San Diego | N/A |
| Not Yet Recruiting | Feasibility Study to Support Cardiorenal Function in Acute Decompensated Heart Failure With Diuretic Resistanc NCT06174623 | Puzzle Medical Devices Inc. | N/A |
| Recruiting | Prediction of Heart-Failure with Machine Learning NCT06819618 | University Medical Center Goettingen | — |
| Recruiting | The ROle of Compression StocKings in Heart Failure Patients NCT06350695 | University of Maryland, Baltimore | N/A |
| Recruiting | The Cardio-share Telemedicine Cross-sector Collaboration Model for Managing Vulnerable Patients With Heart Fai NCT06176131 | University Hospital Bispebjerg and Frederiksberg | — |
| Recruiting | Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure NCT05677100 | Procyrion | N/A |
| Not Yet Recruiting | Artificial Intelligence and Smart Wearable Technologies for Early Detection of Acute Heart Failure NCT05591443 | Centro Cardiologico Monzino | — |
| Recruiting | ConTempoRary Cardiac Stimulation in Clinical practicE: lEft, BivEntriculAr, Right, and conDuction System Pacin NCT06324682 | University Hospital of Ferrara | — |
| Unknown | Evaluation of Nurse-led Integrated Care of Complex Patients Facilitated By Telemonitoring: The SMaRT Study NCT05543720 | University Health Network, Toronto | N/A |
| Completed | Implementing a Digitally-enabled Community Health Worker Intervention for Patients With Heart Failure NCT05130008 | Massachusetts General Hospital | N/A |
| Terminated | Above-Knee-High Application of Lower Limb Compression and Its Impact on Clinical Outcome in Patients Hospitali NCT05467735 | The University of Texas Medical Branch, Galveston | N/A |
| Completed | COVID-19, Patients' Evolution and the Influence of the Pandemic on Health Care and Outcomes in Chronic Disease NCT05168722 | Hospital Galdakao-Usansolo | — |
| Completed | Virtual Remote Physiological Monitoring Program of Children With Heart Disease NCT05034354 | University of Alberta | N/A |
| Unknown | PVP-Guided Decongestive Therapy in HF NCT05217342 | Marmara University | Phase 4 |
| Unknown | PVF in Decongestion of Heart Failure NCT05227872 | Assiut University | — |
| Unknown | Home BIA Management System in Patients With Heart Failure NCT05177081 | Korea University Guro Hospital | N/A |
| Completed | Project to Improve Communication About Serious Illness--Hospital Study: Comparative Effectiveness Trial (Trial NCT04283994 | University of Washington | N/A |
| Recruiting | Diuretics vs. Afterload Reduction for Treatment of HeartLogic Alerts NCT06218199 | Heart Center Research, LLC | Phase 4 |
| Completed | Heart Failure in Southern Sweden NCT04129658 | Region Skane | — |
| Completed | HIS-Purkinje Conduction System Pacing Optimized Trial of Cardiac Resynchronization Therapy NCT04561778 | Pugazhendhi Vijayaraman | N/A |
| Completed | Dapagliflozin on Volume Vascular Outcomes. NCT04869124 | Frank Ruschitzka | Phase 4 |
| Completed | The Aortix CRS Pilot Study NCT04145635 | Procyrion | N/A |
| Unknown | Apple-CPET Ted Rogers Understanding Exacerbations of Heart Failure NCT05008692 | University Health Network, Toronto | — |
| Terminated | RELieving Increasing oEdema Due to Heart Failure NCT04142788 | NHS Greater Glasgow and Clyde | Phase 4 |
| Completed | Balance, Aerobic Capacity, Mobility and Strength in Patients Hospitalized for Heart Failure (BAMS-HF) Program NCT04281849 | VA Eastern Colorado Health Care System | N/A |
| Unknown | Telemonitoring of Patients Admitted in Hospital at Home With Acute Decompensated Heart Failure - Pilot Study NCT04403659 | A.O.U. Città della Salute e della Scienza | N/A |
| Completed | Project to Improve Communication About Serious Illness--Hospital Study: Pragmatic Trial (Trial 1) NCT04281784 | University of Washington | N/A |
| Terminated | Comparison of Non-invasive Vs. Invasive Hemodynamic Measurements NCT04180202 | Nihon Kohden | — |
| Unknown | Utilizing Technology for Optimization of Pain Management and Mobilization in High Risk Cardiac Surgical ICU Pa NCT04146727 | Cedars-Sinai Medical Center | — |
| Active Not Recruiting | AB-1002 in Patients With Class III Heart Failure NCT04179643 | AskBio Inc | Phase 1 |
| Completed | Facilitating Communication Study NCT03721952 | University of Washington | N/A |
| Withdrawn | Early Feasibility Study to Assess Safety and Device Performance of AcoustiCare™ NCT03751904 | Signature Medical, Inc. | N/A |
| Unknown | Congestive Heart Failure and Atrial Tachyarrhythmias in Pmk Patients NCT03813589 | San Leonardo Hospital | — |
| Unknown | Efficacy and Safety of Ivabradine to Reduce Heart Rate Prior to Coronary CT-angiography in Advanced Heart Fail NCT03830957 | Rajaie Cardiovascular Medical and Research Center | N/A |
| Completed | Virtual Reality for Pain Management in Advanced Heart Failure NCT04572425 | Medstar Health Research Institute | N/A |
| Completed | Nicotinamide Riboside in LVAD Recipients NCT03727646 | University of Washington | EARLY_Phase 1 |
| Withdrawn | Comprehensive Medication Monitoring on Heart Failure Patient Outcomes NCT03519477 | Precera Bioscience, Inc. | N/A |
| Active Not Recruiting | HEARTBiT: Multi-Marker Blood Test for Acute Cardiac Transplant Rejection NCT03575910 | University of British Columbia | — |
| Unknown | Wrist Worn Blood Pressure Measurement NCT03919136 | LiveMetric S.A. | — |
| Terminated | Administration of Prothrombin Complex Concentrate vs. Standard Transfusion During/After Heart Transplantation NCT03341156 | University of Maryland, Baltimore | Phase 3 |
| Terminated | ANTHEM-HFrEF Pivotal Study NCT03425422 | LivaNova | N/A |
| Completed | Hemodynamic-GUIDEd Management of Heart Failure NCT03387813 | Abbott Medical Devices | N/A |
| Completed | Serum Catestatin Expression and Cardiometabolic Parameters in Patients With Congestive Heart Failure NCT03389386 | Josko Bozic | — |
| Completed | Personal Decision Support System for Heart Failure Management NCT03497871 | Jozef Stefan Institute | N/A |
| Completed | Personal Decision Support System for Heart Failure Management NCT05651698 | University Ghent | N/A |
| Completed | Effects of Empagliflozin on Clinical Outcomes in Patients With Acute Decompensated Heart Failure NCT03200860 | University Medical Center Groningen | Phase 2 |
| Unknown | Evaluation of Post-operative, Nurse-based Heart Failure Care in Non-cardiac Surgery NCT03202329 | Birgit Assmus | N/A |
| Completed | Multiple Cardiac Sensors for the Management of Heart Failure NCT03237858 | Boston Scientific Corporation | N/A |
| Unknown | Effect of mechanIcal circulatoRy Support ON Exercise Capacity aMong pAtieNts With Heart Failure NCT03078972 | University of Colorado, Denver | — |
| Completed | Left Ventricular Dyssynchrony in Multipole Pacing NCT03187470 | Adnan Kastrati, MD | N/A |
| Completed | Effects of Furosemide Plus Small HSS in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF) NCT04628325 | University of Palermo | Phase 3 |
| Terminated | High-Flow-Therapy for the Treatment of Cheyne-Stokes-Respiration in Chronic Heart Failure NCT03102827 | Heart and Diabetes Center North-Rhine Westfalia | Phase 3 |
| Withdrawn | Mobile App With Patient Financial Incentives for Adherence to Heart Failure Medications & Daily Self-Weighing NCT03034551 | Wellth Inc. | N/A |
| Completed | Pocket-sized Ultrasound for Point-of-care Diagnosis of Heart Failure NCT02939157 | Umeå University | — |
| Completed | A Phase I Study to Assess the Pharmacokinetics of GSK2798745 Tablets NCT02925546 | GlaxoSmithKline | Phase 1 |
| Withdrawn | LV Endocardial CRT for Patients With Intermediate QRS Width NCT03573427 | Jaimie Manlucu | — |
| Completed | Insomnia Self-Management in Heart Failure NCT02660385 | Yale University | N/A |
| Completed | Registry of Patients With CardioMEMS NCT02729922 | University of Pennsylvania | — |
| Completed | My Recordable On-Demand Audio Discharge Instructions NCT02901314 | The Cleveland Clinic | N/A |
| Unknown | Clinical Research to Explore Manifestations of Heart Failure Using Infrared Thermal Imaging Technology NCT02672618 | Jing Huang | — |
| Completed | Hemodynamic Response to Exercise in HFpEF Patients After Upregulation of SERCA2a NCT02772068 | Benjamin Levine | EARLY_Phase 1 |
| Terminated | Clinical Evaluation of the TRVD™ System in ADHF NCT03621436 | Magenta Medical Ltd. | N/A |
| Completed | Activity Level and Barriers to Participate of Cardiac Rehabilitation in Advanced Heart Failure Patients NCT03385837 | Hospital Israelita Albert Einstein | — |
| Unknown | Pilot Study for the Evaluation of the Safety and Performance of the RenaSense System in Hospitalized Acute Dec NCT02324400 | Nephera Ltd. | Phase 1 / Phase 2 |
| Completed | PREFERS (Preserved and Reduced Ejection Fraction Epidemiological Regional Study) Stockholm Heart Failure Study NCT03671122 | Karolinska Institutet | — |
| Completed | A Method Validation Study for Evaluation of Novel Treatments Limiting Pulmonary Oedema in Cardiac Failure NCT02135861 | GlaxoSmithKline | Phase 1 |
| Completed | Dietary Sodium Intake in Acute Heart Failure NCT03722069 | University of Sao Paulo | N/A |
| Terminated | AAV1-CMV-Serca2a GENe Therapy Trial in Heart Failure NCT01966887 | Assistance Publique - Hôpitaux de Paris | Phase 2 |
| Completed | ENABLE: CHF-PC (Comprehensive Heartcare For Patients and Caregivers) NCT03177447 | University of Alabama at Birmingham | N/A |
| Completed | MobileMedMinder: A Networked Aide for Medication Compliances NCT01597583 | University of Maryland, Baltimore | N/A |
| Completed | The Congestive Heart Failure Adherence Redesign Trial NCT01698242 | Lynda Powell, PhD, MEd | Phase 3 |
| Completed | SUrvey of Guideline Adherence for Treatment of Systolic Heart Failure in Real World NCT01390935 | GlaxoSmithKline | — |
| Completed | Effect of Targeting Left Ventricular Lead Position on the Rate of Response to Cardiac Resynchronization Therap NCT00399594 | University of Calgary | Phase 2 / Phase 3 |
| Completed | Evaluation of MRI Measures of Lung Water With Posture Changes in Healthy Volunteers and in Patients With Cardi NCT01277679 | GlaxoSmithKline | Phase 1 |
| Completed | A Multi-center, Placebo-controlled Study to Evaluate the Safety of GSK716155 and Its Effects on Myocardial Met NCT01357850 | GlaxoSmithKline | Phase 2 |
| Completed | A Prospective, Open-labeled, Multi-centric Trial in Subjects With Systolic Heart Failure to Evaluate Bisoprolo NCT01074307 | Merck KGaA, Darmstadt, Germany | Phase 4 |
| Completed | Enhancing Caregiver Support for Heart Failure Patients: the CarePartner Study NCT00555360 | US Department of Veterans Affairs | N/A |
| Completed | Effects of Adaptive Servoventilation in Patients With Systolic Heart Failure and Sleep-Disordered Breathing NCT01657188 | Ruhr University of Bochum | — |
| Completed | Patient-Centered Heart Failure Trial NCT00461513 | VA Office of Research and Development | — |
| Unknown | Torsion Optimization to Reduce Symptoms and Improve Outcomes in Non-responders NCT00867984 | University of Calgary | Phase 3 |
| Completed | Effect of omega3 on Congestive Heart Failure NCT01227837 | Shiraz University of Medical Sciences | N/A |
| Completed | A Phase I/II Clinical Study of SK&F-105517-D in Japanese Patients With Chronic Heart Failure NCT00742508 | GlaxoSmithKline | Phase 1 |
| Completed | Study of the Effect of Sitagliptin on Glucose (Sugar) Metabolism in Patients With Heart Failure NCT00657280 | Stanford University | EARLY_Phase 1 |
| Completed | A Family Intervention for Improving Self-Care of Patients With Heart Failure NCT00645489 | US Department of Veterans Affairs | EARLY_Phase 1 |
| Completed | The Role of Sleep Apnea in the Acute Exacerbation of Heart Failure NCT00679549 | Ohio State University | N/A |
| Completed | Exercise After an ICD NCT00522340 | University of Washington | Phase 2 |
| Completed | Telemonitoring in Patients With Heart Failure NCT00502255 | Maastricht University Medical Center | N/A |
| Completed | Efficacy and Safety of Relaxin for the Treatment of Acute Heart Failure NCT00520806 | Corthera, Inc.(formerly BAS Medical, Inc.), a member of the Novartis group of companies | Phase 2 / Phase 3 |
| Completed | CardioMEMS Heart Sensor Allows Monitoring of Pressure to Improve Outcomes in NYHA Class III Heart Failure Pati NCT00531661 | CardioMEMS | N/A |
| Unknown | N-Acetylcysteine in Heart Failure With Coexistent Chronic Renal Failure NCT00532688 | Bayside Health | Phase 2 / Phase 3 |
| Terminated | Bone Marrow Cell Transplantation to Improve Heart Function in Individuals With End-Stage Heart Failure NCT00383630 | Columbia University | Phase 2 |
| Withdrawn | Double Blind Randomized Placebo Controlled Trial of Natrecor in Acute Decompensated Heart Failure With Normal NCT00505791 | University of Medicine and Dentistry of New Jersey | Phase 4 |
| Completed | Transforming Psychotherapy for Chronically Ill Patients NCT00520429 | US Department of Veterans Affairs | Phase 1 / Phase 2 |
| Completed | Placebo-Controlled Randomized Study of KW-3902 for Subjects Hospitalized With Worsening Renal Function and Hea NCT00443690 | NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | Phase 3 |
| Withdrawn | Heart Failure Evaluation Acute Referral Team Trial (HEARTT) NCT00355511 | University of Alberta | N/A |
| Completed | RESynchronisation in Patients With Heart Failure and a Normal QRS Duration NCT00480051 | Heart of England NHS Trust | Phase 3 |
| Completed | Evaluation of a Portable Device for Assessing Sleep Disordered Breathing in Congestive Heart Failure NCT00493948 | ResMed | — |
| Completed | Investigation of Heart Failure Status Over Time Using Respiratory Parameters NCT00494117 | ResMed | — |
| Completed | A Study of Iron Oligosaccharide in CHF Patients NCT00537186 | Pharmacosmos A/S | Phase 3 |
| Completed | Cardiovascular Responses in Congestive Heart Failure With Cheyne- Stokes Respiration NCT00495196 | ResMed | N/A |
| Completed | Using Magnetic Resonance Imaging to Predict People Who Are Likely to Develop Flash Pulmonary Edema (The PREDIC NCT00542503 | Wake Forest University Health Sciences | — |
| Completed | Effectiveness of Peer Support in Improving Heart Failure Self-Management and Care NCT00508508 | University of Michigan | N/A |
| Completed | Acoustic Cardiographic Assessment of Heart Function in Comparison to Doppler-echocardiography NCT00541801 | Luzerner Kantonsspital | N/A |
| Completed | Educational Program for Various Health Literacy Levels to Improve the Health of Individuals With Heart Failure NCT00378950 | University of North Carolina, Chapel Hill | N/A |
| Completed | An Exploratory Study of Nesiritide in Participants With Acute Heart Failure NCT00490724 | Janssen Pharmaceutical K.K. | Phase 2 |
| Completed | Efficacy and Safety Study of Genetically Targeted Enzyme Replacement Therapy for Advanced Heart Failure NCT00454818 | Celladon Corporation | Phase 1 / Phase 2 |
| Completed | Self-Management and Care of Heart Failure With Group Clinics (SMAC-HF) NCT00439842 | Carol Smith, RN, PhD, FAAN | N/A |
| Terminated | HEAL-HF: A Cardiac Resynchronization Therapy (CRT) Outcomes Study NCT00370526 | Stereotaxis | Phase 4 |
| Completed | Acoustic Cardiographic Assessment of Heart Function and the Role of Phrenic Nerve Stimulation NCT00541541 | Luzerner Kantonsspital | N/A |
| Unknown | PREVENT-HF: Prevention of Heart Failure Events With Impedance Cardiography Testing NCT00409916 | CardioDynamics | Phase 4 |
| Completed | Mechanisms of Erythropoietin Action in the Cardiorenal Syndrome NCT00356733 | UMC Utrecht | Phase 3 |
| Completed | Safety and Pharmacodynamic Study of CD-NP NCT00482937 | Nile Therapeutics | Phase 1 |
| Completed | Educational Program to Improve Heart Failure Outcomes in Adults Living in Rural Areas NCT00415545 | University of California, San Francisco | Phase 3 |
| Completed | Optivol Diagnostic Data for Discharge in Heart Failure NCT00420108 | Thomas Jefferson University | — |
| Completed | IMMEDIATE Trial - Out of Hospital Administration of Glucose, Insulin and Potassium. NCT00091507 | Tufts Medical Center | Phase 3 |
| Suspended | Prednisone for Decompensated Congestive Heart Failure NCT00369044 | Hebei Medical University | Phase 2 / Phase 3 |
| Completed | TReatment of Atrial Fibrillation With Dual dEfibrillator in Heart Failure Patients NCT00345592 | Boston Scientific Corporation | Phase 4 |
| Unknown | Right Ventricular Defibrillation Lead Select Site Study NCT00385749 | Associates in Cardiology, PA | N/A |
| Completed | Clinical Assessment of Patients With Chronic Obstructive Pulmonary Disease (COPD) and/or Chronic Heart Failure NCT01114386 | University of Modena and Reggio Emilia | — |
| Completed | PROTECT-2: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Ac NCT00354458 | NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | Phase 3 |
| Completed | Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function NCT00094302 | Carelon Research | Phase 3 |
| Completed | PROTECT-1: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Ac NCT00328692 | NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | Phase 3 |
| Completed | Influence of Angiotensin Converting Enzyme (ACE) Genotype on Lung Diffusion in Heart Failure NCT00361127 | Piergiuseppe Agostoni | N/A |
| Unknown | Implantable Cardioverter Defibrillators And Magnetic Resonance Imaging of the Heart at 1.5 Tesla NCT00356239 | University Hospital, Bonn | — |
| Withdrawn | HEARTS: Heart, Exercise, and Resistance Training Study NCT00094250 | National Heart, Lung, and Blood Institute (NHLBI) | N/A |
| Completed | Lifetime Risk for Cardiovascular Disease Among Non-White Ethnic Groups NCT00377702 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | Interpersonal Psychotherapy for Depression in People With Heart Failure NCT00353223 | University of Iowa | Phase 1 / Phase 2 |
| Terminated | Patients With Heart Failure ANd Type 2 Diabetes Treated With Placebo Or Metformin (PHANTOM) Pilot Study NCT00325910 | University of Alberta | Phase 3 |
| Withdrawn | Effects of CPAP on Ventricular Function Modifications NCT00455611 | Ospedale S. Giovanni Bosco | N/A |
| Suspended | Diuretic Efficacy of Dexamethasone in Heart Failure NCT00263302 | Hebei Medical University | Phase 1 |
| Completed | Capturing Outcomes of Clinical Activities Performed by a Rounding Pharmacist Practising in a Team Environment NCT00351676 | University of Alberta | Phase 4 |
| Completed | Collaborative Care for Heart Failure Patients With the Metabolic Syndrome NCT00293852 | Baylor College of Medicine | N/A |
| Completed | MINERVA: MINimizE Right Ventricular Pacing to Prevent Atrial Fibrillation and Heart Failure NCT00262119 | Medtronic Cardiac Rhythm and Heart Failure | Phase 4 |
| Completed | Validation of a Mortality Prediction Model for Acutely Decompensated Heart Failure Patients NCT00536367 | Brian Hiestand MD | — |
| Terminated | ZP120 Add-on to Furosemide in Treatment of Acute or Sub-Acute Decompensated Heart Failure NCT00283361 | Zealand Pharma | Phase 2 |
| Terminated | Early Assessment of Anthracycline-induced Cardiotoxicity (CARDIOTOX) NCT00195897 | Centre Henri Becquerel | — |
| Unknown | Correlations Between BNP & Dry Weight, and Between Troponin & Mortality, in Hemodialysis Patients NCT00416013 | Eastern Virginia Medical School | — |
| Terminated | Renal Effects of Intrarenal Nesiritide NCT00270829 | University of Maryland, Baltimore | Phase 4 |
| Completed | Effect of 48 Hours of Treatment With the Natural Peptide-Hormone GLP-1 in Patients With Chronic Heart Failure NCT00264199 | Aarhus University Hospital Skejby | N/A |
| Completed | A Pilot Study of Recombinant Human Relaxin (rhRlx) in Compensated Congestive Heart Failure NCT00259116 | Corthera, Inc.(formerly BAS Medical, Inc.), a member of the Novartis group of companies | Phase 2 |
| Unknown | Safety and Effects of Implanted (Autologous) Skeletal Myoblasts (MyoCell) Using an Injection Catheter = SEISMI NCT00375817 | Bioheart, Inc. | Phase 2 |
| Completed | Stem Cell Therapy in Chronic Ischemic Heart Failure NCT00235417 | Odense University Hospital | Phase 2 |
| Completed | After Discharge Management of Low Income Frail Elderly NCT00328848 | Summa Health System | N/A |
| Completed | Help Veterans Experience Less Pain Study (HELP-Vets) NCT00230932 | US Department of Veterans Affairs | — |
| Terminated | Larger Dose of Spironolactone for the Treatment of Patients With Nonischemic Cardiomyopathy NCT00125437 | Hebei Medical University | N/A |
| Completed | Epidemiology of Depression and Heart Failure in Aging NCT00241761 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | Effect of KW-3902IV in Combination With IV Furosemide on Renal Function in Subjects With CHF and Renal Impairm NCT00159614 | NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | Phase 2 |
| Completed | Cardiovascular Health Study (CHS) Events Follow-up Study NCT00149435 | University of Washington | — |
| Unknown | The Effect of Alfa-Adrenergic Receptor Blockade on Insulin-Stimulated Forearm Glucose Uptake and Metabolism in NCT00132106 | Radboud University Medical Center | N/A |
| Unknown | BNP Testing in Patients With SOB on Presentation to ED NCT00163709 | Bayside Health | Phase 1 |
| Completed | Statin Therapy in Heart Failure: Potential Mechanisms of Benefit NCT00233480 | University of California, Los Angeles | Phase 4 |
| Terminated | OMNI Study--Assessing Therapies in Medtronic Pacemaker, Defibrillator, and Cardiac Resynchronization Therapy D NCT00277524 | Medtronic Cardiac Rhythm and Heart Failure | — |
| Completed | Meta-Iodobenzylguanidine Scintigraphy Imaging in Patients With Heart Failure and Control Subjects Without Card NCT00126425 | GE Healthcare | Phase 3 |
| Completed | Meta-Iodobenzylguanidine (123I-mIBG) Scintigraphy Imaging in Patients With Heart Failure and Control Subjects NCT00126438 | GE Healthcare | Phase 3 |
| Completed | Interagency Registry for Mechanically Assisted Circulatory Support (Intermacs) NCT00119834 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | Health E Heart Study (South Texas Veterans Health Care System Heart Failure Disease Management Program/Study) NCT00141856 | US Department of Veterans Affairs | Phase 4 |
| Completed | IMPROVE HF: Registry to Improve the Use of Evidence-Based Heart Failure Therapies in the Outpatient Setting NCT00303979 | Medtronic Cardiac Rhythm and Heart Failure | — |
| Terminated | Autologous/Allogeneic Progenitor Stem Cell Therapy for Congestive Heart Failure NCT00128258 | Amit, Patel N, M.D. | Phase 1 |
| Completed | PIE II: Pharmacological Intervention in the Elderly II NCT00123955 | Wake Forest University | Phase 3 |
| Completed | The Effect of Diet and Exercise in Heart Failure NCT00297154 | Baylor College of Medicine | N/A |
| Completed | Thoratec HeartMate II Left Ventricular Assist System (LVAS) for Bridge to Cardiac Transplantation NCT00121472 | Abbott Medical Devices | N/A |
| Unknown | Skeletal Muscle Dysfunction in Heart Failure NCT00156234 | Ullevaal University Hospital | N/A |
| Completed | Home Monitoring in Cardiac Resynchronisation Therapy NCT00376116 | Biotronik SE & Co. KG | — |
| Completed | Evaluation of the Safety and Effectiveness of the OPTIMIZER System in Subjects With Heart Failure: FIX-HF-5 NCT00112125 | Impulse Dynamics | N/A |
| Completed | Catheterization Laboratory Study: Acute Responses in Diastolic Heart Failure NCT00204945 | University of Wisconsin, Madison | N/A |
| Completed | Thoratec HeartMate II Left Ventricular Assist System (LVAS) for Destination Therapy NCT00121485 | Abbott Medical Devices | N/A |
| Terminated | Paracor Ventricular Support System (PVSS) for Patients With Heart Failure NCT00291551 | Paracor Medical, Inc | Phase 1 |
| Completed | Sensitivity of the InSync Sentry OptiVol Feature for the Prediction of Heart Failure NCT00400985 | Medtronic Cardiac Rhythm and Heart Failure | N/A |
| Terminated | Angiotensin Converting Enzyme Inhibition in Children With Mitral Regurgitation NCT00113698 | University of Utah | Phase 3 |
| Completed | Heart Pressure Assessment Study With Tolvaptan to Treat Congestive Heart Failure NCT00132886 | Otsuka Pharmaceutical Development & Commercialization, Inc. | Phase 2 |
| Terminated | Study of DITPA in Patients With Congestive Heart Failure NCT00103519 | Titan Pharmaceuticals | Phase 2 |
| Completed | MR, Myocardial Infarct and Heart Failure NCT00465868 | Helse Stavanger HF | — |
| Completed | Beta-Blocker Continuation Versus Interruption in Heart Failure Worsening NCT00162565 | Assistance Publique - Hôpitaux de Paris | Phase 4 |
| Completed | Efficacy and Safety of Ivabradine in Severe Congestive Heart Failure NCT00202579 | Institut de Recherches Internationales Servier | Phase 2 |
| Completed | Long-Term Predictors of Morbidity in Older Age NCT00094263 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Terminated | Randomized Trial for Patients With Chronic Heart Failure With Acute Decompensation NCT00357591 | Orqis Medical Corporation | N/A |
| Completed | Dose Escalation Study of KW-3902 on Diuresis in Subjects With Congestive Heart Failure (CHF). NCT00159627 | NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | Phase 2 |
| Completed | Biventricular Pacing In Patients With Left Ventricular Dysfunction After Cardiovascular Surgery NCT00321295 | Corewell Health East | Phase 3 |
| Completed | A Dose-finding Study of OPC-41061 in Treatment of Cardiac Edema (Congestive Heart Failure) NCT00234104 | Otsuka Pharmaceutical Co., Ltd. | Phase 2 |
| Completed | Registry for Acute Decompensated Heart Failure Patients Admitted to the ER NCT00364325 | Scios, Inc. | — |
| Completed | Epidemiology of Insulin Growth Factor (IGF) and Cardiovascular Events NCT00086424 | Albert Einstein College of Medicine | — |
| Completed | Effects of Exercise Training on Diastolic Heart Function in Postmenopausal Women NCT00125476 | National Heart, Lung, and Blood Institute (NHLBI) | N/A |
| Completed | PARTNERS HF: Program to Access and Review Trending Information and Evaluate Correlation to Symptoms in Patient NCT00279955 | Medtronic Cardiac Rhythm and Heart Failure | — |
| Completed | Effect of NT-proBNP Guided Treatment of Chronic Heart Failure NCT00149422 | Netherlands Heart Foundation | N/A |
| Completed | Progenitor Cell Therapy in Dilative Cardiomyopathy NCT00284713 | Johann Wolfgang Goethe University Hospital | Phase 1 / Phase 2 |
| Unknown | Ursodeoxycholic Acid in Chronic Heart Failure NCT00285597 | National Heart and Lung Institute | Phase 2 |
| Completed | The Purpose of This Study is to Determine if Eplerenone is Effective in Treatment of Mild to Moderate Heart Fa NCT00082589 | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Phase 4 |
| Completed | A Study of the Safety and Efficacy of Follow-up Serial Infusions of Natrecor(Nesiritide) for the Management of NCT00091520 | Scios, Inc. | Phase 2 |
| Completed | Heart Failure, Functional and Cognitive Decline, and Psychiatric Symptoms in Nursing Home Patients NCT00182065 | McMaster University | — |
| Unknown | The Early High Risk Period for Patients With Heart Failure NCT00127322 | Royal Brompton & Harefield NHS Foundation Trust | — |
| Completed | Heart Muscle Viability and Remodeling in Individuals Post-Heart Attack NCT00099411 | Tufts Medical Center | — |
| Completed | Evaluation of the Effects of Carperitide in Patients With Congestive Heart Failure NCT00259038 | Daiichi Sankyo | Phase 2 |
| Completed | Impact of Nesiritide Infusion for Decompensated Heart Failure in the Emergency Department NCT00559338 | University of Texas Southwestern Medical Center | Phase 4 |
| Completed | Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart Failure NCT00078286 | Duke University | Phase 2 / Phase 3 |
| Completed | Evaluation of Myocardial Viability by Means of Low-dose Dobutamine Gated SPECT (the DOGS Study) NCT00213746 | University Hospital, Rouen | — |
| Terminated | X-Change HF - Exchange of the Existing Pacemaker/ICD in Bradycardia Patients Suffering From Heart Failure NCT00157846 | Medtronic Cardiac Rhythm and Heart Failure | Phase 4 |
| Completed | Functional Circuit Training in Older Adults With Congestive Heart Failure NCT00108147 | US Department of Veterans Affairs | N/A |
| Completed | Trial of Angiotensin Converting Enzyme Inhibition in Infants With Single Ventricle--Pediatric Heart Network NCT00113087 | National Heart, Lung, and Blood Institute (NHLBI) | Phase 3 |
| Completed | Evaluation of Enalapril Versus Placebo in Patients With Diastolic Heart Failure NCT01411735 | Wake Forest University | Phase 3 |
| Terminated | Enoximone Plus Extended-Release Metoprolol Succinate in Subjects With Advanced Chronic Heart Failure NCT00077948 | Gilead Sciences | Phase 3 |
| Completed | ACCLAIM - Advanced Chronic Heart Failure CLinical Assessment of Immune Modulation Therapy NCT00111969 | Vasogen | Phase 3 |
| Withdrawn | Intravenous Allopurinol to Improve Heart Function in Individuals With Dilated Cardiomyopathy NCT00281255 | University of Pennsylvania | Phase 1 / Phase 2 |
| Recruiting | Prospective Observational Study of the ICD in Sudden Cardiac Death Prevention NCT00733590 | Johns Hopkins University | — |
| Completed | Dobutamine Echocardiography In Patients With Ischemic Heart Failure Evaluated for Revascularization NCT00074724 | Medstar Health Research Institute | N/A |
| Completed | Exercise Training Program to Improve Clinical Outcomes in Individuals With Congestive Heart Failure NCT00047437 | Duke University | Phase 3 |
| Completed | Resynchronization/Defibrillation for Ambulatory Heart Failure Trial NCT00251251 | Ottawa Heart Institute Research Corporation | N/A |
| Completed | Rosuvastatin Impact on Ventricular Remodelling Lipids and Cytokines NCT00240292 | AstraZeneca | Phase 3 |
| Completed | SAVEPACe - Search AV Extension and Managed Ventricular Pacing for Promoting Atrio-Ventricular Conduction NCT00284830 | Medtronic Cardiac Rhythm and Heart Failure | N/A |
| Completed | Organized Program To Initiate Lifesaving Treatment In Hospitalized Patients With Heart Failure (OPTIMIZE-HF) NCT00344513 | GlaxoSmithKline | Phase 4 |
| Completed | Effects of Carvedilol on Health Outcomes in Heart Failure NCT00381030 | Denver Health and Hospital Authority | Phase 4 |
| Completed | Longitudinal Registry for Advanced Heart Failure Patients NCT00364416 | Scios, Inc. | — |
| Completed | Evaluation of Intravenous Levosimendan Efficacy in the Short Term Treatment of Decompensated Chronic Heart Fai NCT00048425 | Abbott | Phase 3 |
| Completed | Mapping Novel Disease Genes for Dilated Cardiomyopathy NCT00046618 | Mayo Clinic | — |
| Completed | The DIAMOND Study: Distensibility Improvement And Remodeling in Diastolic Heart Failure NCT00043836 | Synvista Therapeutics, Inc | Phase 2 |
| Completed | Multi-Ethnic Study of Atherosclerosis (MESA) - Ancillary Eye Study NCT00041444 | University of Wisconsin, Madison | — |
| Completed | Monitoring Community Trends in Heart Failure NCT00035724 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | Multidisciplinary Inpatient Palliative Care Intervention NCT00325611 | Kaiser Permanente | N/A |
| Completed | Evaluation of a Nurse Case Management Model for Chronic Heart Failure NCT00105703 | US Department of Veterans Affairs | N/A |
| Terminated | ESSENTIAL-"The Studies of Oral Enoximone Therapy in Advanced Heart Failure" NCT00051285 | Gilead Sciences | Phase 3 |
| Completed | Comparison of Surgical and Medical Treatment for Congestive Heart Failure and Coronary Artery Disease NCT00023595 | Duke University | Phase 3 |
| Completed | FUSION I Assesses Safety and Tolerability of Two Doses of NATRECOR (Nesiritide) Administered to Patients With NCT00270361 | Scios, Inc. | Phase 3 |
| Completed | Estrogen, Cytokines and Heart Failure in Women NCT00041431 | National Heart, Lung, and Blood Institute (NHLBI) | N/A |
| Completed | Effect of Chronic Changes in Heart Rate on Congestive Heart Failure NCT00389649 | University of Maryland, Baltimore | N/A |
| Completed | Registry for Acute Decompensated Heart Failure Patients NCT00366639 | Scios, Inc. | — |
| Completed | Heart Failure Registry NCT00530426 | Scios, Inc. | — |
| Completed | Genetic Architecture of Heart Disease in Rural Brazil NCT00023556 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | Reversal of Ventricular Remodeling With Toprol-XL NCT00038077 | AstraZeneca | Phase 3 |
| Completed | Ventricular Matrix Remodeling: Correlates and Prognosis NCT00021892 | Boston University | — |
| Completed | A Self-Management Intervention for Mild to Moderate Heart Failure NCT00018005 | Lynda Powell, PhD, MEd | Phase 3 |
| Completed | Clinical Reminders in Test Reports to Improve Guideline Compliance NCT00414401 | US Department of Veterans Affairs | N/A |
| Completed | Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE) NCT00000619 | National Heart, Lung, and Blood Institute (NHLBI) | Phase 3 |
| Completed | ESCAPE Mechanistic Substudies - Ancillary to ESCAPE NCT00021957 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | A Study of Short-Term Outcomes and Economic Impact For Patients With Worsening Congestive Heart Failure When N NCT00270387 | Scios, Inc. | Phase 3 |
| Terminated | Growth Hormone and Heart Failure NCT00190359 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Occluded Artery Trial (OAT) NCT00004562 | NYU Langone Health | Phase 3 |
| Completed | Telmisartan in Haemodialysis Patients With Chronic Heart Failure NCT00490958 | University of Campania Luigi Vanvitelli | Phase 4 |
| Completed | Community Surveillance of Congestive Heart Failure NCT00005517 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | A Safety Study Comparing Natrecor (Nesiritide) Versus Dobutamine Therapy for Worsening Congestive Heart Failur NCT00270400 | Scios, Inc. | Phase 3 |
| Completed | Congestive Heart Failure Trends in the Elderly 1970-94 NCT00005499 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | Safety and Effectiveness of Cardiac Resynchronization Therapy With Defibrillation NCT00387803 | Boston Scientific Corporation | Phase 2 / Phase 3 |
| Completed | Salt Sensitivity, Cardiovascular and Metabolic Disease NCT00005489 | Indiana University | — |
| Completed | Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) NCT00000607 | Columbia University | Phase 3 |
| Completed | The Role of Angiotensin Type I Receptor in the Regulation of Human Peripheral Vascular Function NCT00001628 | National Heart, Lung, and Blood Institute (NHLBI) | Phase 3 |
| Completed | The Role of Angiotensin Type I Receptor in the Regulation of Human Coronary Vascular Function NCT00001629 | National Heart, Lung, and Blood Institute (NHLBI) | Phase 3 |
| Completed | Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) NCT00000609 | National Heart, Lung, and Blood Institute (NHLBI) | Phase 3 |
| Completed | Prevalence of Asymptomatic Ventricular Dysfunction NCT00005534 | Mayo Clinic | — |
| Completed | A Study to Develop Additional Safety and Clinical Experience With NATRECOR hBNP (Nesiritide) in the Treatment NCT00271557 | Scios, Inc. | Phase 3 |
| Completed | A Study of Two Doses of Intravenous NATRECOR hBNP (Nesiritide) in Patients With Worsening Congestive Heart Fai NCT00288730 | Scios, Inc. | Phase 3 |
| Completed | Beta-Blocker Evaluation in Survival Trial (BEST) NCT00000560 | National Heart, Lung, and Blood Institute (NHLBI) | Phase 3 |
| Completed | PET Scan to Determine Areas of Blood Flow and Activity in the Hearts of Patients With Heart Disease Taking Bet NCT00001402 | National Heart, Lung, and Blood Institute (NHLBI) | Phase 2 |
| Completed | Epidemiology of Cardiotoxicity in Children With Cancer NCT00005418 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | Natural History of Coronary Heart Disease NCT00005265 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | Digitalis Investigation Group (DIG) NCT00000476 | National Heart, Lung, and Blood Institute (NHLBI) | Phase 3 |
| Completed | Prevention of Early Readmission in Elderly Congestive Heart Failure Patients NCT00000475 | National Heart, Lung, and Blood Institute (NHLBI) | Phase 2 |
| Completed | Evaluating the Relationship Between Fatty Acids and Heart Disease NCT00404872 | Brigham and Women's Hospital | — |
| Active Not Recruiting | Cardiovascular Health Study (CHS) NCT00005133 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Recruiting | Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism NCT00181259 | Johns Hopkins University | — |
| Completed | Atherosclerosis Risk in Communities (ARIC) NCT00005131 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | Honolulu Heart Program NCT00005123 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Completed | Framingham Heart Study NCT00005121 | National Heart, Lung, and Blood Institute (NHLBI) | — |
| Withdrawn | A Study of Ularitide in the Treatment of Subjects With Acute Decompensated Heart Failure NCT00487799 | Facet Biotech | Phase 1 |
| Completed | Telephone Intervention in Heart Failure Patients NCT00057057 | US Department of Veterans Affairs | N/A |
| Withdrawn | An Efficacy and Safety Study for Nesiritide in Heart Failure Patients With Reduced Kidney Function Undergoing NCT00530361 | Scios, Inc. | Phase 3 |
| Completed | Exercise Effect on Aerobic Capacity and QOL in Heart Failure NCT00013221 | US Department of Veterans Affairs | Phase 4 |