NCT01321424

Diurnal Variation in Tear Osmolarity

Investigator Sponsored, Pilot Study to Assess the Diurnal Variation in Tear Osmolarity as a Predictor of Dry Eye Disease Etiology

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Ophthalmic Consultants of Long Island · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to measure the change in Tear Osmolarity during the course of the day to support clinical diagnosis of aqueous deficiency or meibomian gland disease and differentiate between the two forms of dry eye.

Detailed description

The premise of this study is that dry eye disease, specifically tear osmolarity, changes during the course of the day based on the etiology of the dry eye and that aqueous-deficiency dry eye will worsen during the course of the day while meibomian gland deficiency will stabilize or possibly even improve during the course of the day.

Conditions

• Dry Eye Disease

Timeline

• Start date: 2011-03-01
• Primary completion: 2016-02-01
• Completion: 2016-03-01
• First posted: 2011-03-23
• Last updated: 2016-04-25

Locations

6 sites across 1 country: United States