NCT02042820

Ocular Surface Immune Response in Dry Eye Disease

Ocular Surface Immune Response in Dry Eye Disease: Analysis of Conjunctival and Peripheral Corneal Immune Cell Alterations by In Vivo Confocal Microscopy and Clinical Correlation

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 67 (actual)
• Sponsor: Tufts Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

In vivo confocal microscopy (IVCM) is a sensitive imaging tool for detecting dry eye-associated subclinical inflammation. Studies have previously shown that IVCM provides an in vivo metric to measure inflammatory changes in the central cornea. The objective of the current study is to assess inflammatory response changes in the peripheral cornea and the conjunctiva by analyzing epithelial immune cell density and morphology in these areas and then correlating the IVCM findings to clinical signs and symptoms to establish novel objective imaging biomarkers.

Conditions

• Dry Eye Disease

Interventions

Type	Name	Description
OTHER	In vivo confocal microscopy (IVCM)	IVCM is a sensitive tool for detecting dry eye-associated subclinical inflammation.

Timeline

• Start date: 2014-01-01
• Primary completion: 2015-07-01
• Completion: 2015-07-01
• First posted: 2014-01-23
• Last updated: 2017-10-18

Locations

1 site across 1 country: United States