Trials / Enrolling By Invitation
Enrolling By InvitationNCT06471140
Maternal Cardiovascular Adaption to Pregnancy in IVF Patients Following Frozen Embryo Transfer (FET)
MRI Evaluation of Maternal Cardiovascular Response to Pregnancy in IVF Women Following Autologous Natural Cycle FET, Programmed FET and After Donor Embryo Transfer
- Status
- Enrolling By Invitation
- Phase
- —
- Study type
- Observational
- Enrollment
- 75 (estimated)
- Sponsor
- Aalborg University Hospital · Academic / Other
- Sex
- Female
- Age
- 18 Years – 40 Years
- Healthy volunteers
- Accepted
Summary
Aim of the study is to explore the effect of a lacking corpus luteum on maternal cardiovascular and metabolic adaption to pregnancy by the use of magnetic resonance imaging (MRI).
Detailed description
The use of programmed frozen embryo transfer cycle (FET) in IVF women is associated with an increased risk of obstetric complications (pregnancy-induced hypertension, preeclampsia, postpartum hemorrhage and placenta accreta) compared to FET in natural cycle. The lack of corpus luteum in programmed cycles and the subsequent absence of circulating vasoactive substances may lead to an impaired cardio-vascular adaption to pregnancy and thereby an increased risk of pregnancy-induced hypertension and preeclampsia. The cardiovascular and metabolic adaption to pregnancy is evaluated throughout pregnancy by use of Magnetic Resonance Imaging (MRI) as well as non-invasive measurements by use of elastography and seismocardiography. Patients are screened for preeclampsia throughout pregnancy with measurements of blood pressure, urine samples as well as blood samples.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | magnetic resonance imaging (MRI) | MRI performed three times during pregnancy and 6 months postpartum |
Timeline
- Start date
- 2025-03-01
- Primary completion
- 2027-08-01
- Completion
- 2028-08-01
- First posted
- 2024-06-24
- Last updated
- 2025-05-29
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT06471140. Inclusion in this directory is not an endorsement.