NCT07028736

Dry Eye Disease and Retinal Nerve Fiber Layer Thickness in Chronic Smokers

Assessment of Dry Eye Disease and Retinal Nerve Fiber Layer Thickness in Chronic Smokers

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 50 (actual)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 30 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

This study aimed to examine the impact of long-term smoking on dry eye parameters and retinal nerve fiber layer thickness in individuals who are chronic smokers.

Detailed description

Dry eye disease (DED) is a multifaceted disorder of the ocular surface characterized by instability of the tear film, which subsequently leads to symptoms such as ocular discomfort, visual disturbances, and potential damage to the surface of the eye. Cigarette smoking has been recognized as a possible contributing factor to the development of DED, with various reports suggesting that it may alter tear film composition and stability, leading to ocular surface damage. Chronic smoking can lead to oxidative stress, vascular dysfunction, and inflammation, which may contribute to retinal nerve fiber layer (RNFL) thinning and optic nerve damage.

Conditions

• Dry Eye Disease
• Retinal Nerve Fiber Layer
• Chronic Smoking

Interventions

Type	Name	Description
OTHER	Dry eye assessment	Dry eye assessment was performed using the Mediworks Dry Eye Diagnostic System.

Timeline

• Start date: 2023-05-02
• Primary completion: 2024-05-01
• Completion: 2024-05-01
• First posted: 2025-06-19
• Last updated: 2025-06-19

Locations

1 site across 1 country: Egypt