NCT04001712

Effect of Early Use of Caffeine Citrate in Preterm Neonates

Effect of Early Use of Caffeine Citrate in Preterm Neonates Needing Respiratory Support.

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 54 (actual)
• Sponsor: Ain Shams University · Academic / Other
• Sex: All
• Age: 24 Hours
• Healthy volunteers: Not accepted

Summary

This work is designed to study the effect of the early use of caffeine citrate in preterm neonates who need respiratory support on morbidity and short term neonatal outcome.

Detailed description

Caffeine citrate is one of the most widely used drugs in neonatal intensive care units. It is a respiratory stimulant which has well established therapeutic effects in apnea and facilitation of extubation. Caffeine is an adenosine antagonist ; it blocks selectively A2 receptors and non selective blocks A1 receptors. Its effects include improved lung compliance, minute ventilation, respiratory muscle contractility, increased sensitivity to carbon dioxide, enhanced catecholamine activity and decreased airway resistance Early caffeine therapy was associated with a shorter duration of respiratory support and reduction in bronchopulmonary dysplasia , cerebral palsy, patent ductus arteriosis ligation, intracranial hemorrhage, apnea and death Despite its widespread use, information regarding optimal time to initiate therapy and appropriate time to discontinue therapy is limited. Recent studies have indicated that early initiation of caffeine therapy is associated with improved neonatal outcomes Little is known about the early use of caffeine citrate in preterm neonates. The investigators aim to explore the effectiveness of its very early use in reducing the duration of respiratory support.

Conditions

• Preterm Birth

Interventions

Type	Name	Description
DRUG	Caffeine Citrate	caffeine citrate is given early to preterm neonates in need of respiratory support

Timeline

• Start date: 2019-04-05
• Primary completion: 2019-05-05
• Completion: 2019-06-10
• First posted: 2019-06-28
• Last updated: 2019-07-02

Locations

1 site across 1 country: Egypt