NCT04777929

The Relationship of Phthalate Exposure During Pregnancy and Preeclampsia

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Second Affiliated Hospital of Wenzhou Medical University · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Phthalates are a group of ubiquitous synthetic endocrine-disrupting chemicals. Fetal and neonatal periods are particularly susceptible to endocrine disorders, which prenatal exposure to phthalates causes. There is increasing evidence concerning the potential endocrine disrupting for phthalate exposure during pregnancy. Prenatal exposure phthalates would disrupt the level of sex hormone in pregnant women, which results in preeclampsia. The relationship of prenatal phthalate exposure with maternal and neonatal outcomes in human beings was often sex-specific associations. Because of the potentially harmful influence of prenatal phthalate exposure, steps should be taken to prevent or reduce phthalate exposure during pregnancy.

Conditions

• Phthalate Exposure
• Preeclampsia
• Estrogen
• Progestin

Interventions

Type	Name	Description
OTHER	test Phthalates, estrogen and progesterone	test mothers Phthalates in their urine, and test estrogen and progesterone receptor in placental tissue

Timeline

• Start date: 2021-01-01
• Primary completion: 2022-09-30
• Completion: 2022-10-31
• First posted: 2021-03-02
• Last updated: 2022-11-29

Locations

1 site across 1 country: China