Trials / Completed

CompletedNCT04820556

Gut Microbiota in Chronic Noncommunicable Diseases

The Development of Preventive Methods for Chronic Noncommunicable Diseases Based on Modulation of Gut Microbiota Composition and Function

Status: Completed
Phase: —
Study type: Observational
Enrollment: 1,084 (actual)

Sponsor: National Medical Research Center for Therapy and Preventive Medicine · Other Government
Sex: All
Age: 18 Years – 79 Years
Healthy volunteers: Not accepted

Summary

It is an observational study in patients with chronic noncommunicable diseases (i.e. cardiovascular diseases, diabetes mellitus, non-alcoholic fatty liver disease, chronic obstructive pulmonary disease and asthma ) and control group with no signs of these conditions. The study has a prospective part planned for 2021 and a retrospective part which includes the patients enrolled between 2018-2020. The aim of the study is to investigate gut microbiota composition, its metabolites, levels of inflammatory and other markers of the disease in prospective groups (arterial hypertension, type 2 diabetes mellitus, chronic obstructive pulmonary disease, asthma, non-alcoholic fatty liver disease and control patients) as well as in retrospective groups (chronic heart failure with preserved and reduced ejection fraction, obstructive atherosclerosis of any vascular bed, arterial hypertension, type 2 diabetes mellitus, chronic obstructive pulmonary disease, asthma, non-alcoholic fatty liver disease, and control patients). Also we are planning to investigate the association between gut microbiota composition and its metabolites, levels of inflammatory and other markers of the disease in retrospective and prospective groups.

Conditions

Timeline

Start date: 2021-04-12
Primary completion: 2021-12-01
Completion: 2021-12-01
First posted: 2021-03-29
Last updated: 2022-04-19

Locations

2 sites across 1 country: Russia

Source: ClinicalTrials.gov record NCT04820556. Inclusion in this directory is not an endorsement.