NCT05061641

Prediction and Prevention of Twin Premature Birth 2021

Study on the Prediction and Prevention of Twin Premature Birth

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: Caixia Liu · Academic / Other
• Sex: Female
• Age: 20 Years – 60 Years
• Healthy volunteers: Accepted

Summary

Research Objectives: 1. Establish a prediction and scoring system for twin premature birth. 2. To investigate the curative effect of 200mg,400mg and 600mg of vaginal progesterone in the prevention of twin premature birth. 3. To investigate the effect of stress cervical ligation in preventing premature delivery of twins. 4. The optimal dose of atosiban for the treatment of twin premature birth. 5. The influence of delivery mode on twin premature infants under 32 weeks.

Detailed description

Research Objectives: 1. Establish a prediction and scoring system for twin premature birth. 2. To investigate the curative effect of 200mg,400mg and 600mg of vaginal progesterone in the prevention of twin premature birth. 3. To investigate the effect of stress cervical ligation in preventing premature delivery of twins. 4. The optimal dose of atosiban for the treatment of twin premature birth. 5. The influence of delivery mode on twin premature infants under 32 weeks. It has now entered the second phase: clinical data collection

Conditions

• Preterm Birth

Interventions

Type	Name	Description
DRUG	Progesterone	The delivery outcomes of the three groups were compared, including the rate of premature delivery (\<37 weeks of gestation), the rate of early premature delivery (\<32 weeks of gestation), and the need for anti-tocolysis treatment. Rates of premature rupture of membranes (\<37 weeks), neonatal perinatal mortality and morbidity.

Timeline

• Start date: 2021-05-01
• Primary completion: 2022-06-01
• Completion: 2022-06-01
• First posted: 2021-09-29
• Last updated: 2021-09-29

Locations

1 site across 1 country: China