Trials / Unknown
UnknownNCT05055180
Right Ventricular Function and Pulmonary Hypertension in HFpEF
Afterload Dependence of Right Ventricular Myocardial Remodeling and Intrinsic Right Ventricular Myocardial Function in Heart Failure With Preserved Ejection Fraction
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 45 (estimated)
- Sponsor
- Heart Center Leipzig - University Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
In patients with heart failure and preserved ejection fraction (HFpEF) right ventricular (RV) systolic and diastolic dysfunction are prognostically and functionally relevant factors but have mechanistically been neglected so far. In the present study alterations of intrinsic RV (systolic and diastolic) function, as assessed by invasive pressure volume loops, are examined in relation to tissue alterations on myocardial level and to the degree of RV afterload (pulmonary hypertension). Study aim is to gain insights into mechanisms contributing to the development of RV dysfunction and potentially identify new therapeutic targets.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Invasive hemodynamics and myocardial biopsies | Invasive hemodynamic characterization (biventricular pressure volume loop assessment) and biventricular myocardial biopsies |
Timeline
- Start date
- 2018-10-01
- Primary completion
- 2021-11-30
- Completion
- 2021-12-30
- First posted
- 2021-09-24
- Last updated
- 2021-09-24
Locations
1 site across 1 country: Germany
Source: ClinicalTrials.gov record NCT05055180. Inclusion in this directory is not an endorsement.