NCT02797249

Low Dose Aspirin in the Prevention of Preeclampsia in China

Low Dose Aspirin in the Prevention of Preeclampsia in Chinese Pregnant Women.

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 1,000 (actual)
• Sponsor: Peking University First Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

Preeclampsia is one of the three leading causes of maternal morbidity and mortality all over the world. The use of low dose aspirin has been mentioned in several studies with promising results. The investigators decided to evaluate the use of low dose aspirin in Chinese pregnant women, starting between 12+ and 20 weeks of pregnancy, based on clinical characteristics aiming to reduce the incidence of preeclampsia.

Detailed description

Detailed Description: The investigators will conduct a randomized control trial to estimate the efficacy of low dose aspirin in preventing preeclampsia in Chinese pregnant women who are evaluated with risk factors. The investigators will also obtain biological specimen including maternal blood, cord blood, placenta specimen and etc. for basic science studies. Rationale for Design:There is a lack of evidences or guideline of aspirin using in preventing PE for Chinese women. The investigators will conduct a randomized control trial, which is the 'gold standard' of research design, hoping to answer the question.

Conditions

• Preeclampsia

Interventions

Type	Name	Description
DRUG	Aspirin	Low dose aspirin（100mg）per day starting between 12+ and 20 weeks of pregnancy until 34 weeks of pregnancy,taking at night.
OTHER	Blank	Routine examination during pregnancy.

Timeline

• Start date: 2016-12-07
• Primary completion: 2019-01-19
• Completion: 2019-03-30
• First posted: 2016-06-13
• Last updated: 2019-05-01

Locations

1 site across 1 country: China