NCT00369044

Prednisone for Decompensated Congestive Heart Failure

Chronic Administration of Prednisone in Management of Patients With Decompensated Congestive Heart Failure

• Status: Suspended
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Hebei Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

We designed this, randomized, double-blind, placebo-controlled trial to determine the clinical efficacy of chronic administration of prednisone on renal function and clinical status when added to standard care.

Detailed description

Studies showed that glucocorticoids could specifically dilate renal vessel, increase in GFR, and regulate synthesis and release of atrial natriuretic peptide (ANP), upregulate ANP receptors on vascular endothelial cells, leading to significant diuresis and natriuresis. Adding glucocorticoids to standard care may potentiate the diuretic and natriuretic effects of diuretics and improve renal function, thus improve the clinical outcomes.

Conditions

• Heart Failure, Congestive

Interventions

Type	Name	Description
DRUG	prednisone

Timeline

• Start date: 2006-10-01
• Completion: 2008-07-01
• First posted: 2006-08-29
• Last updated: 2009-04-08

Locations

1 site across 1 country: China