| Not Yet Recruiting | PCI With Guideline-Directed Medical Therapy for HFpEF Patients With Ischemic Cardiomyopathy NCT07349979 | Nanjing First Hospital, Nanjing Medical University | N/A |
| Recruiting | Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure NCT06552637 | VisCardia Inc. | N/A |
| Recruiting | Mechanistic Clinical Trial Comparing the Pharmacokinetics/Pharmacodynamics of Metoprolol in Heart Failure With NCT07490067 | University of Michigan | Phase 4 |
| Not Yet Recruiting | A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evalu NCT07214376 | Pulnovo Medical, Inc. | N/A |
| Recruiting | A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction NCT07465653 | Novartis Pharmaceuticals | Phase 1 |
| Active Not Recruiting | A Real-world Study of Clinical Treatment Guidelines for Patients With Heart Failure With Reduced Ejection Frac NCT07465679 | Novartis Pharmaceuticals | — |
| Not Yet Recruiting | Digital Remote Management for Care and Continuous Optimization Versus Usual Care to Improve Prognosis in Patie NCT07352891 | Chang sheng Ma | N/A |
| Recruiting | Digital Support Program for Patients With Heart Failure - a Cluster-Randomized Hybrid Type 2 Study NCT07275931 | Linkoeping University | N/A |
| Not Yet Recruiting | Optimising Pacing Therapy, Integrated Medical Therapy, and Catheter AbLation for Atrial Fibrillation in Heart NCT07238452 | University of British Columbia | Phase 4 |
| Withdrawn | Evaluation of the HekaHeart Platform in Medication Management for Heart Failure Patients NCT06433687 | Yale University | — |
| Recruiting | A Study Investigating the Impact of IMT With CR On Exercise Responses In HF NCT07086131 | Mayo Clinic | N/A |
| Completed | Pulsed Field or Cryoballoon Pulmonary Vein Isolation for Atrial Fibrillation in Heart Failure NCT07181291 | St. Josefs-Hospital Wiesbaden GmbH | — |
| Recruiting | Digital Solutions in Heart Therapy (DIGNITY) NCT06942221 | University Hospital, Basel, Switzerland | N/A |
| Recruiting | Deep Learning Detection of Pulmonary Hypertension and Low Ejection Fraction Via Digital Stethoscope and 3-Lead NCT07087613 | Eko Devices, Inc. | — |
| Recruiting | An Early Feasibility Study Evaluation of an Implant Free Interatrial Shunt to Improve Heart Failure NCT06859970 | InterShunt Technologies, Inc. | N/A |
| Completed | EHR Nudges to Improve Quality of Care in HF NCT06103565 | Northwestern University | N/A |
| Not Yet Recruiting | Neuromuscular Fatigability in Individuals With Heart Failure NCT06551012 | Newcastle University | N/A |
| Enrolling By Invitation | Whole Heart Radiotherapy for End-stage Heart Failure NCT06299176 | McGill University Health Centre/Research Institute of the McGill University Health Centre | Phase 1 |
| Recruiting | Study Assessing Left Ventricular Administration of a Genetic Medicine Directing Organ Regeneration in Heart Fa NCT06831825 | YAP Therapeutics, Inc. | Phase 1 |
| Recruiting | Efficacy of Remote Monitoring of Patients With Heart Failure and Reduced Ejection Fraction by Using Caaring® S NCT06920160 | Persei Vivarium | N/A |
| Recruiting | Implementation and Interaction of Clinician And Patient-facing Tools Aiming to Intensify Neurohormonal Medicin NCT06526988 | University of Colorado, Denver | N/A |
| Recruiting | Comparative Effectiveness of Prophylactic ICD Versus Non-ICD Therapy NCT06543446 | University of Rochester | N/A |
| Completed | Heart Failure With Reduced Ejection Fraction Polypill Implementation Strategy in Sri Lanka NCT06831864 | Washington University School of Medicine | Phase 1 |
| Recruiting | Withdrawal of Treatment for Heart Failure Patients With Recovery From Tachycardia-induced Cardiomyopathy NCT06128980 | Herlev and Gentofte Hospital | Phase 2 / Phase 3 |
| Recruiting | Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fract NCT06736574 | Cytokinetics | Phase 3 |
| Enrolling By Invitation | Subspecialty Ambulatory Quality Cardiology Program NCT07283666 | NYU Langone Health | — |
| Recruiting | The CardioClip Study NCT06241430 | Columbia University | N/A |
| Recruiting | Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure NCT06299436 | Johns Hopkins University | — |
| Recruiting | Respiratory Sinus Arrhythmia (RSA) Pacing Post-CABG Surgery in Patients With HFrEF NCT06359938 | Ceryx Medical Ltd | N/A |
| Recruiting | Vsling™ I: Clinical Evaluation of the Vsling™ Device for Ventricular Repair in Patients With Heart Failure NCT06851949 | Cardiac Success | Phase 2 |
| Recruiting | Feasibility and Effectiveness of Eccentric Exercise in Sarcopenic Older Adults with Heart Failure: a Pilot Stu NCT06826963 | Universita di Verona | N/A |
| Not Yet Recruiting | VITAL - the Heart Failure With Reduced Ejection Fraction Sub-study NCT06534151 | University College, London | — |
| Recruiting | Respiratory Sinus Arrhythmia Pacing Post-CABG Surgery in Patients With HFrEF NCT06384963 | Ceryx Medical Australia | N/A |
| Recruiting | Home-Based Cardiac Rehabilitation for Patients With Heart Failure NCT06479876 | Vanderbilt University Medical Center | N/A |
| Not Yet Recruiting | Feasibility Study to Support Cardiorenal Function in Acute Decompensated Heart Failure With Diuretic Resistanc NCT06174623 | Puzzle Medical Devices Inc. | N/A |
| Not Yet Recruiting | Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension NCT06405555 | Ottawa Heart Institute Research Corporation | Phase 2 / Phase 3 |
| Not Yet Recruiting | Pumps for Kids, Infants and Neonates (PumpKIN): The Jarvik 2015 Pivotal Trial NCT06348043 | Stanford University | N/A |
| Not Yet Recruiting | PhotobiomoduLation for pAtientS With Advanced hEart failuRe NCT06501313 | Semmelweis University Heart and Vascular Center | N/A |
| Not Yet Recruiting | Efficacy and Safety of Lactoferrin in Heart Failure Patients NCT06427200 | Cairo University | Phase 4 |
| Active Not Recruiting | Novel Respiratory Training as Part of Palliative Care for Older Adults With Heart Failure NCT06576297 | University of Pittsburgh | N/A |
| Recruiting | Mobile Applet for Weight Management in Obese Heart Failure Patients NCT06455878 | Heart Health Research Center | N/A |
| Active Not Recruiting | Left Bundle Branch Area Pacing in Patients With Heart Failure NCT06488989 | National Research Center for Cardiac Surgery, Kazakhstan | N/A |
| Not Yet Recruiting | SGLT-2 Inhibitor and High-Dose Furosemide Plus Small-Volume Hypertonic Saline Solution in Acute HF NCT06442280 | University of Palermo | Phase 4 |
| Recruiting | Colchicine in Acutely Decompensated HFREF NCT06286423 | University of Virginia | Phase 4 |
| Recruiting | PRagmatic Study Of Messaging to Providers of Patients With Heart Failure in Amsterdam UMC NCT06344910 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | — |
| Recruiting | Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart Failure NCT06423599 | Jens D Hove, MD,PHD | Phase 2 / Phase 3 |
| Not Yet Recruiting | TRAnscutaneous vaGUS Nerve Stimulation in Patients With Chronic Heart Failure NCT06355388 | Fondazione Toscana Gabriele Monasterio | N/A |
| Recruiting | Prediction of Heart-Failure with Machine Learning NCT06819618 | University Medical Center Goettingen | — |
| Recruiting | Study of JK07 in Patients With Chronic Heart Failure NCT06369298 | Salubris Biotherapeutics Inc | Phase 2 |
| Recruiting | Empagliflozin in Heart Failure with Reduced Ejection Fraction and End Stage Renal Disease NCT06249932 | National Taiwan University Hospital | Phase 4 |
| Enrolling By Invitation | Ketones in Heart Failure With Reduced Ejection Fraction NCT06195982 | Duke University | Phase 2 |
| Not Yet Recruiting | Determination of Drug Levels for Pharmacotherapy of Heart Failure NCT06035978 | University Hospital Ostrava | Phase 4 |
| Completed | Heart Failure Polypill at a Safety Net Hospital NCT06029712 | University of California, San Francisco | Phase 2 |
| Unknown | Renal-based Optimization of QUADruple Therapy in Patients With Heart Failure With Reduced Ejection Fraction. NCT06273280 | Ziekenhuis Oost-Limburg | N/A |
| Completed | A Study to Assess Safety & Effectiveness of Tovinontrine in Chronic Heart Failure With Reduced Ejection Fracti NCT06215911 | Cardurion Pharmaceuticals, Inc. | Phase 2 |
| Completed | Effect of Vericiguat on Acute Coronary Syndrome( ACS）Patients With Ejection Fraction <45% NCT06321094 | The First Affiliated Hospital with Nanjing Medical University | — |
| Recruiting | Ketones, SGLT2, HFrEF NCT06229678 | The University of Texas Health Science Center at San Antonio | EARLY_Phase 1 |
| Recruiting | Pulmonary Artery Catheterization and Carvedilol Early Initiation in Cardiogenic SHOCK Due to HFrEF NCT06078436 | Min-Seok Kim | N/A |
| Recruiting | Improving CRT Outcome With Non-Invasive Cardiac Mapping NCT05564793 | EP Solutions SA | N/A |
| Recruiting | Exercise Capacity Improvement by Conduction System Pacing in heArt Failure patieNts Without Compelling CRT inD NCT06278844 | University Hospital, Antwerp | N/A |
| Recruiting | The Sarcopenia Study NCT05888688 | University of Leicester | — |
| Unknown | Pacertool Early Feasibility Study - Safety and Performance NCT06103539 | Pacertool AS | — |
| Completed | Effects of 2-week Ketosis on the Heart's Ketone Body Consumption, Utilization, and Energetic Efficiency in Pat NCT06398964 | Aarhus University Hospital | N/A |
| Recruiting | Conduction System Vs Surgical Left Ventricular Epicardial Pacing For Coronary Sinus Lead Failure NCT06342492 | Kansas City Heart Rhythm Research Foundation | — |
| Active Not Recruiting | Triple Cardiovascular Disease Detection With an Artificial Intelligence-enabled Stethoscope NCT05987670 | Imperial College London | N/A |
| Completed | Gender-Based Differences in Heart Failure Hospitalizations Among Patients With Heart Failure Treated With Spir NCT06641284 | Ahmad Abdullah Salawi | — |
| Recruiting | Left vs Left Randomized Clinical Trial NCT05650658 | Baylor College of Medicine | N/A |
| Completed | Iron Deficiency in Patients With Heart Failure and Reduced and Mildly Reduced Ejection Fraction NCT05992116 | Jordan Collaborating Cardiology Group | — |
| Completed | A Study to Assess the Effect of Danicamtiv on the Drug Levels of Midazolam in Participants With Stable Heart F NCT05952089 | Bristol-Myers Squibb | Phase 1 |
| Recruiting | A Trial to Evaluate the Safety and Efficacy of Pulmonary Artery Denervation for the Treatment of Pulmonary Hyp NCT05824923 | Pulnovo Medical (Wuxi) Co., Ltd. | Phase 3 |
| Completed | Initiation of ARNi and SGLT2i in Patients With HFrEF NCT05989503 | Universidade do Porto | Phase 4 |
| Recruiting | Demographic, Clinical, Biological, Treatment Characteristics and Cardiovascular Events of Patients With Heart NCT06516562 | University Medical Center Ho Chi Minh City (UMC) | — |
| Unknown | Efficacy and Safety of Finerenone in Heart Failure With Reduced Ejection Fraction NCT05974566 | Chongqing Medical University | — |
| Completed | Evaluating Strategies to Improve Guideline Directed Medical Therapy: The GDMT Research, Education & Assist Tri NCT05990296 | Geisinger Clinic | N/A |
| Unknown | The Effects of Ferric Derisomaltose in Patients With Acute Heart Failure and Iron Deficiency on Exercise Capac NCT05971732 | China-Japan Friendship Hospital | Phase 4 |
| Unknown | Interest of Levosimendan Preconditioning for Cardiac Surgery Under CEC in Heart Failure Patients With Impaired NCT06021587 | Central Hospital, Nancy, France | — |
| Recruiting | Revascularization Versus Medical Treatment in Patients With Ischemic Left Ventricular Dysfunction NCT05828719 | Samsung Medical Center | N/A |
| Completed | Uncertainty in HFrEF Patients NCT05632198 | Abant Izzet Baysal University | — |
| Completed | Ketone Pharmacokinetic Study in HFrEF NCT05757193 | Duke University | Phase 1 |
| Unknown | Comparison Between Endogenous and Exogenous Ketosis in Patients With Non-ischemic Chronic Heart Failure With R NCT04921293 | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | N/A |
| Recruiting | Treatment of Non-ischemic Cardiomyopathies by Intravenous Extracellular Vesicles of Cardiovascular Progenitor NCT05774509 | Assistance Publique - Hôpitaux de Paris | Phase 1 |
| Recruiting | The Effect of Obesity and Weight Loss in Heart Failure With Reduced Ejection Fraction. NCT05942287 | University of Oxford | N/A |
| Active Not Recruiting | Assessment of Combined CCM and ICD Device in HFrEF NCT05855135 | Impulse Dynamics | N/A |
| Completed | Efficacy of AI EF Screening by Using Smartphone Application Recorded PLAX View Cardiac Ultrasound Video Clips NCT06330103 | Rayong Hospital | N/A |
| Withdrawn | Evaluation of Left Bundle Branch Area Pacing As A Rescue Strategy for Cardiac Resynchronization Therapy Non-Re NCT05884411 | VA Office of Research and Development | N/A |
| Recruiting | PRIME HFrEF: Novel Exercise for Older Patients With Heart Failure With Reduced Ejection Fraction NCT05609097 | University of Virginia | N/A |
| Withdrawn | Email Nudges to Improve GDMT (MRA) Adherence in Heart Failure NCT05806970 | University of California, Los Angeles | N/A |
| Unknown | ERTU-SODIUM: Study on the Effects of Ertugliflozin on Sodium Storage, Interstitial Volume, and Plasma Volume i NCT05152940 | Icahn School of Medicine at Mount Sinai | Phase 4 |
| Unknown | Consistently Assess Signs and Symptom of Heart Failure NCT05833581 | Board of Trustees of Illinois State University | N/A |
| Active Not Recruiting | PHARM Optimal-HF Pilot NCT05623358 | University of British Columbia | N/A |
| Terminated | SGLT2 Inhibitors and Treatment of Heart Failure in Severe Renal Insufficiency NCT05737186 | Peking University People's Hospital | Phase 4 |
| Unknown | Screening for Advanced Heart Failure IN Stable outPatientS - The SAINTS Study (SAINTS B) NCT05284955 | Finn Gustafsson | Phase 4 |
| Completed | Phase Ib/IIa Trial With AC01 in Patients With HFrEF NCT05642507 | AnaCardio AB | Phase 1 / Phase 2 |
| Recruiting | Pilot Study Lp299v Supplementation in Chronic Heart Failure NCT05752760 | Medical College of Wisconsin | N/A |
| Unknown | " Evaluation of Safety and Efficacy of Empagliflozin and Sacubitril/Valsartan for CHF With Reduced Ejection Fr NCT05580510 | Instituto Nacional de Cardiologia Ignacio Chavez | Phase 2 / Phase 3 |
| Completed | Strategy, Efficacy and Safety of Medication Usage in Heart Failure Patients Who Were Intolerable to GDMT NCT05799638 | Chongqing Medical University | — |
| Unknown | Effect of Empagliflozin on NT-Pro Brain Natriuretic Peptide in Heart Failure Patients With Reduced Ejection Fr NCT05778084 | Alexandria University | Phase 4 |
| Terminated | Improving Knowledge in Heart Failure Inpatient With Therapeutic Education NCT05751772 | University Hospital, Geneva | N/A |
| Completed | Virtual Care to Improve Heart Failure Outcomes (VITAL-HF) NCT05602454 | Duke University | N/A |
| Unknown | Pulmonary Artery Pressure and Right Heart Evaluation for Patients Requiring Physiological Pacing Treatment NCT05575557 | Shanghai 10th People's Hospital | N/A |
| Unknown | Screening for Advanced Heart Failure IN Stable ouTpatientS - The SAINTS Study NCT05299879 | Rigshospitalet, Denmark | — |
| Active Not Recruiting | Telemonitored Fast Track Medical Sequencing for Heart Failure With Reduced Ejection Fraction NCT05637853 | Göteborg University | Phase 4 |
| Completed | Gender-based Differences in the Outcome of Treatment With Aldosterone Antagonists in Patients With Heart Failu NCT06233695 | Alexandria University | — |
| Completed | HF Patients With LVADs Being Treated With SGLT2i NCT05278962 | University of Chicago | Phase 4 |
| Active Not Recruiting | Left Bundle Branch Area Pacing Using Conventional Stylet-driven Pacemaker Leads for Cardiac Resynchronization NCT05365568 | AZ Sint-Jan AV | N/A |
| Completed | RECOVER-HF Pilot Study of SDS in Heart Failure NCT05592392 | VisCardia Inc. | N/A |
| Completed | Efficacy of a Streamlined Heart Failure Optimization Protocol NCT05021419 | The Queen Elizabeth Hospital King's Lynn NHS Foundation Trust | N/A |
| Completed | Heart Failure Therapy and Outcomes in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fr NCT06671314 | Novartis | — |
| Active Not Recruiting | Administration of the SGLT-2 Inhibitor Dapagliflozin in the Patients With Amyloid Cardiomyopathy NCT05795400 | National Medical Research Center for Cardiology, Ministry of Health of Russian Federation | N/A |
| Terminated | Effectiveness of CRD-740 in Heart Failure NCT05409183 | Cardurion Pharmaceuticals, Inc. | Phase 2 |
| Unknown | Effects of Dapagliflozin on Cardiorespiratory Parameters in Heart Failure NCT05770167 | Centro Cardiologico Monzino | — |
| Completed | Building Electronic Tools To Enhance and Reinforce CArdiovascular REcommendations - Heart Failure (BETTER CARE NCT05275920 | NYU Langone Health | N/A |
| Completed | Deformation Imaging by Strain in Chronic Heart Failure Over Gliflozins: an Echocardiographic Register on Sodiu NCT05344963 | Matteo Cameli | — |
| Completed | Effects of a Single Oral Dose of KETone Ester ON Exercise Performance in Patients With Chronic Heart Failure NCT05348460 | University Medical Center Groningen | N/A |
| Completed | The Effect of Oxygen Supplementation in Training in Heart Failure Patients on Aerobic Performance and Quality NCT06481657 | Laniado Hospital | N/A |
| Unknown | Lokelma for RAAS Maximisation in CKD & Heart Failure. NCT05004363 | St George's, University of London | Phase 3 |
| Completed | Endothelial Function in Mechanical Circulatory Support NCT04539093 | Medical College of Wisconsin | — |
| Terminated | Levosimendan In Ambulatory Heart Failure Patients NCT04705337 | Medical University of Bialystok | Phase 4 |
| Completed | Exploration of Clonal Hematopoiesis of Indeterminate Potential in Non-ischemic Heart Failure With Reduced Ejec NCT05981144 | Yonsei University | — |
| Completed | Pragmatic Trial Of Alerts for Use of Mineralocorticoid Receptor Antagonists NCT04903717 | Yale University | N/A |
| Completed | Dashboard Activated Services and Tele-Health for Heart Failure NCT05001165 | VA Greater Los Angeles Healthcare System | N/A |
| Completed | Building Electronic Tools To Enhance and Reinforce Cardiovascular Recommendations - Heart Failure NCT05077293 | NYU Langone Health | — |
| Completed | Benefits of Empagliflozin in Patients With Heart Failure and Reduced Ejection Fraction Without Diabetes Mellit NCT06632561 | Ashraf Wasfy Beshay Aziz | Phase 4 |
| Completed | Hyperkalaemia and Its Impact on Therapy with RAASi NCT04249648 | Portsmouth Hospitals NHS Trust | — |
| Terminated | Ertugliflozin to Reduce Arrhythmic Burden in ICD/CRT patientS (ERASe-Trial) - a Phase III Study NCT04600921 | Medical University of Graz | Phase 3 |
| Completed | The ENVI Study: Effect of Entresto on Left Ventricular Remodelling on Cardiac MRI NCT05348226 | University Hospital Southampton NHS Foundation Trust | — |
| Completed | Gut Microbiota in Chronic Noncommunicable Diseases NCT04820556 | National Medical Research Center for Therapy and Preventive Medicine | — |
| Completed | Study to Assess Efficacy and Safety of SZC for the Management of High Potassium in Patients With Symptomatic H NCT04676646 | AstraZeneca | Phase 4 |
| Withdrawn | Wearable Remote Monitoring of Heart Rate and Respiratory Rate for Heart Failure NCT04455828 | Milton S. Hershey Medical Center | — |
| Completed | Telmisartan Versus Enalapril in Heart Failure With Reduced Ejection Fraction Patients With Moderately Impaired NCT04736329 | Cairo University | N/A |
| Completed | Pragmatic Trial of Messaging to Providers About Treatment of Heart Failure NCT04514458 | Yale University | N/A |
| Unknown | The Effect of Combined Upper and Lower Extremity Endurance Training in Patients With ICD NCT04803968 | Hitit University | N/A |
| Withdrawn | Effects of Iron Therapy and Exercise Training in Patients With Heart Failure and Iron Deficiency NCT03803111 | Herzzentrum Bremen | N/A |
| Unknown | Safety of HMA-CD20 in Patients With HFrEF NCT03332888 | Instituto de Cardiología y Medicina Vascular Hospital Zambrano-Hellion Tec Salud | Phase 2 |
| Completed | Sodium-Glucose Cotransporter 2 Inhibitor Use in a National Heart Failure Telemonitoring Program NCT07022379 | Satelia | — |
| Unknown | Resistance Training in Cardiovascular Disease Patients NCT04638764 | General Hospital Murska Sobota | N/A |
| Unknown | Daily Ambulatory Remote Monitoring System For Post-Dischage Management Of ADHF NCT03072693 | The University of Hong Kong | N/A |
| Recruiting | Effect of the MobiusHD® in Patients With Heart Failure NCT04590001 | Vascular Dynamics, Inc. | N/A |
| Completed | Study of JK07 in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF) NCT04210375 | Salubris Biotherapeutics Inc | Phase 1 |
| Unknown | Effects of Preferential Left Ventricular Pacing on Ventriculoarterial Coupling and Clinical Course of Heart Fa NCT04420065 | National and Kapodistrian University of Athens | N/A |
| Unknown | Follow Up of acuTe Heart failUre: a pRospective Echocardiographic and Clinical Study (FUTURE) NCT05204238 | University of Siena | — |
| Completed | Hemodynamic Effects of ARNI on Noninvasive Pressure-volume Analysis in Patients With Chronic Heart Failure NCT04498780 | University of Leipzig | — |
| Terminated | Cryoballoon Ablation Versus Medical Therapy in Patients With Heart Failure and Atrial Fibrillation NCT04342832 | Maastricht University | N/A |
| Unknown | Optimize Heart Failure Care During TRANSitional Period in Patients With Acute Heart Failure. NCT04900584 | Wonju Severance Christian Hospital | N/A |
| Completed | Balance, Aerobic Capacity, Mobility and Strength in Patients Hospitalized for Heart Failure (BAMS-HF) Program NCT04281849 | VA Eastern Colorado Health Care System | N/A |
| Completed | AF Ablation for HF With Reduced EF NCT05827172 | Shanghai Chest Hospital | N/A |
| Unknown | The Effects of SGLTi on Diabetic Cardiomyopathy NCT04200586 | The University of Hong Kong | Phase 4 |
| Completed | Electronic S3 Prediction of Hospital Readmissions for HF Exacerbation NCT04112849 | Milton S. Hershey Medical Center | — |
| Terminated | Neuromodulation of Inflammation and Vascular Function in Systolic Heart Failure NCT03945058 | University of Oklahoma | N/A |
| Unknown | Heart Failure in Norway: Clinical Characteristics, Mortality and Health Care Resource Use NCT04398563 | University Hospital, Akershus | — |
| Unknown | A Virtual Heart Failure Optimization Program for Guideline Directed Medical Therapy and Cardiac Rehabilitation NCT05689086 | Cambridge Cardiac Care Centre | — |
| Unknown | Comparison of Effects of Atorvastatin Versus Rosuvastatin on Cardiac Function in Heart Failure Patients NCT05072054 | Post Graduate Institute of Medical Education and Research, Chandigarh | Phase 4 |
| Recruiting | Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System NCT04237701 | Yale University | — |
| Unknown | Iron Intravenous Therapy in Reducing the Burden of Severe Arrhythmias in Heart Failure With Reduced Ejection F NCT04974021 | Aristotle University Of Thessaloniki | — |
| Completed | Short-term Effects of Dapagliflozin on Peak VO2 in HFrEF NCT04197635 | Fundación para la Investigación del Hospital Clínico de Valencia | Phase 4 |
| Completed | Spanish Study of Hyperkalaemia Incidence and Prognosis in Patients With Heart Failure and Reduced Ejection Fra NCT04141800 | Spanish Society of Cardiology | — |
| Completed | Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure NCT03759392 | Cytokinetics | Phase 3 |
| Unknown | Finding Gab in the Treatment of Heart Failure in Assiut University Hospital NCT03877887 | Assiut University | — |
| Unknown | CMR Assessment of Cardiac Microvascular Dysfunction in Patients With HFpEF NCT06316661 | Istituto Auxologico Italiano | — |
| Completed | Neuregulin-1 in Patient With Different Forms of Cardiovascular Diseases: a Pilot Study NCT04391491 | I.M. Sechenov First Moscow State Medical University | — |
| Completed | EVOlocumab in Stable Heart Failure With Reduced Ejection Fraction of Ischemic Etiology: EVO-HF Pilot NCT03791593 | Fundació Institut Germans Trias i Pujol | Phase 2 |
| Unknown | Effect of Melatonin on Cardiovascular and Muscle Mass and Function in Patients With Heart Failure NCT03894683 | Isfahan University of Medical Sciences | Phase 2 |
| Unknown | First in Humans to Evaluate Collagen Patches With Stem Cells in Patients With Ischemic Left Ventricular Dysfun NCT03746938 | Viscofan | Phase 1 |
| Terminated | Home Outpatient Monitoring and Engagement to Predict HF Exacerbation NCT03479424 | University of California, San Francisco | — |
| Unknown | Early Use of Ivabradine in Heart Failure NCT03701880 | Ain Shams University | N/A |
| Completed | Direct HIS-pacing as an Alternative to BiV-pacing in Symptomatic HFrEF Patients With True LBBB NCT03614169 | Rigshospitalet, Denmark | N/A |
| Enrolling By Invitation | Gut Microbiome Profiling in Patients With Chronic Heart Failure NCT06361524 | Stanford University | — |
| Unknown | Transcatheter Aortic Valve Replacement With Extracorporeal Life System Support NCT04160624 | Xijing Hospital | N/A |
| Unknown | Assessment of Biomarkers in Patients With Decompensated Heart Failure and Underlying Coronary Artery Disease NCT03551756 | CirQuest Labs, LLC | — |
| Withdrawn | Influence of Right Ventricular Function on Changes in Exercise Capacity After LVAD NCT05916612 | Henry Ford Health System | — |
| Terminated | Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic NCT03574857 | University of Virginia | Phase 4 |
| Completed | Exercise and NO in HFrEF NCT03136029 | VA Office of Research and Development | EARLY_Phase 1 |
| Completed | Six Months Clinical and Echocardiographic Outcome of ARNI LCZ696 Therapy in HFrEF Patients NCT03816306 | Mohammed Alnims | — |
| Completed | UTSW HP [13-C] Pyruvate Injection in HCM NCT03057002 | University of Texas Southwestern Medical Center | — |
| Completed | Thiamine Supplementation in Heart Failure: a Pilot Randomized Controlled Crossover Trial NCT03228030 | Hamilton Health Sciences Corporation | Phase 1 |
| Completed | Hemodynamic-GUIDEd Management of Heart Failure NCT03387813 | Abbott Medical Devices | N/A |
| Unknown | Changes in Intrathoracic Impedance During Sacubitril/Valsartan Treatment NCT03359967 | Central Hospital, Izmir | — |
| Completed | v4 Study Evaluating the Safety, Tolerability and Preliminary Pharmacokinetics and Pharmacodynamics of MYK-491 NCT03447990 | Bristol-Myers Squibb | Phase 1 / Phase 2 |
| Terminated | Bifocal Right Ventricular PAcing in Right Bundle Branch blocK and Heart Failure With Reduced Ejection Fraction NCT03524001 | Azienda Ospedaliero Universitaria Maggiore della Carita | N/A |
| Unknown | Supplementation With Vitamin D to Patients With Heart Failure (D-Heart). NCT03289637 | Linkoeping University | N/A |
| Completed | Electronic Health Record-leveraged, Patient-centered, Intensification of Chronic Care for HF NCT03334188 | University of Colorado, Denver | N/A |
| Completed | Effect of Transcutaneous Vagal Stimulation (TVS) on Endothelial Function and Arterial Stiffness in HFrEF NCT03380156 | University of Oklahoma | N/A |
| Unknown | Bisoprolol Plasma Residual Concentrations in Chronic Heart Failure NCT03644446 | University Hospital, Caen | — |
| Unknown | Safety and Efficacy of High Protein Diet Versus GFR Based Protein Diet in Heart Failure Patients With Renal In NCT03213821 | Rajaie Cardiovascular Medical and Research Center | N/A |
| Completed | Validation of Two Wrist-worn Devices for the Assessment of Energy Expenditure in Cardiac Patients. NCT03951740 | Maxima Medical Center | N/A |
| Unknown | A Pivotal Trial to Establish the Efficacy and Safety of Algisyl in Patients With Moderate to Severe Heart Fail NCT03082508 | LoneStar Heart, Inc. | N/A |
| Withdrawn | Cardiopulmonary Interactions in Patients With Heart Failure NCT03317314 | Hannover Medical School | — |
| Completed | Empagliflozin in Heart Failure Patients With Reduced Ejection Fraction NCT03198585 | Morten Schou | Phase 2 |
| Withdrawn | Comparing ARNI With ACE Inhibitor on Endothelial Function NCT03119623 | Brigham and Women's Hospital | Phase 4 |
| Completed | LYmphangiogenesis FacTors in Heart Failure States NCT03141567 | Medical University of South Carolina | — |
| Unknown | Hyperemic Efficacy of IV Adenosine in HFrEF NCT03235700 | Sejong General Hospital | N/A |
| Unknown | Improving the Criteria for Selecting Patients for Primary Prevention of Sudden Cardiac Death by Arrhythmic Ris NCT05539898 | Astrakhan Federal Centre For Cardiac Surgery | N/A |
| Unknown | Immediate Release Versus Slow Release Carvedilol in Heart Failure NCT03209180 | Seoul National University Bundang Hospital | Phase 4 |
| Active Not Recruiting | Circulating RNAs in Acute Congestive Heart Failure NCT03345446 | Massachusetts General Hospital | — |
| Unknown | Multi-centre Observational Registry on Patients With Implantable Devices Remotely Monitored NCT03061747 | Azienda Ospedaliera Cardinale G. Panico | — |
| Completed | Safety, PK, and Efficacy of Omecamtiv Mecarbil in Japanese Subjects With Heart Failure With Reduced Ejection F NCT02695420 | Cytokinetics | Phase 2 |
| Recruiting | Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure NCT03480633 | Massachusetts General Hospital | — |
| Completed | Comparison of Pre- and Post-discharge Initiation of LCZ696 Therapy in HFrEF Patients After an Acute Decompensa NCT02661217 | Novartis Pharmaceuticals | Phase 4 |
| Completed | Effect of Home Rehabilitation on State of Patients With PAH, HFREF and IHD NCT03780803 | Medical University of Bialystok | N/A |
| Completed | Factors Associated With Sub - Targeted Therapeutic Dose Of Renin - Angiotensin Blockage Among Chronic Heart Fa NCT06382571 | Chulalongkorn University | — |
| Completed | A Single-centre Research Study to Evaluate the Care4Today® Heart Failure Platform. NCT04371731 | Buckinghamshire Healthcare NHS Trust | N/A |
| Unknown | WHISH-2-Prevent Heart Failure NCT03099889 | Memorial Hospital of Rhode Island | N/A |
| Completed | CRTd Responders Optimization NCT04547244 | University of Campania Luigi Vanvitelli | — |
| Completed | VAgal Nerve Stimulation: safeGUARDing Heart Failure Patients NCT02113033 | LivaNova | Phase 2 |
| Completed | AI-ECG for Time-Resolved Prediction of HFrEF NCT07519434 | Shanghai Zhongshan Hospital | — |
| Completed | Safety and Tolerability of Initiating LCZ696 in Heart Failure Patients NCT01922089 | Novartis Pharmaceuticals | Phase 2 |
| Completed | Thoracic Epidural Anesthesia Reduces Mortality and Rehospitalization for Patients With Heart Failure With Redu NCT06068166 | First Affiliated Hospital of Harbin Medical University | N/A |
| Terminated | This Study Will Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of NCT01035255 | Novartis Pharmaceuticals | Phase 3 |
| Completed | CPET Predicts Long-term Survival and Positive Response to CRT NCT03870074 | National Institute of Cardiology, Warsaw, Poland | — |