Dry Eye Disease

213 registered clinical trials studyying Dry Eye Disease — 24 currently recruiting.

Status	Trial	Sponsor	Phase
Recruiting	An Evaluation of the Safety and Tolerability of Ocular Lubricants NCT07238699	Alcon Research	N/A
Recruiting	Efficacy and Safety of BUFY01 Versus SVS20 in the Treatment of Dry Eye Disease NCT05865379	TRB Chemedica International SA	N/A
Not Yet Recruiting	A Study to Evaluate the Safety and Effectiveness of Perfluorohexyloctane Eye Drops on Treatment of Dry Eye Dis NCT07457021	Xiamen Ophthalmology Center Affiliated to Xiamen University	—
Recruiting	A Study on the Correlation Between Tear Iron Levels and the Severity of Dry Eye Disease. NCT07363824	Shanghai Changzheng Hospital	—
Not Yet Recruiting	Study to Evaluating PRO-240 Ophthalmic Solution Compared to Optive® NCT06375343	Laboratorios Sophia S.A de C.V.	Phase 1
Recruiting	Vit-A-Vision® Clinical Investigation NCT06596733	OmniVision GmbH	N/A
Recruiting	A Clinical Study to Evaluate the Effect and Side Effect of a New Artificial Tear Formulation (ABBV-444) Compar NCT07284381	AbbVie	Phase 3
Withdrawn	A Study to Assess the Long-Term Safety of Lifitegrast/Perfluorohexyloctane Fixed-Dose Combination in Subjects NCT07111013	Bausch & Lomb Incorporated	Phase 3
Recruiting	Evaluating the Safety, Tolerability, and Efficacy of GRF312 5% in Participants With Dry Eye Disease (DED). NCT07264517	Instituto Grifols, S.A.	Phase 2
Recruiting	A Study Evaluating the Safety and Efficacy of a Fixed-Dose Combination for Dry Eye Disease NCT07128628	Bausch & Lomb Incorporated	Phase 2
Not Yet Recruiting	Phase III Study of Topical Fibrinogen-Depleted Human Platelet Lysate Compared to Placebo for Moderate to Sever NCT06903611	Cambium Bio Limited	Phase 3
Recruiting	Efficacy and Safety of BUFY02 Versus TRB02 in the Treatment of Dry Eye Disease NCT05865457	TRB Chemedica International SA	N/A
Completed	Phase 2b Controlled Study NCT07140380	IVIEW Therapeutics Inc.	Phase 2
Recruiting	A Study to Explore Signs, Symptoms, and Biomarkers in Dry Eye Disease Participants Following Anti-inflammatory NCT07025811	Hoffmann-La Roche	Phase 4
Not Yet Recruiting	A Study to Evaluate the Efficacy and Safety of Treatment With CsA-PG Ophthalmic Gel in Dry Eye Patients NCT06942793	Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.	Phase 3
Not Yet Recruiting	Efficacy of Lipid-containing Artificial Tears in the Treatment of Dry Eye NCT06955585	University Hospital Sestre Milosrdnice	N/A
Terminated	Evaluation of the Safety and Tolerability of Ocular Lubricants NCT06571656	Alcon Research	N/A
Not Yet Recruiting	Characterization of Subjective Discomfort in Patients With Tear Dysfunction NCT06819631	IRCCS Azienda Ospedaliero-Universitaria di Bologna	—
Completed	A Study to Evaluate 0.003% AR-15512 Safety and Drop Attributes NCT06660290	Alcon Research	Phase 3
Not Yet Recruiting	Effect of Artificial Tears on Ocular Biometry Parameters NCT06656403	He Eye Hospital	N/A
Terminated	Evaluation of Reflex Tear Production NCT06565624	Alcon Research	N/A
Completed	A Study Designed to Evaluate Tear Production NCT06544707	Alcon Research	Phase 3
Completed	A Study to Investigate the Effect of 0.003% AR-15512 on Subjects With Dry Eye Disease NCT06544694	Alcon Research	Phase 3
Completed	Effectiveness of Dry Eye Treatment With Diquafosol Sodium 3% After Phaco Surgery NCT07122635	Le Xuan Cung	—
Completed	Study of Safety and Performance of a Novel Ocular Lubricant in Subjects With Dry Eye Disease NCT06444516	Alcon Research	N/A
Not Yet Recruiting	iTear Single-center, Open-label, Single-arm Study NCT06525961	The University of Hong Kong	Phase 4
Completed	Efficacy of Twinkle Eyez Supplementation in Improving Ocular Health and Immunity NCT06574685	Ecolite Group	N/A
Completed	IVW-1001 Phase 1/2 in Subjects With Dry Eye Disease NCT06400459	IVIEW Therapeutics Inc.	Phase 1 / Phase 2
Completed	A Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease NCT06493604	Aldeyra Therapeutics, Inc.	Phase 3
Completed	Preoperative iLux on Cataract Surgery Derived Dry Eye Disease Due to Meibomian Gland Dysfunction NCT06483750	George Washington University	N/A
Active Not Recruiting	A Phase 3 Study to Evaluate AZR-MD-001 in Patients with Abnormal Meibomian Gland Function and Dry Eye Disease NCT06329791	Azura Ophthalmics	Phase 3
Completed	Clinical Study to Evaluate the Safety and Tolerability of PRO-229 Ophthalmic Solution Compared to Lagricel® Of NCT06370585	Laboratorios Sophia S.A de C.V.	Phase 1
Completed	A Clinical Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease NCT06424444	Aldeyra Therapeutics, Inc.	Phase 3
Completed	A Clinical Trial to Evaluate the Corneal Endothelial Health of DED Subjects Treated With Cyclosporine NCT06329661	Novaliq GmbH	Phase 4
Completed	A Clinical Trial to Assess the Efficacy and Safety of Subjects With Dry Eye Disease NCT06389214	Aldeyra Therapeutics, Inc.	Phase 3
Unknown	Neurological Dry Eye Study Stimulating Both Lacrimal and Vagus Nerves NCT06271005	Genetic Disease Investigators	N/A
Completed	Study of INV-102 Ophthalmic Solution in Adults With Moderate to Severe Dry Eye Disease NCT06370039	Invirsa, Inc.	Phase 2
Enrolling By Invitation	Efficacy of 0.05% Cyclosporine A Eye Drops Combined With Absorbable Tear Duct Plugs in the Treatment of Dry Ey NCT07171710	Tianjin Eye Hospital	N/A
Recruiting	The Pattern of Dry Eye Disease After Cataract Surgery NCT06298890	Lithuanian University of Health Sciences	—
Active Not Recruiting	A Study of TL-925 Ophthalmic Emulsion as a Treatment for Dry Eye Disease NCT06225973	Telios Pharma, Inc.	Phase 2
Recruiting	Evaluation of the Effectiveness of a Community Health Management Program for Dry Eye Disease in Middle-Aged an NCT06443554	Fujian University of Traditional Chinese Medicine	N/A
Completed	A Safety and Efficacy Study of 2 Dosing Regimens of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drop Sol NCT06244316	Dompé Farmaceutici S.p.A	Phase 2
Unknown	Topical Statin Eye Drop in the Management of the Dry Eye NCT06208384	Shahid Beheshti University of Medical Sciences	Phase 1 / Phase 2
Unknown	Efficacy and Safety of USL for Dry Eye Disease NCT06016010	Chan-Sik Kim	Phase 2
Unknown	Corneal and Tear Film Changes in Chinese Patients With Type 2 Diabetes NCT06218992	He Eye Hospital	—
Unknown	Safety and Efficacy of ST-100 (Vezocolmitide) Ophthalmic Solution 60 μg/ml Ophthalmic Solution in Subjects Dia NCT06178679	ORA, Inc.	Phase 3
Completed	Safety and Efficacy of Licaminlimab Ophthalmic Solution for the Treatment of Dry Eye Disease NCT05896670	Oculis	Phase 2
Unknown	Assess the Effects of Spectacles or Orthokeratology on Dry Eye Parameters in Children and Adolescents. NCT06023108	He Eye Hospital	N/A
Unknown	Eye Mask on Sleep Quality and Tear Layer Function in Patients With Dry Eye Disease NCT06016166	Hamideh Sabbaghi	N/A
Completed	Evaluation of Miebo (Perfluorohexyloctane) Eyedrops in Habitual Contact Lens Wearers NCT06176651	Gordon Schanzlin New Vision	Phase 4
Active Not Recruiting	Clinical Study Evaluating Nordlys™ SWT IPL for Dry Eye Disease (DED) Due to MGD NCT06064071	Candela Corporation	N/A
Unknown	Study of Application of Pulse Electrical Stimulation Around Eye in Dry Eye Disease Patients Who Are Scheduled NCT06120348	Nu Eyne Co., Ltd.	N/A
Unknown	The Effects and Safety of Topical Spironolactone Ophthalmic Solution, 0.005 mg/cc in Subjects With Dry Eye Dis NCT05995392	Richard W Yee, MD	EARLY_Phase 1
Withdrawn	Examining the Clinical Characteristics, Treatment Patterns, Real-world Effectiveness, and Healthcare Resource NCT05857748	Novartis Pharmaceuticals	—
Completed	Evaluation of Safety and Tolerability of Investigational Ocular Lubricants NCT05888519	Alcon Research	N/A
Completed	Efficacy and Safety Evaluation of Tavilermide Ophthalmic Solution for the Treatment of Dry Eye NCT05848128	Mimetogen Pharmaceuticals USA, Inc.	Phase 3
Completed	Effect of Sunflower Lecithin Supplementation on Meibomian Gland Function in Adults With Dry Eye Disease NCT06058559	George Washington University	N/A
Completed	Improving Drop Instillation Comfort of a Cyclosporine A Solution NCT05957211	University of Waterloo	N/A
Suspended	QST for Corneal Nerve Function NCT05758753	Tufts Medical Center	N/A
Completed	Dry Eye Disease and Retinal Nerve Fiber Layer Thickness in Chronic Smokers NCT07028736	Cairo University	—
Completed	The Study Evaluating the Efficacy and Safety of OK-101 in Subjects With Dry Eye Disease NCT05759208	Okyo Pharma Ltd	Phase 2
Completed	Prospective Evaluation of Efficacy and Safety of an Intense Pulsed Light Device to Treat Dry Eye Disease" NCT06349356	Quantel Medical	N/A
Completed	HU007 in Patients with Dry Eye Syndrome NCT05743764	Huons Co., Ltd.	Phase 3
Terminated	A Multi-Centre, Randomised, Controlled, Masked Phase 2 Study of the Safety and Efficacy of KIO-101 Ophthalmic NCT05629364	Kiora Pharmaceuticals, Inc.	Phase 2
Unknown	Management of the Ocular Surface With Preservative-Free Lubricants in Patients With Dry Eye NCT06162442	Tecnoquimicas	—
Unknown	Idroflog® for Treatment of Dry Eye Disease (IDROFLOG) NCT05724056	Alfa Intes Industria Terapeutica Splendore s.r.l.	N/A
Unknown	Safety and Efficacy of Pluripotent Stem Cell-derived Mesenchymal Stem Cell Exosome (PSC-MSC-Exo) Eye Drops Tre NCT05738629	Second Affiliated Hospital, School of Medicine, Zhejiang University	Phase 1 / Phase 2
Completed	Assessment of the Safety and Efficacy of BRM421 Ophthalmic Solutions in Dry Eye Subjects. NCT05695781	BRIM Biotechnology Inc.	Phase 3
Completed	A Study of TL-925 as a Treatment for Dry Eye Disease NCT05745064	Telios Pharma, Inc.	Phase 2
Completed	Phase II Study of SHJ002 Sterile Ophthalmic Solution Compared With Vehicle in Participants With Dry Eye Diseas NCT05486728	Dreamhawk Vision Biotech, Inc.	Phase 2
Unknown	Intense Regulated Pulse Light Therapy in Dry Eye Disease NCT05553561	Menoufia University	N/A
Completed	Evaluation of the Tolerability and Efficacy of CWT-f-002 Lubricant Eye Drops NCT05660681	Calm Water Therapeutics LLC	N/A
Completed	Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of OC-01 in Adult Chinese With Dry Eye Disease NCT05576415	Corxel Pharmaceuticals	Phase 1
Completed	PMCF Study to Evaluate Performance and Safety of "Xanoftal Next" NCT05829499	C.O.C. Farmaceutici S.r.l.	N/A
Unknown	Assessment of Efficacy and Safety of the Use of Two Eye Gel Products Containing 5% Dexpanthenol in Patients Wi NCT06210373	Fidia Farmaceutici s.p.a.	N/A
Completed	A Long-Term Safety Study Evaluating the Safety and Systemic Exposure of AR-15512 NCT05493111	Aerie Pharmaceuticals	Phase 3
Unknown	Effectiveness of Diquafosol Prophylactic Therapy to Prevent Dry Eye Disease for Cataract Surgery Patients in I NCT06146881	Indonesia University	Phase 2
Completed	PMCF Study to Evaluate Performance and Safety of "HPMC-based Eyedrops" Used to Relieve Dry Eye Symptoms NCT05825599	C.O.C. Farmaceutici S.r.l.	N/A
Completed	Study of INV-102 Ophthalmic Solution in Adults With Moderate Symptomatic Dry Eye Disease NCT05586152	Invirsa, Inc.	Phase 1 / Phase 2
Unknown	A Randomized, Controlled, Double-masked, Investigator-initiated Trial to Evaluate Tear Film Quality and Stabil NCT05514041	Stephenson Eye Associates	Phase 4
Completed	PMCF Study to Evaluate Performance and Safety of "Distilled Waters-based Eyedrops" Used to Relieve Dry Eye Sym NCT05825586	C.O.C. Farmaceutici S.r.l.	N/A
Completed	A Study for Evaluation of the Efficacy and Safety of SI-614 Ophthalmic Solution in Patient With Dry Eye NCT05411367	Seikagaku Corporation	Phase 3
Completed	Study of SY-201 Ophthalmic Solution in Subjects With Dry Eye Disease NCT05370495	Seinda Pharmaceutical Guangzhou Corporation	Phase 1 / Phase 2
Completed	Clinical Trial to Evaluate the Efficacy and Safety of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of NCT05378945	Corxel Pharmaceuticals	Phase 3
Completed	Feasibility of IPL Combined With RF for Treatment of DED Due to MGD NCT05487547	Lumenis Be Ltd.	N/A
Completed	Study Evaluating the Safety and Efficacy of AR-15512 (COMET-3) NCT05360966	Aerie Pharmaceuticals	Phase 3
Completed	A Study to Confirm the Efficacy and Safety of K-161 Ophthalmic Solution for Treatment of Moderate to Severe Dr NCT05403827	Kowa Research Institute, Inc.	Phase 3
Completed	PMCF Study to Evaluate Performance and Safety of "Hyaluronic Acid (HA)-Based Eyedrops" Used to Relieve Dry Eye NCT05807360	C.O.C. Farmaceutici S.r.l.	N/A
Completed	A Study of AG-80308 in Dry Eye Patients NCT05372107	Allgenesis Biotherapeutics Inc.	Phase 1
Completed	PMCF Study to Evaluate Performance and Safety of "CLHA-based Eyedrops" Used to Improve Lacrimal Abnormalities NCT05823961	C.O.C. Farmaceutici S.r.l.	N/A
Completed	PMCF Study to Evaluate Performance and Safety of "Optrex Double Action Soothing and Lubricating Drops" NCT05824000	C.O.C. Farmaceutici S.r.l.	N/A
Completed	Burden of Illness and Treatment Assessment of Patients With Dry Eye Disease: A Cross-Sectional Survey of Real- NCT06018571	Novartis Pharmaceuticals	—
Completed	Vizol S Lipid Balance Efficacy and Safety Study in Patients With Dry Eye NCT06323395	Jadran Galenski laboratorij d.d.	Phase 3
Completed	Study Evaluating the Safety and Efficacy of AR-15512 NCT05285644	Aerie Pharmaceuticals	Phase 3
Recruiting	2177GCCC:ID'Ing tx Targets and Biomarkers for Ocular Surface Disease in Pt w/ oGVHD NCT04946721	University of Maryland, Baltimore	—
Completed	Diamond Bur Microblepharoexfoliation, Intense Pulse Light and Meibomian Gland Expression for Evaporative Dry E NCT05857579	University of Seville	N/A
Completed	PMCF Study to Evaluate Performance and Safety of "Ocular Drops Based Upon Carmellose" Used to Relieve Dry Eye NCT05825352	C.O.C. Farmaceutici S.r.l.	N/A
Completed	Safety Study of Tivanisiran to Treat Dry Eye NCT05310422	Sylentis, S.A.	Phase 3
Unknown	Comparison of Two Types of Artificial Tears NCT05356728	The Norwegian Dry Eye Clinic	N/A
Completed	Efficacy of Riboflavin-Enhanced Hyaluronic Acid Eye Drops in Treating Dry Eye Disease NCT06122428	University of Naples	—
Completed	Study to Evaluate Safety and Efficacy of Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease NCT05136170	Dompé Farmaceutici S.p.A	Phase 3
Completed	A Study to Evaluate the Safety, Tolerability, and Efficacy of A197 in Subjects With Dry Eye Disease NCT05238597	Aramis Biosciences, Inc.	Phase 2
Completed	Systane Hydration in Subjects Undergoing Cataract Surgery NCT05056233	Alcon Research	N/A
Completed	Sphenopalatine Ganglion Stimulation for Ocular and Oral Dryness NCT05187533	Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA	N/A
Completed	Safety and Efficacy of Pilocarpine Ophthalmic Topical Cream for the Treatment of Dry Eye Disease NCT05119920	Glaukos Corporation	Phase 2
Completed	Safety of Tinted Soft Scleral Eye Shields When IPL is Applied on Eyelids NCT05168670	Lumenis Be Ltd.	N/A
Completed	Study Evaluating Techniques for Measuring Tear Production NCT05497479	Aerie Pharmaceuticals	Phase 1
Completed	Hyaluronic Acid-containing Artificial Tears in Post-cataract Surgery Dry Eye Disease NCT06221345	Chang Gung Memorial Hospital	Phase 4
Unknown	IIT Assessing OC-01Nasal Spray on Symptoms of DED Following CXL NCT05136924	Vance Thompson Vision - MT	Phase 2
Completed	Efficacy and Safety of 20% and 100% Autologous Serum Eye Drops in Patients With Severe Dry Eye Disease (AST) NCT07469865	University Hospital, Ghent	N/A
Completed	Ditefossol Sodium 3% Eye Drops in Patients With Dry Eye NCT06560580	Tianjin Eye Hospital	N/A
Completed	Systane Complete Multi-symptom Relief NCT05056155	Alcon Research	N/A
Completed	Strip Meniscometry in Dry Eye Evaluation NCT06120894	University Hospital Olomouc	—
Completed	Investigator Initiated Study to Assess the Efficacy of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms o NCT05082974	Vance Thompson Vision ND	Phase 3
Completed	Evaluation of the Safety, Tolerability and Efficacy of iNexin™ for the Treatment of the Signs and Symptoms Ass NCT05031806	Xequel Bio, Inc.	Phase 1
Completed	The Evaluation of the Transcutaneous Electrical Stimulation Medical Device's Safety and Effectiveness in Treat NCT05203796	Nu Eyne Co., Ltd.	N/A
Recruiting	Transcutaneous Auricular Vagus Nerve Stimulation in Dry Eye NCT06696625	Beijing Tongren Hospital	N/A
Unknown	Corneal Thickness Changes in Patient Undergoing Dry Eye Managment NCT04970329	University of Faisalabad	N/A
Unknown	Efficacy of Blue Wavelength in Managing Dry Eye NCT04965974	University of Faisalabad	N/A
Recruiting	Transcutaneous Auricular Vagus Nerve Stimulation in Dry Eye Disease NCT04673643	Beijing Tongren Hospital	Phase 2
Completed	Tivanisiran for Dry Eye in Subjects With Sjögren's Syndrome NCT04819269	Sylentis, S.A.	Phase 3
Completed	Study of ST-100 as Treatment for Dry Eye Disease NCT05241470	Stuart Therapeutics, Inc.	Phase 2
Unknown	Effect of Traditional Chinese Medicine on Basic Tear Secretion and Tear Cytokines in Patients With Dry Eye Dis NCT04785261	China Medical University Hospital	Phase 2
Completed	Efficacy and Safety of SHR8028 Eye Drops for the Treatment of Dry Eye Disease NCT05841043	Jiangsu HengRui Medicine Co., Ltd.	Phase 3
Completed	Comparison of Mucin Levels at the Ocular Surface of Visual Display Users With and Without Dry Eye Disease NCT05604651	Peking University Third Hospital	—
Completed	Safety and Efficacy of Two Different Concentrations (0.5% and 1%) of Progesterone Topical Gel Compared to Plac NCT04645446	SIFI SpA	Phase 2
Completed	Comparison of Efficacy Between 100% Platelet-rich Plasma and 100% Serum Eye Drops in Dry Eye Disease NCT04683796	Mahidol University	Phase 3
Unknown	Multimodal Screening of Dry Eye Disease NCT04235400	Assistance Publique - Hôpitaux de Paris	—
Completed	A Multi-Center, Double-Masked, Randomized, Vehicle-Controlled, Parallel-Group Clinical Trial Evaluating the Sa NCT04735393	Aldeyra Therapeutics, Inc.	Phase 3
Unknown	Comprehensive Study on Dry Eye and Ocular Surface Disease Prior and After Cataract Surgery NCT04711642	Fundación Oftalmológica Los Andes	Phase 3
Completed	A Research Study To See How Well an Eye Drop, SURF-100 (A Mycophenolic Acid/Betamethasone Sodium Phosphate Com NCT04734197	Surface Ophthalmics, Inc.	Phase 2
Completed	Research Study To See How Well An Eye Drop (SURF-200) Works, What Side Effects There Are, And To Compare It Wi NCT04734210	Surface Ophthalmics, Inc.	Phase 2
Unknown	Pre-Surgical Ocular Surface Treatment With Intracanalicular Dexamethasone Insert And Effect On Intraocular Len NCT04530864	Prism Vision Group	Phase 4
Completed	ESSENCE 2: CyclASol for the Treatment of Signs and Symptoms of Dry Eye Disease (DED) NCT04523129	Novaliq GmbH	Phase 3
Completed	Effect of NOV03 on Signs and Symptoms of Dry Eye Disease Associated With Meibomian Gland Dysfunction (Mojave S NCT04567329	Bausch & Lomb Incorporated	Phase 3
Completed	A Phase 2b Study Evaluating the Safety and Efficacy of AR-15512 Ophthalmic Solution for the Treatment of Dry E NCT04498182	Aerie Pharmaceuticals	Phase 2
Completed	Study on Safety and Performance of an Artificial Tear in Dry Eye Treatment in Subjects With Ocular Surface Inf NCT04633863	MD Italy	N/A
Recruiting	Ocular Microbiome and Immune System in Dry Eyes NCT04658238	Insel Gruppe AG, University Hospital Bern	—
Completed	Study to Evaluate the Efficacy and Safety of CKD-352 NCT04548427	Chong Kun Dang Pharmaceutical	Phase 3
Completed	Changes in Tear Lipid Layer Thickness After Short Exposure to Light Emitting Diode Displays NCT05003128	National Cheng-Kung University Hospital	N/A
Completed	Effect of Cequa™ in Subjects With Dry Eye Disease NCT04357795	Sun Pharmaceutical Industries Limited	Phase 4
Completed	Study to Evaluate the Safety, Tolerability, and Efficacy of OTX-CSI in Subjects With Dry Eye Disease. NCT04362670	Ocular Therapeutix, Inc.	Phase 1 / Phase 2
Completed	Evaluating the Efficacy of Dry Eye (DE) Disease Treatment Using Novel Tear Film Imager (TFI) NCT04670263	Adom Advanced Optical Technologies Ltd.	Phase 2 / Phase 3
Completed	A Study of the Drugs AGN-242428 and AGN-231868 in Participants With Dry Eye Disease NCT04030962	AbbVie	Phase 1 / Phase 2
Completed	Application of Pulse Electrical Stimulation Around Eye in Dry Eye Disease Patients Scheduled for LASEK Surgery NCT05271422	Nu Eyne Co., Ltd.	N/A
Completed	Efficacy and Safety of PL9643 Ophthalmic Solution in Subjects With Dry Eye NCT04268069	ORA, Inc.	Phase 2
Completed	Phase 1/2a Safety and Efficacy of ALY688 Ophthalmic Solution in Subjects With Dry Eye Disease NCT04201574	Allysta Pharmaceutical	Phase 1 / Phase 2
Unknown	Refractory Meibomian Gland Dysfunction and Plasma Jet NCT04608942	Federal University of São Paulo	N/A
Completed	Safety, PK and Efficacy Study of SJP-0132 in Subjects With Dry Eye Disease NCT04139122	Senju Pharmaceutical Co., Ltd.	Phase 1 / Phase 2
Completed	The Ocular Microbiome in Patients With Dry Eye Disease NCT04656197	Insel Gruppe AG, University Hospital Bern	—
Completed	Concentration of Ofloxacin Into the Aqueous Humour of Patients With Dry Eye Disease NCT05213156	University Hospital of Patras	Phase 4
Completed	A Study Assessing the Safety, Efficacy, and Optimum Dosage of K-161 in Subjects With Moderate to Severe Dry Ey NCT04084483	Kowa Research Institute, Inc.	Phase 2
Completed	Clinical Trial to Evaluate the Chronic Efficacy of OC-01 Nasal Spray on Signs of Dry Eye Disease (The MYSTIC S NCT03873246	Oyster Point Pharma, Inc.	Phase 2
Unknown	Self-care Management Program for Dry Eye Disease Patients Using the heiQ NCT03467490	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's	N/A
Completed	Efficacy of OC-01 Nasal Spray on Goblet Cell and Meibomian Gland Stimulation NCT03688802	Oyster Point Pharma, Inc.	Phase 2
Completed	Study to Assess Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of Palovarot NCT04762355	Clementia Pharmaceuticals Inc.	Phase 1
Completed	Evaluation of the Efficacy of OC-01 Nasal Spray on Signs and Symptoms of Dry Eye Disease NCT03636061	Oyster Point Pharma, Inc.	Phase 2
Completed	Evaluation of the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (the RAINIER Study) NCT03633461	Oyster Point Pharma, Inc.	Phase 2
Completed	Effect of Topical Naltrexone Ophthalmic Solution on the Signs and Symptoms of Dry Eye in Diabetic Subjects NCT03660475	Sassani, Joseph S., MD, MHA	Phase 2
Completed	Study of Efficacy and Tolerability of SYSTANE Complete in Patients With Dry Eye Disease NCT03492541	Alcon Research	N/A
Completed	Clinical Efficacy of H.P. Acthar Gel 80 U/ml to Improve the Signs and Symptoms in Subjects With Dry Eye Diseas NCT03287635	Toyos Clinic	Phase 4
Unknown	Investigating the Effect of At Home Thermal Therapy on Dry Eye Patients With Meibomian Gland Dysfunction NCT03291704	UMay Care Inc.	N/A
Completed	Clinical Trial to Evaluate the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The PEA NCT03452397	Oyster Point Pharma, Inc.	Phase 2
Withdrawn	A Dose-Finding Study Comparing InSite Vision, Inc. 101 to Vehicle and DuraSite Alone for Dry Eye Disease NCT01478555	Sun Pharmaceutical Industries Limited	Phase 2
Completed	CyclASol for the Treatment of Signs and Symptoms of Dry Eye Disease (DED) NCT03292809	Novaliq GmbH	Phase 2 / Phase 3
Completed	Assessing Safety and Efficacy of DE-089 Ophthalmic Solution in Patients With Dry Eye Disease NCT03216096	Santen Pharmaceutical Co., Ltd.	Phase 1
Completed	HELIX, a Double-masked Study of SYL1001 in Patients With Moderate to Severe Dry Eye Disease (DED) NCT03108664	Sylentis, S.A.	Phase 3
Completed	Femtosecond Small Incision Lenticular Extraction in Comparison to Femtosecond Laser Insitu Keratomileusis Rega NCT04477421	Al-Rasheed University College	N/A
Completed	Influence of Perfluorohexyloctane (NovaTears) on Tear Film Thickness in Patients With Mild to Moderate Dry Eye NCT03048526	Novaliq GmbH	N/A
Unknown	Fingerprick Autologous Blood (FAB) in Mebomian Gland Dysfunction (MGD) NCT02943382	Bedford Hospital NHS Trust	N/A
Completed	Pilot Study for Investigating the Effect of the Bruder Eye Hydrating Compress on Contact Lens Discomfort in Co NCT02848222	University of Alabama at Birmingham	N/A
Terminated	Study of the Pharmacodynamic Activity of P-321 Ophthalmic Solution Compared to Placebo in Subjects With Dry Ey NCT02824913	Parion Sciences	Phase 2
Terminated	Evaluation of P-321 Ophthalmic Solution Compared to Placebo in Subjects With Dry Eye Disease NCT02831387	Parion Sciences	Phase 2
Completed	In Vivo Confocal Microscopic Analysis of Corneal Nerve Changes After ProKera Slim® for Dry Eye NCT02764814	BioTissue Holdings, Inc	N/A
Completed	A Study to Evaluate Efficacy and Safety of Lifitegrast in Subjects With Dry Eye (OPUS-3) NCT02284516	Shire	Phase 3
Completed	Optical Coherence Tomography of Tear Film Dynamics In-Vivo NCT02554084	University of Rochester	N/A
Completed	Phase 2/3 Dose-Ranging Study of the Safety and Efficacy of OTX-101 in the Treatment of Keratoconjunctivitis Si NCT02254265	Sun Pharmaceutical Industries Limited	Phase 2 / Phase 3
Completed	Study of the Safety and Tolerability of P 321 Ophthalmic Solution in Subjects With Dry Eye Disease NCT02242032	Parion Sciences	Phase 1
Completed	The Influence of PRN Dry Eye Omega-3 Nutritional Regimen on Tear Osmolarity In Cases Of Dry Eye Disease NCT02260960	Physician Recommended Nutriceuticals	Phase 2 / Phase 3
Completed	The Utility of IVCM to Assess Cellular Response and Efficacy of Long-term Topical Steroid Treatment in Patient NCT02120079	Tufts Medical Center	Phase 4
Completed	Ocular Surface Immune Response in Dry Eye Disease NCT02042820	Tufts Medical Center	—
Withdrawn	A Phase IV, Randomized, Parallel Group, Investigator-Masked Evaluation of the Effect of Loteprednol Etabonate NCT02028312	Edward Holland, MD	Phase 4
Completed	NovaTears® Eye Drops Observational Study NCT02111928	Novaliq GmbH	—
Completed	A Study to Compare the Safety and Efficacy of A New Eye Drop Formulation With OPTIVE™ in Subjects With Dry Eye NCT01664949	Allergan	Phase 3
Completed	A Phase 3 Study to Evaluate the Efficacy of Lifitegrast in Subjects With Dry Eye NCT01743729	Shire	Phase 3
Completed	Safety Study of Lifitegrast to Treat Dry Eye NCT01636206	Shire	Phase 3
Completed	Evaluation of Ocular Comfort With ISTA Tears vs Systane NCT01650584	Bausch & Lomb Incorporated	N/A
Completed	Systane Ultra Versus Maxidex Versus Saline NCT01775540	Icahn School of Medicine at Mount Sinai	N/A
Completed	A Study Assessing the Safety and Efficacy of DE-101 Ophthalmic Suspension in Dry Eye Patients NCT01468168	Santen Inc.	Phase 2
Completed	Safety and Efficacy Study of SAR 1118 to Treat Dry Eye Conducted in a Controlled Adverse Environment (CAE) (OP NCT01421498	Shire	Phase 3
Completed	Diurnal Variation in Tear Osmolarity NCT01321424	Ophthalmic Consultants of Long Island	—
Completed	Evaluation of Anti-Inflammatory Treatment in Dry Eye Patients NCT01276223	Alcon Research	Phase 2
Unknown	Dry Eye Disease in the Vitamin D and Omega-3 Trial (VITAL) NCT01880463	Brigham and Women's Hospital	N/A
Completed	A Four Week Study of Azithromycin Ophthalmic Solution, 1% Versus Placebo in Subjects With Dry Eye Disease NCT01014078	Merck Sharp & Dohme LLC	Phase 4
Completed	Physician's Evaluation of Cyclosporine Ophthalmic Emulsion 0.05% NCT00827255	Allergan	—
Completed	The Effects of Diquafosol Tetrasodium Ophthalmic Solution, 2% in Subjects With Dry Eye Disease (P08637) NCT00831662	Merck Sharp & Dohme LLC	Phase 3
Completed	Exploratory Study Comparing Signs and Symptoms in Patients With Ocular Hypertension or Glaucoma Using Xalatan NCT00799682	Ophthalmic Consultants of Long Island	Phase 4
Completed	Safety and Efficacy of an Ophthalmic Solution in Dry Eye Disease NCT00758784	Bausch & Lomb Incorporated	Phase 2
Completed	Clinical Pharmacological Study of AL-43546 Ophthalmic Product in Subjects With Shortened Tear Film Break Up Ti NCT00760045	Alcon Research	Phase 2
Unknown	The Evaluation of Thiol Redox Status in Conjunctiva of Dry Eye Patients NCT00718926	Meiji University of Oriental Medicine	—
Completed	Efficacy Study of Ecabet Ophthalmic Solution in Dry Eye Disease NCT00667004	Bausch & Lomb Incorporated	Phase 2
Completed	Study of the Effect of Diquafosol Tetrasodium Ophthalmic Solution, 2% Versus Placebo in Dry Eye Subjects (P086 NCT00600288	Merck Sharp & Dohme LLC	Phase 3
Completed	Tear Film Stability After Instillation of Over-the-Counter (OTC) Artificial Drops NCT00610480	University of Texas Southwestern Medical Center	N/A
Completed	Bromfenac 0.09% vs Ketorolac 0.4% for Cyclosporine Induction Phase NCT00520260	Florida Eye Microsurgical Institute	Phase 4
Completed	The Relationship of Residence Time and Visual Effect of Optive and Systane in Dry Eye Subjects NCT00553579	Southern California College of Optometry at Marshall B. Ketchum University	—
Completed	Safety and Efficacy Assessment of Vismed® (Sodium Hyaluronate) for the Treatment of Dry Eye Syndrome NCT00599716	Lantibio	Phase 3
Completed	Multicenter, Randomized, Controlled Study of the Effect of Lotemax on Initiation of Dry Eye Treatment With Res NCT00407043	Ophthalmic Consultants of Long Island	Phase 4
Completed	The Visual Effect of an Investigational Artificial Tear in the Tear Layer. NCT00395759	Southern California College of Optometry at Marshall B. Ketchum University	N/A
Completed	Study of Diquafosol Tetrasodium Ophthalmic Solution in Subjects With Dry Eye Disease NCT00403975	Merck Sharp & Dohme LLC	Phase 3
Completed	Study of INS365 Ophthalmic Solution in Subjects With Dry Eye Disease NCT00404131	Merck Sharp & Dohme LLC	Phase 3
Completed	Study of INS365 Ophthalmic Solution in Subjects With Dry Eye Disease NCT00403715	Merck Sharp & Dohme LLC	Phase 3
Completed	A Study of INS365 Ophthalmic Solution in Patients With Moderate to Severe Dry Eye Disease NCT00679718	Merck Sharp & Dohme LLC	Phase 2
Completed	A Study to Determine the Safety and Tolerability of Escalating Doses of INS365 Ophthalmic Solution NCT00680108	Merck Sharp & Dohme LLC	Phase 2