Trials / Terminated
TerminatedNCT03574857
Prospective Comparison of Metolazone Versus Chlorothiazide for Acute Decompensated Heart Failure With Diuretic Resistance
- Status
- Terminated
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 5 (actual)
- Sponsor
- University of Virginia · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The primary objective of the study is to compare efficacy of metolazone and chlorothiazide as add-on therapy in patients refractory to loop diuretics with heart failure with a reduced ejection fraction (HFrEF). This will be a single-center randomized pilot study.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Metolazone Oral Tablet | Day 1: Metolazone 5 mg PO Day 2: Metolazone 5 mg PO |
| DRUG | Chlorothiazide Injection | Day 1: Chlorothiazide 500 mg IV Day 2: Chlorothiazide 500 mg IV |
Timeline
- Start date
- 2018-06-01
- Primary completion
- 2021-01-01
- Completion
- 2021-01-01
- First posted
- 2018-07-02
- Last updated
- 2021-02-16
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated drug study
Source: ClinicalTrials.gov record NCT03574857. Inclusion in this directory is not an endorsement.