NCT00204945

Catheterization Laboratory Study: Acute Responses in Diastolic Heart Failure

Acute Responses in Diastolic Heart Failure

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University of Wisconsin, Madison · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

1. Research question: What is the response of the heart's pumping function to changes in heart chamber pressures? 2. Experimental design: Patients undergoing routine cardiac catheterization will be studied. A thermodilution pulmonary artery catheter will be inserted through a venous sheath and threaded into the pulmonary artery. After several minutes of quiet rest, baseline hemodynamics will be obtained, including a determination of cardiac output using thermodilution techniques and 30 seconds of pressure recordings from the left ventricle and proximal aorta. In addition, a brief echocardiogram will be performed, to determine ejection fraction and indices of diastolic filling. Finally, arterial tonometry will be obtained in quick succession from the brachial, radial, femoral, and carotid arteries. Following the collection of baseline data, a bolus and infusion of nesiritide will be started. After 10 minutes of nesiritide infusion, with the drug still infusing, a full set of invasive hemodynamics will again be obtained, as well as brief echocardiographic and arterial tonometry examinations.

Conditions

• Heart Failure, Congestive

Interventions

Type	Name	Description
DRUG	nesiritide	a bolus, then infusion of nesiritide for 10-15 minutes

Timeline

• Start date: 2005-02-01
• Primary completion: 2007-06-20
• Completion: 2007-06-20
• First posted: 2005-09-20
• Last updated: 2019-02-08

Locations

1 site across 1 country: United States