NCT04946721

2177GCCC:ID'Ing tx Targets and Biomarkers for Ocular Surface Disease in Pt w/ oGVHD

2177GCCC: Identifying Novel Treatment Targets and Biomarkers for Ocular Surface Disease in Patients With Ocular Graft vs Host Disease (oGVHD) a Biobank Study

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: University of Maryland, Baltimore · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Evaluate and study the immunologic changes to the ocular surface in cancer patients.

Detailed description

This is a longitudinal natural history study to evaluate and study the immunologic changes to the ocular surface in cancer patients. Two groups of subjects will be recruited for the study: 1) Pre-bone marrow transplant cancer patients. They will be evaluated every 3 months for 2 years.2) Normal control patients. They will be evaluated every 6 months for the duration of the study. During each study visit, in addition to standard of care exams, certain biological specimens ( ocular surface wash, mucocellular material, corneal filaments, or impression cytology of conjunctiva, blood, or serum) will be collected.

Conditions

• Dry Eye Disease
• oGVHD

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	The standard care exam and biological specimens' collection	During each visit, in addition to standard of care exams, certain biological specimens ( ocular surface wash, mucocellular material, corneal filaments or impression cytology of conjunctiva, blood or serum) will be collected.

Timeline

• Start date: 2022-04-27
• Primary completion: 2027-12-31
• Completion: 2027-12-31
• First posted: 2021-07-01
• Last updated: 2026-02-03

Locations

1 site across 1 country: United States