NCT00207220

Ventricular-Vascular Coupling in Heart Failure

Ventricular-Vascular Coupling in Patients With Heart Failure and Preserved Ejection Fraction

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 53 (actual)
• Sponsor: Brigham and Women's Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

This study will test the hypothesis that increases in ventricular-vascular stiffness can be demonstrated by arterial tonometry and echocardiography in subjects with heart failure with preserved ejection fraction (HF-nlEF)(i.e. normal left ventricular function.) We will also track changes in pulsatile hemodynamics over time in subjects hospitalized with HF-nlEF.

Detailed description

The pathophysiologic mechanisms responsible for the development of heart failure in people with preserved ejection fraction (i.e. normal left ventricular function) remain poorly understood. One possible mechanism may be the contribution of increased arterial stiffness to changes in pulsatile hemodynamic load during ventricular systole, implicating abnormal ventricular-vascular interactions throughout the cardiac cycle in the pathogenesis of heart failure with normal ejection fraction. To investigate changes in ventricular-vascular stiffness in subjects with heart failure and normal left ventricular function, comparisons will be made between 3 distinct sub-populations: * subjects with heart failure and normal ejection fraction * non-diabetic hypertensive controls * normotensive controls

Conditions

• Heart Failure With Preserved Ejection Fraction

Interventions

Type	Name	Description
PROCEDURE	arterial tonometry	used to determine peripheral arterial vascular tone by measuring blood pressure waveforms via a probe attached to the finger.
PROCEDURE	echocardiography	ultrasound test using sound waves to create a moving picture of the heart

Timeline

• Start date: 2004-01-01
• Completion: 2007-01-01
• First posted: 2005-09-21
• Last updated: 2007-11-09

Locations

1 site across 1 country: United States