NCT00263302

Diuretic Efficacy of Dexamethasone in Heart Failure

Diuretic Efficacy of Dexamethasone in Congestive Heart Failure Patients

• Status: Suspended
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 60 (planned)
• Sponsor: Hebei Medical University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to determine whether glucocorticoids have potent diuretic effects in patients with congestive heart failure.

Detailed description

Glucocorticoids are known to have pronounced physiological effects in the kidney. Conventional teaching dictates that it should be used with caution in patients with congestive heart failure due to its fluid and sodium retention effects. Surprisingly, despite the widespread prevalence of this belief within the medical community, there are few data to support it. In fact, several small animal studies have documented its striking diuretic effects due to increased renal plasma flow and glomerular filtration rate without changes in the glomerular filtration fraction. We design this study to determine whether glucocorticoids have a potent diuretic effect in patients with heart failure.

Conditions

• Heart Failure, Congestive

Interventions

Type	Name	Description
DRUG	dexamethasone

Timeline

• Start date: 2006-03-01
• Completion: 2006-12-01
• First posted: 2005-12-08
• Last updated: 2008-07-04

Locations

2 sites across 1 country: China