| Not Yet Recruiting | An Exploratory Efficacy and Safety Study of DFL24498 Topical Ophthalmic Solution Compared With Vehicle in Part Dry Eye Disease (DED) | Phase 2 | 2026-05-01 |
| Not Yet Recruiting | An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED Persistent Corneal Epithelial Defect | Phase 3 | 2026-04-30 |
| Not Yet Recruiting | Efficacy and Safety of Intranasal Cenegermin in Adult Participants With Non-Arteritic Anterior Ischemic Optic Non-Arteritic Anterior Ischemic Optic Neuropathy | Phase 3 | 2026-03-01 |
| Recruiting | An Efficacy and Safety Study of DFL24498 in the Treatment of AKC Atopic Keratoconjunctivitis | Phase 3 | 2025-12-01 |
| Terminated | Study to Evaluate Corneal Neurosensory Abnormalities in Patients With Sjögren's Dry Eye Sjögren Syndrome, Dry Eye | — | 2024-05-09 |
| Withdrawn | Open-label Trial to Evaluate Efficacy and Safety of rhNGF on Corneal Thickness Via AS-OCT in Neurotrophic Kera Neurotrophic Keratitis, Neurotrophic Keratopathy, Corneal Ulcer | Phase 4 | 2024-04-26 |
| Completed | A Safety and Efficacy Study of 2 Dosing Regimens of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drop Sol Dry Eye Disease | Phase 2 | 2024-01-22 |
| Completed | DEFENDO Long Term Follow-up Study in Stage 1 NK Patients Neurotrophic Keratitis | — | 2023-02-01 |
| Completed | Add-on Reparixin in Adult Patients With ARDS Acute Respiratory Distress Syndrome, Adult | Phase 2 | 2022-12-06 |
| Terminated | Clinical Trial on Ladarixin Adjunctive Therapy to Improve Glycemic Control in Type 1 Diabetes. Type 1 Diabetes | Phase 2 | 2022-09-14 |
| Terminated | Reparixin add-on Therapy to Standard Care to Limit Progression in Pts With COVID19 & Other Community Acquired Infectious Pneumonia, Severe COVID-19 | Phase 3 | 2022-04-27 |
| Withdrawn | To Assess Efficacy and Safety of Oral Reparixin in Patients With Fatigue and Locally Advanced / Metastatic Bre Fatigue, Locally Advanced or Metastatic Breast Cancer | Phase 2 | 2022-04-19 |
| Completed | Study to Evaluate Safety and Efficacy of Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease Dry Eye Disease | Phase 3 | 2022-01-27 |
| Completed | Safety and Efficacy Study on Cenegermin (Oxervate®) vs Vehicle in Severe Sjogren's Dry Eye Disease (PROTEGO-1 Dry Eye | Phase 3 | 2022-01-19 |
| Withdrawn | Ladarixin as Adjunctive Therapy to Improve Insulin Sensitivity and Glucometabolic Outcomes in Type 1 Diabetes Type I Diabetes | Phase 2 | 2021-09-30 |
| Completed | Study on Efficacy and Safety of Reparixin in the Treatment of Hospitalized Patients With Severe COVID-19 Pneum Pneumonia, Viral | Phase 3 | 2021-02-14 |
| Completed | A Study on Ketoprofen Lysine Salt (KLS) + Gabapentin (GABA) vs KLS to Investigate Their Pharmacodynamic in Hea No Condition | Phase 1 | 2021-02-08 |
| Completed | Multicenter Double Blind, Parallel-group Phase 2/3 Trial, to Study Raloxifene in Adult COVID-19 Patients. SARS CoV 2 Infection | Phase 2 / Phase 3 | 2021-01-22 |
| Terminated | A Study of Oral Ladarixin in Recent Onset Type 1 Diabetes and a Low Residual β-cell Function Recent Onset type1 Diabetes | Phase 2 | 2021-01-12 |
| Terminated | A Study to Assess Efficacy/Safety of Ladarixin in Type 1 Diabetes Patients With Preserved ß-cell Function at B New-onset Type 1 Diabetes | Phase 2 | 2020-12-14 |
| Completed | A Single Dose Study About the Influence of Food on the Oral Bioavailability of Ladarixin Capsule in Healthy Vo no Condition | Phase 1 | 2020-10-20 |
| Completed | Study to Evaluate OXERVATE® in Patients With Stage 1 Neurotrophic Keratitis Neurotrophic Keratitis | Phase 4 | 2020-09-09 |
| Terminated | Reparixin in COVID-19 Pneumonia - Efficacy and Safety Severe Pneumonia | Phase 2 / Phase 3 | 2020-05-05 |
| Completed | A Study to Evaluate Safety and Efficacy of rhNGF Eye Solution vs Vehicle in Patients With Moderate to Severe D Dry Eye Syndrome | Phase 2 | 2019-06-10 |
| Terminated | Ascending Dose Tolerability Trial and PK Assessment in Healthy Volunteers After Single & Multiple Oral Intake no Condition | Phase 1 | 2018-11-15 |
| Completed | A Study to Assess Efficacy and Tolerability of Ketoprofen 40 mg Granules vs Placebo Acute Pain | Phase 3 | 2018-04-04 |
| Completed | Study to Evaluate Safety, Tolerability & PK of rhNGF in Healthy Volunteers Healthy Volunteers | Phase 1 | 2018-03-30 |
| Completed | Safety and Efficacy of 2 Concentrations of Lubricin vs Sodium Hyaluronate in Ocular Discomfort After Refractiv Ocular Discomfort | N/A | 2017-06-17 |
| Completed | An 8-week Study to Evaluate Safety and Efficacy of NGF Eye Drops Solution Versus Vehicle in Patients With Dry Dry Eye | Phase 2 | 2017-01-20 |
| Completed | A 8 Weeks Study to Evaluate Efficacy & Safety of rhNGF vs Vehicle in Patients After Cataract and Refractive Su Ocular Discomfort | Phase 2 | 2017-01-12 |
| Completed | Study to Evaluate Safety and Efficacy of rhNGF Eye Drops Solution Versus Vehicle in Patients With Glaucoma Glaucoma | Phase 1 | 2016-12-01 |
| Completed | Clinical Trial of Efficacy and Safety of Levopront® 30 mg/5 ml in Patients With Dry Cough Cough | Phase 3 | 2016-11-09 |
| Completed | A Phase 2, Multicentre, Randomized, Double-blind, Placebo-controlled Study in Patients With New-onset Type 1 D Diabetes Mellitus, Insulin-Dependent | Phase 2 | 2016-08-01 |
| Completed | Crossover, Single Dose, Two-stage Bioequivalence Study of SCMC-Lys Salt 1.35 g Powder vs SCMC-Lys Salt 90 mg/m Bronchitis | Phase 1 | 2016-07-04 |
| Completed | A Double-blind Study of Paclitaxel in Combination With Reparixin or Placebo for Metastatic Triple-Negative Bre Metastatic Breast Cancer | Phase 2 | 2015-07-29 |
| Completed | Tolerability, Safety and Efficacy of Lubricin Versus Sodium Hyaluronate Eye Drops in Patients With Moderate Dr Dry Eye Syndrome | N/A | 2015-06-26 |
| Terminated | Pilot Study of Reparixin for Early Allograft Dysfunction Prevention in Liver Transplantation Ischemia-reperfusion Injury in Liver Transplant, Early Allograft Dysfunction | Phase 2 | 2015-03-10 |
| Completed | Tolerability, Safety and Efficacy of Lubricin vs Sodium Hyaluronate Eye Drops in Subjects With Moderate Dry Ey Dry Eye Syndrome, Tear Film Insufficiency | N/A | 2015-03-09 |
| Completed | Evaluation of Efficacy of 20 µg/ml rhNGF New Formulation (With Anti-oxidant) in Patients With Stage 2 and 3 NK Neurotrophic Keratitis | Phase 2 | 2015-02-01 |
| Completed | Crossover, Single Dose Randomized, Bioequivalence of Ketoprofen Lysine Salt Immediate Release vs Oral Solution Pain Disorders | Phase 1 | 2014-11-26 |
| Completed | Efficacy and Safety of Reparixin in Pancreatic Islet Auto-transplantation Pancreatectomy for Chronic Pancreatitis | Phase 2 / Phase 3 | 2014-02-01 |
| Completed | Safety and Efficacy of rhNGF Eye Drops at Different Doses in Patients With Dry Eye Dry Eye Syndrome | Phase 2 | 2014-01-20 |
| Completed | A Dose Ranging Study to Evaluate the Safety and Potential Efficacy of rhNGF in Patients With Retinitis Pigment Retinitis Pigmentosa | Phase 1 / Phase 2 | 2014-01-01 |
| Terminated | Pilot Study to Evaluate Safety & Biological Effects of Orally Administered Reparixin in Early Breast Cancer Breast Cancer | Phase 2 | 2013-02-01 |
| Completed | Evaluation of Safety and Efficacy of rhNGF in Patients With Stage 2 and 3 Neurotrophic Keratitis. Neurotrophic Keratitis, Keratitis, Corneal Ulcer | Phase 1 / Phase 2 | 2013-01-01 |
| Completed | Study to Assess Efficacy & Safety of Reparixin in Pancreatic Islet Transplantation Islet Transplantation in Diabetes Mellitus Type 1 | Phase 3 | 2012-10-01 |
| Completed | Study to Evaluate Safety, Tolerability and Pharmacokinetics of rhNGF Eye Drops in Healthy Volunteers Healthy | Phase 1 | 2012-07-01 |
| Completed | Pilot Study to Evaluate Reparixin With Weekly Paclitaxel in Patients With HER 2 Negative Metastatic Breast Can Metastatic Breast Cancer | Phase 1 | 2012-02-27 |
| Terminated | Pilot Efficacy and Safety Study of Oral DF2156A in Patients With Active Bullous Pemphigoid Bullous Pemphigoid | Phase 2 | 2012-02-20 |
| Completed | Reparixin in Pancreatic Islet Transplantation Pancreatic Islet Transplantation in Type 1 Diabetes Mellitus | Phase 2 | 2010-07-28 |
| Completed | Reparixin in Prevention of Delayed Graft Function After Kidney Transplantation Ischemia-Reperfusion Injury, Kidney Diseases | Phase 2 | 2005-10-01 |
| Completed | Repertaxin in Prevention of Primary Graft Dysfunction After Lung Transplantation Ischemia-Reperfusion Injury, Lung Transplantation | Phase 2 | 2005-05-01 |