Trials / Completed
CompletedNCT01277679
Evaluation of MRI Measures of Lung Water With Posture Changes in Healthy Volunteers and in Patients With Cardiac Failure
An Evaluation of MRI Measures of Lung Water Increases With Postural Changes in Healthy Subjects and in Patients With Cardiac Failure: A Methods Validation Study for Evaluation of Novel Treatments Limiting Pulmonary Oedema in Cardiac Failure
- Status
- Completed
- Phase
- Phase 1
- Study type
- Interventional
- Enrollment
- 20 (actual)
- Sponsor
- GlaxoSmithKline · Industry
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The aim of this study is to establish a model for the evaluation of drug targets using postural measures to induce changes in lung water concentration as assessed by MRI. A reduction in the magnitude and rate of water transudation with postural changes in patients with congestive heart failure (CHF) could provide a model for the evaluation of various classes of molecules for target validation and for dose selection.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | MRI | MRI of lungs to measure lung water content before and after passive leg raising (PLR) |
Timeline
- Start date
- 2011-01-01
- Primary completion
- 2011-08-01
- Completion
- 2011-08-01
- First posted
- 2011-01-17
- Last updated
- 2014-06-02
Locations
1 site across 1 country: United Kingdom
Source: ClinicalTrials.gov record NCT01277679. Inclusion in this directory is not an endorsement.