| Not Yet Recruiting | Neprilysin Inhibition to Reduce Myocardial Fibrosis in Heart Failure With Preserved Ejection Fraction NCT06536309 | Brigham and Women's Hospital | Phase 4 |
| Not Yet Recruiting | EXercise and Activin Inhibition to Modulate InflammatioN Effects on Heart Failure and Cognition (EXAMINE-HFC) NCT07202000 | Massachusetts General Hospital | Phase 2 |
| Not Yet Recruiting | BOOST: Blended Onsite and Offsite Structured Exercise Training and Coaching NCT07413198 | Wake Forest University Health Sciences | N/A |
| Not Yet Recruiting | A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evalu NCT07214376 | Pulnovo Medical, Inc. | N/A |
| Recruiting | Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction NCT07401771 | Mayo Clinic | — |
| Not Yet Recruiting | CASTLE-HFpEF (Catheter Ablation for Atrial Fibrillation Patients With Heart Failure With Mildly Reduced and Pr NCT07254455 | Tulane University | N/A |
| Not Yet Recruiting | Pulmonary Artery Denervation for Heart Failure With Preserved Left Ventricular Ejection Fraction NCT07331220 | Nanjing First Hospital, Nanjing Medical University | N/A |
| Not Yet Recruiting | A Phase II Clinical Trial of HRS-1893 in the Treatment of Heart Failure With Preserved Ejection Fraction NCT07269717 | Shandong Suncadia Medicine Co., Ltd. | Phase 2 |
| Recruiting | A Study of 68Ga-Fibroblast Activation Protein Inhibitor (FAPI) Positron Emission Tomography in Heart Failure NCT07083011 | Mayo Clinic | Phase 2 |
| Recruiting | A Study Of CS Reducer For Symptomatic Heart Failure With HFpEF And CMD NCT07093528 | Mayo Clinic | — |
| Recruiting | Atrioventricular Node Ablation and Conduction System Pacing in Patients With Well Controlled Permanent Atrial NCT06833138 | French Cardiology Society | N/A |
| Not Yet Recruiting | Study of HS235 in Obese Patients With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fractio NCT07123779 | 35Pharma Inc | Phase 1 |
| Not Yet Recruiting | AI-based Echocardiographic Quantification in Heart Failure NCT07010952 | Mackay Memorial Hospital | — |
| Recruiting | Transitions of Care Clinic (TOCC) NCT06937827 | Hackensack Meridian Health | N/A |
| Recruiting | Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity NCT07037459 | Amgen | Phase 3 |
| Recruiting | SHort Of Pace - Heart Failure (SHOP-HF) NCT06992089 | Fundación para la Investigación del Hospital Clínico de Valencia | N/A |
| Not Yet Recruiting | Staging Heart Failure With Preserved Ejection Fraction NCT06931015 | I.M. Sechenov First Moscow State Medical University | — |
| Recruiting | The PeriCut Catheter System Early Feasibility Study (REIMAGINE-HFpEF) NCT06702501 | Heart Failure Solutions, Inc. | N/A |
| Terminated | Study of HS135 in Obese Patients With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fractio NCT06581159 | 35Pharma Inc | Phase 1 |
| Completed | Sleep Extension to Improve Sleep Efficiency and QoL in HF With Preserved Ejection Fraction: the SLEEP-HF Pilot NCT06567925 | Virginia Commonwealth University | N/A |
| Recruiting | Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction NCT06517186 | Northwestern University | — |
| Recruiting | Manganese-enhanced Magnetic Resonance Imaging (MEMRI) in Heart Failure With Preserved Ejection Fraction NCT06652763 | University of Leicester | — |
| Not Yet Recruiting | Chemoreflex Sensitivity in HFpEF NCT06309537 | Istituto Auxologico Italiano | — |
| Recruiting | Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction NCT05839730 | Medtronic Cardiac Rhythm and Heart Failure | N/A |
| Recruiting | A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection NCT06616974 | Tectonic Therapeutic | Phase 2 |
| Recruiting | Rifaximin and Cardiac Function in Patients with Heart Failure with Preserved Ejection Fraction NCT06652087 | I.M. Sechenov First Moscow State Medical University | N/A |
| Recruiting | HFPEF-project: Heart Failure Phenotyping - Exploring the Fingerprints NCT06465043 | University of Helsinki | — |
| Recruiting | Leg Heat Therapy in Heart Failure With Preserved Ejection Fraction NCT06388226 | Indiana University | N/A |
| Recruiting | Home-Based Cardiac Rehabilitation for Patients With Heart Failure NCT06479876 | Vanderbilt University Medical Center | N/A |
| Not Yet Recruiting | Clinical Study of Active Intervention in High-risk HFpEF Patients NCT06532019 | Xiangtan Central Hospital | N/A |
| Not Yet Recruiting | Feasibility Study to Support Cardiorenal Function in Acute Decompensated Heart Failure With Diuretic Resistanc NCT06174623 | Puzzle Medical Devices Inc. | N/A |
| Not Yet Recruiting | Dapagliflozin in Reducing Epicardial Adipose Tissue in Heart Failure with Preserved Ejection Fraction NCT06510270 | Aswan University | N/A |
| Recruiting | Bariatric Surgery Evaluation and Assessment of Treatment Efficacy - Intervention Trial NCT06065124 | University Medical Center Groningen | N/A |
| Active Not Recruiting | Novel Respiratory Training as Part of Palliative Care for Older Adults With Heart Failure NCT06576297 | University of Pittsburgh | N/A |
| Recruiting | Managing Congestion in Heart Failure: A Mechanistic Study in Patients With HFpEF NCT06977477 | Otto-von-Guericke University Magdeburg | N/A |
| Not Yet Recruiting | SGLT-2 Inhibitor and High-Dose Furosemide Plus Small-Volume Hypertonic Saline Solution in Acute HF NCT06442280 | University of Palermo | Phase 4 |
| Active Not Recruiting | HRS9531 Injection in Obese Subjects With Heart Failure With Preserved Ejection Fraction NCT06391710 | Fujian Shengdi Pharmaceutical Co., Ltd. | Phase 2 |
| Not Yet Recruiting | Intracellular Magnesium and Heart Failure NCT06353750 | University of Oxford | — |
| Unknown | Remote Ischaemic Conditioning (RIC) in Heart Failure NCT06616233 | University of Leicester | N/A |
| Withdrawn | Reverse Remodeling Effects of CDR132L in Patients With Heart Failure With Mildly Reduced or Preserved Ejection NCT05953831 | Cardior Pharmaceuticals GmbH | Phase 2 |
| Recruiting | Fiber Supplementation in Heart Failure With Preserved Ejection Fraction (HFpEF) NCT06337812 | University of Michigan | N/A |
| Recruiting | Study of JK07 in Patients With Chronic Heart Failure NCT06369298 | Salubris Biotherapeutics Inc | Phase 2 |
| Recruiting | EMPAgliflozin in Heart Failure With PReserved Ejection Fraction and End Stage Renal Disease NCT06249945 | National Taiwan University Hospital | Phase 4 |
| Unknown | Shear Wave Elastography for Diagnosis of Heart Failure With Preserved Ejection Fraction NCT06282822 | First Hospital of China Medical University | — |
| Unknown | Reversing Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction NCT06217120 | Montreal Heart Institute | Phase 2 / Phase 3 |
| Active Not Recruiting | Sacubitril-Valsartan in Heart Failure With Preserved Ejection Fraction and Secondary Mitral Valve Regurgitatio NCT05991284 | Ziekenhuis Oost-Limburg | Phase 4 |
| Recruiting | Arterial Stiffening as a Predictor for Diastolic Cardiac Dysfunction and HFpEF NCT06208007 | University Medical Center Goettingen | — |
| Enrolling By Invitation | A Preliminary Study for INFORMED NCT05585125 | Weill Medical College of Cornell University | Phase 4 |
| Recruiting | The COLchicine HEART Failure PRESERVED Trial (COLHEART-PRESERVED) NCT06081049 | Tor Biering-Sørensen | Phase 2 |
| Recruiting | Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease NCT05719714 | Northwestern University | Phase 1 / Phase 2 |
| Recruiting | Myocardial Stiffness Evaluation in Patients With Heart Failure With Preserved Ejection Fraction NCT06196086 | Haiyan Wang | — |
| Recruiting | Application of Multimodal Large Language Model in HFpEF NCT06486649 | Peking University Third Hospital | — |
| Recruiting | Exercise Capacity Improvement by Conduction System Pacing in heArt Failure patieNts Without Compelling CRT inD NCT06278844 | University Hospital, Antwerp | N/A |
| Recruiting | The Sarcopenia Study NCT05888688 | University of Leicester | — |
| Recruiting | A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRES NCT05887271 | University of Leicester | Phase 2 / Phase 3 |
| Unknown | The Effect of Addition of Metformin to SGLT2 In Diabetic Patients With Heart Failure With Preserved Ejection F NCT06080802 | October University for Modern Sciences and Arts | Phase 2 / Phase 3 |
| Active Not Recruiting | Enavogliflozin Outcome Trial in Functional Tricuspid Regurgitation NCT06027307 | Asan Medical Center | Phase 3 |
| Completed | Effects of Sauna on Cardiac and Skeletal Muscle Function in Patients With HFpEF (SAUNA-HFpEF) NCT06978868 | Otto-von-Guericke University Magdeburg | N/A |
| Active Not Recruiting | Hospital Register of Decompensated Heart Failure With Preserved Ejection Fraction NCT06114498 | National Medical Research Center for Therapy and Preventive Medicine | — |
| Recruiting | Renal Denervation in Patients With Chronic Heart Failure With Preserved Ejection Fraction NCT05715697 | Xinjiang Medical University | N/A |
| Recruiting | Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Preserved Ejection Fraction NCT06061549 | Sardocor Corp. | Phase 1 |
| Recruiting | A Trial to Evaluate the Safety and Efficacy of Pulmonary Artery Denervation for the Treatment of Pulmonary Hyp NCT05824923 | Pulnovo Medical (Wuxi) Co., Ltd. | Phase 3 |
| Unknown | The Effects of Ferric Derisomaltose in Patients With Acute Heart Failure and Iron Deficiency on Exercise Capac NCT05991128 | China-Japan Friendship Hospital | Phase 4 |
| Recruiting | Pioglitazone on Heart Failure in Type-2 Diabetes Mellitus Participants NCT05838287 | The University of Texas Health Science Center at San Antonio | Phase 4 |
| Recruiting | Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF NCT05723679 | University of Texas Southwestern Medical Center | N/A |
| Unknown | Cardiac Amyloidosis in HFpEF Tunisian Patients NCT06201832 | University Tunis El Manar | — |
| Unknown | Association Between Coronary and Peripheral Vascular Injury in Heart Failure Patients With Preserved Ejection NCT05884346 | Assistance Publique - Hôpitaux de Paris | N/A |
| Recruiting | PBMC as Biomarkers of Diabetic Cardiomyopathy NCT05651919 | Hospices Civils de Lyon | — |
| Recruiting | Ketogenic Diet vs Mixed Diet in Patients With Heart Failure NCT06081543 | Ohio State University | N/A |
| Recruiting | Study on Heart Failure with Preserved Ejection Fraction with Qishen Granules NCT06377761 | Guangdong Provincial Hospital of Traditional Chinese Medicine | N/A |
| Active Not Recruiting | Heart Failure With Preserved Ejection Fraction and Its Cardiac MR Characteristics of Different Subtypes NCT06916611 | The Affiliated Hospital of Xuzhou Medical University | — |
| Recruiting | Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transitio NCT06409585 | University of Edinburgh | — |
| Unknown | CHIP in Endothelial Dysfunction Associated With HEpEF NCT05828888 | University Hospital, Bordeaux | — |
| Unknown | Relationship Between Heart Failure With Preserved Ejection Fraction and Nonalcoholic Fatty Liver Disease. NCT05822622 | Sohag University | — |
| Completed | Evaluation of GeranylGeranylAcetone in Heart Failure With Preserved Ejection Fraction NCT05672134 | Amsterdam UMC, location VUmc | Phase 2 |
| Active Not Recruiting | Longitudinal Multimarker Risk Models for Very Elderly Patients With Heart Failure and Preserved Ejection Fract NCT05992558 | Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal | — |
| Unknown | Consistently Assess Signs and Symptom of Heart Failure NCT05833581 | Board of Trustees of Illinois State University | N/A |
| Recruiting | Provocative Tests for HFpEF NCT06309550 | Istituto Auxologico Italiano | — |
| Completed | Effectiveness of a Cardiac Rehabilitation Program in Elderly Patients With Heart Failure. NCT05393362 | University of Malaga | N/A |
| Recruiting | HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Tr NCT05873634 | Northwestern University | — |
| Recruiting | CAtheter-Based Ablation of Atrial Fibrillation Compared to Conventional Treatment in Patients With Heart Failu NCT05508256 | Charite University, Berlin, Germany | Phase 4 |
| Recruiting | Pilot Study Lp299v Supplementation in Chronic Heart Failure NCT05752760 | Medical College of Wisconsin | N/A |
| Recruiting | Physical Rehabilitation for Older Patients With Acute Heart Failure With Preserved Ejection Fraction NCT05525663 | Wake Forest University Health Sciences | N/A |
| Unknown | Empagliflozin for Peripheral Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction NCT06046612 | Maastricht University Medical Center | Phase 4 |
| Terminated | A Study of LY3540378 in Participants With Worsening Chronic Heart Failure With Preserved Ejection Fraction (HF NCT05592275 | Eli Lilly and Company | Phase 2 |
| Recruiting | Biomarkers in Patients With Suspected HFpEF NCT06101693 | NHS Greater Glasgow and Clyde | — |
| Not Yet Recruiting | Training in HFpEF-PH NCT05464238 | Heidelberg University | N/A |
| Completed | Modulation of Circulating Levels of the Ketone Body 3-hydroxybutyrate in Patients With Type 2 Diabetes and Hea NCT05159570 | University of Aarhus | N/A |
| Recruiting | Exercise Lower-body Negative Pressure in Heart Failure With Preserved Ejection Fraction NCT05582044 | University of British Columbia | N/A |
| Recruiting | The Effect of Obesity and Weight Loss in Heart Failure With Preserved Ejection Fraction NCT05878912 | University of Oxford | N/A |
| Completed | Effects of a Supervised Training Program on Functional Capacity in Patients With HFpEF and Chronotropic Incomp NCT05649787 | Fundación para la Investigación del Hospital Clínico de Valencia | N/A |
| Unknown | EMPAGUM: Effects of Empagliflozin on Gut Microbiota in Heart Failure With a Preserved Ejection Fraction NCT05584319 | Zhijun Sun | Phase 4 |
| Recruiting | Multiple-biomarker Approach for Individualized Treatment of Heart Failure with Preserved Ejection Fraction NCT06785506 | Erasmus Medical Center | — |
| Unknown | Empagliflozin on the Function of Left Atrium in Heart Failure With Mildly Reduced or Preserved Ejection Fracti NCT05600387 | Zhijun Sun | Phase 4 |
| Enrolling By Invitation | Enhancing the Natriuretic Peptide System in HFpEF NCT05279742 | Horng Chen | Phase 1 / Phase 2 |
| Unknown | Isometric Exercise Training in Participants With Heart Failure With Preserved Ejection Fraction NCT05551663 | St George's, University of London | N/A |
| Completed | Exploratory Ph 2A, Double-Blind, Placebo-Controlled Dose Escalation Study of Safety, Tolerability, PD, & PK of NCT05284617 | Rivus Pharmaceuticals, Inc. | Phase 2 |
| Completed | Sotagliflozin in Heart Failure With Preserved Ejection Fraction (HFpEF) Patients NCT05562063 | Juan Badimon | Phase 4 |
| Withdrawn | Single-Ascending Dose Study of JK07 in Subjects With HFpEF NCT05322616 | Salubris Biotherapeutics Inc | Phase 1 |
| Active Not Recruiting | Mechanisms of LV Remodeling in Hypertensive Patients Working on a Rotational Expeditionary Basis in the Arctic NCT05839028 | Tomsk National Research Medical Center of the Russian Academy of Sciences | — |
| Terminated | Polydiuretic Therapy for HFpEF, a Randomised Controlled Trial NCT05129722 | The George Institute | Phase 4 |
| Completed | Dapagliflozin With or Without Spironolactone for HFpEF NCT05676684 | Universidade do Porto | Phase 2 / Phase 3 |
| Recruiting | Use of SGLT2i in noHCM With HFpEF NCT06401343 | China National Center for Cardiovascular Diseases | Phase 4 |
| Completed | Heart Failure Therapy and Outcomes in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fr NCT06671314 | Novartis | — |
| Active Not Recruiting | Administration of the SGLT-2 Inhibitor Dapagliflozin in the Patients With Amyloid Cardiomyopathy NCT05795400 | National Medical Research Center for Cardiology, Ministry of Health of Russian Federation | N/A |
| Terminated | Effectiveness of CRD-740 in Heart Failure NCT05409183 | Cardurion Pharmaceuticals, Inc. | Phase 2 |
| Active Not Recruiting | Cardiac Rehab Effects in HFpEF NCT04506606 | VA Office of Research and Development | N/A |
| Unknown | Exercise Capacity Before and After AF Ablation in Patients With HFpEF NCT05376748 | University of Vermont | — |
| Recruiting | The Effect of a High Fiber Diet and High-Intensity Interval Exercise in Patients With HFpEF NCT05236413 | University of Virginia | N/A |
| Withdrawn | Selective PDE9 Inhibition With IMR-687 in Adults With Heart Failure With Preserved Ejection Fraction NCT05312021 | Cardurion Pharmaceuticals, Inc. | Phase 2 |
| Terminated | HEART Camp Connect: A Feasibility Study NCT05985395 | University of Nebraska | N/A |
| Completed | NMES in HF Patients to Improve Functional Recovery Following Hospitalization NCT05338437 | University of Vermont Medical Center | N/A |
| Recruiting | Assessment of CCM in HF With Higher Ejection Fraction NCT05064709 | Impulse Dynamics | N/A |
| Unknown | Sex Related Differences in Cardiac Function NCT05796050 | Heinrich-Heine University, Duesseldorf | — |
| Unknown | PErirenal Adipose Tissue and RenaL Hemodynamics in Patients With Heart Failure With Preserved Ejection Fractio NCT05219188 | University Medical Center Groningen | — |
| Completed | Modulation of Circulating Levels of the Ketone Body 3-hydroxybutyrate in Patients With Type 2 Diabetes and Hea NCT05236335 | University of Aarhus | N/A |
| Completed | Optimising CMR Scan Acquisitions for Novel Equipment/Sequences in Clinical Cardiovascular Populations. NCT06311552 | University of Leicester | — |
| Active Not Recruiting | WeighT LOSS Surgery and Comprehensive Cardiometabolic Responses to to EXercise NCT06576050 | Massachusetts General Hospital | — |
| Recruiting | SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial NCT05138575 | University of Pennsylvania | Phase 2 |
| Active Not Recruiting | Metformin for Older Patients With Heart Failure With Preserved Ejection Fraction NCT05093959 | Wake Forest University Health Sciences | Phase 2 |
| Not Yet Recruiting | Heart Failure With Preserved Ejection Fraction: Evaluation and Recognition by CMR NCT05114785 | University of East Anglia | — |
| Recruiting | Beta-blocker Discontinuation in Heart Failure With Preserved Ejection Fraction NCT05174351 | UConn Health | N/A |
| Withdrawn | Randomized Controlled Pilot Trial of DASH Feeding in Older Low Socioeconomic Adults Without Heart Failure NCT04113291 | Wake Forest University Health Sciences | N/A |
| Completed | BLOCKade of Calcium Channels and Beta Adrenergic Receptors for the Treatment of Hypertension in HFpEF NCT04434664 | University of Pennsylvania | Phase 4 |
| Withdrawn | Extended IASD Investigation: REDUCE LAP-HF IV NCT04632160 | Corvia Medical | N/A |
| Recruiting | Renal Denervation to Treat Heart Failure With Preserved Ejection Fraction NCT05030987 | University of Leipzig | N/A |
| Recruiting | Impact of Intravenous Iron Repletion On Mechanisms of Exercise InTolerance in HFpEF (IRONMET-HFpEF) NCT04945707 | Massachusetts General Hospital | Phase 4 |
| Completed | Efficacy of an m-Health Cardiac Rehabilitation Program in Heart Failure With Preserved Ejection Fraction NCT05002075 | University of Texas Southwestern Medical Center | N/A |
| Unknown | Carvedilol in HF With Preserved EF NCT05553314 | Seoul National University Bundang Hospital | Phase 4 |
| Completed | Impact of Empagliflozin on Functional Capacity in Heart Failure with Preserved Ejection Fraction NCT05139472 | University of Texas Southwestern Medical Center | Phase 4 |
| Unknown | The Effect of Angiotensin Receptor-Neprilysin Inhibition on Cardiac Fibrosis in Patients With HFpEF NCT05089539 | Chongqing Medical University | Phase 2 |
| Unknown | Exercise Right Ventricular Coupling in HFpEF NCT05731466 | Universitaire Ziekenhuizen KU Leuven | N/A |
| Recruiting | Matching Perfusion and Metabolic Activity in HFpEF NCT04913805 | University of Pennsylvania | Phase 2 |
| Unknown | The Relationship Between Heart Function and Metabolism in HFpEF Patients NCT05053256 | Chongqing Medical University | — |
| Completed | Cilostazol for HFpEF NCT05126836 | University of Minnesota | Phase 2 |
| Completed | A Single-center Retrospective Cohort Study to Explore the Prognostic Significance of CONUT in Elderly CAD Pati NCT05586828 | Beijing Tongren Hospital | — |
| Unknown | PeRsonalIzed remOtely Guided Preventive exeRcIse Therapy for a healThY Heart NCT04745013 | KU Leuven | N/A |
| Terminated | Diastolic Exercise Stress Testing in Heart Failure NCT04970953 | University Hospital, Essen | — |
| Active Not Recruiting | Physical Activity, Cardiac and Skeletal Muscle Energetics in Healthy Subjects and HFpEF Patients NCT04998877 | Johns Hopkins University | — |
| Terminated | HFpEF and Symptomatic Obstructive Iliofemoral Venous Disease Study NCT04964817 | Prairie Education and Research Cooperative | — |
| Completed | Study to Evaluate the Efficacy and Safety of AZD4831 in Participants With Heart Failure With Left Ventricular NCT04986202 | AstraZeneca | Phase 2 / Phase 3 |
| Active Not Recruiting | "HerzCheck" - Detection of Early Heart Failure Using Telemedicine in Structurally Weak Regions NCT05122793 | German Heart Institute | N/A |
| Recruiting | Novel Approaches for Improving Vascular Function in Veterans With HFpEF NCT06312748 | VA Office of Research and Development | Phase 1 |
| Completed | Gut Microbiota in Chronic Noncommunicable Diseases NCT04820556 | National Medical Research Center for Therapy and Preventive Medicine | — |
| Completed | Pilot Deprescribing N-of-1 Trials for Beta-blockers in HFpEF NCT04757584 | Weill Medical College of Cornell University | Phase 4 |
| Completed | CMR T1 Mapping for Diagnosis of Cardiac Amyloidosis NCT04862273 | University of Leipzig | — |
| Completed | Impact of Beta-blockers on Physical Function in HFpEF NCT04767061 | Weill Medical College of Cornell University | Phase 4 |
| Completed | A Study of Mavacamten in Participants With HFpEF and Elevation of NT-proBNP With or Without Elevation of cTnT NCT04766892 | Bristol-Myers Squibb | Phase 2 |
| Unknown | Incidence and Echocardiographic Predictors of HFpEF in High-Risk Population Afferent to Italian Echo-labs Netw NCT05753553 | IRCCS Policlinico S. Donato | — |
| Withdrawn | Wearable Remote Monitoring of Heart Rate and Respiratory Rate for Heart Failure NCT04455828 | Milton S. Hershey Medical Center | — |
| Completed | Dapagliflozin (DAPA) Effects in HFpEF NCT04730947 | Mayo Clinic | Phase 2 |
| Terminated | Radiofrequency (RF) Ablation for Atrial Fibrillation (AF) in Patients With Heart Failure With Preserved Ejecti NCT04327596 | University of Rochester | N/A |
| Unknown | Distribution and Clinical Implication of CMD in Patients With HFpEF Without Significant CAD NCT04788576 | Samsung Medical Center | — |
| Completed | Effort-Lung Ultra Sound NCT04644692 | Central Hospital, Nancy, France | — |
| Unknown | Effects of SGLT2 Inhibition on the Mechanisms of Cardiac Damage in the Diabetic Patient With HFpEF NCT04739215 | Hospital General Universitario Gregorio Marañon | Phase 4 |
| Recruiting | SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan NCT05057806 | The University of Texas Health Science Center at San Antonio | EARLY_Phase 1 |
| Terminated | Global Prevalence of ATTR-CM in Participants With HFpEF NCT04424914 | Pfizer | N/A |
| Completed | Phenotypes and Outcomes of Heart Failure With Preserved Ejection Fraction in Patients With Hypertension and Di NCT04835194 | University of Medicine and Pharmacy at Ho Chi Minh City | — |
| Terminated | Study to Evaluate Sex Differences in the Acute Effects of PL-3994 in Heart Failure Subjects NCT04318145 | Palatin Technologies, Inc | Phase 2 |
| Completed | The Relationship Between Epicardial Fat Tissue and Cardiac Function in HFpEF Patients NCT05068934 | Dongying Zhang | — |
| Unknown | Relationship Between Ambulatory Arterial Stiffness Index and Left Ventricular Diastolic Function in Patients W NCT05059769 | Dongying Zhang | — |
| Completed | Acute Effects of Exogenous Ketone Ester Administration in Heart Failure NCT04633460 | University of Pennsylvania | Phase 2 |
| Unknown | Relationship Between Adipose Tissue Distribution and Arterial Stiffness in HFpEF NCT05095688 | Chongqing Medical University | — |
| Recruiting | Effect of Bilirubin on Prognosis in Heart Failure With Preserved Ejection Fraction NCT06379152 | Chongqing Medical University | — |
| Completed | The ENCHANTMENT HIV Study NCT04153136 | Massachusetts General Hospital | Phase 2 |
| Unknown | Follow Up of acuTe Heart failUre: a pRospective Echocardiographic and Clinical Study (FUTURE) NCT05204238 | University of Siena | — |
| Completed | The Relationship Between Blood Pressure and Arterial Stiffness in HFpEF Patients With Different Levels of Obes NCT04535726 | Chongqing Medical University | — |
| Unknown | The Relationship Between Pericardial Fat Thickness and Arterial Stiffness in HFpEF Patients NCT04594499 | Chongqing Medical University | — |
| Terminated | Heart Failure Monitoring With Eko Electronic Stethoscopes NCT04404452 | Eko Devices, Inc. | — |
| Completed | Balance, Aerobic Capacity, Mobility and Strength in Patients Hospitalized for Heart Failure (BAMS-HF) Program NCT04281849 | VA Eastern Colorado Health Care System | N/A |
| Completed | Transcutaneous Vagus Nerve Stimulation in Heart Failure NCT05789147 | Istituti Clinici Scientifici Maugeri SpA | N/A |
| Unknown | The Efficacy and Safety of Zhigancao Tang Granule for HFpEF of Qi-Yin Dificiency NCT04317339 | Shanghai University of Traditional Chinese Medicine | Phase 2 |
| Recruiting | The Prognostic Role and Diagnostic Efficacy of Exercise Right Heart Catheterization With a Simultaneous Echoca NCT05490901 | Samsung Medical Center | — |
| Completed | Electronic S3 Prediction of Hospital Readmissions for HF Exacerbation NCT04112849 | Milton S. Hershey Medical Center | — |
| Completed | Developing Oral LT3 Therapy for Heart Failure - HFpEF NCT04111536 | University of Pennsylvania | Phase 1 / Phase 2 |
| Active Not Recruiting | Heart Failure and Preserved Ejection Fraction: Observation of Its Progression and Prognosis (HOPP-BERN) NCT04395846 | Insel Gruppe AG, University Hospital Bern | — |
| Unknown | Ambulatory Blood Pressure in HFPEF Outcomes Global Registry NCT04065620 | Hospital Clinic of Barcelona | — |
| Unknown | 3-Month Home-based Training With Whole Body Vibration (WBV) Device in Patients With Heart Failure and Preserve NCT04239807 | Klinikum der Universität Köln | N/A |
| Completed | Study of the Prognosis of Patients With Heart Failure With Preserved Ejection Fraction NCT05496439 | Chongqing Medical University | — |
| Completed | Retrospective Observational Analysis of a Cohort With Heart Failure With Preserved Ejection Fraction NCT04233086 | Portsmouth Hospitals NHS Trust | — |
| Unknown | Endovascular GSN Ablation in Subjects With HFpEF NCT04287946 | Axon Therapies, Inc. | N/A |
| Withdrawn | Study of Sacubitril/ValsarTan on MyocardIal OxygenatioN and Fibrosis in Heart Failure With Preserved Ejection NCT04128891 | Flinders University | Phase 3 |
| Unknown | Heart Failure in Norway: Clinical Characteristics, Mortality and Health Care Resource Use NCT04398563 | University Hospital, Akershus | — |
| Unknown | Association of Epicardial Adipose Tissue Volume Axnd Radiodensity With Coronary Artery Calcification in Patien NCT05556785 | Chongqing Medical University | — |
| Terminated | Ketogenic Diet in Patients With Heart Failure NCT04235699 | Ohio State University | N/A |
| Completed | Invasive Left Heart Catheterization Registry NCT04505449 | Samsung Medical Center | — |
| Unknown | PACIFIC-PRESERVED : PhenomApping, ClassIFication, and Innovation for Cardiac Dysfunction - HF With PRESERVED L NCT04189029 | Assistance Publique - Hôpitaux de Paris | — |
| Terminated | Assessment of Pulmonary Congestion During Cardiac Hemodynamic Stress Testing NCT04019613 | Mayo Clinic | N/A |
| Unknown | Adipose Tissue Inflammation in HFpEF NCT04886713 | Heart Center Leipzig - University Hospital | — |
| Recruiting | Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System NCT04237701 | Yale University | — |
| Completed | Virtual Visits to Optimize Research Trial Offerings to HF Patients NCT04064541 | The Cleveland Clinic | N/A |
| Recruiting | Cardiac Amyloidosis in HFpEF NCT04587648 | National Taiwan University Hospital | — |
| Completed | Chronic Kidney Disease and Heart Failure With Preserved Ejection Fraction: The Role of Mitochondrial Dysfuncti NCT03960073 | Virginia Commonwealth University | N/A |
| Recruiting | Purinergic Signaling and the Postmenopausal Heart NCT06015776 | Beth Israel Deaconess Medical Center | — |
| Completed | Pressure Assessment to Improve Outcomes After TAVR: a Registry NCT03923530 | North Florida Foundation for Research and Education | EARLY_Phase 1 |
| Completed | Evaluation of Renal Sodium Excretion After Salt Loading in Heart Failure With Preserved Ejection Fraction NCT03837470 | Adhish Agarwal | EARLY_Phase 1 |
| Unknown | Carvedilol SR Study for Biomarkers From Blood and Urine and Safety of in Patients With Heart Failure With Pres NCT03948685 | Yonsei University | Phase 4 |
| Completed | Neuregulin-1 in Patient With Different Forms of Cardiovascular Diseases: a Pilot Study NCT04391491 | I.M. Sechenov First Moscow State Medical University | — |
| Unknown | Prediction of the Development of Heart Failure With Preserved Ejection Fraction NCT04894968 | Heart Center Leipzig - University Hospital | — |
| Terminated | Spironolactone in the Treatment of Heart Failure NCT04727073 | Charite University, Berlin, Germany | Phase 3 |
| Unknown | Exploration of Dyspnea at Non-high Brain Natriuretic Peptide (BNP) NCT03550235 | Assistance Publique - Hôpitaux de Paris | — |
| Unknown | Right Ventricular Function and Pulmonary Hypertension in HFpEF NCT05055180 | Heart Center Leipzig - University Hospital | — |
| Completed | Dapagliflozin Evaluation to Improve the LIVEs of Patients With PReserved Ejection Fraction Heart Failure. NCT03619213 | AstraZeneca | Phase 3 |
| Completed | Optimising Management of Patients With Heart Failure With Preserved Ejection Fraction in Primary Care NCT03617848 | Professor Christi Deaton | — |
| Completed | Circulating NEP and NEP Inhibition Study in Heart Failure With Preserved Ejection Fraction NCT03506412 | Mayo Clinic | Phase 4 |
| Completed | Cardiac Magnetic Resonance Assessment for Heart Failure With Preserved Ejection Fraction NCT04063579 | The University of Hong Kong | N/A |
| Withdrawn | Understanding the Mechanisms of Diastolic Dysfunction NCT03340233 | University of California, Los Angeles | N/A |
| Completed | Frequency and Magnitude of Subclinical Systolic Dysfunction by Strain Imaging in Heart Failure With Preserved NCT04163861 | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | — |
| Completed | UTSW HP [13-C] Pyruvate Injection in HCM NCT03057002 | University of Texas Southwestern Medical Center | — |
| Completed | Transthyretin Cardiac Amyloidosis in HFpEF NCT03414632 | Mayo Clinic | EARLY_Phase 1 |
| Recruiting | Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fr NCT02901184 | Uppsala University | Phase 3 |
| Completed | A Study of the Effect of IW-1973 on the Exercise Capacity of Patients With Heart Failure With Preserved Ejecti NCT03254485 | Akebia Therapeutics | Phase 2 |
| Completed | A Randomized, Double-blind Controlled Study Comparing LCZ696 to Medical Therapy for Comorbidities in HFpEF Pat NCT03066804 | Novartis Pharmaceuticals | Phase 3 |
| Terminated | Oral Treprostinil in Subjects With Pulmonary Hypertension Associated With Heart Failure With Preserved Ejectio NCT03037580 | United Therapeutics | Phase 3 |
| Completed | Heart Function in Patients Assessed for Sleep Apnoea NCT03226652 | Imperial College London | — |
| Completed | A Study to Evaluate Whether Macitentan is an Effective and Safe Treatment for Patients With Heart Failure With NCT03153111 | Actelion | Phase 2 |
| Withdrawn | Evaluation of Rate Adaptive Pacing on Chronotropic Response in Preserved Ejection Fraction HF NCT03160625 | Medtronic Cardiac Rhythm and Heart Failure | N/A |
| Completed | Biomarkers in HF: Circulating Biomarkers of Fibrosis and Cardiovascular Disease NCT05826821 | Manchester University NHS Foundation Trust | — |
| Unknown | Clinical Significance and Diagnosis of Sarcopenia in Cardiac Patients NCT04175080 | Medical University of Lodz | — |
| Completed | Surgical Resection of the Greater Splanchnic Nerve in Subjects Having Heart Failure With Preserved Ejection Fr NCT03715543 | Noblewell | N/A |
| Completed | Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function NCT05058833 | Samsung Medical Center | — |
| Completed | Clinical Characteristics and Predictors of Adverse Outcomes in HFpEF NCT06228807 | Ya-Wei Xu | — |
| Completed | Optimizing Exercise Training in Prevention and Treatment of Diastolic Heart Failure NCT02078947 | Technical University of Munich | N/A |
| Completed | Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With NCT01920711 | Novartis Pharmaceuticals | Phase 3 |
| Completed | Risk Factors In Heart Failure Patients With Preserved Ejection Fraction NCT06487468 | Xiangtan Central Hospital | — |
| Terminated | Improving Treatment Personalization of Pulmonary Hypertension Associated With Diastolic Heart Failure NCT02053246 | University of Florida | Phase 4 |
| Completed | Acute Effects of Inorganic Nitrite on Cardiovascular Hemodynamics in Heart Failure With Preserved Ejection Fra NCT01932606 | Barry Borlaug | Phase 2 |
| Unknown | Predictors and Outcomes of In-hospital HFpEF in AMI Patients NCT03351179 | Xiangjun Yang | — |
| Completed | LEft Atrial Pacing in Diastolic Heart Failure NCT01618981 | Centre Hospitalier Universitaire Dijon | N/A |
| Completed | Reduced Contractile Reserve: a Therapeutic Target in Heart Failure With Preserved Ejection Fraction(HFpEF) NCT01354613 | University of Wisconsin, Madison | N/A |
| Unknown | The Impact of Exercise Training on Functional Capacity in Heart Failure NCT01288365 | Meir Medical Center | N/A |
| Completed | The Effects of Ranolazine on Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction NCT01505179 | University of California, San Diego | N/A |
| Completed | Physiological Effects of Grape Seed Extract in Diastolic Heart Failure NCT01185067 | University of Michigan | Phase 1 |
| Terminated | Safety and Efficacy Trial to Treat Diastolic Heart Failure Using Ambrisentan NCT00840463 | University of Texas Southwestern Medical Center | Phase 4 |
| Completed | Role of Exercise in Diastolic Heart Failure NCT01047631 | University of Michigan | N/A |
| Completed | Prospective Study of Heart Failure With Preserved Left Ventricular Ejection Fraction NCT01091467 | French Cardiology Society | — |
| Completed | Classification of Heart Failure With Preserved Ejection Fraction NCT01030991 | Northwestern University | — |
| Completed | Ventricular-Vascular Coupling in Heart Failure NCT00207220 | Brigham and Women's Hospital | — |
| Completed | Evaluation of Enalapril Versus Placebo in Patients With Diastolic Heart Failure NCT01411735 | Wake Forest University | Phase 3 |