NCT00284713

Progenitor Cell Therapy in Dilative Cardiomyopathy

Transplantation Of Progenitor Cells And Recovery Of Left Ventricular Function In Patients With Nonischemic Dilatative Cardiomyopathy

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Johann Wolfgang Goethe University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Intracoronary infusion of bone marrow derived progenitor cells into the LAD in patients with non ischemic dilated cardiomyopathy.

Detailed description

Initial clinical pilot trials suggested that intracoronary infusion of bone marrow-derived progenitor cells (BMC) may enhance left ventricular functional recovery in patients with acute myocardial infarction. It is unknown, however, whether such a strategy might also be applicable to patients with non-ischemic dilated cardiomyopathy (DCM). Therefore, we initiated the TOPCARE-DCM - trial (Transplantation Of Progenitor Cells And Recovery of Left Ventricular Function in Patients with non ischemic Dilatative CardioMyopathy) aiming to regionally improve left ventricular contractility by selective infusion of BMC into the left anterior descending coronary artery. Patients will be randomized 2:1 (20/10) BMC Infusion versus standard medical therapy

Conditions

• Heart Failure, Congestive
• Cardiomyopathy, Dilated
• Stem Cell Transplantation

Interventions

Type	Name	Description
PROCEDURE	intracoronary infusion of BMC	catheter delivery of stem cells

Timeline

• Start date: 2004-05-01
• Primary completion: 2009-01-01
• Completion: 2009-01-01
• First posted: 2006-02-01
• Last updated: 2009-02-18