| Suspended | Evaluation of Hemodynamics in People With Untreated Preeclampsia Using Echocardiography NCT06099275 | Brigham and Women's Hospital | — |
| Not Yet Recruiting | Use of Allied-health Professionals to Improve Treatment of Disease NCT06337799 | University of Iowa | N/A |
| Not Yet Recruiting | Antenatal Breastmilk Expression in Pregnant Women at High Risk of Preterm Birth NCT07191366 | Odense University Hospital | N/A |
| Not Yet Recruiting | Mechanistic Underpinnings of Preeclampsia NCT06567899 | University of Arizona | — |
| Not Yet Recruiting | A Randomized Feasibility Trial Comparing Drospirenone and Norethindrone for Postpartum Hypertension Management NCT07293728 | Oregon Health and Science University | Phase 4 |
| Not Yet Recruiting | Optimizing Preeclampsia Postpartum With Point-of-care Ultrasound NCT07167862 | University of California, Irvine | Phase 4 |
| Not Yet Recruiting | Vitamin D Supplementation Among Pregnant Women in Uganda for the Prevention of Hypertensive Disorders in Pregn NCT07510568 | St Mary's Hospital, Lacor | Phase 4 |
| Not Yet Recruiting | Progesterone Preeclampsia NCT07448597 | Medical University of South Carolina | Phase 4 |
| Not Yet Recruiting | Investigation of the Role of Internal Jugular Vein Collapsibility Index in Predicting Spinal Anesthesia-Induce NCT07496788 | Ankara City Hospital Bilkent | — |
| Recruiting | Vagal Stimulation Therapy and Preeclampsia NCT06953115 | Fundación Internacional René Mey | N/A |
| Not Yet Recruiting | Estimated Risk of Preeclampsia in the First Trimester and Its Association With Subclinical Atherosclerosis and NCT07479329 | Institut d'Investigacions Biomèdiques August Pi i Sunyer | — |
| Recruiting | Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders NCT06333652 | Mayo Clinic | Phase 2 |
| Not Yet Recruiting | Mindfulness and Wearable Biosensors to Prevent Hypertensive Disorders of Pregnancy NCT07218237 | Medical College of Wisconsin | N/A |
| Not Yet Recruiting | Kynurenine Concentrations During Pregnancy in Women With or Without Chronic Kidney Disease - A Prospective Mul NCT07411937 | CHU de Reims | N/A |
| Not Yet Recruiting | Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) Disparities NCT06915428 | University of North Carolina, Chapel Hill | N/A |
| Not Yet Recruiting | Topefilgrastim Injection in the Treatment of High-Risk Pregnant Patients With Preeclampsia NCT07384936 | Fang Wang | N/A |
| Not Yet Recruiting | Evaluation of Patients With Hypertensive Disorders of Pregnancy: An Ambispective Observational Study NCT07299773 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Not Yet Recruiting | fullPIERS Model in the Prediction of Adverse Maternal Outcomes in Preeclampsia NCT07316140 | Sohag University | — |
| Recruiting | A Study to Investigate the Safety, Pharmacodynamic and Pharmacokinetic Characteristics of CBP-4888 in Hospital NCT07282171 | Comanche Biopharma | Phase 1 |
| Active Not Recruiting | MR and Inflammation After Preeclampsia NCT07345845 | Anna Stanhewicz, PhD | EARLY_Phase 1 |
| Recruiting | NOPE37: Angiogenic Factors for Managing Term Preeclampsia NCT07193680 | Hospital Universitari Vall d'Hebron Research Institute | N/A |
| Not Yet Recruiting | MitoQ to Improve Vascular Funciton in Preeclampsia NCT07229261 | Medical College of Wisconsin | N/A |
| Not Yet Recruiting | Effect of Stretching Exercises Versus Aerobic Exercises on Preeclampsia NCT07255677 | Cairo University | N/A |
| Not Yet Recruiting | Cardiovascular Protection After Preeclampsia With Enalapril NCT07222852 | Women and Infants Hospital of Rhode Island | Phase 3 |
| Not Yet Recruiting | The PreEclampsia Postpartum Prevention Trial NCT07199283 | Karolinska Institutet | N/A |
| Recruiting | Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories NCT07041281 | Massachusetts General Hospital | Phase 2 |
| Recruiting | Evaluation of sFlt-1/PlGF Ratio ,OPG and sEng as Predictive Biomarkers in the Diagnosis and Treatment Evaluati NCT07349277 | Ammar Jassim Abed | — |
| Recruiting | AtorvaStatin Postpartum and Reduction of Cardiovascular risK NCT06632379 | Ohio State University | Phase 4 |
| Recruiting | Lung Ultrasound for the Detection of Volume Overload in Patients With Severe Preeclampsia NCT07261956 | Saint Thomas Hospital, Panama | N/A |
| Recruiting | Hyperspectral Imaging for Prediction of Preeclampsia NCT07106294 | Heidelberg University | — |
| Recruiting | Excess Base Comparison Between Pregnant Subjects With Severe Preeclampsia vs. Normotensive Pregnant Women NCT07265336 | Saint Thomas Hospital, Panama | N/A |
| Recruiting | Identifying Biomarkers for Endothelial Dysfunction in Women With Preeclampsia NCT07084727 | University Hospital, Antwerp | N/A |
| Recruiting | Daily Aspirin vs Split Dosing in High-risk Pregnancies (DASH) NCT06826859 | Thomas Jefferson University | Phase 1 / Phase 2 |
| Recruiting | Accuracy of Venous Excess Ultrasound Score at Hospital Admission to Predict Acute Kidney Injury NCT07040696 | Cairo University | — |
| Not Yet Recruiting | Placental Organoids Development: Application in the Study of the Human Reproduction Pathophysiology. NCT06893978 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Not Yet Recruiting | Aspirin 150 mg vs 100 mg for Prevention of Preeclampsia in High-Risk Obese Pregnant Women NCT06952712 | FANG HE | Phase 3 |
| Recruiting | Placental Imaging Techniques NCT06861309 | Carilion Clinic | — |
| Completed | Safety, Tolerability, and PK/PD of Telpegfilgrastim Injection in Non-pregnant Females of Childbearing NCT06924385 | Xiamen Amoytop Biotech Co., Ltd. | Phase 1 |
| Completed | Safety, Tolerability, and PK/PD of Telpegfilgrastim in Premenopausal Non-pregnant Females NCT06893796 | Xiamen Amoytop Biotech Co., Ltd. | Phase 1 |
| Enrolling By Invitation | Maternal Cardiovascular Adaption to Pregnancy in IVF Patients Following Frozen Embryo Transfer (FET) NCT06471140 | Aalborg University Hospital | — |
| Completed | Diastolic Dysfunction 2025 NCT07190846 | University Tunis El Manar | — |
| Recruiting | Optimizing Cardiovascular Preventive Care for Women Following Hypertensive Disorders of Pregnancy NCT05826925 | University of Utah | N/A |
| Recruiting | Exercise Testing After Preeclampsia NCT06741436 | Vanderbilt University Medical Center | — |
| Recruiting | Birth & Breastfeeding Support Study NCT06844019 | Herlev Hospital | — |
| Recruiting | Vascular Effects of High-Salt After Preeclampsia NCT06749418 | Anna Stanhewicz, PhD | EARLY_Phase 1 |
| Recruiting | Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of NCT06802861 | University of Tennessee Graduate School of Medicine | — |
| Recruiting | Study of Maternal and Fetal Cardiovascular Function in Hypertensive States of Pregnancy NCT06858345 | Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia | — |
| Recruiting | Association of Urinary Tract Infection With Preeclampsia During Pregnancy NCT06962644 | Pakistan Air Force (PAF) Hospital Islamabad | — |
| Not Yet Recruiting | The Effect of Augmented Reality Based Training on Preeclampsia Case NCT06730048 | Inonu University | N/A |
| Recruiting | Probiotic Supplementation During Pregnancy in Women With High-Risk Pregnancies NCT06700044 | Region Skane | N/A |
| Recruiting | Pilot Project Renal and Cardiovascular Tertiary Prevention in Preeclampsia NCT07151339 | University Hospital Schleswig-Holstein | — |
| Completed | Investigating CD 71 in Preeclamptic Pregnancies NCT06668545 | Celal Bayar University | — |
| Recruiting | Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL NCT06468202 | Ohio State University | Phase 4 |
| Recruiting | Association of Assisted Reproductive Technologies Parameters With the Perinatal Outcome NCT06918236 | Aristotle University Of Thessaloniki | — |
| Active Not Recruiting | Preeclampsia Educational Program Study (PrEPS) NCT06373367 | MemorialCare Health System | N/A |
| Not Yet Recruiting | Assessment of Optic Nerve Sheath Diameter in Preeclamptic Pregnant Women Using Ultrasonography and Anesthetic NCT06522295 | Kocaeli University | — |
| Not Yet Recruiting | Feasibility of a Telemonitoring Program for Pregnant Women at High-Risk for Preeclampsia in Pakistan NCT05662696 | University Health Network, Toronto | N/A |
| Active Not Recruiting | Assessment of Volume Status in Preeclampsia Post- SpinalAnasthesia:Utilizing Ultrasound " Evaluation of Lung a NCT07514130 | Menoufia University | EARLY_Phase 1 |
| Recruiting | EV Based Platform for Monitoring Therapeutics Response During Pregnancy (ARISE) NCT06249178 | Ohio State University | — |
| Recruiting | MSC Exosome Therapy for Post-Preeclampsia Endothelial Dysfunction NCT07183384 | Universitas Padjadjaran | Phase 1 / Phase 2 |
| Enrolling By Invitation | MumCare: Mum's Cardiovascular Health for Life NCT05835596 | Oslo University Hospital | N/A |
| Recruiting | Preventing Obstetric Complications With Dietary Intervention NCT06320054 | Medical College of Wisconsin | N/A |
| Not Yet Recruiting | Management of Early-onset Fetal Growth Restriction: Angiogenic Factors Versus Feto-placental Doppler NCT05284474 | Hospital Universitari Vall d'Hebron Research Institute | N/A |
| Not Yet Recruiting | New Therapeutic Strategy Against Preeclampsia NCT06464159 | Assistance Publique - Hôpitaux de Paris | — |
| Enrolling By Invitation | Biological Changes Associated With High Risk of Preeclampsia in Nulliparous Women NCT06200571 | Norwegian University of Science and Technology | — |
| Enrolling By Invitation | Developing & Evaluating Models for Early Predicting Obstetrical Diseases in Pregnant Women by Non-invasive Pre NCT06385366 | Gene Solutions | — |
| Not Yet Recruiting | Pregnancy Repository NCT06339606 | Sunnybrook Health Sciences Centre | — |
| Not Yet Recruiting | Optimization of Cervical Collections in Pregnancy NCT06323187 | Dr. Sascha Drewlo | — |
| Recruiting | Pregnancy Outcomes in Normotensive VS stage1 Hypertension: a Prospective Observational Study NCT06339749 | FANG HE | — |
| Enrolling By Invitation | The Role and Mechanism of GPER-Hippo-CBS/H2S Pathway in Preeclampsia NCT06205771 | Hao Feng | N/A |
| Completed | Psychosocial Effects of Coloring in Preeclamptic Pregnant Women NCT06925841 | Necmettin Erbakan University | N/A |
| Completed | EFFECT OF BLOOD PRESSURE MEASUREMENT IN DIFFERENT POSITIONS ON BLOOD PRESSURE VALUES AND ANXIETY LEVELS IN PRE NCT06898567 | Istanbul University - Cerrahpasa | N/A |
| Recruiting | PI4 - A Trial Assessing Metformin to Prolong Gestation in Preterm Preeclampsia NCT06033131 | Lina Bergman | Phase 3 |
| Recruiting | Dietary Salicylates and Preeclampsia NCT06239363 | Poznan University of Life Sciences | — |
| Completed | MATERNAL SERUM CADHERİN-6 AS A PREDİCTOR OF PREECLAMPSİA NCT07467226 | Samsun University | — |
| Completed | Knowledge and Attitude of Pregnant Women Towards Preeclampsia in Assiut Governorate NCT05955690 | Assiut University | — |
| Completed | Balance of Angiotensin II Receptors in Vessel Function After Preeclampsia NCT06157580 | Anna Stanhewicz, PhD | EARLY_Phase 1 |
| Recruiting | Molecular Study of the Maternal-fetal Interface in Preeclampsia. NCT06232668 | Carlos Simon Foundation | — |
| Unknown | Use of Lumella-glycosylated Fibronectin for Diagnosis of Preeclampsia NCT06085001 | Croydon University Hospital | — |
| Recruiting | Daily Aspirin Treatment After Preeclampsia NCT06168461 | Anna Stanhewicz, PhD | EARLY_Phase 1 |
| Recruiting | Aspirin Discontinuation in High-Risk Pregnant Women of Preeclampsia NCT06111079 | FANG HE | Phase 3 |
| Recruiting | Fetal Renal Artery Doppler in Patients With Preeclampsia NCT06395974 | Assiut University | — |
| Completed | Blood Pressure Variability Effect on Right Ventricular Strain in Women With Hypertensive Disorders With Pregna NCT06100484 | Aswan University | — |
| Completed | The Effect of Massage Ball Application on Blood Pressure, Fatigue and Anxiety in Pregnant With Preeclampsia NCT06066411 | Saglik Bilimleri Universitesi | N/A |
| Recruiting | mHealth for Hypertensive Disorder of Pregnancy NCT05995106 | Seoul National University Hospital | N/A |
| Unknown | Fetal, Obstetrics and Reproduction Genomics NCT05720169 | Fundación Ginemed | — |
| Unknown | Mindfulness Breath Awareness Meditation and Preeclampsia NCT06065709 | Aysegul Kilicli | N/A |
| Recruiting | Multiparametric Assessment of Maternal Vascular Function in the Prediction of Hypertensive Disorders of Pregna NCT05999851 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | N/A |
| Recruiting | The Project of Gestational Hypertension and Preeclampsia Screening and Prevention Center NCT06383858 | The Third Affiliated Hospital of Guangzhou Medical University | — |
| Unknown | Aspirin Versus Metformin in Pregnancies at High Risk of Preterm Preeclampsia: a 3-arm Randomized Controlled Tr NCT05580523 | Chinese University of Hong Kong | N/A |
| Completed | Analysis of Biological Progression and Regression of HELLP Syndrome in Time NCT06758960 | CHU Mohammed VI Marrakech | — |
| Unknown | Selected Immunological Indicators and Microbiota in Patients With Premature Birth and Preeclampsia NCT06281262 | General University Hospital, Prague | — |
| Recruiting | Eliminating Severe Maternal Morbidity With Heart Health Doulas Trial NCT05655936 | University of Pittsburgh | N/A |
| Active Not Recruiting | Low Dose Aspirin Alerts in High-Risk Pregnancies NCT05802940 | Geisinger Clinic | N/A |
| Withdrawn | B Vitamin Deficiency and Pregnancy Complications NCT05720650 | Westlake University | — |
| Terminated | PROtecting Maternal Brains From Injury and Stroke NCT05726279 | Columbia University | N/A |
| Recruiting | Predictors of Aspirin Failure in Preeclampsia Prevention NCT05709483 | Rockefeller University | EARLY_Phase 1 |
| Unknown | Nutrition Optimalization Among Pregnant Women to Improve Maternal and Neonatal Outcome in DKI Jakarta NCT06268509 | Dr Cipto Mangunkusumo General Hospital | N/A |
| Recruiting | Serum Vasohibin, Cardiotrophin, Endocan & Perinatal Outcomes NCT06416995 | Umraniye Education and Research Hospital | — |
| Recruiting | A Novel Multiomic AI Approach for Early Preeclampsia Prediction in Pregnancy NCT06430398 | Istituto Clinico Humanitas | — |
| Recruiting | The ACHIEVE Trial: Achieving Longer Gestation in Preeclampsia Via Antihypertensive Therapy. NCT05676476 | University of Alabama at Birmingham | N/A |
| Completed | Aspirin Role for Preventing Clinical Risks Related to High Risk Pregnancy NCT07087067 | Galala University | N/A |
| Recruiting | LDA and LMWH vs LDA Alone in High-risk Patients for Preeclampsia Prevention NCT07361679 | Alexandra Hospital, Athens, Greece | Phase 4 |
| Recruiting | Prenatal Aspirin and Postpartum Vascular Function NCT05653973 | Anna Stanhewicz, PhD | EARLY_Phase 1 |
| Terminated | Maternal Serum Stathmin-1 Levels in Preeclampsia NCT06481683 | Burak Yücel Special Clinic | — |
| Recruiting | Patients Pregnant Women With or Without Primary Antiphospholipid Antibody Syndrome NCT05786235 | IRCCS San Raffaele | — |
| Unknown | Point-of-care Ultrasound Abnormalities in Early Onset Preeclampsia NCT05662995 | University of Cape Town | N/A |
| Enrolling By Invitation | HOME: Home Monitoring of High-risk Pregnancies NCT05763069 | Oslo University Hospital | — |
| Completed | App-based Remote Blood Pressure Monitoring NCT05595629 | Women and Infants Hospital of Rhode Island | N/A |
| Unknown | Docosahexaenoic Acid Serum Levels in Patients With Preeclampsia NCT05591638 | Recep Tayyip Erdogan University Training and Research Hospital | — |
| Recruiting | A Multicenter Cohort Study on Maternal and Infant Microecology and New Targets for Pre-eclampsia Screening in NCT05445544 | Zhujiang Hospital | — |
| Completed | Ibuprofen vs Dipyrone After C-section in Preeclampsia NCT05586373 | Instituto Materno Infantil Prof. Fernando Figueira | Phase 4 |
| Unknown | Chronic Remote Ischemic Preconditioning as a Complement to Conventional Prenatal Care for Preeclampsia NCT05564988 | DAVID DESSEAUVE | N/A |
| Active Not Recruiting | Low Dose Aspirin for Preterm Preeclampsia Preventionmg/day Dose in High-risk Patients NCT05514847 | University of Virginia | Phase 4 |
| Active Not Recruiting | Analysis of the Levels of HLADR+ Extracellular Vesicles in Women With Preeclampsia as a Early Potential Biomar NCT06873737 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Unknown | Blood Pressure Monitoring in Postpartum Women at Risk of Hypertension NCT05457504 | Massachusetts General Hospital | N/A |
| Completed | Placental Expression of EG-VEGF and Its PROKR1 and PROKR2 Receptors in Preeclampsia Patients. NCT04846686 | Centre Hospitalier Universitaire de Saint Etienne | — |
| Recruiting | The Efficacy of Aspirin Combined With Hydroxychloroquine Treatment in High Risk Pregnancies for Preeclampsia NCT05287321 | Yoo-min Kim | Phase 3 |
| Recruiting | Prediction of Chronic Kidney Disease Following Pre-eclampsia: Diagnosis and Early Care NCT05056701 | Centre Hospitalier le Mans | N/A |
| Recruiting | Aspirin and Neutrophils in Preeclampsia NCT04974892 | Queen Mary University of London | — |
| Recruiting | Cardiovascular Risk After Preeclampsia NCT05277233 | Charite University, Berlin, Germany | — |
| Completed | Stress Reduction in Formerly Preeclamptic Women; Sofa or Sports NCT06402604 | Radboud University Medical Center | N/A |
| Unknown | Women's Perspective on First-trimester Preeclampsia Screening NCT05123560 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | — |
| Completed | Social Risks-Focused Lifestyle Intervention to Reduce Preeclampsia (SAIL) NCT04958057 | Medical College of Wisconsin | N/A |
| Unknown | Prevention of Pre-eclampsia Using Metformin: a Randomized Control Trial NCT04855513 | Hamad Medical Corporation | N/A |
| Completed | Remote Monitoring and Follow-up for Postpartum Hypertensive Disorders of Pregnancy NCT05124327 | Cedars-Sinai Medical Center | N/A |
| Unknown | Peripartum Anesthetic Management of Patients With Preeclampsia NCT05237011 | Shaare Zedek Medical Center | — |
| Unknown | Effects of Nitrate-rich Beetroot Juice in Pregnant Women With High Blood Pressure NCT05241327 | Karolinska Institutet | N/A |
| Unknown | Effects of Recurrent PE on Women and Offspring NCT05134285 | Dunjin Chen | — |
| Recruiting | Oral Health and Adverse Pregnancy Complications NCT06110143 | University Hospital Bispebjerg and Frederiksberg | N/A |
| Completed | Molecular Screening Method for Preeclampsia (PREMOM) NCT04990141 | iPremom | — |
| Terminated | Complement Regulation to Undo Systemic Harm in Preeclampsia NCT04725812 | Cedars-Sinai Medical Center | Phase 2 |
| Completed | Bedside Monitoring to Identify Impaired Cerebral Autoregulation in Women with Postpartum Hypertension NCT05155852 | Columbia University | — |
| Unknown | Virtual Cardiac Wellness Program Following Hypertensive Disorders of Pregnancy NCT04998942 | Massachusetts General Hospital | N/A |
| Active Not Recruiting | MIRACLE of LIFE Study NCT06074601 | Mirvie | — |
| Unknown | 162 mg of Aspirin for Prevention of Preeclampsia NCT05221164 | Methodist Medical Center of Illinois | Phase 4 |
| Completed | Artificial Intelligence in Lung Ultrasound for Preeclampsia NCT05487014 | Gazi University | — |
| Completed | Postpartum Weight Loss for Women at Elevated Cardiovascular Risk NCT04914819 | University of Pennsylvania | N/A |
| Completed | Pregnancy-Related Hypertension: Adherence to a New Type of Monitoring NCT04823949 | Prisma Health-Upstate | N/A |
| Unknown | Efficiency of the Web-Based Support Program Based on the Health Promotion Model in Pregnant Women With Preecla NCT05021692 | Istanbul University - Cerrahpasa | N/A |
| Unknown | The START Clinic: a Feasibility Study NCT04488861 | Manchester Academic Health Science Centre | — |
| Withdrawn | Adherence to Universal Aspirin Compared to Screening Indicated Aspirin for Prevention of Preeclampsia NCT04797949 | Women and Infants Hospital of Rhode Island | Phase 4 |
| Recruiting | sFlt1/PlGF and Planned Delivery to Prevent Preeclampsia at Term. NCT04766866 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | N/A |
| Completed | Hydroxychloroquine in Prevention of Preeclampsia NCT04755322 | Assiut University | N/A |
| Unknown | Risk Prediction Model of Preeclampsia NCT04794855 | Peking University Third Hospital | — |
| Terminated | Metformin and Esomeprazole in Preterm Pre-eclampsia NCT06359015 | Christiana Care Health Services | Phase 4 |
| Completed | Nudge to Drive Transitions of Care NCT04660032 | University of Pennsylvania | N/A |
| Completed | The Relationship of Phthalate Exposure During Pregnancy and Preeclampsia NCT04777929 | Second Affiliated Hospital of Wenzhou Medical University | — |
| Completed | Antenatal Platelet Response on Aspirin: a Pharmacokinetic Study Through Pregnancy NCT04645004 | Thomas Jefferson University | Phase 1 / Phase 2 |
| Unknown | Early Prediction and Randomised Prevention of Preeclampsia With Low Dose Aspirin in Chinese Cohort NCT04631627 | Peking Union Medical College Hospital | Phase 4 |
| Unknown | The Correlation Between Immunological Reaction of the Seminal Fluid in the Mother's Blood and Pregnancy Compli NCT04314518 | Sheba Medical Center | — |
| Completed | The Clinical and Prognostic Features of PRES NCT05143710 | Dunjin Chen | — |
| Unknown | Effect of Rosuvastatin on the Clinical Features of Preeclampsia NCT04303806 | Assiut University | Phase 2 |
| Completed | Validation of the French Translation of a Self-questionnaire Looking for a History of Pre-eclampsia. NCT04658966 | University Hospital, Brest | — |
| Completed | Antenatal Platelet Response On Aspirin and Correlation With HDP (Hypertensive Disorders of Pregnancy) NCT04295850 | Thomas Jefferson University | — |
| Active Not Recruiting | Preeclampsia Postpartum Antihypertensive Treatment NCT04298034 | Medical College of Wisconsin | Phase 3 |
| Completed | Preeclamptic Pregnancy Care Education NCT04915794 | Istanbul University - Cerrahpasa | N/A |
| Completed | Is a History of Pre-eclampsia a Risk Factor for Vascular Phenotype in Women With Systemic Sclerosis? NCT04363021 | University Hospital, Brest | — |
| Completed | Low Dose Aspirin for Preventing Intrauterine Growth Restriction and Preeclampsia in Sickle Cell Pregnancy (PIP NCT05253781 | University of Lagos, Nigeria | Phase 3 |
| Recruiting | Role of the Maternal Microbiota on the Immune Response and Metabolism During Hypertensive Disorders NCT06421493 | Istituto Clinico Humanitas | — |
| Completed | Ultrasonography for Fluid Assessment in Parturients With Preeclampsia Undergoing Cesarean Section NCT04370847 | Mansoura University | — |
| Withdrawn | Aspirin (ASA) Therapy and Preeclampsia Prevention NCT04158830 | University of Tennessee | Phase 4 |
| Completed | Magnesium and Vanadium Levels in Preeclampsia NCT04387565 | Cengiz Gokcek Women's and Children's Hospital | — |
| Completed | The Effect of Epidural Anesthesia on the Optic Nerve Sheath Diameter in Preeclampsia NCT04095832 | Seoul National University Hospital | — |
| Completed | Preeclampsia-like Syndrome Induced by COVID-19: Is it a Real Public Health Issue in Pregnancy During the Pande NCT04443140 | Zeynep Kamil Maternity and Pediatric Research and Training Hospital | — |
| Unknown | Cardiac Dysfunction and Remodeling in Patients With Preeclampsia NCT04162236 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | — |
| Completed | Preeclampsia and Contact Activation NCT04825145 | University of Southern Denmark | — |
| Completed | Cardiac and Immune Cell Function in Preeclampsia NCT04508582 | Queen Mary University of London | — |
| Unknown | Immunological and Cardiovascular Phenotyping of Oocyte-donation Pregnancies NCT04731012 | Charite University, Berlin, Germany | — |
| Unknown | Cardiac Biomarkers in Preeclampsia: Prediction of Disease and the Risk of Future Cardiovascular Events in Surv NCT04468763 | Babcock University | — |
| Completed | Progesterone in Expectantly Managed Early-onset Preeclampsia NCT04077853 | Assiut University | Phase 4 |
| Recruiting | Exosome Cargo From Preeclampsia Patients NCT04154332 | University of Alabama at Birmingham | — |
| Completed | KW-3357 Study in Patients With Early Onset Severe Preeclampsia NCT04182373 | Kyowa Kirin Co., Ltd. | Phase 3 |
| Completed | Low Doses of Aspirin in the Prevention of Preeclampsia NCT04070573 | Weill Medical College of Cornell University | Phase 3 |
| Completed | Randomized Clinical Trial to Increase Physical Activity After a a Hypertensive Pregnancy NCT04119232 | University of Pennsylvania | N/A |
| Completed | Soluble Factors and Renal Outcome in Preeclampsia NCT04940260 | Bangkok Metropolitan Administration Medical College and Vajira Hospital | — |
| Completed | Predicting Late-onset Preeclampsia at 10-14 Weeks of Pregnancy NCT04075708 | University of Southern Denmark | — |
| Terminated | Pravastatin to Prevent Preeclampsia NCT03944512 | The George Washington University Biostatistics Center | Phase 3 |
| Unknown | MYPP-trial: Myo-inositol Supplementation to Prevent Pregnancy Complications in Women With Polycystic Ovary Syn NCT05524259 | Erasmus Medical Center | N/A |
| Completed | Thiol/Disulphide Homeostasis and Preeclampsia NCT03927014 | Cengiz Gokcek Women's and Children's Hospital | — |
| Unknown | Human Epididymis Protein 4 in Women With Severe Preeclampsia / HELLP Syndrome NCT03891394 | Ain Shams University | — |
| Withdrawn | The Impact of Pregnancy and Pregnancy-associated Hypertension on Human Uterine Myometrial Artery Reactivity NCT03888170 | University of Arizona | — |
| Unknown | Serum LncRNAs as Early Potential Biomarkers for the Prediction of Preeclampsia NCT03903393 | First Affiliated Hospital of Harbin Medical University | — |
| Completed | The Effects of Labor Stages and Interventions on Hemodynamic Measures During & After Childbirth With Noninvasi NCT03838965 | Hillel Yaffe Medical Center | N/A |
| Unknown | The Effect of Loading Dose of Magnesium Sulfate on Uterine, Umbilical, and Fetal Middle Cerebral Arteries Dopp NCT03891498 | Cairo University | N/A |
| Completed | Heart Health 4 New Moms: A Randomized Trial in the First Year After Preeclampsia NCT03749746 | University of Pittsburgh | N/A |
| Terminated | The Effect of Two Aspirin Dosing Strategies for Obese Women at High Risk for Preeclampsia NCT03735433 | Ohio State University | Phase 4 |
| Unknown | The Correlation Between Vitamin A / E Levels and Preeclampsia NCT03971604 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Completed | miRNA-452 in Patients With Preeclampsia and Its Correlation With MMP-9 NCT03258125 | Assiut University | — |
| Unknown | Detection of Epileptiform Activity in Severe Preeclampsia NCT03494517 | Pascal Vuilleumier | — |
| Unknown | Postpartum NSAIDS and Maternal Hypertension NCT03824119 | University of Southern California | Phase 4 |
| Unknown | Esomeprazole With Sildenafil Citrate in Women With Early-onset Preeclampsia NCT03724838 | Aswan University Hospital | N/A |
| Unknown | Aspirin for Prevention of Preeclampsia in Healthy, Nulliparous Obese and Overweight Pregnant Women NCT03725891 | Aswan University Hospital | N/A |
| Unknown | Aspirin for Prevention of Preeclampsia NCT03726177 | Aswan University Hospital | N/A |
| Completed | Assessing the Usability and Clinical Utility of the Congo Red Dot Test: A Case-control Study NCT02610972 | Gynuity Health Projects | — |
| Unknown | Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies NCT04051567 | Ministry of Science and Technology of the People´s Republic of China | Phase 4 |
| Completed | Validation of a PrCr Dipstick Diagnostic Test in Ghana NCT03510286 | PATH | — |
| Completed | Angiotensin II and Chronic Inflammation in Persistent Microvascular Dysfunction Following Preeclampsia NCT03482440 | University of Iowa | EARLY_Phase 1 |
| Recruiting | Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy NCT03487185 | The George Washington University Biostatistics Center | N/A |
| Completed | Analyses of Interleukin-6, Presepsin and Pentraxin-3 in the Diagnosis and Severity of Late-onset Preeclampsia NCT04126902 | Cengiz Gokcek Women's and Children's Hospital | — |
| Completed | Thromboelastogram in Postdelivery Preeclamptic Patients NCT03555630 | Augusta University | — |
| Completed | Preeclampsia Ratio (sFlt-1/PlGF) NCT03289611 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Biomarkers and Preeclampsia Outcomes NCT03801447 | Dacima Consulting | — |
| Completed | Esomeprazole in Treatment of Early Onset Preeclampsia (ESOPE Trial) NCT03213639 | Assiut University | Phase 2 / Phase 3 |
| Completed | Assessing the Usability and Clinical Utility of the Congo Red Dot Test: A Survey NCT02611011 | Gynuity Health Projects | — |
| Completed | Vanadium in Late-onset Preeclampsia NCT04200222 | Cengiz Gokcek Women's and Children's Hospital | — |
| Unknown | Evaluation of the Possible Relationship Between Preeclampsia and Periodontal Disease NCT03603236 | Recep Tayyip Erdogan University Training and Research Hospital | — |
| Completed | Randomizated Open-label Control Trial to Evaluate if the Incorporation of sFlt1/PlGF Ratio in the Diagnosis an NCT03231657 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | N/A |
| Completed | Serum Soluble Endoglin and Matrix Metalloproteinase 14 With Elisa Method in Early/Late-onset Preeclampsia NCT03932877 | Cengiz Gokcek Women's and Children's Hospital | — |
| Unknown | Combined 3D Power Doppler Placental Volume and Vascular Flow Indices In the First Trimester of Pregnancy as Pr NCT03399006 | Cairo University | — |
| Completed | Use of Nitrous Oxide Donor for Labor Induction in Women With PreEclampsia NCT03171480 | Ohio State University | Phase 4 |
| Recruiting | Berlin-Brandenburg Pregnancy Cohort NCT03313024 | Charite University, Berlin, Germany | — |
| Completed | Response to Anti-hypertensives in Pregnant and Postpartum Patients NCT03506724 | Icahn School of Medicine at Mount Sinai | Phase 4 |
| Completed | Fit After Baby: Increasing Postpartum Weight Loss in Women at Increased Risk for Cardiometabolic Disease NCT03215173 | University of Colorado, Denver | N/A |
| Completed | Post-Pregnancy Cardio Trial NCT03313063 | Charite University, Berlin, Germany | — |
| Unknown | Effect of Administering Intravenous Magnesium Sulfate on Fetal Cardiotocography and Neonatal Outcome in Preecl NCT03237000 | Cairo University | Phase 4 |
| Completed | Blood Pressure After PREeclampsia/HELLP by SELF Monitoring Study NCT03228082 | Radboud University Medical Center | N/A |
| Completed | Blood Collection to Validated New Therapeutics Strategies Against Preeclampsia NCT03188900 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Novel Biomarkers of Preeclampsia, Aquaporin, Fatty Acid, and S110B NCT03567551 | University of Alabama at Birmingham | — |
| Withdrawn | Impedance Cardiography to Decrease the Risk of Preeclampsia NCT03245970 | University of Tennessee Medical Center | EARLY_Phase 1 |
| Unknown | Use of Impedance Cardiography to Decrease the Risk of Pre-eclampsia in Obese Patients NCT03105661 | University of Tennessee Graduate School of Medicine | EARLY_Phase 1 |
| Completed | First Trimester Fetal Thymus Volume May Predict Preeclampsia NCT04264247 | Karadeniz Technical University | — |
| Completed | Advanced MRI for Uteroplacental Flow, Perfusion, Oxygenation & Inflammation NCT02791568 | University of Wisconsin, Madison | — |
| Unknown | China Obstetrics Alliance Cohort Study NCT03038555 | The Third Affiliated Hospital of Guangzhou Medical University | — |
| Unknown | China Obstetrics Alliance Cohort Study NCT03615560 | Guangzhou Medical University | — |
| Completed | Vascular Endothelial Factor Gene Polymorphism in Preeclampsia NCT03500588 | Beni-Suef University | — |
| Completed | Prevalence of Antiphospholipid Antibodies Among Women With Preeclampsia NCT02699437 | Mohamed Sayed Abdelhafez | — |
| Unknown | Longitudinal Study: Diagnosis and Prediction of Pre-Eclampsia by Using Congo Red Dot Test in Bangladesh and Me NCT02381197 | Gynuity Health Projects | — |
| Completed | Low Dose Aspirin in the Prevention of Preeclampsia in China NCT02797249 | Peking University First Hospital | Phase 3 |
| Completed | microRNAs Role in Pre-eclampsia Diagnosis NCT03562715 | Cairo University | — |
| Completed | Prediction of Preeclampsia and Other Pregnancy Complications Following Combined Iterative Screening NCT03067298 | Emmanuel Bujold | — |
| Completed | Proof-of-Concept Trial on Selective Removal of sFlt-1 in Pregnant Women With Preeclampsia Via Apheresis NCT02923206 | Miltenyi Biomedicine GmbH | N/A |
| Completed | ToRsemide for pOstpartum HYpertension NCT02813551 | The University of Texas Health Science Center, Houston | Phase 2 |
| Completed | First Trimester Placental Assessment in the Screening of Preeclampsia and Intrauterine Growth Restriction NCT02879942 | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | — |
| Completed | Magnesium Sulfate in Obese Preeclamptics NCT02835339 | Oregon Health and Science University | Phase 4 |
| Completed | Diagnosis and Prediction of Pre-Eclampsia by Using Congo Red Dot Test in Bangladesh and Mexico NCT02381210 | Gynuity Health Projects | — |
| Completed | Comparing Different Methods of Patient Education on Preeclampsia NCT02765906 | Geisinger Clinic | N/A |
| Unknown | Different Regulation of Immune Cells in Patients With Preeclampsia NCT02691364 | University Medical Center Groningen | — |
| Completed | Influence of Conditional Workout Postpartum on Arterial Stiffness Among Women With Status After Preeclampsia, NCT02754778 | Martin-Luther-Universität Halle-Wittenberg | N/A |
| Completed | Adding MgSO4 to Epidural Levobupivacaine in CS for Patients With Preeclampsia NCT02699827 | Mohamed Sayed Abdelhafez | Phase 4 |
| Completed | Development of a Next Generation Sequencing (NGS) -Based Assay to Detect Preeclampsia Molecular Markers NCT02808494 | Illumina, Inc. | — |
| Completed | Anti-Angiogenic Preeclampsia Milieu Impairs Infant Lung and Vascular Development NCT02639676 | Indiana University | — |
| Completed | sFlt-1:PlGF Ratio in Diagnosing Superimposed Preeclampsia NCT03441711 | University of Tennessee | — |
| Unknown | Prediction of Adverse Perinatal Outcome for Preeclampsia in Sichuan Province of China NCT01804751 | West China Second University Hospital | — |
| Recruiting | Effects of High Altitude on AMPK Activation NCT02391519 | University of Colorado, Denver | — |
| Completed | Collection of Samples From Pregnant Women for the Evaluation of Preeclampsia (Pre-E) Biomarkers NCT02780414 | Progenity, Inc. | — |
| Unknown | Spinal Anaesthesia and Severe Preeclampsia NCT02633995 | Kasr El Aini Hospital | — |
| Completed | Combined Multi-marker Screening and Treatment With Aspirin for Pre-eclampsia Prevention NCT02301780 | Rabin Medical Center | Phase 3 |
| Completed | Heart Health 4 Moms Trial to Reduce CVD Risk After Preeclampsia NCT02147626 | Brigham and Women's Hospital | N/A |
| Completed | Identifying HDL Composition and Function in Preeclamptic and Normal Pregnancies NCT02554604 | Meir Medical Center | — |
| Completed | Second Trimester Maternal Serum Homocysteine Levels and Uterine Artery Doppler for Prediction of Preeclampsia NCT02854501 | Cairo University | — |
| Completed | User Testing and Feedback for a Mobile Health Program for Postpartum Women: A Pilot Study NCT02384226 | University of Colorado, Denver | — |
| Unknown | Prediction of Preeclampsia & Other Obstetric Complications by Serum Homocysteine & Doppler NCT02541110 | Kasr El Aini Hospital | — |
| Terminated | The Treatment of Hypertension Associated With Severe Preeclampsia (PE). A Trial of Urapidil Versus Nicardipine NCT02558023 | University Hospital, Strasbourg, France | Phase 3 |
| Withdrawn | Lisinopril for Renal Protection in Postpartum Preeclamptic Women NCT05016440 | Eastern Virginia Medical School | N/A |
| Unknown | Determining the Risk Elevation After Maternity NCT02305745 | Ottawa Hospital Research Institute | — |
| Completed | microRNA 155 Levels and Periodontal Microflora (Bacteria and Virus) in Preeclampsia. NCT04277390 | Meenakshi Ammal Dental College and Hospital | — |
| Active Not Recruiting | Positive Airway Pressure, Sleep Apnea, and the Placenta (PAP-SAP) NCT02412696 | The Miriam Hospital | N/A |
| Withdrawn | Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial NCT00293735 | Baylor College of Medicine | Phase 2 / Phase 3 |
| Unknown | A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disor NCT02336243 | Pontificia Universidad Catolica de Chile | Phase 3 |
| Unknown | Impact of Particulate Matter on Mothers and Babies in Antwerp (IPANEMA) NCT02592005 | Universiteit Antwerpen | — |
| Recruiting | Biobank on Prematurity, Preeclampsia and Other Pregnancy Complications NCT02744365 | CHU de Quebec-Universite Laval | — |
| Completed | Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy NCT01912677 | Gynuity Health Projects | Phase 4 |
| Completed | The Study of Cardiovascular Outcomes in Women With Preeclampsia Using Echocardiography: The SCOPE Study NCT02357667 | University of Pennsylvania | — |
| Terminated | Different Schemes of Magnesium Sulfate for Preeclampsia NCT02396030 | Instituto Materno Infantil Prof. Fernando Figueira | Phase 4 |
| Terminated | Usefulness of Extracorporeal Removal of sFLT-1 in Women With Very Early Severe Preeclampsia NCT02286284 | Assistance Publique - Hôpitaux de Paris | Phase 2 |
| Withdrawn | Postprandial Walking in Obese Pregnant Women and Perinatal Outcomes - a Multicenter Randomized Clinical Trial NCT02180152 | Professor Fernando Figueira Integral Medicine Institute | N/A |
| Completed | Pre-Eclampsia And Growth Restriction: a Longitudinal Study NCT02379832 | CHU de Quebec-Universite Laval | — |
| Completed | Maternal Periodontal Status and Cytokines in Preeclampsia NCT03088228 | Hacer Sahin Aydinyurt | — |
| Completed | Postpartum Hemorrhage Prevention in Patients With Preeclampsia (PHP3 Study) NCT02221830 | University of Colorado, Denver | EARLY_Phase 1 |
| Terminated | CPAP in Preeclampsia NCT02303834 | University of Sydney | N/A |
| Completed | Placental Protein 13 Serum Endoglin and Uterine Doppler Indeces as Predictors of Pre-eclampsia NCT02350036 | Cairo University | — |
| Completed | A Trial Comparing Treatment With the Springfusor Infusion Pump to the IV Magnesium Sulfate Regimen NCT02091401 | Gynuity Health Projects | Phase 4 |
| Completed | Early Vascular Adjustments to Prevent Preeclampsia NCT04216706 | Maastricht University Medical Center | — |
| Unknown | uChek Pilot Study for Urinalysis in the Antenatal Care Setting NCT02256995 | Maternova Research | — |
| Completed | First-trimester Prediction of Preeclampsia NCT02189148 | CHU de Quebec-Universite Laval | — |
| Completed | Effect of Low Dose Aspirin on Birthweight in Twins: The GAP Trial. NCT02280031 | CHU de Quebec-Universite Laval | Phase 2 |
| Completed | A Comparison of BNP Levels Using the Nexfin Device in Healthy Pregnant and Preeclamptic Women NCT02527018 | University of California, Irvine | — |
| Completed | Cornell University-Micronutrient Initiative Calcium Supplementation Study NCT02238704 | Cornell University | N/A |
| Unknown | Preeclampsia Subtypes and Surrogate Markers of CVD Risk NCT02337049 | University of Aarhus | — |
| Unknown | Pancreatic Stone Protein (PSP) in Pregnant Women NCT02247297 | Nicole Ochsenbein | — |
| Completed | The Clinical Utility of the Congo-Red Dot Test for Diagnosis and Early Prediction of Preeclampsia During Pregn NCT02455544 | Catalin S Buhimschi, MD | — |
| Completed | Pharmacokinetics, Safety and Efficacy Study of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia NCT02059135 | rEVO Biologics | Phase 3 |
| Unknown | Ephedrine, Phenylephrine and Metaraminol Effects on Maternal Cardiac Output, Uterine Blood Flow and Fetal Circ NCT02245191 | University of Sao Paulo General Hospital | N/A |
| Completed | Diuretics for Postpartum High Blood Pressure in Preeclampsia NCT02163655 | Instituto Materno Infantil Prof. Fernando Figueira | Phase 4 |
| Completed | Evaluation of Educational Tools for Pregnant Women NCT01858324 | Université de Sherbrooke | N/A |
| Unknown | The Expression of Aquaporin 3, 8 and 9 in Placenta in Normal and Preeclamptic Pregnancies: Perinatal and Neona NCT02045316 | Rakhshanda Aslanova | — |
| Unknown | Utero-placental Vascularisation in Normal and Preeclamptic and Intra-uterine Growth Restriction Pregnancies NCT02825277 | Central Hospital, Nancy, France | N/A |
| Unknown | Calcium Supplementation to Prevent Preeclampsia in Sichuan Province of China NCT01806454 | West China Second University Hospital | N/A |
| Recruiting | The Preeclampsia Registry NCT06377878 | Preeclampsia Foundation | — |
| Unknown | Low Dose Aspirin for the Prevention of Preeclampsia NCT01890005 | Saint Thomas Hospital, Panama | Phase 3 |
| Completed | Urine-plasminogen as a Predictor for Development Of Preeclampsia in Pregnant Women With Type 1 Diabetes Mellit NCT01821053 | Odense University Hospital | — |
| Completed | Standard 24-hour Urine Protein vs Shorter Period for Diagnosis of Pre-eclampsia NCT01881542 | HaEmek Medical Center, Israel | — |
| Completed | Removal of Anti-Angiogenic Proteins in Preeclampsia Before Delivery NCT01404910 | Massachusetts General Hospital | N/A |
| Completed | Hypertension and Urine Protease Activity in Preeclampsia NCT01828138 | Odense University Hospital | N/A |
| Unknown | The Effect of neutrophil-to Lymphocyte Ratio in Preeclampsia- Eclampsia NCT01856387 | Zekai Tahir Burak Women's Health Research and Education Hospital | — |
| Completed | Prolongation of Pregnancy in Preeclampsia by Therapeutic Lipid Apheresis NCT01967355 | Karl Winkler | N/A |
| Completed | First Trimester Prediction of Preeclampsia and Fetal Growth Restriction NCT02379494 | Fetal Medicine Foundation | — |
| Completed | Clonidine Versus Captopril for Treatment of Postpartum Very High Blood Pressure NCT01761916 | Instituto Materno Infantil Prof. Fernando Figueira | Phase 4 |
| Completed | Pravastatin for Prevention of Preeclampsia NCT01717586 | The University of Texas Medical Branch, Galveston | Phase 1 |