| Not Yet Recruiting | Antenatal Breastmilk Expression in Pregnant Women at High Risk of Preterm Birth NCT07191366 | Odense University Hospital | N/A |
| Not Yet Recruiting | Initial Oxygen Concentration at Birth in Late-Preterm Infants NCT07315594 | University of Alberta | N/A |
| Not Yet Recruiting | Caffeine for Infants Born at 28 to 34 Weeks Receiving Respiratory Support NCT07456670 | Queen's University | Phase 2 |
| Not Yet Recruiting | Milk Volume Outcomes Following Oral Nicotinamide Riboside Supplementation in Mothers of Extremely Preterm Infa NCT04614714 | University of California, Davis | Phase 2 / Phase 3 |
| Not Yet Recruiting | Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial NCT07424846 | University of Washington | Phase 2 / Phase 3 |
| Not Yet Recruiting | Music Intervention for Preterm Birth NCT05945264 | Columbia University | N/A |
| Not Yet Recruiting | Effectiveness of Targeted Cervical Length Screening Guided by a Preterm Birth Risk Scoring System in Reducing NCT07415070 | Ningbo University | N/A |
| Not Yet Recruiting | Pivotal Study to Assess Safety and Performance of Neola®, a Novel Lung Monitoring Device for Neonates NCT07060911 | Neola Medical Inc | N/A |
| Recruiting | Does AI Make Clinicians More Appropriately Confident? A Randomized Study in Preterm Birth Prediction NCT07402668 | Rigshospitalet, Denmark | N/A |
| Not Yet Recruiting | Healthy Expectancy Through Routine Antenatal STI Screening NCT07458802 | Adriane Wynn | N/A |
| Not Yet Recruiting | Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) Disparities NCT06915428 | University of North Carolina, Chapel Hill | N/A |
| Not Yet Recruiting | Environmental Enrichment Intervention and Brain Development in Preterm Infants NCT07343505 | Eskisehir Osmangazi University | N/A |
| Recruiting | Asymptomatic Bacteriuria in Pregnancy in Low- and Middle-IncomE Countries NCT06723392 | NICHD Global Network for Women's and Children's Health | Phase 3 |
| Not Yet Recruiting | PLatform for Adaptive Trials In Perinatal UnitS - [Core Protocol] NCT06461429 | University of Melbourne | N/A |
| Recruiting | Comparison of Early Caffeine Administration Vs Supportive Therapy in Preventing Acute Kidney Injury NCT07305935 | Muhammad Aamir Latif | N/A |
| Recruiting | Early Prediction of Lung Injury in Preterm Infants Score NCT07265583 | Fondazione IRCCS Policlinico San Matteo di Pavia | — |
| Not Yet Recruiting | AI-POCUS for Maternal and Neonatal Health in Ethiopia NCT07171086 | Tsinghua University | Phase 4 |
| Not Yet Recruiting | Impact of Colostrum Oropharyngeal Immunotherapy on Postnatal Growth in Preterm Infants NCT07082881 | Suqian First Hospital | N/A |
| Recruiting | Health-Related Quality-of-Life and Household Financial and Wellbeing Impacts of Prematurity and Necrotising En NCT07192393 | Imperial College London | — |
| Enrolling By Invitation | Reading-FREE Markers for Early Detection of Developmental Dyslexia NCT07072104 | Università Vita-Salute San Raffaele | N/A |
| Recruiting | Daily Aspirin vs Split Dosing in High-risk Pregnancies (DASH) NCT06826859 | Thomas Jefferson University | Phase 1 / Phase 2 |
| Active Not Recruiting | Promoting Kangaroo Care for Preterm or Low Birthweight Infants in Rural India NCT07231432 | University of Massachusetts, Worcester | N/A |
| Completed | Study to Assess Safety and Performance of Neola®, a Novel Lung Monitoring Device for Neonates NCT06917326 | Neola Medical AB | N/A |
| Not Yet Recruiting | Placental Organoids Development: Application in the Study of the Human Reproduction Pathophysiology. NCT06893978 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Recruiting | Biological Impacts of Rising Temperatures on Maternal, Fetal, and Newborn Health: A Cohort Study (BIRTH Cohort NCT06957769 | Aga Khan University | — |
| Completed | Effect of Vaginal Progesterone Treatment on Pregnancy and Newborn Outcomes in Women With Preterm Labor NCT07523295 | Medicare Hospital (Pvt) Limited | Phase 4 |
| Recruiting | Transition From Donor Milk: a Feasibility Study NCT06514014 | Augusta University | N/A |
| Withdrawn | Swaddling to Improve Neurodevelopment for Preterm Babies NCT04715451 | Johns Hopkins University | N/A |
| Active Not Recruiting | The Placental Secretome as a Therapeutic Tool to Prevent Inflammation-induced Preterm Birth NCT06891508 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Recruiting | Sodium Awareness in Lactation Trial NCT06563726 | The Hospital for Sick Children | N/A |
| Recruiting | Optimal Timing of Routine Cervical Length Measurements During Anatomy Survey NCT06822647 | Henry Ford Health System | N/A |
| Enrolling By Invitation | The Social Determinants of Health Screening and Referral Project NCT06582147 | University of Massachusetts, Worcester | N/A |
| Recruiting | Blood Glucose in Pregnant Non-diabetic Women During Treatment With Betamethasone for Fetal Lung Maturation NCT06794307 | University of Aarhus | — |
| Withdrawn | Kangaroo Mother Care With Plastic Bag (Trials 1A & 1B) NCT03141736 | University of Alabama at Birmingham | N/A |
| Completed | Effect of a Bathing Care Package on Comfort and Skin Moisture in Preterm Infants in a Neonatal Intensive Care NCT07068737 | Kiymet Aygün | N/A |
| Not Yet Recruiting | Post-extubation Pressures in Preterm Neonates: A CER Study NCT06552455 | McMaster Children's Hospital | — |
| Recruiting | COntact RElationship in Neonatal Intensive Care Unit NCT06462638 | Istituto per la Ricerca e l'Innovazione Biomedica | — |
| Recruiting | Effect of Support for Low-Income Mothers of Preterm Infants NCT06362798 | University of Massachusetts, Worcester | N/A |
| Not Yet Recruiting | Skincubator, a Novel Incubator for Skin to Skin Contact Feasibility Study NCT06543433 | Itamar Nitzan | Phase 2 / Phase 3 |
| Recruiting | Exercise in Prematurely Born Preadolescents to Mitigate Cardiovascular Risk and Improve Cognitive Impairment NCT06500910 | Henner Hanssen | N/A |
| Recruiting | Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT) NCT06396078 | Ohio State University | Phase 4 |
| Recruiting | Expected and Actual Preterm-Birth and Parental Distress: Impact on Children's Mental Health NCT06627140 | Goethe University | — |
| Recruiting | Cerclage With Progesterone Versus Progesterone Only in Singleton Pregnancies NCT06463652 | Mỹ Đức Hospital | N/A |
| Enrolling By Invitation | Developing & Evaluating Models for Early Predicting Obstetrical Diseases in Pregnant Women by Non-invasive Pre NCT06385366 | Gene Solutions | — |
| Completed | Low Birthweight and Preterm Infant Feeding Trial and Supportive Care Package: Implementation Research NCT06390943 | Harvard School of Public Health (HSPH) | N/A |
| Recruiting | Mitochondrial DNA Signatures of Poor Aerobic Exercise Trainability in Young Adults Born Preterm NCT06334107 | Texas Tech University | N/A |
| Not Yet Recruiting | Selective Antibiotics When Symptoms Develop Versus Universal Antibiotics for Preterm Neonates NCT06377397 | Indian Council of Medical Research | Phase 3 |
| Completed | Adverse Neonatal Outcomes With a Shortened Clinical Regimen of Dexamethasone. NCT06569251 | Ricardo A Gutierrez Ramirez, MD, MSc, FACOG | Phase 2 |
| Unknown | Preterm Infant Oral Motor Intervention (PIOMI) NCT06259604 | Suleyman Demirel University | N/A |
| Recruiting | Bilateral Infant Stimulation Study NCT06353243 | Oregon Health and Science University | N/A |
| Unknown | Study of the Influence of Intraperitoneal Insufflation of CO2 by Laparoscopy on the Short-term Evolution of Pr NCT05882448 | Assistance Publique - Hôpitaux de Paris | N/A |
| Recruiting | Peking University Birth Cohort in Weifang (PKUBC-WF) NCT06234332 | Peking University | — |
| Recruiting | Nordic Randomized Trial on Laparoscopic Versus Vaginal Cerclage NCT06122506 | University of Aarhus | N/A |
| Recruiting | E-health-supported Diagnostic and Intervention in Preterm Born Children and Their Families NCT06939192 | University Hospital Tuebingen | N/A |
| Recruiting | L-ArGinine to pRevent advErse prEgnancy Outcomes (AGREE) NCT05934318 | Liverpool School of Tropical Medicine | N/A |
| Active Not Recruiting | The Effect of Kangaroo Father Care Transport on Preterm Infants NCT06725914 | Zeynep Büşra GÜÇLÜ | N/A |
| Unknown | Continuous Non-invasive Electrophysiological Monitoring in High Risk Pregnancies NCT06151613 | Maxima Medical Center | N/A |
| Completed | Perinatal Conditions Influencing Morbidity, Mortality, and Medical Care in Newborns NCT06653374 | HOSPITAL GINECO OBSTETRICO ISIDRO AYORA | — |
| Completed | The Effect of Low Doses of Prednisone on the Prolongation of Pregnancy in Threatened Preterm Birth NCT06103227 | University of Mostar | Phase 2 / Phase 3 |
| Recruiting | Improving Neonatal Health Through Rapid Malaria Testing in Early Pregnancy With High-Sensitivity Diagnostics NCT05757167 | Duke University | Phase 4 |
| Unknown | Cerebral Magnetic Resonance Spectroscopy at Term Corrected Age and Dysexecutive Syndrome in Very Preterm Child NCT06055062 | Assistance Publique Hopitaux De Marseille | — |
| Enrolling By Invitation | Evaluation of Intravascular Monitoring of Partial PRessure of Oxygen for Neonatal IntensiVE Care Patients -3 NCT06616012 | Neosense Technologies | N/A |
| Active Not Recruiting | Evaluation of Maternal and Neonatal Outcomes in Women Are Conceived Through Assisted Reproductive Technology C NCT06836843 | Lebanese University | — |
| Unknown | Antenatal Dexamethasone for Late Preterm Deliveries NCT05841121 | Chulalongkorn University | Phase 1 |
| Active Not Recruiting | Improving Cognition and Gestational Duration With Targeted Nutrition NCT05949190 | Washington University School of Medicine | N/A |
| Active Not Recruiting | The Alkmaar MLPTI Cohort Study: Outcomes at 9 Years NCT05990582 | Noordwest Ziekenhuisgroep | N/A |
| Recruiting | BEP Targeting Strategies in Ethiopia NCT06125860 | Harvard School of Public Health (HSPH) | N/A |
| Recruiting | Continuous Delivery Room Skin-to-skin-study for Moderate and Late Preterm Infants NCT05975203 | University of Cologne | N/A |
| Completed | COIN: A Pilot Study of Cash Transfers to Improve Outcomes in Low-Income Preterm Neonates and Their Families NCT05930327 | Children's Hospital of Philadelphia | N/A |
| Recruiting | Single Dose of Antenatal Corticosteroids for Pregnancies at Risk of Preterm Delivery (SNACS) NCT05114096 | McMaster University | Phase 4 |
| Completed | Health and Wellness After Preterm Birth NCT05756634 | Children's Hospital of Philadelphia | N/A |
| Completed | Can Cervical Stiffness in the Second Trimester Predict Preterm Birth in High-Risk Singleton Pregnancies? NCT05837390 | University of Liverpool | — |
| Unknown | Selected Immunological Indicators and Microbiota in Patients With Premature Birth and Preeclampsia NCT06281262 | General University Hospital, Prague | — |
| Suspended | Matching Donor Human Milk On Maternal Secretor Status (MMOMSS) Study NCT04130165 | University of Manitoba | N/A |
| Recruiting | Cerclage for the Reduction of Extreme Preterm Birth in Twin Pregnancies With a Short Cervix or Dilatation NCT05968794 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N/A |
| Unknown | Labor Status Monitor for Diagnosing True vs False Labor in Preterm Patients NCT06157203 | PreTeL, Inc | — |
| Unknown | Preventing Preterm Birth With a Negative Pressure Cervical Cup: a Feasibility Study NCT05512052 | Galena Innovations, LLC | Phase 1 |
| Active Not Recruiting | Movement Imitation Therapy for Preterm Babies (MIT-PB) - A Pilot Study NCT07449312 | University of Zurich | N/A |
| Unknown | Nutrition Optimalization Among Pregnant Women to Improve Maternal and Neonatal Outcome in DKI Jakarta NCT06268509 | Dr Cipto Mangunkusumo General Hospital | N/A |
| Unknown | Prolonged Progesterone to Prevent Preterm Birth From IVF - ET NCT05787509 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Phase 4 |
| Recruiting | Synbiotics in Patients at RIsk fOr Preterm Birth NCT05966649 | Ziekenhuis Oost-Limburg | N/A |
| Recruiting | Serum Vasohibin, Cardiotrophin, Endocan & Perinatal Outcomes NCT06416995 | Umraniye Education and Research Hospital | — |
| Recruiting | The Effect of Sulfasalazine on CRH Levels in Pregnant Women NCT05703425 | Rutgers, The State University of New Jersey | Phase 2 |
| Completed | Sensory Processing Associated With Motor Skills NCT06216379 | Gazi University | — |
| Recruiting | Interdisciplinary E-health Based Follow-up of Preterm Born Children NCT06345664 | University Hospital Tuebingen | N/A |
| Unknown | Development, ADL, Participation, and Quality of Life in Preterm Infants: A Longitudinal Follow Up Study NCT05498753 | Chang Gung Memorial Hospital | — |
| Completed | Impact of Dietary Sodium Supplementation on Growth & Intestinal Microbiome NCT05546814 | Medical College of Wisconsin | N/A |
| Recruiting | Description and Comparison of Biological Vulnerability in Small Vulnerable Newborns Versus Healthy Community C NCT05730569 | University Ghent | — |
| Active Not Recruiting | PRECISE - Objective Measures and Observations of Physical Exposures Among Pregnant Employees in the Danish Wor NCT05670145 | Bispebjerg Hospital | — |
| Unknown | QTc Intervals in Former Preterm/Extreme Low Birth Weight Infants: a Pooled Study Proposal NCT05243537 | Universitaire Ziekenhuizen KU Leuven | — |
| Completed | Study of the Feasibility of Early Lung Ultrasound in Neonatal Respiratory Distress in Premature Newborns Born NCT05737095 | Centre Hospitalier Universitaire Dijon | — |
| Completed | Preterm Birth and Biomarkers for Cardiovascular Disease NCT05693285 | Uppsala University | — |
| Completed | Diagnostic Accuracy of Foot Length in Predicting Preterm and Low Birth Weight Using Ultrasound Dating as The G NCT05515211 | Aga Khan University | — |
| Active Not Recruiting | BEP Supplementation Research in Bangladesh (JiVitA-BEP-IR) NCT05576207 | Johns Hopkins Bloomberg School of Public Health | N/A |
| Unknown | Effectiveness of Positioning in Preterm Neonates NCT04251260 | University of Patras | N/A |
| Completed | Examination of the Relationship Between Home Affordances With Development NCT05210985 | Gazi University | — |
| Recruiting | Assessment Of Dose-Dependent Immunomodulatory Effect Of Alveofact With or Without Steroisd In Neonatal RDS NCT06367881 | Ain Shams University | Phase 1 |
| Unknown | Cervical Softening and the Prediction of Preterm Birth NCT05477381 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Completed | Amniochorionic Membrane Cells in the Maternal Blood as a Biomarker for Preterm Birth NCT04705935 | University of Aarhus | — |
| Active Not Recruiting | The Use of Wireless Sensors in Neonatal Intensive Care NCT04956354 | McGill University Health Centre/Research Institute of the McGill University Health Centre | — |
| Unknown | Physical Exam Indicated Cerclage in Singleton Gestation 24 Weeks to 25 Weeks and 6 Days Gestation NCT05501938 | Albany Medical College | N/A |
| Unknown | Towards Life-Long Healthy Lungs: A Multidisciplinary Follow-up Framework for Preterm Infants NCT05618769 | Franciscus Gasthuis | N/A |
| Completed | Effect of Banana Blossom on Breast Milk Volume in Mothers of Preterm Newborns NCT05465460 | Chulalongkorn University | Phase 4 |
| Active Not Recruiting | Is the Vaginal Microbiome and Metabolome Associated With Spontaneous Preterm Birth (sPTB) in Multiple Pregnanc NCT06053697 | University of Liverpool | — |
| Terminated | PAL to Improve Oral Feeding for Infants With Chronic Lung Disease NCT05446389 | University of Missouri-Columbia | N/A |
| Unknown | Metformin to Prevent Preterm Birth in Twin Pregnancy NCT05412056 | The University of Hong Kong | Phase 2 / Phase 3 |
| Completed | Evaluation of Preoperative Risk Factors in Children NCT05852899 | Istanbul University - Cerrahpasa | — |
| Unknown | Navigating the Grey Zone for Antenatal Corticosteroids NCT04792112 | University of British Columbia | N/A |
| Unknown | Human Milk in Preterm Infants NCT05228535 | Augusta University | N/A |
| Unknown | Aspiration Technique-based Device for Preterm Labor NCT05355649 | Federico II University | N/A |
| Completed | The Effects of Making Pregnant Women With Preterm Birth Threat Watch Nature Images With Virtual Reality Goggle NCT05352503 | Selcuk University | N/A |
| Completed | Comparison of the Acute Effects of Chest Physiotherapy Methods Applied in Different Positions in Preterm Newbo NCT05036603 | Sanko University | N/A |
| Completed | Comparative Study Between Vaginal Progesterone Alone or Combined With Aspirin in Prevention of Recurrent Prete NCT05319834 | Menoufia University | Phase 4 |
| Completed | Maternal Role in Oral Feed Establishment in Preterm Neonates NCT05484726 | Fatima Memorial Hospital | N/A |
| Unknown | Reducing Pain During Heel Blood Collection in Preterm Newborns NCT05431452 | Suleyman Demirel University | N/A |
| Unknown | Optimal High CPAP Pressures in Preterm Neonates Post-extubation NCT05230485 | McMaster Children's Hospital | N/A |
| Active Not Recruiting | Glycemic Control After Antenatal Corticosteroids in Women With Pregestational and Gestational Diabetes NCT04542148 | University of Alabama at Birmingham | Phase 2 |
| Recruiting | Prospective Evaluation of Pathways for Preterm Birth NCT05246579 | John O'Brien, MD | — |
| Terminated | Testing Feasibility of Care Coordination and Motivational Interviewing for Women With a Recent Preterm Birth NCT05120843 | Children's Hospital of Philadelphia | N/A |
| Recruiting | Blood Warming in Preterm Infants to Decrease Hypothermia NCT05170633 | University of South Carolina | N/A |
| Unknown | Azithromycin to Improve Latency in Exam Indicated Cerclage Control Trial NCT05132829 | Thomas Jefferson University | Phase 4 |
| Completed | Prophylactic Cerclage for Twin Pregnancy With Shortened Cervix NCT05338164 | Zagazig University | N/A |
| Unknown | Prophylactic Cervical Cerclage in Twin Pregnancies With Non-shortened Cervix NCT05334264 | Zagazig University | N/A |
| Completed | LISA vs INSURE in Extremely Low Birth Weight Infants. A Manikin Study NCT04944108 | University Hospital Padova | N/A |
| Recruiting | Stress Phenotypes and Preterm Birth NCT05229666 | Columbia University | N/A |
| Enrolling By Invitation | Omega Tots Long Term Follow-up NCT05191823 | Sarah Keim | N/A |
| Unknown | Impact of Pessary Treatment on Cervical Stiffness Measurement and Birth Outcomes in Patients at Risk for Prete NCT05267717 | Asklepios proresearch | — |
| Completed | Mobile Strategy to Reduce the Risk of Recurrent Preterm Birth NCT04663607 | Stanford University | N/A |
| Completed | Cerebral Oxygenation in Preterm Neonates with Respiratory Support During Skin-to-skin Care on the First Day Af NCT04865302 | Medical University of Graz | — |
| Unknown | Evaluation of a Novel Diagnostic Kit for the Detection of Placental Alpha-Microglobulin-1 in the Prediction of NCT05742997 | Ziekenhuis Oost-Limburg | N/A |
| Unknown | Comparison of Two Different Skin-to-skin Contact Techniques: Sustained Diagonal Flexion vs. Traditional NCT06154148 | Erasme University Hospital | N/A |
| Recruiting | Effect of Nasal CPAP Versus NIPPV On Diaphragm Electrical Activity (Edi) In VLBW Preterm Infants NCT06295484 | Sunnybrook Health Sciences Centre | N/A |
| Active Not Recruiting | MIRACLE of LIFE Study NCT06074601 | Mirvie | — |
| Recruiting | Reducing Pregnancy Risks: The Mastery Lifestyle Intervention NCT05012072 | Microgen LLC | N/A |
| Unknown | Biological Underpinnings of Socio-emotional Regulation in Preterm Infants and Healthy Controls NCT05253924 | IRCCS Eugenio Medea | — |
| Completed | EngagINg the COmmunity to Reduce Preterm Birth Via Adherence To an Individualized Prematurity Prevention Plan NCT04933812 | Duke University | N/A |
| Unknown | Phone Breastfeeding Support for Premature Babies NCT04883866 | Akdeniz University | N/A |
| Completed | Development of a Screening Tool By Utilising Cervical Length Measurement In Relation To Body Mass Index (BMI) NCT04922671 | Universiti Putra Malaysia | — |
| Completed | Preterm Labor Prevention Using Vaginal Antiseptics Prior to 16 Weeks of Gestation NCT05944094 | Instituto de Investigacion Sanitaria La Fe | — |
| Completed | To Optimize Antenatal Management of Women With Pre Term Labor Using Amniocentesis NCT04831086 | Fundacion Clinic per a la Recerca Biomédica | Phase 3 |
| Active Not Recruiting | Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Tri NCT04372953 | Murdoch Childrens Research Institute | N/A |
| Unknown | Prediction and Prevention of Twin Premature Birth 2021 NCT05061641 | Caixia Liu | Phase 4 |
| Unknown | Oxygen Assist Module in Preterm Infants on High Flow Nasal Cannula Support. NCT04687618 | South Tees Hospitals NHS Foundation Trust | N/A |
| Completed | Mother's Recorded Voice for Preterm Infants NCT04559620 | AdventHealth | N/A |
| Completed | Surfactant Nebulization for the Early Aeration of the Preterm Lung NCT04315636 | University of Zurich | Phase 3 |
| Completed | The Effect of Rocking Bed on Preterm Newborns NCT05978674 | Selcuk University | N/A |
| Completed | Single Dose Antenatal Corticosteroids (SNACS) for Women at Risk of Preterm Birth NCT04494529 | McMaster University | Phase 3 |
| Completed | Safety, Testing/Transmission, and Outcomes in Pregnancies With COVID-19 NCT04718220 | Washington University School of Medicine | N/A |
| Recruiting | Peripheral Fractional Tissue Oxygen Extraction and Infection in Term and Preterm Neonates NCT04818762 | Medical University of Graz | — |
| Completed | Antenatal Chlamydia Trachomatis and Neisseria Gonorrhoeae Testing to Prevent Adverse Neonatal Consequences NCT04955717 | University of Southern California | N/A |
| Unknown | Air Pollution and Daily Mobility of Pregnant Women Identification of Critical Windows of Exposure NCT04725734 | University Hospital, Strasbourg, France | — |
| Completed | Online Mother-Baby Yoga With Preterm Infants and Their Mothers NCT05147480 | Halic University | N/A |
| Recruiting | AttachMent Preterm in the Loire Infant Follow-up Team NCT04304846 | University Hospital, Angers | — |
| Completed | Predictive Value of Maternal Blood Protein Signatures in Preterm Birth NCT06664554 | HBI Solutions Inc. | — |
| Recruiting | Surfactant for Neonatal Respiratory Distress Syndrome(NRDS) and Neonatal Acute Respiratory Distress Syndrome(N NCT04777760 | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | — |
| Completed | Surfactant Replacement Guided by Early Lung Ultrasound Score in Preterm Newborns With Respiratory Distress Syn NCT04775459 | Centre Hospitalier Universitaire de Saint Etienne | — |
| Recruiting | Maternal and Fetal/Neonatal Pharmacokinetics and - Dynamics of Corticosteroids During Pregnancy NCT06264973 | Erasmus Medical Center | — |
| Unknown | COVID-19 Infection and Fetal-neonatal Outcomes NCT04699578 | University of Campania Luigi Vanvitelli | — |
| Unknown | The Efficacy of Nifedipine in the Management of Preterm Labor NCT04644354 | Ethem Unal, M.D., PhD, Associate Prof of Surgery & Surgic | — |
| Unknown | The Effect of Breast Milk Smell on Nutrition in Preterms NCT04843293 | Selcuk University | N/A |
| Completed | Reducing Disparity in Receipt of Mother's Own Milk in Very Low Birth Weight Infants NCT04540575 | Rush University Medical Center | N/A |
| Completed | Efficacy of A Novel in Prevention of Neonatal Hypothermia NCT05729698 | Istanbul University - Cerrahpasa | N/A |
| Completed | B-vitamin Levels and Adverse Pregnancy Outcomes NCT05073978 | Westlake University | — |
| Completed | PremCry Study : Study of Ontogeny of Crying in Preterm Infants. NCT04522414 | Centre Hospitalier Universitaire de Saint Etienne | — |
| Terminated | Effects of Music Based Intervention (MBI) on Pain Response and Neurodevelopment in Preterm Infants NCT04286269 | University of Minnesota | N/A |
| Active Not Recruiting | Prematurity Risk Assessment Combined With Clinical Interventions for Improving Neonatal outcoMEs NCT04301518 | Sera Prognostics, Inc. | N/A |
| Unknown | Prediction of the Onset of Term and Preterm Labour NCT04590677 | Chelsea and Westminster NHS Foundation Trust | — |
| Completed | Multi Modal Stimulations in Pre-term Neonates NCT04247308 | Asir John Samuel | N/A |
| Completed | The Effect Of Risk Factors Considered Together With Preterm Birth History on Development NCT05087511 | Gazi University | — |
| Unknown | Prevention of sPTB With Early Cervical Pessary Treatment in Women at High Risk for PTB NCT03418012 | Bürgerhospital Frankfurt | N/A |
| Unknown | Cervical Pessary Treatment for Prevention of s PTB in Twin Pregnancies on Children's Long-Term Outcome NCT03418311 | Bürgerhospital Frankfurt | N/A |
| Recruiting | How to Optimize Enteral Feeding of the Full Enteral Feeding Preterm Infant NCT06760832 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Terminated | 17-OHPC in Pregnancy: IM vs SC Routes NCT04183452 | Steve N. Caritis, MD | — |
| Completed | Fetal Haemoglobin and Cerebral and Peripheral Oxygenation. NCT04802629 | Medical University of Graz | — |
| Completed | Exposure to Plasticisers in the Neonatal Intensive Care Unit NCT05404815 | University Hospital, Antwerp | — |
| Unknown | Physical Activity and Preterm Birth With Cervical Dynamics NCT04409678 | Wolfson Medical Center | N/A |
| Unknown | Pessary Versus Progesterone in Singletons NCT04300322 | Mỹ Đức Hospital | N/A |
| Unknown | Prevention of Preterm Birth by Screening of the Consistency Index and Length of the Uterine Cervix in Women Wi NCT04444206 | University of Campania Luigi Vanvitelli | N/A |
| Unknown | Vaginal, Placental and Neonatal Buccal Mycobiota and Microbiome in Preterm Birth NCT04165252 | Koç University | — |
| Completed | The Effect of Nursing Counseling Perceived Stress, Coping and Birth Outcomes Among Pregnant Women NCT06101186 | Erzurum Technical University | N/A |
| Completed | Health of Pessary Versus Progesterone Supplement for Preventing Preterm Birth Children NCT04295187 | Mỹ Đức Hospital | — |
| Withdrawn | Enhancing Nutrition and Antenatal Infection Treatment for Maternal and Child Health in Ethiopia NCT04171388 | Brigham and Women's Hospital | Phase 4 |
| Unknown | Point-of-care Tests for Bacterial Vaginosis and Candidosis NCT04287504 | Medical University of Vienna | — |
| Completed | Improving the Clinical Encounter to Enhance Delivery of an Individualized Prematurity Prevention Plan NCT04149002 | Duke University | N/A |
| Active Not Recruiting | Assessment of Body Composition in Premature Children Submitted to an Early Stimulation Program NCT05399667 | Hospital de Clinicas de Porto Alegre | — |
| Active Not Recruiting | Targeting Human Milk Fortification to Improve Preterm Infant Growth and Brain Development NCT03977259 | Brigham and Women's Hospital | N/A |
| Completed | Cervical Stiffness Measurement in Cervical Insufficiency NCT04158401 | Tufts Medical Center | — |
| Unknown | Cervix Monitor for Detection Conditions Leading to Spontaneous Preterm Delivery NCT04247555 | Advanced Tactile Imaging, Inc. | — |
| Unknown | Skin-to-skin Contact in Neonatal Intensive Care Unit (NICU), Caregiving Touch and Neural Correlates of Slow St NCT04293939 | IRCCS Eugenio Medea | — |
| Completed | Prediction of Preterm Delivery by Serum Ischemia Modified Albumin, Biglycan and Decorin Levels in Women With T NCT04451928 | Ismail Biyik | — |
| Terminated | Evaluation of an Early Support Programme in Orthophony NCT04384328 | Centre Hospitalier Sud Francilien | N/A |
| Unknown | Activity Restriction for Women With Arrested Preterm Labor NCT03501030 | Federico II University | N/A |
| Completed | Eye and Growth in Adolescents Born Moderate-to-late Preterm NCT04190147 | Vastra Gotaland Region | — |
| Unknown | Stratifying Risk for Intracerebral Haemorrhage NCT04140812 | University of Erlangen-Nürnberg Medical School | N/A |
| Completed | eHealth as an Aid for Facilitating and Supporting Self-management in Families With Long-term Childhood Illness NCT04150120 | Lund University | N/A |
| Unknown | Cerclage After Full Dilatation Caesarean Section NCT04110704 | Guy's and St Thomas' NHS Foundation Trust | N/A |
| Completed | Comparison Between Vaginal Pessary and Progestogen in Twin Pregnancy With Short Cervical Length NCT04342585 | National University of Malaysia | Phase 3 |
| Completed | Assessing the Effectiveness and Efficacy of the MyHealthyPregnancy Application NCT05502510 | Naima Health LLC | — |
| Unknown | The FLIP-1 Study: Vaginal Lactobacillus Supplementation in Women at High Risk of Preterm Birth NCT03992534 | Imperial College London | Phase 1 |
| Recruiting | Latency Antibiotics in Previable PPROM, 18 0/7- 22 6/7 WGA NCT04047849 | Woman's | Phase 4 |
| Unknown | Environmental Factors and Embryonic Development Project NCT04182503 | Jinling Hospital, China | — |
| Unknown | MYPP-trial: Myo-inositol Supplementation to Prevent Pregnancy Complications in Women With Polycystic Ovary Syn NCT05524259 | Erasmus Medical Center | N/A |
| Terminated | Inpatient vs Outpatient Management of Short Cervix NCT03979196 | Sunnybrook Health Sciences Centre | N/A |
| Completed | Use of CO2 Detectors to Help Provide Effective Breaths During Resuscitation of Preterm Newborns NCT04287907 | KK Women's and Children's Hospital | N/A |
| Completed | Transvaginal Ultrasound: Preterm Birth Prevention in Appalachia NCT03833284 | Niraj Chavan | N/A |
| Completed | α-lipoic Acid (ALA), Magnesium, Vitamin B6 and Vitamin D and Risk Factor for Pre-term Birth NCT03952533 | University of Modena and Reggio Emilia | N/A |
| Unknown | Preterm Birth Prediction by Measurement of Biomarkers in Cervical Vaginal Fluid NCT03974724 | Peking Union Medical College Hospital | — |
| Completed | Happy Mother-Healthy Baby: An Anxiety-focused Early Prenatal Intervention NCT03880032 | Johns Hopkins Bloomberg School of Public Health | N/A |
| Completed | Antenatal Azithromycin to Prevent Preterm Birth in Pregnant Women With Vaginal Cerclage NCT04278937 | Ain Shams Maternity Hospital | Phase 4 |
| Completed | Effect of Early Use of Caffeine Citrate in Preterm Neonates NCT04001712 | Ain Shams University | Phase 3 |
| Completed | Gastric Bacterial Colonization of Preterm Neonates NCT05385939 | Christiana Care Health Services | — |
| Terminated | Pessary Versus Cerclage With or Without Progesterone in Twins NCT03863613 | Mỹ Đức Hospital | N/A |
| Withdrawn | Clinical Evaluation of the "NICU Clinical Decision Support Dashboard" - CHMCO NCT03673566 | Philips Healthcare | N/A |
| Completed | The Expression Heparanase in Term and Preterm Placentas NCT03798964 | Hillel Yaffe Medical Center | — |
| Terminated | Micronutrient Supplementation Before and During 1st Pregnancy to Improve Birth Outcomes (JiVitA-5) NCT03921177 | Johns Hopkins Bloomberg School of Public Health | N/A |
| Unknown | Progesterone to Prevent Preterm Delivery NCT03428685 | The University of Hong Kong | Phase 2 / Phase 3 |
| Completed | Maternal Serum Markers Predicting Preeclampsia At Early Gestations NCT05131282 | HBI Solutions Inc. | — |
| Unknown | Evaluation of Digital Follow up of Preterm Infants NCT05238168 | Turku University Hospital | — |
| Unknown | Epigenetics and Protective Factors in the Preterm Infant NCT04804280 | IRCCS Eugenio Medea | — |
| Completed | Facilitated Tucking Position's Effect on Comfort and Breastfeeding NCT04704180 | Selcuk University | N/A |
| Completed | A Study Evaluating Sleep, Stress and Infant Nutrition Using a Chatbot NCT03630679 | Danone Asia Pacific Holdings Pte, Ltd. | — |
| Completed | Prenatal Breast Pump Education of Mothers and Their Support Person NCT04006509 | University of Florida | N/A |
| Unknown | Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies NCT04051567 | Ministry of Science and Technology of the People´s Republic of China | Phase 4 |
| Completed | Multiperfusion Neonatal System NCT05058534 | Hospices Civils de Lyon | — |
| Completed | India Dexamethasone and Betamethasone NCT03668860 | Children's Hospital Medical Center, Cincinnati | Phase 1 |
| Unknown | Correlation Between Maternal Vitamin D Level And Preterm Birth NCT03638037 | Ain Shams Maternity Hospital | — |
| Completed | What is the Future of Vulnerable New-borns NCT04021654 | Hôpital NOVO | — |
| Completed | Effect of Immersion Bathing and Showering Applications on Comfort Level and Physiological Parameters of Newbor NCT04811742 | Okan University | N/A |
| Completed | Longitudinal Study of Music Therapy's Effectiveness for Premature Infants and Their Caregivers NCT03564184 | NORCE Norwegian Research Centre AS | N/A |
| Completed | A RCT of CenteringPregnancy on Birth Outcomes and Maternal Inflammation NCT04097548 | Endeavor Health | N/A |
| Withdrawn | Transvaginal Ultrasound Cervical Length Screening in Singleton Pregnancy Without Prior Spontaneous Preterm Bir NCT02928302 | Federico II University | Phase 3 |
| Unknown | Universal Transvaginal Cervical Length Screening Program for Prevention of Preterm Birth in Singletons Without NCT03591042 | Federico II University | N/A |
| Unknown | Preterm Birth and Long Term Consequences on Myocardial Functions and Structure NCT03589365 | Assistance Publique Hopitaux De Marseille | N/A |
| Unknown | Peking University Birth Cohort in Tongzhou NCT03814395 | Peking University | — |
| Completed | Serum Assessment of Preterm Birth Outcomes Compared to Historical Controls: AVERT PRETERM TRIAL NCT03151330 | Christiana Care Health Services | N/A |
| Withdrawn | Clinical Evaluation of the "NICU Clinical Decision Support Dashboard" - MHSB NCT03673579 | Philips Healthcare | N/A |
| Completed | Canadian Study on the Association of Pessary With Progesterone NCT03227705 | Université de Sherbrooke | N/A |
| Withdrawn | VF Test for Prediction of Extremely PTB After Cerclage NCT03443154 | Pediatrix | — |
| Terminated | Cervical Pessary for Prevention of Spontaneous Preterm Birth in Singleton Pregnancies With Arrested Preterm La NCT03543475 | Federico II University | N/A |
| Recruiting | Transvaginal Ultrasound Cervical Length Screening in Singleton Pregnancy With Prior Spontaneous Preterm Birth NCT02923973 | Federico II University | N/A |
| Terminated | Prediction and Prevention of Preterm Birth (PREVENT-PTB Study) NCT03530332 | Ware Branch | N/A |
| Completed | Improving SCBU Care for Preterm Babies NCT03512093 | University of Oxford | — |
| Completed | Clinical Grade MIS Device for Cervical Assessment to Predict Preterm Birth NCT04008485 | Sheffield Teaching Hospitals NHS Foundation Trust | N/A |
| Completed | Fetal Thymus Volume of Dichorionic Diamniotic Twin NCT04055701 | Karadeniz Technical University | N/A |
| Completed | Maternal Speech Decreases Pain Scores and Increases Oxytocin Levels in Preterm Infants During Painful Procedur NCT04762004 | University of Geneva, Switzerland | N/A |
| Completed | Biomarkers in Obstetrical Complications NCT03480139 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | — |
| Completed | Interest of a Vaginal Swab in Detection of Placental Alpha-Microglobulin-1 in the Prediction of Preterm Birth NCT03401255 | Nantes University Hospital | — |
| Completed | Hemodynamic Responses to Cardio-respiratory Events in Preterm Infants NCT04184245 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Completed | Transitional Cerebrovascular Reactivity in Very Preterm Infants NCT04423016 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Terminated | Relationship Between Plasma Concentration of Hydroxyprogesterone Caproate (17-OHPC) and Preterm Birth NCT03292731 | Steve N. Caritis, MD | Phase 1 / Phase 2 |
| Unknown | Transition to Home (TtH) After Preterm Birth NCT03460496 | Insel Gruppe AG, University Hospital Bern | N/A |
| Completed | Parent-child Interactions, Child Developmental Health, and Health System Costs at 6 Months Corrected Age NCT03357458 | University of Calgary | N/A |
| Completed | SURVIVAL PLUSS: Increasing Capacity for Mama-baby Survival in Post-conflict Uganda and South Sudan NCT02605369 | Makerere University | N/A |
| Completed | A Novel Technique for Prediction of Preterm Birth: Fetal Breathing Patterns NCT03655379 | Baskent University Ankara Hospital | N/A |
| Unknown | Which Needs for Premature New-born Babies' Parents Facing Environmental and Social Difficulties ? NCT03394443 | Centre Hospitalier Universitaire de Besancon | — |
| Completed | Mentors Offering Maternal Support (M-O-M-S™): A Prenatal Program for Decreasing Maternal Anxiety and Depressio NCT03393637 | University of the Incarnate Word | N/A |
| Completed | Atosiban Versus Placebo in the Treatment of Late Threatened Pre-term Birth NCT05693688 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Phase 4 |
| Unknown | Cervical Pessary to Prevent Preterm Singleton Birth in High Risk Population NCT04147117 | Hospital Sant Joan de Deu | N/A |
| Completed | Fitbit Activity Tracker to Predict Risk of Preterm Birth NCT03304782 | Columbia University | — |
| Completed | Effect of Probiotics on the Preterm Delivery Rate in Pregnant Women at High Risk for Preterm Birth NCT03689166 | Maternal-Infantil Vall d´Hebron Hospital | N/A |
| Completed | An Electronic Medical Record Alert of Progesterone NCT03219489 | McMaster University | N/A |
| Withdrawn | Cerclage for Twins With Short Cervix NCT03077633 | Pediatrix | Phase 2 / Phase 3 |
| Completed | Association Between EHG and Risk of Preterm Delivery in Women Hospitalized for Threatened Premature Delivery NCT03144141 | Centre Hospitalier Universitaire, Amiens | N/A |
| Completed | Fit After Baby: Increasing Postpartum Weight Loss in Women at Increased Risk for Cardiometabolic Disease NCT03215173 | University of Colorado, Denver | N/A |
| Completed | The Contribution of Parent-infant Interaction While Singing During Kangaroo Care, on Preterm-infants' Autonomi NCT03023267 | Meir Medical Center | N/A |
| Completed | Enhanced Nutrition for Preterm Infants NCT03238768 | University of Minnesota | N/A |
| Unknown | Prediction of Spontaneous Preterm Birth by Cervical Elastogram NCT03601195 | Chinese University of Hong Kong | — |
| Completed | Feasibility of Vaginal Progesterone to Reduce HIV-Associated Preterm Birth NCT02970552 | University of North Carolina, Chapel Hill | Phase 4 |
| Unknown | Cerclage for Twins With Short Cervical Length ≤ 15mm NCT03340688 | Thomas Jefferson University | N/A |
| Completed | Mechanical Environment Pregnancy With Short Cervix NCT03865108 | Columbia University | N/A |
| Unknown | Emergency Cerclage in Twin Pregnancies at Imminent Risk of Preterm Birth: an Open-Label Randomised Controlled NCT03818867 | St George's, University of London | N/A |
| Completed | Group Antenatal/Postnatal Care in Rwanda NCT03154177 | University of California, San Francisco | N/A |
| Completed | Cervix Monitor for Elasticity and Length Measurements NCT03199079 | Advanced Tactile Imaging, Inc. | — |
| Completed | Molecular Signature Children NCT03104673 | University of Oxford | — |
| Completed | The Relationship Between School Readiness and Sensory Processing Disorder in Preterm Preschooler NCT03172767 | Gazi University | — |
| Completed | Comparative Effectiveness of Treatment Options for Genital Herpes Infection to Reduce Adverse Pregnancy Outcom NCT02986802 | Kaiser Permanente | — |
| Completed | Tandem: Skin-to-skin Transfer From the Delivery Room to the Neonatal Unit NCT06198478 | Erasme University Hospital | — |
| Suspended | Electrical Inhibition of Human Preterm Contractions NCT02983240 | e-Bio Corp | N/A |
| Completed | Screening and Treating Asymptomatic Bacteriuria Every Trimester and Preterm Birth NCT03274960 | University of Zimbabwe | N/A |
| Unknown | Progesterone and Cervical Pessary in Twins NCT03058536 | Mario Henrique Burlacchini de Carvalho | Phase 2 / Phase 3 |
| Completed | The Effect of Zinc, β-carotene, and Vitamin D3 in Preterm Delivery Through Placental MyD88, TRIF, NFkB, and IL NCT03005496 | Indonesia University | Phase 4 |
| Completed | Supporting Mothers of Preterm Infants NCT03013660 | Tufts Medical Center | N/A |
| Completed | This Study Was to Investigate the Efficacy of Fetal Right Heart Doppler Findings in Determination of Pulmonary NCT04296591 | Karadeniz Technical University | — |
| Unknown | Deferred Cord Clamping Compared to Umbilical Cord Milking in Preterm Infants NCT02996799 | King Abdulaziz University | N/A |
| Unknown | Auditory Environment by Parents of Preterm Infants NCT04826978 | Turku University Hospital | — |
| Completed | Prevalence of Dental Caries in Preterm Birth Children Aged 2-5 Years in Primary Dentition NCT02999061 | Cairo University | — |
| Unknown | New Tool to Predict Risk of Spontaneous Preterm Birth in Asymptomatic High-risk Women NCT03062020 | Hospital Clinic of Barcelona | N/A |
| Terminated | The Reproductive Microbiome & Perinatal Health Outcomes NCT02948192 | Baylor Research Institute | — |
| Withdrawn | Physical Examination-Indicated Pessary NCT02967445 | Federico II University | Phase 3 |
| Completed | Prediction of Preeclampsia and Other Pregnancy Complications Following Combined Iterative Screening NCT03067298 | Emmanuel Bujold | — |
| Completed | Glucose Monitoring During Threatening Preterm Birth in Patients With and Without Gestational Diabetes Mellitus NCT03007186 | Medical University of Vienna | — |
| Completed | Strengthening Facility-based Intrapartum/Immediate Newborn Care to Reduce Mortality of Preterm Infants in Migo NCT03112018 | University of California, San Francisco | N/A |
| Unknown | Building the Path to Resilience in Preterm Infants: Mindfulness-based Intervention NCT04638101 | Pediatric Clinical Research Platform | N/A |
| Completed | Maternal Inflammatory Parameters Within Routine Treatment With Betamethasone NCT02993744 | Medical University of Vienna | — |
| Completed | A Multicenter Assessment of a Spontaneous Preterm Birth Risk Predictor NCT02787213 | Sera Prognostics, Inc. | — |
| Unknown | The Periviable Birth Plan NCT03061864 | Albany Medical College | N/A |
| Withdrawn | Cervical Pessary in Women With Arrested Preterm Labor and Short Cervix NCT02849301 | Federico II University | Phase 3 |
| Completed | Assessment of DHA On Reducing Early Preterm Birth NCT02626299 | University of Kansas Medical Center | Phase 3 |
| Completed | Feeding Tube Practices and Colonization of the Preterm Stomach in the First Week of Life NCT02830503 | Gorm Greisen | N/A |
| Completed | Preventing Preterm Birth With Probiotics NCT02692820 | Queen Mary University of London | N/A |