NCT06893978

Placental Organoids Development: Application in the Study of the Human Reproduction Pathophysiology.

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 20 (estimated)
• Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: —

Summary

Placental organoids represent an in vitro 3D reconstruction model of the human placenta and of its complex cellular organization to evaluate the pharmacological effect in terms of placentation, gene expression, protein synthesis and placental secretomics.

Detailed description

Placental organoids represent an in vitro 3D reconstruction model of the human placenta and of its complex cellular organization. Placental organoid model can be used in the study of placental pathophysiology. In in particular, it provides a personalized model for sartorial in vitro evaluation of personalized therapeutic efficacy of different pharmacological therapies. In particular, with placental organoid it is possible to evaluate the pharmacological effect in terms of placentation, gene expression, protein synthesis and placental secretomics.

Conditions

• Preeclampsia
• Pregnancy Loss
• Preterm Birth
• Healthy

Interventions

Type	Name	Description
DRUG	Placenta organoids treatment	Placenta organoids in vitro treatment with heparin, aspirin, IVIG, filgrastim and metformin

Timeline

• Start date: 2025-05-20
• Primary completion: 2027-11-01
• Completion: 2027-11-01
• First posted: 2025-03-25
• Last updated: 2025-05-20

Locations

1 site across 1 country: Italy